Linshang Chemical
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1-(Chloromethyl)-3-Nitrobenzene
Linshang Chemical
|
HS Code |
807197 |
| Chemical Formula | C7H6ClNO2 |
| Molar Mass | 171.58 g/mol |
| Appearance | Yellow - to - brown liquid |
| Boiling Point | 260 - 261 °C |
| Melting Point | 14 - 16 °C |
| Density | 1.336 g/cm³ (at 20 °C) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 122 °C |
| Vapor Pressure | Low at room temperature |
| Odor | Pungent |
As an accredited 1-(Chloromethyl)-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(chloromethyl)-3 -nitrobenzene in a tightly - sealed glass bottle. |
| Storage | 1-(Chloromethyl)-3-nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat and ignition sources. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and bases, as it may react with them. Adhere to local safety regulations for chemical storage. |
| Shipping | 1-(Chloromethyl)-3-nitrobenzene is shipped in accordance with strict hazardous chemical regulations. Packed in specialized, leak - proof containers, it's transported by carriers trained in handling such substances to ensure safety during transit. |
Competitive 1-(Chloromethyl)-3-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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What are the main uses of 1- (chloromethyl) -3-nitrobenzene?
1- (cyanomethyl) -3 -pyridyl boron has a wide range of main uses. In the field of organic synthesis, this compound is a key reagent.
In the process of organic synthesis, 1- (cyanomethyl) -3 -pyridyl boron can often participate in the formation of important chemical bonds such as carbon-carbon bonds and carbon-heteroatomic bonds. For example, in many coupling reactions, it can be used as a nucleophilic reagent or electrophilic reagent, ingeniously combined with other organic molecules, providing an effective path for the synthesis of complex organic compounds.
Furthermore, in the field of medicinal chemistry, its use should not be underestimated. In the synthesis of many biologically active compounds, 1- (cyanomethyl) -3-pyridyl boron can act as a key intermediate. With its unique structure and reactivity, it can precisely introduce specific functional groups, thereby optimizing the activity, selectivity and other pharmacological properties of the target compound, and assisting the development of new drugs.
In addition, it also has certain uses in the field of materials science. For example, in the preparation of some functional materials, through the rational use of 1- (cyanomethyl) -3-pyridyl boron to participate in the reaction, the material can be endowed with unique electrical and optical properties to meet the specific needs of different application scenarios for material properties. In conclusion, 1 - (cyanomethyl) - 3 - pyridyl boron plays an important role in many fields such as organic synthesis, pharmaceutical chemistry, and materials science due to its special chemical structure and reactivity, providing a powerful chemical tool for the development of various fields.
In the process of organic synthesis, 1- (cyanomethyl) -3 -pyridyl boron can often participate in the formation of important chemical bonds such as carbon-carbon bonds and carbon-heteroatomic bonds. For example, in many coupling reactions, it can be used as a nucleophilic reagent or electrophilic reagent, ingeniously combined with other organic molecules, providing an effective path for the synthesis of complex organic compounds.
Furthermore, in the field of medicinal chemistry, its use should not be underestimated. In the synthesis of many biologically active compounds, 1- (cyanomethyl) -3-pyridyl boron can act as a key intermediate. With its unique structure and reactivity, it can precisely introduce specific functional groups, thereby optimizing the activity, selectivity and other pharmacological properties of the target compound, and assisting the development of new drugs.
In addition, it also has certain uses in the field of materials science. For example, in the preparation of some functional materials, through the rational use of 1- (cyanomethyl) -3-pyridyl boron to participate in the reaction, the material can be endowed with unique electrical and optical properties to meet the specific needs of different application scenarios for material properties. In conclusion, 1 - (cyanomethyl) - 3 - pyridyl boron plays an important role in many fields such as organic synthesis, pharmaceutical chemistry, and materials science due to its special chemical structure and reactivity, providing a powerful chemical tool for the development of various fields.
What are the synthesis methods of 1- (chloromethyl) -3-nitrobenzene?
To prepare 1 - (methoxy) - 3 - cyanobenzene, the synthesis method is as follows:
First, start with halogenated benzene. Select a suitable halogenated benzene, such as bromobenzene or chlorobenzene, and first react with metal magnesium to obtain Grignard reagent. If bromobenzene and magnesium are in an anhydrous ether environment, phenyl magnesium bromide can be obtained. Then, the Grignard reagent reacts with methoxy halogenated hydrocarbons to introduce methoxy groups. Then, through a cyanidation step, a cyanide group is introduced with a suitable cyanide reagent, such as cuprous cyanide, to obtain 1 - (methoxy) - 3 - cyanobenzene. This route requires attention to the anhydrous and oxygen-free conditions during the preparation of Grignard's reagent, and the toxicity of the reagents used in the cyanidation step, so the operation should be cautious.
Second, anisole is used as the starting material. First nitrate the anisole, and then use a suitable nitrifying agent, such as mixed acid (concentrated sulfuric acid and concentrated nitric acid), to obtain nitroanisole. Then the nitro group is reduced to an amino group, and a reduction method such as iron filings-hydrochloric acid method or catalytic hydrogenation method is used. After the aminoanisole is obtained, it is reacted by diazotization with sodium nitrite and hydrochloric acid to obtain the diazonium salt. Finally, the diazonium group is replaced by a cyanide group by a cyanide reagent such as cuprous cyanide to obtain the target product. During this process, the diazotization reaction needs to
Third, m-methoxybenzoic acid is used as raw material. First, m-methoxybenzoic acid is converted into its acyl chloride, and reagents such as dichlorosulfoxide are used. The acyl chloride is then reacted with ammonia to obtain m-methoxybenzamide. Finally, by the action of dehydrating agents such as phosphorus pentoxide, 1 - (methoxy) - 3 - cyanobenzene is obtained. This route is relatively convenient to operate, but the acquisition of raw material m-methoxybenzoic acid may have cost considerations.
First, start with halogenated benzene. Select a suitable halogenated benzene, such as bromobenzene or chlorobenzene, and first react with metal magnesium to obtain Grignard reagent. If bromobenzene and magnesium are in an anhydrous ether environment, phenyl magnesium bromide can be obtained. Then, the Grignard reagent reacts with methoxy halogenated hydrocarbons to introduce methoxy groups. Then, through a cyanidation step, a cyanide group is introduced with a suitable cyanide reagent, such as cuprous cyanide, to obtain 1 - (methoxy) - 3 - cyanobenzene. This route requires attention to the anhydrous and oxygen-free conditions during the preparation of Grignard's reagent, and the toxicity of the reagents used in the cyanidation step, so the operation should be cautious.
Second, anisole is used as the starting material. First nitrate the anisole, and then use a suitable nitrifying agent, such as mixed acid (concentrated sulfuric acid and concentrated nitric acid), to obtain nitroanisole. Then the nitro group is reduced to an amino group, and a reduction method such as iron filings-hydrochloric acid method or catalytic hydrogenation method is used. After the aminoanisole is obtained, it is reacted by diazotization with sodium nitrite and hydrochloric acid to obtain the diazonium salt. Finally, the diazonium group is replaced by a cyanide group by a cyanide reagent such as cuprous cyanide to obtain the target product. During this process, the diazotization reaction needs to
Third, m-methoxybenzoic acid is used as raw material. First, m-methoxybenzoic acid is converted into its acyl chloride, and reagents such as dichlorosulfoxide are used. The acyl chloride is then reacted with ammonia to obtain m-methoxybenzamide. Finally, by the action of dehydrating agents such as phosphorus pentoxide, 1 - (methoxy) - 3 - cyanobenzene is obtained. This route is relatively convenient to operate, but the acquisition of raw material m-methoxybenzoic acid may have cost considerations.
What are the precautions for storing and transporting 1- (chloromethyl) -3-nitrobenzene?
1 - (cyanomethyl) - 3 -furanopyridine in storage and transportation, be sure to pay attention to the following matters:
First, because of its specific chemical activity, the temperature and humidity requirements of the storage environment are strict. The temperature should be kept constant in a specific range to prevent the chemical reaction from being intensified due to excessive temperature, or the physical state change due to too low temperature, which affects the quality and stability. Humidity also needs to be strictly controlled. Excessive humidity can easily cause moisture and cause adverse reactions such as hydrolysis. Therefore, the storage place should be kept dry, and the humidity should usually be maintained below [X]%.
Second, this substance may have certain toxicity and irritation. When storing and transporting, protective measures must be taken. Storage places should be equipped with complete ventilation facilities to ensure air circulation to prevent the accumulation of harmful substances. When transporting, staff need professional protective equipment, such as protective clothing, gloves, goggles and gas masks, to avoid direct contact and inhalation risks.
Third, 1- (cyanomethyl) -3-furanylpyridine should not be co-stored and transported with oxidizing substances, acids, bases, etc. Oxidizing substances are easy to neutralize, causing severe oxidation and reduction reactions. Acids and bases may react chemically with them, causing them to deteriorate and even causing safety accidents. When storing, it should be classified according to chemical properties, and obvious intervals and labels should be set between different categories of substances.
Fourth, whether it is storage or transportation, it is necessary to strictly label and record 1- (cyanomethyl) -3 -furanopyridine. Key information such as its name, chemical properties, hazard characteristics and emergency treatment methods should be clearly indicated on the label. At the same time, the time, quantity, source and whereabouts of warehousing should be recorded in detail for traceability and management. Once there is an abnormal situation, the cause can be quickly identified and countermeasures can be taken.
Fifth, during transportation, ensure that the packaging is intact. Choose suitable packaging materials, such as containers with good sealing and corrosion resistance, to prevent leakage. When loading and unloading, the operation must be gentle to avoid collision, drop, and prevent package damage. If the transportation journey is long, it is necessary to check the packaging status regularly to ensure transportation safety.
First, because of its specific chemical activity, the temperature and humidity requirements of the storage environment are strict. The temperature should be kept constant in a specific range to prevent the chemical reaction from being intensified due to excessive temperature, or the physical state change due to too low temperature, which affects the quality and stability. Humidity also needs to be strictly controlled. Excessive humidity can easily cause moisture and cause adverse reactions such as hydrolysis. Therefore, the storage place should be kept dry, and the humidity should usually be maintained below [X]%.
Second, this substance may have certain toxicity and irritation. When storing and transporting, protective measures must be taken. Storage places should be equipped with complete ventilation facilities to ensure air circulation to prevent the accumulation of harmful substances. When transporting, staff need professional protective equipment, such as protective clothing, gloves, goggles and gas masks, to avoid direct contact and inhalation risks.
Third, 1- (cyanomethyl) -3-furanylpyridine should not be co-stored and transported with oxidizing substances, acids, bases, etc. Oxidizing substances are easy to neutralize, causing severe oxidation and reduction reactions. Acids and bases may react chemically with them, causing them to deteriorate and even causing safety accidents. When storing, it should be classified according to chemical properties, and obvious intervals and labels should be set between different categories of substances.
Fourth, whether it is storage or transportation, it is necessary to strictly label and record 1- (cyanomethyl) -3 -furanopyridine. Key information such as its name, chemical properties, hazard characteristics and emergency treatment methods should be clearly indicated on the label. At the same time, the time, quantity, source and whereabouts of warehousing should be recorded in detail for traceability and management. Once there is an abnormal situation, the cause can be quickly identified and countermeasures can be taken.
Fifth, during transportation, ensure that the packaging is intact. Choose suitable packaging materials, such as containers with good sealing and corrosion resistance, to prevent leakage. When loading and unloading, the operation must be gentle to avoid collision, drop, and prevent package damage. If the transportation journey is long, it is necessary to check the packaging status regularly to ensure transportation safety.
What are the physical and chemical properties of 1- (chloromethyl) -3-nitrobenzene?
(1) Overview of physical and chemical properties
1 - (cyanomethyl) - 3 - pyridyl formamide This substance has unique physical and chemical characteristics. Under normal conditions, its appearance often takes on a specific shape. Or it is in the form of crystallization, white and pure in color, like a fine salt, shining; or it is in the state of powder, delicate as dust, and easy to drift away when touched.
(2) Physical properties
1. ** Melting point **: Its melting point is within a certain range, and this temperature is the critical point for it to change from solid to liquid. When external heat is applied and the temperature gradually rises to a certain exact value, the lattice structure of the substance begins to be destroyed, and the thermal motion of the molecule intensifies, and then it melts from the solid state to the liquid state. The melting point is of great significance for identifying the substance and determining its purity.
2. ** Boiling point **: Under certain pressure conditions, when the temperature rises to the corresponding boiling point value, 1- (cyanomethyl) -3-pyridyl formamide will change sharply from the liquid state to the gaseous state. The boiling point is greatly affected by external pressure. When the pressure changes, the boiling point also changes. This property can be used in the process of separation and purification of substances.
3. ** Solubility **: This substance exhibits different solubility in different solvents. In water, or only slightly soluble, some molecules can interact with water molecules, but it is difficult to disperse uniformly in large quantities; while in some organic solvents, such as ethanol and acetone, their solubility is significantly better, and they can be fully mixed with solvent molecules to form a uniform and stable solution. This property lays the foundation for its application in chemical synthesis and drug preparation.
(3) Chemical properties
1. ** Stability **: Under general environmental conditions, 1- (cyanomethyl) -3-pyridyl formamide has certain chemical stability. The chemical bonds between atoms in its molecular structure are relatively stable and are not prone to spontaneous chemical reactions. However, when the ambient temperature, pH and other conditions change significantly, the stability may be damaged, and the molecular structure may change.
2. ** Reactivity **: Because its molecular structure contains specific functional groups such as cyanomethyl and pyridyl formamide, it exhibits unique reactivity. The cyanyl group in the cyanomethyl group can participate in a variety of nucleophilic substitution reactions, and the pyridyl formamide part can undergo hydrolysis and condensation reactions under specific conditions. Such reactivity provides the possibility for it to be used as an important intermediate in the field of organic synthesis. Through rational design of the reaction path, more complex molecular structures of organic compounds can be constructed with the help of its reactivity.
1 - (cyanomethyl) - 3 - pyridyl formamide This substance has unique physical and chemical characteristics. Under normal conditions, its appearance often takes on a specific shape. Or it is in the form of crystallization, white and pure in color, like a fine salt, shining; or it is in the state of powder, delicate as dust, and easy to drift away when touched.
(2) Physical properties
1. ** Melting point **: Its melting point is within a certain range, and this temperature is the critical point for it to change from solid to liquid. When external heat is applied and the temperature gradually rises to a certain exact value, the lattice structure of the substance begins to be destroyed, and the thermal motion of the molecule intensifies, and then it melts from the solid state to the liquid state. The melting point is of great significance for identifying the substance and determining its purity.
2. ** Boiling point **: Under certain pressure conditions, when the temperature rises to the corresponding boiling point value, 1- (cyanomethyl) -3-pyridyl formamide will change sharply from the liquid state to the gaseous state. The boiling point is greatly affected by external pressure. When the pressure changes, the boiling point also changes. This property can be used in the process of separation and purification of substances.
3. ** Solubility **: This substance exhibits different solubility in different solvents. In water, or only slightly soluble, some molecules can interact with water molecules, but it is difficult to disperse uniformly in large quantities; while in some organic solvents, such as ethanol and acetone, their solubility is significantly better, and they can be fully mixed with solvent molecules to form a uniform and stable solution. This property lays the foundation for its application in chemical synthesis and drug preparation.
(3) Chemical properties
1. ** Stability **: Under general environmental conditions, 1- (cyanomethyl) -3-pyridyl formamide has certain chemical stability. The chemical bonds between atoms in its molecular structure are relatively stable and are not prone to spontaneous chemical reactions. However, when the ambient temperature, pH and other conditions change significantly, the stability may be damaged, and the molecular structure may change.
2. ** Reactivity **: Because its molecular structure contains specific functional groups such as cyanomethyl and pyridyl formamide, it exhibits unique reactivity. The cyanyl group in the cyanomethyl group can participate in a variety of nucleophilic substitution reactions, and the pyridyl formamide part can undergo hydrolysis and condensation reactions under specific conditions. Such reactivity provides the possibility for it to be used as an important intermediate in the field of organic synthesis. Through rational design of the reaction path, more complex molecular structures of organic compounds can be constructed with the help of its reactivity.
What are the effects of 1- (chloromethyl) -3-nitrobenzene on the environment and human health?
(1) Halomethyl-3-furanyl ethers are involved in the environment and human health, and have many conditions.
The first is the environment. If this halomethyl-3-furanyl ether escapes into nature, it will affect water bodies, soils, and atmospheres. Entering water bodies may cause harm to aquatic organisms. Due to its chemical characteristics, it may interfere with the physiological processes of aquatic organisms, such as hindering their growth and development, causing reproductive disorders. In some fish, it may increase the aberration rate of their larvae, affecting population reproduction. If it falls on the soil, or changes the chemical composition of the soil, it will hinder the normal activities of soil microorganisms. Soil microorganisms are crucial to maintaining soil fertility and material circulation. If they are disturbed, the soil ecological balance is easily destroyed. As for the atmosphere, if halomethyl-3-furanyl ether volatilizes in it, or participates in atmospheric photochemical reactions, it has adverse effects on air quality, or causes local regional air pollution to intensify.
Times and human health. If people come into contact with halomethyl-3-furanyl ether, there are various ways, or inhalation through breathing, or contact through skin, or even ingestion of substances containing this substance. Through breathing and inhalation, this substance can reach the lungs, then enter the blood circulation, and flow to the whole body with the blood. It may irritate the mucosa of the respiratory tract, cause cough, asthma, etc., and even cause respiratory inflammation and lung diseases after long-term exposure. Skin contact can cause skin allergies, itching, redness and swelling. If ingested by mistake, or damage the digestive system, causing nausea, vomiting, abdominal pain and other symptoms. What's more, studies have concluded that halomethyl-3-furan ether may be potentially carcinogenic, and long-term exposure to this environment may increase the risk of cancer.
Therefore, halomethyl-3-furan ether poses a hidden danger to the environment and human health. Daily care should be taken. Its production, use and disposal must be strictly controlled to reduce its harm.
The first is the environment. If this halomethyl-3-furanyl ether escapes into nature, it will affect water bodies, soils, and atmospheres. Entering water bodies may cause harm to aquatic organisms. Due to its chemical characteristics, it may interfere with the physiological processes of aquatic organisms, such as hindering their growth and development, causing reproductive disorders. In some fish, it may increase the aberration rate of their larvae, affecting population reproduction. If it falls on the soil, or changes the chemical composition of the soil, it will hinder the normal activities of soil microorganisms. Soil microorganisms are crucial to maintaining soil fertility and material circulation. If they are disturbed, the soil ecological balance is easily destroyed. As for the atmosphere, if halomethyl-3-furanyl ether volatilizes in it, or participates in atmospheric photochemical reactions, it has adverse effects on air quality, or causes local regional air pollution to intensify.
Times and human health. If people come into contact with halomethyl-3-furanyl ether, there are various ways, or inhalation through breathing, or contact through skin, or even ingestion of substances containing this substance. Through breathing and inhalation, this substance can reach the lungs, then enter the blood circulation, and flow to the whole body with the blood. It may irritate the mucosa of the respiratory tract, cause cough, asthma, etc., and even cause respiratory inflammation and lung diseases after long-term exposure. Skin contact can cause skin allergies, itching, redness and swelling. If ingested by mistake, or damage the digestive system, causing nausea, vomiting, abdominal pain and other symptoms. What's more, studies have concluded that halomethyl-3-furan ether may be potentially carcinogenic, and long-term exposure to this environment may increase the risk of cancer.
Therefore, halomethyl-3-furan ether poses a hidden danger to the environment and human health. Daily care should be taken. Its production, use and disposal must be strictly controlled to reduce its harm.
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