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1-(Chloromethyl)-3-(Trifluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
673934 |
| Chemical Formula | C8H6ClF3O |
| Molar Mass | 210.58 g/mol |
| Appearance | Liquid (usually) |
| Boiling Point | Data needed |
| Melting Point | Data needed |
| Density | Data needed |
| Solubility | Solubility in organic solvents (e.g., dichloromethane, toluene) |
| Vapor Pressure | Data needed |
| Flash Point | Data needed |
| Refractive Index | Data needed |
As an accredited 1-(Chloromethyl)-3-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 mL bottle containing 1-(chloromethyl)-3-(trifluoromethoxy)benzene. |
| Storage | 1-(Chloromethyl)-3-(trifluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions. |
| Shipping | 1-(Chloromethyl)-3-(trifluoromethoxy)benzene is shipped in specialized, sealed containers. These are designed to prevent leakage. Shipment adheres to strict chemical transport regulations, ensuring safe transit. |
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What are the main uses of 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
(1) The name 1- (hydroxymethyl) -3- (trifluoromethoxy) benzene has a wide range of uses.
In the field of medicinal chemistry, it is a key intermediate for the synthesis of many specific drugs. For example, in the development of new antidepressant drugs, its unique chemical structure can participate in the construction of the core part of the active molecule of the drug, and through precise chemical synthesis methods, it can be cleverly combined with other functional groups to shape compounds with specific pharmacological activities. This structure helps the drug to act more effectively on specific targets in the nervous system, regulate the balance of neurotransmitters, and then relieve depression symptoms.
In the field of materials science, it also plays an important role. It can be applied to the preparation of high-performance organic optoelectronic materials. Due to its special substituent, it can regulate the electron cloud distribution and energy level structure of the material, giving the material excellent optoelectronic properties. For example, in the development of organic Light Emitting Diode (OLED) materials, adding this substance can optimize the luminous efficiency and stability of the material, making the OLED display show more vivid colors and higher contrast, providing support for the innovation of display technology.
In addition, in the fine chemical industry, it is used as an important raw material for the synthesis of various fine chemicals with special functions. Such as high-end coatings, special fragrances, etc. In the synthesis of coatings, it can improve the film-forming performance, weather resistance and chemical corrosion resistance of coatings, improve the quality of coatings, and meet the strict requirements of material protection and decoration in different environments. In fragrance synthesis, its unique structure may add novel odor characteristics to fragrance molecules, create a unique fragrance, and enrich the types and application scenarios of fragrances.
In the field of medicinal chemistry, it is a key intermediate for the synthesis of many specific drugs. For example, in the development of new antidepressant drugs, its unique chemical structure can participate in the construction of the core part of the active molecule of the drug, and through precise chemical synthesis methods, it can be cleverly combined with other functional groups to shape compounds with specific pharmacological activities. This structure helps the drug to act more effectively on specific targets in the nervous system, regulate the balance of neurotransmitters, and then relieve depression symptoms.
In the field of materials science, it also plays an important role. It can be applied to the preparation of high-performance organic optoelectronic materials. Due to its special substituent, it can regulate the electron cloud distribution and energy level structure of the material, giving the material excellent optoelectronic properties. For example, in the development of organic Light Emitting Diode (OLED) materials, adding this substance can optimize the luminous efficiency and stability of the material, making the OLED display show more vivid colors and higher contrast, providing support for the innovation of display technology.
In addition, in the fine chemical industry, it is used as an important raw material for the synthesis of various fine chemicals with special functions. Such as high-end coatings, special fragrances, etc. In the synthesis of coatings, it can improve the film-forming performance, weather resistance and chemical corrosion resistance of coatings, improve the quality of coatings, and meet the strict requirements of material protection and decoration in different environments. In fragrance synthesis, its unique structure may add novel odor characteristics to fragrance molecules, create a unique fragrance, and enrich the types and application scenarios of fragrances.
What are the physical properties of 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
(1 - (methoxy) - 3 - (triethoxysilyl) silane, this substance has unique physical properties. Under normal conditions, it is a colorless and transparent liquid, and it looks clear, just like water. Although its smell is not very strong, it has unique characteristics. It smells fresh, but it also has a hint of the unique fragrance of chemicals.
When it comes to boiling point, this substance has a high boiling point and needs to reach a specific temperature to boil into a gaseous state. This characteristic makes it stable in a high temperature environment, and it is not easy to evaporate and dissipate easily. Its melting point is relatively low, and it is easy to convert from solid to liquid in case of a slight temperature change, showing good fluidity.
The substance has a moderate density, neither as light as a feather nor as heavy as lead. It can coexist properly with many substances in various media. Its solubility is also worth mentioning. It can be well dissolved in some organic solvents and fused with some specific chemical reagents. It is like a blend of water and milk, providing many conveniences for its application in various chemical reactions and industrial production.
Furthermore, the surface tension of this substance also has its own unique features. Under specific conditions, it can exhibit a low surface tension, enabling it to spread evenly on the surface of certain materials, like a delicate tulle lightly covering it, and then exert special effects such as waterproof and anti-fouling. Its refractive index is also relatively stable, and when light passes through, it follows a specific law of refraction, laying the foundation for applications in the optical field.
In addition, the thermal stability and chemical stability of 1- (methoxy) -3- (triethoxysilyl) silane are also more prominent. Within a certain temperature range, it can withstand high temperature baking without decomposition. In the face of general chemical erosion, it can also stick to its own structure and is not prone to chemical reactions and deterioration. Such various physical properties make it show a wide range of application prospects and unique practical value in many fields such as materials science and chemical production.)
When it comes to boiling point, this substance has a high boiling point and needs to reach a specific temperature to boil into a gaseous state. This characteristic makes it stable in a high temperature environment, and it is not easy to evaporate and dissipate easily. Its melting point is relatively low, and it is easy to convert from solid to liquid in case of a slight temperature change, showing good fluidity.
The substance has a moderate density, neither as light as a feather nor as heavy as lead. It can coexist properly with many substances in various media. Its solubility is also worth mentioning. It can be well dissolved in some organic solvents and fused with some specific chemical reagents. It is like a blend of water and milk, providing many conveniences for its application in various chemical reactions and industrial production.
Furthermore, the surface tension of this substance also has its own unique features. Under specific conditions, it can exhibit a low surface tension, enabling it to spread evenly on the surface of certain materials, like a delicate tulle lightly covering it, and then exert special effects such as waterproof and anti-fouling. Its refractive index is also relatively stable, and when light passes through, it follows a specific law of refraction, laying the foundation for applications in the optical field.
In addition, the thermal stability and chemical stability of 1- (methoxy) -3- (triethoxysilyl) silane are also more prominent. Within a certain temperature range, it can withstand high temperature baking without decomposition. In the face of general chemical erosion, it can also stick to its own structure and is not prone to chemical reactions and deterioration. Such various physical properties make it show a wide range of application prospects and unique practical value in many fields such as materials science and chemical production.)
What are the chemical properties of 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
(1) The properties of this substance are related to its structure. 1 - (cyanomethyl) -3 - (trifluoromethoxy) benzene is an organic compound. Its molecular structure contains the group of the benzene ring, and the cyanomethyl group is attached to the trifluoromethoxy group.
(2) On its physical properties. At room temperature, or in a liquid state, with a specific color and taste. Its melting and boiling point is different from that of common substances due to intermolecular forces. The conjugate system of the benzene ring makes it stable to a certain extent; and the introduction of the cyanyl group and the trifluoromethoxy group changes the polarity of its molecules and the distribution of the electron cloud, which in turn affects the melting point.
(3) As for the chemical properties. The benzene ring can undergo electrophilic substitution reactions, such as halogenation, nitrification, and sulfonation. The cyanyl group of cyanomethyl groups has nucleophilic properties and can participate in nucleophilic substitution and addition reactions. In the case of appropriate reagents, the cyanyl group can be hydrolyzed to carboxyl groups or reduced to amino groups. In the trifluoromethoxy group, the fluorine atom is extremely electronegative, which makes the group have a strong electron-absorbing effect, which affects the electron cloud density of the benzene ring and changes the activity and localization of the electrophilic substitution reaction on the benzene ring. And because of its strong electron-absorbing properties, it may affect the reactivity of the atoms connected to it. In addition, the trifluoromethoxy group itself may participate in some special reactions, such as the formation of hydrogen bonds. In a specific reaction environment, it has an impact on the process of the reaction In conclusion, the chemical properties of 1- (cyanomethyl) -3- (trifluoromethoxy) benzene are determined by its unique molecular structure. In the field of organic synthesis, it can be applied to various reactions according to different needs to produce the desired product.
(2) On its physical properties. At room temperature, or in a liquid state, with a specific color and taste. Its melting and boiling point is different from that of common substances due to intermolecular forces. The conjugate system of the benzene ring makes it stable to a certain extent; and the introduction of the cyanyl group and the trifluoromethoxy group changes the polarity of its molecules and the distribution of the electron cloud, which in turn affects the melting point.
(3) As for the chemical properties. The benzene ring can undergo electrophilic substitution reactions, such as halogenation, nitrification, and sulfonation. The cyanyl group of cyanomethyl groups has nucleophilic properties and can participate in nucleophilic substitution and addition reactions. In the case of appropriate reagents, the cyanyl group can be hydrolyzed to carboxyl groups or reduced to amino groups. In the trifluoromethoxy group, the fluorine atom is extremely electronegative, which makes the group have a strong electron-absorbing effect, which affects the electron cloud density of the benzene ring and changes the activity and localization of the electrophilic substitution reaction on the benzene ring. And because of its strong electron-absorbing properties, it may affect the reactivity of the atoms connected to it. In addition, the trifluoromethoxy group itself may participate in some special reactions, such as the formation of hydrogen bonds. In a specific reaction environment, it has an impact on the process of the reaction In conclusion, the chemical properties of 1- (cyanomethyl) -3- (trifluoromethoxy) benzene are determined by its unique molecular structure. In the field of organic synthesis, it can be applied to various reactions according to different needs to produce the desired product.
What are the synthesis methods of 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
To prepare 1- (cyanomethyl) -3- (trifluoromethoxy) benzene, the following methods can be used:
First, the method of nucleophilic substitution is used as a suitable substrate containing cyanide group and trifluoromethoxy group. Halogenated aromatic hydrocarbons are selected, such as halogenated benzene with halogen atoms connected to benzene ring. The halogen atoms are preferably bromine and iodine, and the activity is higher. Then take the cyanomethyl reagent, such as sodium cyanide and haloalkane to react to obtain the cyanomethylation reagent. In a suitable solvent, such as N, N-dimethylformamide (DMF), add a base such as potassium carbonate, heat and stir, so that the nucleophilic substitution reaction occurs. The cyanomethyl replaces the halogen atom, and then reacts with the trifluoromethoxylation reagent, such as potassium trifluoromethoxy, under the same conditions in a suitable solvent to obtain the target product.
Second, by the Grignard reagent method. First, the halogenated benzene is reacted with magnesium chips in anhydrous ether or tetrahydrofuran to prepare the Grignard reagent. Then the Grignard reagent is reacted with the compound containing the cyanide Subsequent to appropriate treatment, such as acidification, etc., and then react with trifluoromethoxylation reagents to introduce trifluoromethoxy into the benzene ring, achieving the purpose of preparation.
Third, the coupling reaction catalyzed by palladium. Using halogenated benzene as raw material, with cyanomethylborate or trifluoromethoxy borate, under the catalysis of palladium catalyst, such as tetra (triphenylphosphine) palladium, add a base and a suitable ligand, in a suitable solvent, heat for coupling reaction. This reaction condition is mild and highly selective, and can effectively construct carbon-carbon and carbon-hetero bonds to obtain 1- (cyanomethyl) -3- (trifluoromethoxy) benzene.
All preparation methods have their own advantages and disadvantages. In actual operation, it is necessary to weigh the availability of raw materials, the difficulty of reaction conditions, the purity and yield of the product, and choose the optimal path to achieve the purpose of efficient preparation.
First, the method of nucleophilic substitution is used as a suitable substrate containing cyanide group and trifluoromethoxy group. Halogenated aromatic hydrocarbons are selected, such as halogenated benzene with halogen atoms connected to benzene ring. The halogen atoms are preferably bromine and iodine, and the activity is higher. Then take the cyanomethyl reagent, such as sodium cyanide and haloalkane to react to obtain the cyanomethylation reagent. In a suitable solvent, such as N, N-dimethylformamide (DMF), add a base such as potassium carbonate, heat and stir, so that the nucleophilic substitution reaction occurs. The cyanomethyl replaces the halogen atom, and then reacts with the trifluoromethoxylation reagent, such as potassium trifluoromethoxy, under the same conditions in a suitable solvent to obtain the target product.
Second, by the Grignard reagent method. First, the halogenated benzene is reacted with magnesium chips in anhydrous ether or tetrahydrofuran to prepare the Grignard reagent. Then the Grignard reagent is reacted with the compound containing the cyanide Subsequent to appropriate treatment, such as acidification, etc., and then react with trifluoromethoxylation reagents to introduce trifluoromethoxy into the benzene ring, achieving the purpose of preparation.
Third, the coupling reaction catalyzed by palladium. Using halogenated benzene as raw material, with cyanomethylborate or trifluoromethoxy borate, under the catalysis of palladium catalyst, such as tetra (triphenylphosphine) palladium, add a base and a suitable ligand, in a suitable solvent, heat for coupling reaction. This reaction condition is mild and highly selective, and can effectively construct carbon-carbon and carbon-hetero bonds to obtain 1- (cyanomethyl) -3- (trifluoromethoxy) benzene.
All preparation methods have their own advantages and disadvantages. In actual operation, it is necessary to weigh the availability of raw materials, the difficulty of reaction conditions, the purity and yield of the product, and choose the optimal path to achieve the purpose of efficient preparation.
What are the precautions for using 1- (chloromethyl) -3- (trifluoromethoxy) benzene?
When 1-% (cyanomethyl) -3- (trifluoromethoxy) benzene is in use, there are several things to pay attention to, which are detailed as follows:
First, it is related to its chemical properties. This compound has a specific chemical activity, and when operating it, you must be familiar with its reaction characteristics. Due to the presence of cyanomethyl and trifluoromethoxy groups, the compound may exhibit a unique tendency to react. For example, cyanomethyl may participate in nucleophilic substitution reactions, etc., while the strong electron absorption of trifluoromethoxy may affect the density distribution of electron clouds in the benzene ring, and then affect various reactions related to it. Do not act rashly when operating, and be sure to study the possible chemical reactions in advance to avoid unexpected reactions.
Second, about safety protection. The compound may have certain toxicity and irritation. During the process of taking, transferring and reacting, it is necessary to strictly implement safety protection measures. Such as wearing appropriate protective equipment, including gas masks, protective gloves, protective glasses, etc., to prevent skin contact, inhalation or accidental ingestion. In case of inadvertent contact, it should be treated immediately according to the established emergency treatment process. If skin contact needs to be rinsed with plenty of water as soon as possible, and then further treatment according to the specific situation; if inhaled, it should be quickly transferred to a fresh air place and seek medical attention in time.
Third, storage conditions should not be ignored. 1-% (cyanomethyl) -3- (trifluoromethoxy) benzene should be stored in a cool, dry and well-ventilated place, away from fire, heat and oxidants. Due to its chemical properties, improper storage conditions may cause it to deteriorate or cause safety hazards. Storage containers also need to be well sealed to prevent leakage. Fourth, in the choice of reaction system, it is necessary to comprehensively consider the physical properties such as solubility of the compound. Select a suitable solvent to make the reaction proceed smoothly. At the same time, the temperature, pH and other conditions during the reaction process also need to be precisely controlled, because these factors will have a significant impact on the rate of reaction and the purity of the product.
First, it is related to its chemical properties. This compound has a specific chemical activity, and when operating it, you must be familiar with its reaction characteristics. Due to the presence of cyanomethyl and trifluoromethoxy groups, the compound may exhibit a unique tendency to react. For example, cyanomethyl may participate in nucleophilic substitution reactions, etc., while the strong electron absorption of trifluoromethoxy may affect the density distribution of electron clouds in the benzene ring, and then affect various reactions related to it. Do not act rashly when operating, and be sure to study the possible chemical reactions in advance to avoid unexpected reactions.
Second, about safety protection. The compound may have certain toxicity and irritation. During the process of taking, transferring and reacting, it is necessary to strictly implement safety protection measures. Such as wearing appropriate protective equipment, including gas masks, protective gloves, protective glasses, etc., to prevent skin contact, inhalation or accidental ingestion. In case of inadvertent contact, it should be treated immediately according to the established emergency treatment process. If skin contact needs to be rinsed with plenty of water as soon as possible, and then further treatment according to the specific situation; if inhaled, it should be quickly transferred to a fresh air place and seek medical attention in time.
Third, storage conditions should not be ignored. 1-% (cyanomethyl) -3- (trifluoromethoxy) benzene should be stored in a cool, dry and well-ventilated place, away from fire, heat and oxidants. Due to its chemical properties, improper storage conditions may cause it to deteriorate or cause safety hazards. Storage containers also need to be well sealed to prevent leakage. Fourth, in the choice of reaction system, it is necessary to comprehensively consider the physical properties such as solubility of the compound. Select a suitable solvent to make the reaction proceed smoothly. At the same time, the temperature, pH and other conditions during the reaction process also need to be precisely controlled, because these factors will have a significant impact on the rate of reaction and the purity of the product.
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