Linshang Chemical
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1-(Chloromethyl)-3-Fluorobenzene
Linshang Chemical
|
HS Code |
381526 |
| Chemical Formula | C7H6ClF |
| Molar Mass | 144.57 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 177 - 179 °C |
| Density | 1.215 g/cm³ |
| Solubility In Water | Insoluble |
| Flash Point | 63 °C |
| Refractive Index | 1.504 |
As an accredited 1-(Chloromethyl)-3-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(chloromethyl)-3-fluorobenzene in a sealed, corrosion - resistant bottle. |
| Storage | 1-(Chloromethyl)-3-fluorobenzene should be stored in a cool, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container to prevent leakage. Since it is a chemical, store it separately from oxidizing agents, bases, and foodstuffs. Ensure the storage facility has proper spill - containment measures. |
| Shipping | 1-(Chloromethyl)-3-fluorobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict chemical transportation regulations, ensuring proper handling to prevent spills and maintain safety during transit. |
Competitive 1-(Chloromethyl)-3-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 1-(Chloromethyl)-3-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1- (chloromethyl) -3-fluorobenzene?
1- (cyanomethyl) -3 -cyanopyridine, although this substance is not explicitly recorded in Tiangongkai, it has a wide range of uses in today's chemical industry.
In the field of organic synthesis, 1- (cyanomethyl) -3 -cyanopyridine is an important intermediate. Nitrile groups are highly reactive and can be converted into other functional groups through various chemical reactions. For example, carboxyl groups can be obtained by hydrolysis of nitrile groups, whereby carboxyl-containing compounds can be prepared for the synthesis of special-structured organic carboxylic acids. In pharmaceutical chemistry, such carboxylic acids are often the key structural units for constructing pharmaceutically active molecules. Or the nitrile group can be converted into an amino group by reduction reaction, providing a way for the synthesis of amino-containing compounds. Many bioactive substances and functional materials require such amino-containing structures.
In the field of materials science, using this as a raw material, through polymerization and other reactions, polymer materials with unique properties can be prepared. Due to its molecular structure characteristics, the prepared materials may have good stability, heat resistance and other properties, and can be used in aerospace, electronics and electrical appliances and other fields that require strict material properties, as high-performance structural materials or insulating materials.
In addition, in the process of pharmaceutical research and development, 1- (cyanomethyl) -3 -cyanopyridine also plays an important role. Due to its structural similarity to some bioactive molecules, it can be used as a lead compound for structural modification and optimization to develop new drugs for the treatment of specific diseases, such as certain cardiovascular diseases, neurological diseases, and other drugs. It is possible to use this as a starting material for in-depth research.
In the field of organic synthesis, 1- (cyanomethyl) -3 -cyanopyridine is an important intermediate. Nitrile groups are highly reactive and can be converted into other functional groups through various chemical reactions. For example, carboxyl groups can be obtained by hydrolysis of nitrile groups, whereby carboxyl-containing compounds can be prepared for the synthesis of special-structured organic carboxylic acids. In pharmaceutical chemistry, such carboxylic acids are often the key structural units for constructing pharmaceutically active molecules. Or the nitrile group can be converted into an amino group by reduction reaction, providing a way for the synthesis of amino-containing compounds. Many bioactive substances and functional materials require such amino-containing structures.
In the field of materials science, using this as a raw material, through polymerization and other reactions, polymer materials with unique properties can be prepared. Due to its molecular structure characteristics, the prepared materials may have good stability, heat resistance and other properties, and can be used in aerospace, electronics and electrical appliances and other fields that require strict material properties, as high-performance structural materials or insulating materials.
In addition, in the process of pharmaceutical research and development, 1- (cyanomethyl) -3 -cyanopyridine also plays an important role. Due to its structural similarity to some bioactive molecules, it can be used as a lead compound for structural modification and optimization to develop new drugs for the treatment of specific diseases, such as certain cardiovascular diseases, neurological diseases, and other drugs. It is possible to use this as a starting material for in-depth research.
What are the physical properties of 1- (chloromethyl) -3-fluorobenzene?
(1) The properties of this thing
(1- (methoxy) -3-ethylbenzene) are different and relate to various physical characteristics, which are hereby described.
(2) State of matter and color
At room temperature, it is a colorless and transparent liquid, just like clear water, clear and free of variegated colors, pure in appearance, and does not carry the slightest cloudy state.
(3) Odor characteristics
Smell it, it has a fragrant smell, but this fragrance is not rich and pungent, but is elegant and elegant, faintly emitting, just like the fragrance of the forest. Although it is light, it can attract people's attention, and it will not be bored after hearing it for a long time.
(4) The nature of the melting point
In terms of its melting point, the value is quite low, about below zero, so in a normal temperature environment, it is difficult to see its solidification state; As for the boiling point, it is not very high. Under a specific pressure, it can boil at a certain temperature range. This characteristic makes it prone to phase changes in many thermal processing processes. It can be separated and purified in industrial operations according to this characteristic.
(5) Density characteristic
Its density is slightly smaller than that of water. If it is placed in one place with water, it can be seen that it floats on the water, and the two are clearly defined. This characteristic can be used for separation purposes in some scenarios involving liquid-liquid separation.
(VI) Solubility
In organic solvents, such as ethanol, ether, etc., their solubility is quite good, and they can be mutually soluble into a uniform phase; while in water, the solubility is very small, and the two are mixed. Shortly after standing, they will stratify themselves. This difference in solubility also lays the foundation for its application in chemical, pharmaceutical and other fields, allowing for the extraction and dissolution of specific substances.
(7) Signs of Volatility
This substance is volatile to a certain extent. In an open environment, over time, its amount will gradually decrease. This volatility makes it necessary to pay attention to sealing when storing it to prevent it from escaping and causing loss. It is also necessary to pay attention to the safety and environmental problems that may be caused by its evaporation in the air.
(1- (methoxy) -3-ethylbenzene) are different and relate to various physical characteristics, which are hereby described.
(2) State of matter and color
At room temperature, it is a colorless and transparent liquid, just like clear water, clear and free of variegated colors, pure in appearance, and does not carry the slightest cloudy state.
(3) Odor characteristics
Smell it, it has a fragrant smell, but this fragrance is not rich and pungent, but is elegant and elegant, faintly emitting, just like the fragrance of the forest. Although it is light, it can attract people's attention, and it will not be bored after hearing it for a long time.
(4) The nature of the melting point
In terms of its melting point, the value is quite low, about below zero, so in a normal temperature environment, it is difficult to see its solidification state; As for the boiling point, it is not very high. Under a specific pressure, it can boil at a certain temperature range. This characteristic makes it prone to phase changes in many thermal processing processes. It can be separated and purified in industrial operations according to this characteristic.
(5) Density characteristic
Its density is slightly smaller than that of water. If it is placed in one place with water, it can be seen that it floats on the water, and the two are clearly defined. This characteristic can be used for separation purposes in some scenarios involving liquid-liquid separation.
(VI) Solubility
In organic solvents, such as ethanol, ether, etc., their solubility is quite good, and they can be mutually soluble into a uniform phase; while in water, the solubility is very small, and the two are mixed. Shortly after standing, they will stratify themselves. This difference in solubility also lays the foundation for its application in chemical, pharmaceutical and other fields, allowing for the extraction and dissolution of specific substances.
(7) Signs of Volatility
This substance is volatile to a certain extent. In an open environment, over time, its amount will gradually decrease. This volatility makes it necessary to pay attention to sealing when storing it to prevent it from escaping and causing loss. It is also necessary to pay attention to the safety and environmental problems that may be caused by its evaporation in the air.
What are the synthesis methods of 1- (chloromethyl) -3-fluorobenzene?
There are various ways to synthesize 1- (methoxy) -3 -methionyl compounds, which can be selected according to different needs and situations.
First, the nucleophilic substitution method of halogenated hydrocarbons. Take the halogenated 1- (methoxy) -3 -halogen, and the methanethiol salt in a suitable solvent, such as N, N-dimethylformamide (DMF), at an appropriate temperature, or at room temperature, or by heating, so that the nucleophilic substitution reaction occurs. The sulfur atom of the methanethiol salt is nucleophilic and can attack the carbon site attached to the halogen atom of the halogen. The halogen atom leaves, and then the 1- (methoxy) -3 -methionyl compound is obtained. This method is easy to obtain raw materials, and the operation is not complicated. However, it is necessary to pay attention to the activity of halogenates and the selectivity of substitution reactions.
Second, metal catalytic coupling method. Methoxy-containing aryl boronic acid or its esters are used as raw materials with methylthiohalides. With the help of metal catalysts, such as palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.), in the presence of bases, in organic solvents such as toluene, dioxane, etc. The metal catalyst promotes the coupling of aryl boric acid and halides to form 1- (methoxy) -3-methylthio compounds. This method has good selectivity and can construct complex structures. However, the cost of catalysts is high, and the reaction conditions may need to be carefully regulated.
Third, mercaptan and olefin addition method. If there are olefins containing 1 - (methoxy), they can be added with methyl mercaptan under the action of initiator or catalyst. If a radical initiator is used, under light or heating conditions, the sulfur-hydrogen bonds of methyl mercaptan are homogenized to form methyl thio radicals, which are added to the olefin double bond to obtain the target 1 - (methoxy) -3 -methylthio compound. This approach has high atomic economy and mild conditions, but the olefin substrate may need to be prepared in advance.
First, the nucleophilic substitution method of halogenated hydrocarbons. Take the halogenated 1- (methoxy) -3 -halogen, and the methanethiol salt in a suitable solvent, such as N, N-dimethylformamide (DMF), at an appropriate temperature, or at room temperature, or by heating, so that the nucleophilic substitution reaction occurs. The sulfur atom of the methanethiol salt is nucleophilic and can attack the carbon site attached to the halogen atom of the halogen. The halogen atom leaves, and then the 1- (methoxy) -3 -methionyl compound is obtained. This method is easy to obtain raw materials, and the operation is not complicated. However, it is necessary to pay attention to the activity of halogenates and the selectivity of substitution reactions.
Second, metal catalytic coupling method. Methoxy-containing aryl boronic acid or its esters are used as raw materials with methylthiohalides. With the help of metal catalysts, such as palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.), in the presence of bases, in organic solvents such as toluene, dioxane, etc. The metal catalyst promotes the coupling of aryl boric acid and halides to form 1- (methoxy) -3-methylthio compounds. This method has good selectivity and can construct complex structures. However, the cost of catalysts is high, and the reaction conditions may need to be carefully regulated.
Third, mercaptan and olefin addition method. If there are olefins containing 1 - (methoxy), they can be added with methyl mercaptan under the action of initiator or catalyst. If a radical initiator is used, under light or heating conditions, the sulfur-hydrogen bonds of methyl mercaptan are homogenized to form methyl thio radicals, which are added to the olefin double bond to obtain the target 1 - (methoxy) -3 -methylthio compound. This approach has high atomic economy and mild conditions, but the olefin substrate may need to be prepared in advance.
What are the precautions for 1- (chloromethyl) -3-fluorobenzene during storage and transportation?
When storing (1- (cyanomethyl) -3-cyanopyridine) this material, pay attention to the general situation.
The first environment where it is stored. It is appropriate to create a good place where things are dry, dry, and good. Because (1- (cyanomethyl) -3-cyanopyridine) encounters moisture and is easy to produce and melt in contact with water, its properties are not good. If it is not in the tide, or absorbs moisture, it will be changed and made, and the product will be made; if it is in the high-quality place, it may cause chemical reactions, and even have ignition and explosion.
Furthermore, the place where it exists is not the source of fire, coal and oxidation. ( 1 - (cyanomethyl) - 3 -cyanopyridine) is flammable, and in case of open flame, it is flammable at high temperature. The oxidation energy can cause a strong reaction, increasing the risk of ignition and explosion. Therefore, there must be no fire in the storage area, and the equipment should be explosion-proof, and there must be a combination of fire equipment.
It is necessary to pack the container for use, and the packaging material should be able to withstand external forces and prevent leakage. In this way, it can ensure that (1 - (cyanomethyl) - 3 -cyanopyridine) will not be exposed on the way. Once it is exposed, it will not pollute the environment, and it will improve the safety of humans and animals.
The human body is also well-versed in the dangerous characteristics and emergency treatment methods of (1- (cyanomethyl) -3-cyanopyridine). On the way, it is necessary to pay close attention to the material. If there is any dew, smell, etc., take immediate measures.
In addition, there are also requirements for safety. Do not mix flammable, explosive, oxidized and other dangerous products to prevent mutual reaction. And it should be equipped with perfect communication, fire protection and explosion-proof equipment to ensure safety.
The first environment where it is stored. It is appropriate to create a good place where things are dry, dry, and good. Because (1- (cyanomethyl) -3-cyanopyridine) encounters moisture and is easy to produce and melt in contact with water, its properties are not good. If it is not in the tide, or absorbs moisture, it will be changed and made, and the product will be made; if it is in the high-quality place, it may cause chemical reactions, and even have ignition and explosion.
Furthermore, the place where it exists is not the source of fire, coal and oxidation. ( 1 - (cyanomethyl) - 3 -cyanopyridine) is flammable, and in case of open flame, it is flammable at high temperature. The oxidation energy can cause a strong reaction, increasing the risk of ignition and explosion. Therefore, there must be no fire in the storage area, and the equipment should be explosion-proof, and there must be a combination of fire equipment.
It is necessary to pack the container for use, and the packaging material should be able to withstand external forces and prevent leakage. In this way, it can ensure that (1 - (cyanomethyl) - 3 -cyanopyridine) will not be exposed on the way. Once it is exposed, it will not pollute the environment, and it will improve the safety of humans and animals.
The human body is also well-versed in the dangerous characteristics and emergency treatment methods of (1- (cyanomethyl) -3-cyanopyridine). On the way, it is necessary to pay close attention to the material. If there is any dew, smell, etc., take immediate measures.
In addition, there are also requirements for safety. Do not mix flammable, explosive, oxidized and other dangerous products to prevent mutual reaction. And it should be equipped with perfect communication, fire protection and explosion-proof equipment to ensure safety.
What are the effects of 1- (chloromethyl) -3-fluorobenzene on the environment and human health?
"Tiangong Kaiwu" says: Halomethyl-3-bromobenzene, this substance has an impact on the environment and human health.
Halomethyl is active and easily reacts with surrounding substances. Its existence in the environment may interfere with the ecological balance. In water bodies, it may affect the survival and reproduction of aquatic organisms, causing physiological disorders and population changes. In soil, it may change the chemical properties of the soil, affect the absorption of nutrients by plants, and hinder plant growth.
3-bromobenzene is also not good. It has certain toxicity and bioaccumulation. Bioaccumulators, that is, after organisms ingest this substance, it is difficult to metabolize and excrete, and will accumulate in the body. If 3-bromobenzene is ingested by organisms at the bottom of the food chain, it will be transmitted through the layers of the food chain, and the concentration in organisms at the top will increase significantly. If humans eat contaminated organisms, 3-bromobenzene will enter the human body.
In terms of human health, halomethyl-3-bromobenzene may damage many human systems. The first to bear the brunt is the respiratory system, inhaling the air containing this substance, or causing respiratory irritation symptoms such as cough, asthma, long-term exposure, and even lung diseases. It may also affect the nervous system, interfere with nerve conduction, causing dizziness, fatigue, memory loss, etc. Furthermore, it may affect the human body's immune system, weaken the body's ability to resist diseases, and make people more susceptible to diseases. Therefore, halomethyl-3-bromobenzene has a significant impact on the environment and human health, and needs to be treated with caution and proper disposal.
Halomethyl is active and easily reacts with surrounding substances. Its existence in the environment may interfere with the ecological balance. In water bodies, it may affect the survival and reproduction of aquatic organisms, causing physiological disorders and population changes. In soil, it may change the chemical properties of the soil, affect the absorption of nutrients by plants, and hinder plant growth.
3-bromobenzene is also not good. It has certain toxicity and bioaccumulation. Bioaccumulators, that is, after organisms ingest this substance, it is difficult to metabolize and excrete, and will accumulate in the body. If 3-bromobenzene is ingested by organisms at the bottom of the food chain, it will be transmitted through the layers of the food chain, and the concentration in organisms at the top will increase significantly. If humans eat contaminated organisms, 3-bromobenzene will enter the human body.
In terms of human health, halomethyl-3-bromobenzene may damage many human systems. The first to bear the brunt is the respiratory system, inhaling the air containing this substance, or causing respiratory irritation symptoms such as cough, asthma, long-term exposure, and even lung diseases. It may also affect the nervous system, interfere with nerve conduction, causing dizziness, fatigue, memory loss, etc. Furthermore, it may affect the human body's immune system, weaken the body's ability to resist diseases, and make people more susceptible to diseases. Therefore, halomethyl-3-bromobenzene has a significant impact on the environment and human health, and needs to be treated with caution and proper disposal.
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