Linshang Chemical
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1-(Chloromethyl)-3-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
203666 |
| Chemical Formula | C8H6ClF3 |
| Molar Mass | 194.58 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 173 - 175 °C |
| Density | 1.29 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Flash Point | 59 °C |
| Refractive Index | 1.457 - 1.459 |
As an accredited 1-(Chloromethyl)-3-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 mL bottle of 1-(chloromethyl)-3-(trifluoromethyl)benzene with secure chemical - grade packaging. |
| Storage | 1-(Chloromethyl)-3-(trifluoromethyl)benzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. Keep it in a tightly closed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances. Ensure the storage location has proper spill - containment measures due to its potentially hazardous nature. |
| Shipping | 1-(Chloromethyl)-3-(trifluoromethyl)benzene is shipped in specialized, tightly - sealed containers. These containers prevent leakage. Shipments follow strict chemical transportation regulations to ensure safety during transit. |
Competitive 1-(Chloromethyl)-3-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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As a leading 1-(Chloromethyl)-3-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1- (chloromethyl) -3- (trifluoromethyl) benzene?
(1- (cyanomethyl) -3- (trifluoromethyl) pyridine has important uses in many fields.)
In the field of medicinal chemistry, this compound can be said to be a key cornerstone for the creation of new drugs. Due to its special chemical structure, it has unique biological activities and pharmacological properties. For example, in the development of anti-tumor drugs, it can precisely combine with specific targets of cancer cells by virtue of its own structure, interfering with the growth, proliferation and metastasis of cancer cells, bringing new light to the fight against cancer problems; in the field of antibacterial drugs, it can effectively inhibit the key metabolic pathways of bacteria or destroy the cell walls and cell membranes of bacteria, thus demonstrating strong antibacterial effects and helping to solve the difficult problem of bacterial drug resistance.
In the field of materials science, 1- (cyanomethyl) -3- (trifluoromethyl) pyridine also shines. When synthesizing high-performance polymer materials, introducing them into the polymer main chain or side chain can significantly improve the thermal stability, chemical stability and mechanical properties of the materials. For example, the addition of this compound to high-performance composites used in the aerospace field allows the material to maintain good performance in extreme temperatures and complex chemical environments, ensuring the safe and stable operation of aircraft; in the field of electronic materials, it helps to improve the charge transport performance and stability of organic semiconductor materials, laying the foundation for the development of high-performance electronic devices such as organic Light Emitting Diodes (OLEDs), field effect transistors (FETs), etc.
In the field of agricultural chemistry, this compound also plays an indispensable role. It can be used as an important raw material for the creation of new pesticides, and its special structure can have specific effects on the nervous system and respiratory system of pests. While killing pests efficiently, it has minimal impact on the environment and non-target organisms. It is in line with the current green agricultural development concept and contributes to ensuring crop yield and quality and promoting sustainable agricultural development.
In the field of medicinal chemistry, this compound can be said to be a key cornerstone for the creation of new drugs. Due to its special chemical structure, it has unique biological activities and pharmacological properties. For example, in the development of anti-tumor drugs, it can precisely combine with specific targets of cancer cells by virtue of its own structure, interfering with the growth, proliferation and metastasis of cancer cells, bringing new light to the fight against cancer problems; in the field of antibacterial drugs, it can effectively inhibit the key metabolic pathways of bacteria or destroy the cell walls and cell membranes of bacteria, thus demonstrating strong antibacterial effects and helping to solve the difficult problem of bacterial drug resistance.
In the field of materials science, 1- (cyanomethyl) -3- (trifluoromethyl) pyridine also shines. When synthesizing high-performance polymer materials, introducing them into the polymer main chain or side chain can significantly improve the thermal stability, chemical stability and mechanical properties of the materials. For example, the addition of this compound to high-performance composites used in the aerospace field allows the material to maintain good performance in extreme temperatures and complex chemical environments, ensuring the safe and stable operation of aircraft; in the field of electronic materials, it helps to improve the charge transport performance and stability of organic semiconductor materials, laying the foundation for the development of high-performance electronic devices such as organic Light Emitting Diodes (OLEDs), field effect transistors (FETs), etc.
In the field of agricultural chemistry, this compound also plays an indispensable role. It can be used as an important raw material for the creation of new pesticides, and its special structure can have specific effects on the nervous system and respiratory system of pests. While killing pests efficiently, it has minimal impact on the environment and non-target organisms. It is in line with the current green agricultural development concept and contributes to ensuring crop yield and quality and promoting sustainable agricultural development.
What are the physical properties of 1- (chloromethyl) -3- (trifluoromethyl) benzene?
1- (deuterium methyl) -3- (trifluoromethyl) benzene, its physical properties are as follows:
This compound is mostly liquid at room temperature. Looking at its appearance, when it is pure, it is often colorless and transparent, like clear water, but its smell is specific and aromatic, and its unique charm can be recognized when smelled.
When it comes to density, compared to water, 1- (deuterium methyl) -3- (trifluoromethyl) benzene has a slightly smaller density. If placed in water, it can float above the water surface.
A boiling point, about a specific temperature range. When the external pressure is at standard atmospheric pressure, its boiling point can reach a certain value. At this temperature, the compound gradually changes from liquid to gaseous state, the intermolecular force weakens, and begins to dissipate freely in space.
In terms of solubility, it has good solubility in organic solvents. Organic solvents such as common ethanol and ether can be miscible with it to form a uniform solution. However, in water, its solubility is poor. Due to the characteristics of its molecular structure, it is difficult to form a good interaction with water molecules, so it is difficult to dissolve in water.
In addition, the compound has a certain volatility. Under normal temperature, its molecules are constantly moving, and some molecules overcome intermolecular forces, evaporate from the liquid surface to the air, and because of their certain vapor pressure, they can form corresponding vapor concentrations in confined spaces.
The above are all the physical properties of 1- (deuteromethyl) -3- (trifluoromethyl) benzene, which are important considerations in chemical research and industrial applications.
This compound is mostly liquid at room temperature. Looking at its appearance, when it is pure, it is often colorless and transparent, like clear water, but its smell is specific and aromatic, and its unique charm can be recognized when smelled.
When it comes to density, compared to water, 1- (deuterium methyl) -3- (trifluoromethyl) benzene has a slightly smaller density. If placed in water, it can float above the water surface.
A boiling point, about a specific temperature range. When the external pressure is at standard atmospheric pressure, its boiling point can reach a certain value. At this temperature, the compound gradually changes from liquid to gaseous state, the intermolecular force weakens, and begins to dissipate freely in space.
In terms of solubility, it has good solubility in organic solvents. Organic solvents such as common ethanol and ether can be miscible with it to form a uniform solution. However, in water, its solubility is poor. Due to the characteristics of its molecular structure, it is difficult to form a good interaction with water molecules, so it is difficult to dissolve in water.
In addition, the compound has a certain volatility. Under normal temperature, its molecules are constantly moving, and some molecules overcome intermolecular forces, evaporate from the liquid surface to the air, and because of their certain vapor pressure, they can form corresponding vapor concentrations in confined spaces.
The above are all the physical properties of 1- (deuteromethyl) -3- (trifluoromethyl) benzene, which are important considerations in chemical research and industrial applications.
What are the chemical properties of 1- (chloromethyl) -3- (trifluoromethyl) benzene?
1 - (methoxy) - 3 - (trifluoromethoxy) benzene has unique chemical properties and many specificities.
In this compound, methoxy and trifluoromethoxy are two types of substituents, which have far-reaching effects on its chemical properties. Methoxy is rich in electrons and exhibits the characteristics of electrons. Due to the solitary pair of electrons of oxygen atoms, the electron cloud can be transferred to the benzene ring by the conjugation effect, resulting in an increase in the density of the electron cloud of the benzene ring. This property makes the benzene ring more vulnerable to the attack of electrophilic reagents in the electrophilic substitution reaction, showing higher reactivity. In electrophilic substitution reactions such as halogenation reactions and nitrification reactions, the presence of methoxy groups can make the reaction conditions milder and promote the reaction to occur preferentially over ortho and para-sites.
However, trifluoromethoxy groups are quite different, showing strong electron-absorbing properties. Fluorine atoms are extremely electronegative, and trifluoromethoxy groups strongly attract benzene ring electron clouds through induction effects, which greatly reduce the density of benzene ring electron clouds. This effect results in a significant decrease in the activity of benzene rings in electrophilic substitution reactions, and the reaction conditions are often more severe. However, in some nucleophilic substitution reactions, due to the reduction of benzene ring electron cloud density, benzene rings are more susceptible to nucleophilic attack, showing different reactivity.
The two coexist on the same benzene ring and interact with each other, resulting in the complex and unique chemical properties of 1- (methoxy) -3- (trifluoromethoxy) benzene. In the field of organic synthesis, it can be used to construct various organic compounds with novel structures by virtue of its unique properties, and the application prospect is quite broad. For example, in pharmaceutical chemistry, it can be used to optimize the activity and selectivity of drug molecules by virtue of its unique electronic effects; in materials science, it can be used to prepare functional materials with special properties by virtue of its chemical properties.
In this compound, methoxy and trifluoromethoxy are two types of substituents, which have far-reaching effects on its chemical properties. Methoxy is rich in electrons and exhibits the characteristics of electrons. Due to the solitary pair of electrons of oxygen atoms, the electron cloud can be transferred to the benzene ring by the conjugation effect, resulting in an increase in the density of the electron cloud of the benzene ring. This property makes the benzene ring more vulnerable to the attack of electrophilic reagents in the electrophilic substitution reaction, showing higher reactivity. In electrophilic substitution reactions such as halogenation reactions and nitrification reactions, the presence of methoxy groups can make the reaction conditions milder and promote the reaction to occur preferentially over ortho and para-sites.
However, trifluoromethoxy groups are quite different, showing strong electron-absorbing properties. Fluorine atoms are extremely electronegative, and trifluoromethoxy groups strongly attract benzene ring electron clouds through induction effects, which greatly reduce the density of benzene ring electron clouds. This effect results in a significant decrease in the activity of benzene rings in electrophilic substitution reactions, and the reaction conditions are often more severe. However, in some nucleophilic substitution reactions, due to the reduction of benzene ring electron cloud density, benzene rings are more susceptible to nucleophilic attack, showing different reactivity.
The two coexist on the same benzene ring and interact with each other, resulting in the complex and unique chemical properties of 1- (methoxy) -3- (trifluoromethoxy) benzene. In the field of organic synthesis, it can be used to construct various organic compounds with novel structures by virtue of its unique properties, and the application prospect is quite broad. For example, in pharmaceutical chemistry, it can be used to optimize the activity and selectivity of drug molecules by virtue of its unique electronic effects; in materials science, it can be used to prepare functional materials with special properties by virtue of its chemical properties.
What are the preparation methods of 1- (chloromethyl) -3- (trifluoromethyl) benzene?
To prepare 1 - (cyanomethyl) -3 - (trifluoromethyl) benzene, the following ancient methods can be used.
First, start with benzene, and first make benzene and halogenated cyanomethyl reagents undergo electrophilic substitution reaction. Halogenated cyanomethyl reagents, such as chloroacetonitrile. In the presence of appropriate catalysts, such as aluminum trichloride, the electron cloud density of the benzene ring is higher, and the chlorine atom of chloroacetonitrile is electrophilic attack, leaving chloride ions to form 1 - (cyanomethyl) benzene intermediates. This step requires attention to the reaction temperature and catalyst dosage. If the temperature is too high or the by-product of multiple substitution is generated, the reaction rate will be slow if the temperature is too low.
Second, further convert 1- (cyanomethyl) benzene. Take appropriate trifluoromethylation reagents, such as trifluoromethyl magnesium halide, and perform nucleophilic substitution in suitable solvents, such as tetrahydrofuran. Trifluoromethyl negative ions attack the ortho or meta-position of the benzene ring of 1- (cyanomethyl) benzene, and select the substitution check point according to the positioning rules and reaction conditions. After a series of electron transfer and chemical bond recombination, 1- (cyanomethyl) -3- (trifluoromethyl) benzene can be obtained. In this process, the properties of the solvent, the reaction time and temperature all have a great influence on the reaction, which needs to be carefully regulated.
Another method is to carry out trifluoromethylation of benzene first. With a suitable trifluoromethylation reagent, such as trifluoromethyl sulfonic anhydride, etc., under the action of a specific catalyst, the benzene ring is introduced into trifluoromethyl to obtain benzene derivatives containing trifluoromethyl. Subsequently, it is reacted with halogenated cyanomethyl reagents. The reaction mechanism is similar to the above. By electrophilic or nucleophilic substitution reaction, cyanomethyl is introduced at a suitable check point, and the final product is 1 - (cyanomethyl) -3 - (trifluoromethyl) benzene. This path also requires attention to the control of reaction conditions at each step, such as the proportion of reactants, the pH of the reaction environment, etc., so as to avoid side
First, start with benzene, and first make benzene and halogenated cyanomethyl reagents undergo electrophilic substitution reaction. Halogenated cyanomethyl reagents, such as chloroacetonitrile. In the presence of appropriate catalysts, such as aluminum trichloride, the electron cloud density of the benzene ring is higher, and the chlorine atom of chloroacetonitrile is electrophilic attack, leaving chloride ions to form 1 - (cyanomethyl) benzene intermediates. This step requires attention to the reaction temperature and catalyst dosage. If the temperature is too high or the by-product of multiple substitution is generated, the reaction rate will be slow if the temperature is too low.
Second, further convert 1- (cyanomethyl) benzene. Take appropriate trifluoromethylation reagents, such as trifluoromethyl magnesium halide, and perform nucleophilic substitution in suitable solvents, such as tetrahydrofuran. Trifluoromethyl negative ions attack the ortho or meta-position of the benzene ring of 1- (cyanomethyl) benzene, and select the substitution check point according to the positioning rules and reaction conditions. After a series of electron transfer and chemical bond recombination, 1- (cyanomethyl) -3- (trifluoromethyl) benzene can be obtained. In this process, the properties of the solvent, the reaction time and temperature all have a great influence on the reaction, which needs to be carefully regulated.
Another method is to carry out trifluoromethylation of benzene first. With a suitable trifluoromethylation reagent, such as trifluoromethyl sulfonic anhydride, etc., under the action of a specific catalyst, the benzene ring is introduced into trifluoromethyl to obtain benzene derivatives containing trifluoromethyl. Subsequently, it is reacted with halogenated cyanomethyl reagents. The reaction mechanism is similar to the above. By electrophilic or nucleophilic substitution reaction, cyanomethyl is introduced at a suitable check point, and the final product is 1 - (cyanomethyl) -3 - (trifluoromethyl) benzene. This path also requires attention to the control of reaction conditions at each step, such as the proportion of reactants, the pH of the reaction environment, etc., so as to avoid side
What are the precautions for using 1- (chloromethyl) -3- (trifluoromethyl) benzene?
1 - (cyanomethyl) -3 - (trifluoromethyl) pyridine is a compound commonly used in the field of organic synthesis. During use, be sure to pay attention to the following general matters:
First, safety protection is of paramount importance. This compound may be toxic and irritating. When operating, you must wear appropriate protective equipment, such as laboratory clothes, gloves, goggles, etc., to avoid skin contact and eye splashing. In case of inadvertent contact, you should immediately rinse with plenty of water and seek medical treatment according to the specific situation. And because of its or volatile production of harmful gases, the operation should be carried out in a well-ventilated environment, preferably in a fume hood to prevent inhalation of harmful gases and damage to the respiratory system.
Second, the storage conditions should not be ignored. It should be stored in a cool, dry and ventilated place, away from fire and heat sources, and away from direct sunlight. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and should not be stored in combination to prevent chemical reactions from occurring and causing danger.
Third, precise control of the dosage during use is crucial. In view of its high reactivity, the dosage difference or reaction results are very different. Therefore, before use, it is necessary to measure with the help of precise gauges according to the reaction requirements to ensure that the reaction proceeds as expected and improve the purity and yield of the product.
Fourth, it is essential to be familiar with the reaction characteristics. When participating in a chemical reaction, it is necessary to clarify the reaction mechanism, conditions and possible side reactions in advance. For example, factors such as reaction temperature and solvent selection will affect the reaction process and product formation. Reasonable regulation of reaction conditions can achieve the desired reaction effect.
Fifth, waste treatment should not be underestimated. After the experiment is completed, the waste containing the compound must be properly disposed of in accordance with relevant regulations and cannot be dumped at will to avoid pollution to the environment. Generally speaking, waste should be collected in a specific container and disposed of by a professional organization.
First, safety protection is of paramount importance. This compound may be toxic and irritating. When operating, you must wear appropriate protective equipment, such as laboratory clothes, gloves, goggles, etc., to avoid skin contact and eye splashing. In case of inadvertent contact, you should immediately rinse with plenty of water and seek medical treatment according to the specific situation. And because of its or volatile production of harmful gases, the operation should be carried out in a well-ventilated environment, preferably in a fume hood to prevent inhalation of harmful gases and damage to the respiratory system.
Second, the storage conditions should not be ignored. It should be stored in a cool, dry and ventilated place, away from fire and heat sources, and away from direct sunlight. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and should not be stored in combination to prevent chemical reactions from occurring and causing danger.
Third, precise control of the dosage during use is crucial. In view of its high reactivity, the dosage difference or reaction results are very different. Therefore, before use, it is necessary to measure with the help of precise gauges according to the reaction requirements to ensure that the reaction proceeds as expected and improve the purity and yield of the product.
Fourth, it is essential to be familiar with the reaction characteristics. When participating in a chemical reaction, it is necessary to clarify the reaction mechanism, conditions and possible side reactions in advance. For example, factors such as reaction temperature and solvent selection will affect the reaction process and product formation. Reasonable regulation of reaction conditions can achieve the desired reaction effect.
Fifth, waste treatment should not be underestimated. After the experiment is completed, the waste containing the compound must be properly disposed of in accordance with relevant regulations and cannot be dumped at will to avoid pollution to the environment. Generally speaking, waste should be collected in a specific container and disposed of by a professional organization.
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