Linshang Chemical
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1-Chloromethyl-3-Methoxybenzene
Linshang Chemical
|
HS Code |
103302 |
| Chemical Formula | C8H9ClO |
| Molar Mass | 156.609 g/mol |
| Appearance | Liquid (assumed, typical for such organic compounds) |
| Solubility In Water | Insoluble (organic halide with alkoxy group, typical for non - polar or low - polar organics) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, etc. (typical for such organic compounds) |
| Odor | Pungent or characteristic organic odor (common for aromatic - halide - alkoxy compounds) |
As an accredited 1-Chloromethyl-3-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - Chloromethyl - 3 - methoxybenzene packaged in 500 - gram bottles. |
| Storage | 1 - Chloromethyl - 3 - methoxybenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, acids, and bases. This helps prevent potential reactions and ensures the chemical's stability during storage. |
| Shipping | 1 - Chloromethyl - 3 - methoxybenzene is shipped in accordance with strict chemical regulations. It's packaged in secure, corrosion - resistant containers. Shipment is via approved carriers, ensuring proper handling to prevent spills and maintain safety during transit. |
Competitive 1-Chloromethyl-3-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Chloromethyl-3-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1-chloromethyl-3-methoxybenzene?
1 - chloromethyl - 3 - methoxybenzene, the Chinese name is often referred to as m-methoxybenzyl chloride. This substance has a wide range of uses and is a key raw material in the field of organic synthesis.
In terms of drug synthesis, it can be used as an important intermediate. As far as the preparation of drugs with specific structures is concerned, its chloromethyl activity can react with many nucleophiles. By substitution, the required functional groups are introduced to build the basic structure of drug molecules, laying the foundation for the synthesis of drugs with specific pharmacological activities.
In the field of materials science, it also has its uses. For example, the preparation of special functional polymer materials, m-methoxybenzyl chloride participates in the polymerization reaction, which can endow the material with unique properties, such as changing the surface activity of the material, improving its compatibility with other substances, etc., so that the resulting material can be used in specific fields, such as coatings, adhesives, etc., to show excellent performance.
In the field of fragrance synthesis, it is also indispensable. Due to its unique chemical structure, it can introduce specific groups into fragrance molecules, change the aroma characteristics of fragrances, or enhance the stability of fragrances, which helps to develop novel and high-quality fragrance products to meet the diverse needs of different consumer groups for aroma.
Furthermore, in the preparation of fine chemical products, m-methoxybenzyl chloride participates in many reactions, assisting in the synthesis of various fine chemicals, such as special additives, additives, etc. These fine chemicals are widely used in many industrial sectors, which is of great significance for improving product quality and performance.
In terms of drug synthesis, it can be used as an important intermediate. As far as the preparation of drugs with specific structures is concerned, its chloromethyl activity can react with many nucleophiles. By substitution, the required functional groups are introduced to build the basic structure of drug molecules, laying the foundation for the synthesis of drugs with specific pharmacological activities.
In the field of materials science, it also has its uses. For example, the preparation of special functional polymer materials, m-methoxybenzyl chloride participates in the polymerization reaction, which can endow the material with unique properties, such as changing the surface activity of the material, improving its compatibility with other substances, etc., so that the resulting material can be used in specific fields, such as coatings, adhesives, etc., to show excellent performance.
In the field of fragrance synthesis, it is also indispensable. Due to its unique chemical structure, it can introduce specific groups into fragrance molecules, change the aroma characteristics of fragrances, or enhance the stability of fragrances, which helps to develop novel and high-quality fragrance products to meet the diverse needs of different consumer groups for aroma.
Furthermore, in the preparation of fine chemical products, m-methoxybenzyl chloride participates in many reactions, assisting in the synthesis of various fine chemicals, such as special additives, additives, etc. These fine chemicals are widely used in many industrial sectors, which is of great significance for improving product quality and performance.
What are the physical properties of 1-chloromethyl-3-methoxybenzene?
1-Chloromethyl-3-methoxybenzene is a kind of organic compound. Its physical properties are quite unique, let me tell you in detail.
Let me talk about its properties first. At room temperature, this substance is often colorless to light yellow liquid. It looks clear and transparent, and seems to have a shimmer flow. Its smell is not a pungent and unpleasant odor, but it also has a unique smell, which is slightly irritating and slightly uncomfortable to smell.
Let's talk about its melting and boiling point. The melting point is low, and it is difficult to form a solid state at common ambient temperatures. The boiling point is relatively high, and it needs to be changed from liquid to gas under specific temperature conditions. Specifically, the value of the boiling point varies slightly according to the experimental conditions, but it is roughly within a certain range. This property makes it stable in a liquid state within a specific temperature range, providing convenience for many reactions and applications.
Solubility is also one of the important physical properties. 1-chloromethyl-3-methoxybenzene is insoluble in water, and in the environment of water molecules, the two seem to be distinct and difficult to blend. However, it can exhibit good solubility in organic solvents, and common organic solvents such as ethanol and ether can be mutually soluble with it. This property is of critical significance in the process of organic synthesis and separation, so that suitable solvents can be selected to achieve effective treatment and utilization of the substance.
In terms of density, 1-chloromethyl-3-methoxybenzene is heavier than water. When it is placed in the same container as water, it can be seen that it slowly sinks to the bottom of the water, just like a pearl falling on the abyss. This density characteristic can be used as an important basis for judgment and operation in mixture separation and some chemical operations.
In addition, its volatility is weak. Under normal temperature and pressure, the volatilization rate is relatively slow, and it does not disappear into the air as quickly as some volatile substances. This makes the substance relatively easy to control during storage and use, and there is no need to worry about its rapid volatilization and loss or other problems at all times.
In summary, 1-chloromethyl-3-methoxybenzene has unique physical properties and plays an important role in the field of organic chemistry and related industrial production.
Let me talk about its properties first. At room temperature, this substance is often colorless to light yellow liquid. It looks clear and transparent, and seems to have a shimmer flow. Its smell is not a pungent and unpleasant odor, but it also has a unique smell, which is slightly irritating and slightly uncomfortable to smell.
Let's talk about its melting and boiling point. The melting point is low, and it is difficult to form a solid state at common ambient temperatures. The boiling point is relatively high, and it needs to be changed from liquid to gas under specific temperature conditions. Specifically, the value of the boiling point varies slightly according to the experimental conditions, but it is roughly within a certain range. This property makes it stable in a liquid state within a specific temperature range, providing convenience for many reactions and applications.
Solubility is also one of the important physical properties. 1-chloromethyl-3-methoxybenzene is insoluble in water, and in the environment of water molecules, the two seem to be distinct and difficult to blend. However, it can exhibit good solubility in organic solvents, and common organic solvents such as ethanol and ether can be mutually soluble with it. This property is of critical significance in the process of organic synthesis and separation, so that suitable solvents can be selected to achieve effective treatment and utilization of the substance.
In terms of density, 1-chloromethyl-3-methoxybenzene is heavier than water. When it is placed in the same container as water, it can be seen that it slowly sinks to the bottom of the water, just like a pearl falling on the abyss. This density characteristic can be used as an important basis for judgment and operation in mixture separation and some chemical operations.
In addition, its volatility is weak. Under normal temperature and pressure, the volatilization rate is relatively slow, and it does not disappear into the air as quickly as some volatile substances. This makes the substance relatively easy to control during storage and use, and there is no need to worry about its rapid volatilization and loss or other problems at all times.
In summary, 1-chloromethyl-3-methoxybenzene has unique physical properties and plays an important role in the field of organic chemistry and related industrial production.
What is the chemical synthesis method of 1-chloromethyl-3-methoxybenzene?
The synthesis of 1-chloromethyl-3-methoxybenzene is an important issue in the field of organic synthesis. The synthesis method follows the following methods.
First, it can be started by m-methoxytoluene. Using N-chlorosuccinimide (NCS) as a chlorination reagent, a free radical substitution reaction is carried out in the presence of light or an initiator. In this process, NCS provides chlorine radicals to attack the benzyl position hydrogen atom of m-methoxytoluene, thereby generating 1-chloromethyl-3-methoxybenzene. When reacting, factors such as reaction temperature, light intensity, and the amount of NCS should be paid attention to. If the temperature is too high, the by-products of polychlorination will be feared; if the light is too strong or too weak, the reaction rate and yield will also be affected. Generally speaking, the reaction temperature is usually controlled at 60-80 ° C, and the molar ratio of NCS to m-methoxy toluene is about 1.1-1.3:1.
Second, m-methoxy phenol can be used as the raw material. First, m-methoxy phenol is reacted with dimethyl sulfate for methoxylation to obtain m-methoxy anisole. Subsequently, using formaldehyde and hydrogen chloride gas as raw materials, under the catalysis of Lewis acid such as anhydrous zinc chloride, p-methoxyanisole is chloromethylated to obtain the target product 1-chloromethyl-3-methoxybenzene. In this route, the methoxylation reaction needs to be carried out under basic conditions to promote the nucleophilicity of phenolic hydroxyl groups. In the chloromethylation reaction, the activity and dosage of Lewis acid, and the anhydrous degree of the reaction system are all critical. If the amount of anhydrous zinc chloride is too small, the catalytic effect is not good; if the system has water, it is easy to cause side reactions and reduce the yield.
Third, the Grignard reagent method can also be passed. 3-Methoxybenzyl alcohol is obtained by using m-bromoanisole as the starting material, and then reacting with formaldehyde to obtain 3-methoxybenzyl alcohol. Then 3-methoxybenzyl alcohol is chlorinated with chlorination reagents such as thionyl chloride to obtain 1-chloromethyl-3-methoxybenzene. The preparation process of Grignard reagent needs to be strictly anhydrous and oxygen-free, otherwise Grignard reagent is easy to decompose. When thionyl chloride is chlorinated, the reaction temperature and time also need to be carefully adjusted to prevent excessive chlorination or other side reactions.
First, it can be started by m-methoxytoluene. Using N-chlorosuccinimide (NCS) as a chlorination reagent, a free radical substitution reaction is carried out in the presence of light or an initiator. In this process, NCS provides chlorine radicals to attack the benzyl position hydrogen atom of m-methoxytoluene, thereby generating 1-chloromethyl-3-methoxybenzene. When reacting, factors such as reaction temperature, light intensity, and the amount of NCS should be paid attention to. If the temperature is too high, the by-products of polychlorination will be feared; if the light is too strong or too weak, the reaction rate and yield will also be affected. Generally speaking, the reaction temperature is usually controlled at 60-80 ° C, and the molar ratio of NCS to m-methoxy toluene is about 1.1-1.3:1.
Second, m-methoxy phenol can be used as the raw material. First, m-methoxy phenol is reacted with dimethyl sulfate for methoxylation to obtain m-methoxy anisole. Subsequently, using formaldehyde and hydrogen chloride gas as raw materials, under the catalysis of Lewis acid such as anhydrous zinc chloride, p-methoxyanisole is chloromethylated to obtain the target product 1-chloromethyl-3-methoxybenzene. In this route, the methoxylation reaction needs to be carried out under basic conditions to promote the nucleophilicity of phenolic hydroxyl groups. In the chloromethylation reaction, the activity and dosage of Lewis acid, and the anhydrous degree of the reaction system are all critical. If the amount of anhydrous zinc chloride is too small, the catalytic effect is not good; if the system has water, it is easy to cause side reactions and reduce the yield.
Third, the Grignard reagent method can also be passed. 3-Methoxybenzyl alcohol is obtained by using m-bromoanisole as the starting material, and then reacting with formaldehyde to obtain 3-methoxybenzyl alcohol. Then 3-methoxybenzyl alcohol is chlorinated with chlorination reagents such as thionyl chloride to obtain 1-chloromethyl-3-methoxybenzene. The preparation process of Grignard reagent needs to be strictly anhydrous and oxygen-free, otherwise Grignard reagent is easy to decompose. When thionyl chloride is chlorinated, the reaction temperature and time also need to be carefully adjusted to prevent excessive chlorination or other side reactions.
1-chloromethyl-3-methoxybenzene What are the precautions during storage and transportation?
1-Chloromethyl-3-methoxybenzene is also an organic compound. When storing and transporting, it is necessary to pay attention to many matters to ensure safety.
The first thing to pay attention to is its chemical properties. This substance has certain reactivity and is prone to chemical reactions with many substances. Therefore, when storing, it must be kept away from active substances such as oxidants and strong bases. If it comes into contact with it, it may cause a violent reaction, causing fire and explosion. For example, oxidants are often highly oxidizing, and they meet with 1-chloromethyl-3-methoxybenzene or cause it to oxidize, which in turn triggers a chain reaction, with unimaginable consequences.
Furthermore, the storage environment is very important. It should be placed in a cool and well-ventilated place. High temperature is easy to cause its volatilization to intensify, not only to lose substances, but also to accumulate in the air, or to form a flammable mixed gas, which will explode in case of open flame. At the same time, humid environment is also not advisable, because it may react with moisture and cause material deterioration. If some halogenated hydrocarbons will undergo hydrolysis in contact with water, 1-chloromethyl-3-methoxybenzene may also be at risk.
During transportation, the packaging must be solid and reliable. Suitable packaging materials must be used to prevent leakage. Once leaked, it will not only pollute the environment, but also pose a threat to the transportation personnel and surrounding people. The packaging container should be able to withstand a certain pressure and vibration to ensure that the transportation process is not damaged.
In addition, whether it is storage or transportation, relevant regulations and operating procedures must be strictly followed. Operators should be professionally trained and familiar with its characteristics and emergency handling methods. In the event of an accident, they can respond quickly and correctly to minimize losses and hazards.
In short, 1-chloromethyl-3-methoxybenzene needs to pay attention to many aspects such as chemical properties, environmental conditions, packaging conditions and personnel operation during storage and transportation to ensure safety and avoid accidents.
The first thing to pay attention to is its chemical properties. This substance has certain reactivity and is prone to chemical reactions with many substances. Therefore, when storing, it must be kept away from active substances such as oxidants and strong bases. If it comes into contact with it, it may cause a violent reaction, causing fire and explosion. For example, oxidants are often highly oxidizing, and they meet with 1-chloromethyl-3-methoxybenzene or cause it to oxidize, which in turn triggers a chain reaction, with unimaginable consequences.
Furthermore, the storage environment is very important. It should be placed in a cool and well-ventilated place. High temperature is easy to cause its volatilization to intensify, not only to lose substances, but also to accumulate in the air, or to form a flammable mixed gas, which will explode in case of open flame. At the same time, humid environment is also not advisable, because it may react with moisture and cause material deterioration. If some halogenated hydrocarbons will undergo hydrolysis in contact with water, 1-chloromethyl-3-methoxybenzene may also be at risk.
During transportation, the packaging must be solid and reliable. Suitable packaging materials must be used to prevent leakage. Once leaked, it will not only pollute the environment, but also pose a threat to the transportation personnel and surrounding people. The packaging container should be able to withstand a certain pressure and vibration to ensure that the transportation process is not damaged.
In addition, whether it is storage or transportation, relevant regulations and operating procedures must be strictly followed. Operators should be professionally trained and familiar with its characteristics and emergency handling methods. In the event of an accident, they can respond quickly and correctly to minimize losses and hazards.
In short, 1-chloromethyl-3-methoxybenzene needs to pay attention to many aspects such as chemical properties, environmental conditions, packaging conditions and personnel operation during storage and transportation to ensure safety and avoid accidents.
1-chloromethyl-3-methoxybenzene impact on the environment and human health
1-Chloromethyl-3-methoxybenzene, its impact on the environment and human health cannot be ignored.
At the environmental end, if this substance is released in nature, it may cause all kinds of hazards. It may have a certain degree of bioaccumulation, and it accumulates in the food chain of aquatic organisms and terrestrial organisms. When entering rivers, lakes and seas, aquatic organisms bear the brunt, either damaging their physiological functions or causing population changes. In the soil, it may affect the balance of soil microbial communities, hinder the normal operation of soil ecosystems, cause changes in soil fertility and other properties, and affect plant growth. And it may evaporate in the atmosphere, participate in photochemical reactions, affect atmospheric quality, and even have a potential impact on global climate change.
As for personal health, the risk should not be underestimated. Inhalation through the respiratory tract, or irritation of respiratory mucosa, causing cough, asthma and other discomfort. Long-term exposure may damage lung function and increase the risk of respiratory diseases. Contact through skin may be irritating, causing skin redness, swelling, itching, and even allergic reactions. If accidentally ingested, or injure the stomach, causing nausea, vomiting, abdominal pain and other diseases. Even more terrifying, this substance may be potentially carcinogenic. Long-term exposure, genetic material or damage to human cells, causing genetic mutations and increasing the risk of cancer.
Therefore, 1-chloromethyl-3-methoxybenzene poses many hidden dangers to both the environment and human health. It should be handled with caution to prevent its wanton spread to ensure environmental safety and personal health.
At the environmental end, if this substance is released in nature, it may cause all kinds of hazards. It may have a certain degree of bioaccumulation, and it accumulates in the food chain of aquatic organisms and terrestrial organisms. When entering rivers, lakes and seas, aquatic organisms bear the brunt, either damaging their physiological functions or causing population changes. In the soil, it may affect the balance of soil microbial communities, hinder the normal operation of soil ecosystems, cause changes in soil fertility and other properties, and affect plant growth. And it may evaporate in the atmosphere, participate in photochemical reactions, affect atmospheric quality, and even have a potential impact on global climate change.
As for personal health, the risk should not be underestimated. Inhalation through the respiratory tract, or irritation of respiratory mucosa, causing cough, asthma and other discomfort. Long-term exposure may damage lung function and increase the risk of respiratory diseases. Contact through skin may be irritating, causing skin redness, swelling, itching, and even allergic reactions. If accidentally ingested, or injure the stomach, causing nausea, vomiting, abdominal pain and other diseases. Even more terrifying, this substance may be potentially carcinogenic. Long-term exposure, genetic material or damage to human cells, causing genetic mutations and increasing the risk of cancer.
Therefore, 1-chloromethyl-3-methoxybenzene poses many hidden dangers to both the environment and human health. It should be handled with caution to prevent its wanton spread to ensure environmental safety and personal health.
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