1-(Chloromethyl)-3-Methylbenzene
Linshang Chemical
HS Code |
492562 |
Chemical Formula | C8H9Cl |
Molar Mass | 140.61 g/mol |
Appearance | Colorless to pale yellow liquid |
Odor | Pungent |
Density | 1.069 g/cm³ at 20 °C |
Boiling Point | 195 - 197 °C |
Melting Point | -35 °C |
Solubility In Water | Insoluble |
Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
Flash Point | 72 °C |
Vapor Pressure | 0.25 mmHg at 25 °C |
Refractive Index | 1.538 - 1.540 at 20 °C |
As an accredited 1-(Chloromethyl)-3-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 500g of 1-(chloromethyl)-3 -methylbenzene packaged in a sealed, corrosion - resistant bottle. |
Storage | 1-(Chloromethyl)-3-methylbenzene should be stored in a cool, well - ventilated area, away from direct sunlight and heat sources. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, bases, and reactive chemicals to avoid potential reactions. Ensure the storage area has proper fire - fighting equipment in case of an emergency. |
Shipping | 1-(Chloromethyl)-3-methylbenzene is shipped in accordance with strict chemical transport regulations. It is packaged in suitable containers to prevent leakage, and transported by carriers trained in handling hazardous chemicals. |
Competitive 1-(Chloromethyl)-3-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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As a leading 1-(Chloromethyl)-3-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
This compound is very useful in the field of medicine. The unique chemical structure of 1 - (methoxy) - 3 - methylpyridine makes it an intermediate in the synthesis of many drugs. Taking the preparation of some antibacterial drugs as an example, it can be used as a key starting material, and through a series of delicate chemical reactions, complex molecular structures with antibacterial activity can be constructed. These antibacterial drugs have remarkable efficacy in the treatment of various bacterial infections and can effectively relieve the pain of patients and save lives.
In the field of pesticides, 1- (methoxy) -3-methylpyridine is also indispensable. It can be used to synthesize specific insecticides and herbicides. With its chemical properties, it can precisely act on the physiological system of pests and interfere with their normal life activities, so as to achieve the purpose of killing pests and protect crops from insect attacks. In the synthesis of herbicides, it can participate in the construction of molecules that inhibit weed growth, inhibit weeds and crops from competing for nutrients, sunlight and other resources, ensure the growth of crops and improve crop yield.
In the field of materials science, 1- (methoxy) -3-methylpyridine also has applications. In the preparation of some functional materials, this compound is introduced. Due to its special properties, it can endow materials with better stability, electrical conductivity or optical properties. For example, in the synthesis of some new conductive polymer materials, 1- (methoxy) -3-methylpyridine can be used as a structural modifier to optimize the electrical properties of the material and provide assistance for the development of electronic devices and other fields.)
Under normal temperature and pressure, it is mostly in a liquid state, with a clear texture and fluidity. It is like a smart water, but it also contains unique chemical characteristics. Looking at its color, it is often colorless and transparent, just like a pure crystal, without noise, highlighting its purity.
When it comes to odor, (mono-methylamino) -3-methylpyridine emits an irritating smell. This smell is quite strong. If you accidentally smell it, it is like a sharp needle, piercing the nasal cavity, making it instantly aware of its existence.
Boiling point is also one of its important physical properties. After rigorous determination, its boiling point is in a specific temperature range. At this temperature, the substance changes from liquid to gaseous, and the molecules break free from the shackles of the liquid phase and dance freely in the gas phase. This boiling point characteristic plays a key guiding role in many chemical processes such as material separation and purification.
Melting point is also not negligible. When the temperature drops to a specific value, (methylamino) -3-methylpyridine will condense from liquid to solid, and the molecular arrangement will tend to be ordered from disorder, forming a regular lattice structure.
In terms of solubility, it exhibits good solubility in some organic solvents, like being integrated into the arms of close partners and blending with them. In water, the solubility is different, and it shows a specific degree of solubility according to its chemical structure and the interaction characteristics of water molecules. This difference in solubility provides an important basis for chemists to choose in practical application scenarios such as chemical synthesis and separation operations, which can be used to achieve the purpose of material separation and reaction environment regulation.
From its structural point of view, cyanomethyl is connected to methylpyridine, giving it unique reactivity. In nucleophilic substitution reactions, cyano-CN has high activity because its carbon atoms are electrophilic and vulnerable to nucleophilic reagents. This property makes 1- (cyanomethyl) - 3 -methylpyridine participate in many bonding reactions, forming new carbon-carbon bonds or carbon-heteroatomic bonds, which is an important part of organic synthesis.
In the methylpyridine part, the pyridine ring is aromatic, and the electronic effect of the nitrogen atom affects the overall electron cloud distribution of the molecule. The nitrogen atom of pyridine has a lone pair of electrons, which can be used as an electron donor to participate in the coordination reaction and form complexes with metal ions. At the same time, its methyl substituent also has an effect. Because methyl is the power supply, it can increase the electron cloud density of the pyridine ring and affect the selectivity of the electrophilic substitution reaction region on the ring.
In the hydrolysis reaction, the cyano group can be gradually converted into a carboxyl group - COOH or an amide group - CONH -2. Under acidic or basic conditions, the hydrolysis mechanism is different, but eventually the functional group transformation is achieved, and new compounds containing carboxyl groups or amide groups are formed, which expands their applications in organic synthesis and medicinal chemistry.
In addition, 1- (cyanomethyl) -3-methylpyridine may also participate in redox reactions. Pyridine rings can be oxidized under specific conditions to change their electronic structure and chemical properties; cyanyl groups can also participate in oxidation reactions, such as being oxidized to derivatives such as cyanate esters. These reaction properties make 1- (cyanomethyl) -3-methylpyridine potentially useful in various fields such as organic synthesis, drug development, and materials science. Chemists can use its unique chemical properties to design and synthesize a variety of organic compounds to meet the needs of different fields.
First, the method of using indole as the starting material. First, indole is reacted with halogenated acetonitrile under appropriate conditions, and cyanomethyl can be introduced to obtain 1- (cyanomethyl) indole intermediates. This reaction requires attention to the reaction temperature and the choice of solvent. Halogenated acetonitrile has high activity. If the temperature is too high, side reactions will occur. Acetonitrile, N, N-dimethylformamide, etc. are commonly used as solvents. After that, 1- (cyanomethyl) indole is methylated again, and the target product 1- (cyanomethyl) -3 -methylindole can be obtained by reacting with suitable methylating reagents, such as iodomethane and dimethyl sulfate, in the presence of bases. In this process, the strength and dosage of bases have a great impact on the reaction, and excessive bases or indole rings are damaged.
Second, start from o-methylaniline. First, by diazotization, o-methylaniline is reacted with sodium nitrite in an acidic medium to form a diazonium salt, and then by coupling reaction with acrylonitrile, an intermediate containing cyanyl and alkenyl groups is obtained. This diazotization reaction requires low temperature operation to prevent the decomposition of diazonium salts. After cyclization, an indole ring can be constructed to form 1- (cyanomethyl) -3-methylindole. This cyclization step may require the help of a catalyst, and the type and amount of catalyst depend on the cyclization efficiency and product purity.
Third, by the method of Fu-gram reaction. Using suitable aromatic derivatives and halogenated acetonitrile as raw materials, under the catalysis of Lewis acid, the Fu-gram acylation reaction is carried out to obtain the acylation product containing cyanide. Lewis acids such as aluminum trichloride and boron trifluoride are commonly used, and their dosage and activity have a great influence on the reaction process. Subsequent reactions such as reduction and cyclization can obtain the target product. In the reduction step, select suitable reducing agents, such as sodium borohydride, lithium aluminum hydride, etc. The reduction ability of different reducing agents is different, which needs to be considered according to the reaction requirements. The cyclization reaction conditions also need to be carefully adjusted to obtain high purity 1- (cyanomethyl) -3-methylindole.
When storing, the first environment. Choose a cool, dry and well-ventilated place, away from fire and heat sources. Due to its chemical properties, high temperature or open flame can easily cause it to react and cause danger. If placed in a humid environment, it may react with water vapor, affecting its quality and stability.
Furthermore, the packaging must be tight. Suitable packaging materials must be used to ensure a good seal to prevent leakage. Packaging materials must withstand their chemical properties and do not react with them. For example, use a specific plastic or metal container packaging, depending on its specific chemical properties.
When storing, it should be separated from oxidants, acids, alkalis, etc. Contact with these substances can easily cause violent chemical reactions, which may lead to serious consequences such as combustion and explosion.
Safety is also a top priority during transportation. Transportation vehicles must comply with relevant regulations on the transportation of hazardous chemicals, and be equipped with corresponding fire protection equipment and leakage emergency treatment equipment.
When loading a vehicle, it needs to be handled lightly to avoid collision, heavy pressure and friction. This substance may decompose or other dangerous reactions under impact or heavy pressure.
During transportation, it should be protected from exposure to sun, rain and high temperature. Special attention should be paid to summer transportation, and shading and cooling measures should be taken if necessary.
In short, the storage and transportation of 1- (cyanomethyl) -3-methylindole should not be ignored. It is necessary to operate in strict accordance with relevant specifications to ensure personnel safety and material stability.

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