Linshang Chemical
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1-(Chloromethyl)-4-(1,1-Dimethylethyl)-Benzene
Linshang Chemical
|
HS Code |
953658 |
| Chemical Formula | C11H15Cl |
| Molar Mass | 182.69 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 212 - 213 °C |
| Density | 0.98 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether, and benzene |
| Flash Point | 81 °C |
| Vapor Pressure | Low at room temperature |
As an accredited 1-(Chloromethyl)-4-(1,1-Dimethylethyl)-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - (Chloromethyl)-4-(1,1 - dimethylethyl) - benzene in 500g sealed glass bottle packaging. |
| Storage | 1-(Chloromethyl)-4-(1,1 -dimethylethyl)benzene should be stored in a cool, dry, well - ventilated area away from sources of ignition. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, bases, and reactive chemicals to prevent hazardous reactions. |
| Shipping | 1-(Chloromethyl)-4-(1,1 -dimethylethyl) -benzene is shipped in tightly sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling and safe transportation to prevent any spills or hazards. |
Competitive 1-(Chloromethyl)-4-(1,1-Dimethylethyl)-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 1- (chloromethyl) -4- (1,1-dimethylethyl) benzene?
1 - (hydroxymethyl) -4 - (1,1 - dimethyl ethyl) benzene, also known as p-tert-butylbenzyl alcohol, has a wide range of main uses.
In the field of organic synthesis, this is a key intermediate. For example, in fragrance synthesis, it can be converted into fragrant and rich fragrance components through specific chemical reactions. Because the compound has a unique chemical structure, after ingenious modification, it can endow fragrances with different aroma characteristics, which can be used in the preparation of various perfumes and fragrances to increase the layering and uniqueness of its aroma.
It also plays an important role in medicinal chemistry. In the synthesis of many drugs, this is the starting material or key intermediate. Its structure can provide specific chemical groups for drug molecules, which can help to enhance the activity of drugs, improve their solubility, or adjust the metabolic properties of drugs in the body, thereby improving the efficacy and safety of drugs.
In the field of materials science, 1- (hydroxymethyl) -4- (1,1-dimethylethyl) benzene is also used. In the preparation process of some polymer materials, it can be introduced as a functional monomer to give the material special properties. For example, to enhance the heat resistance and chemical corrosion resistance of materials, or to adjust the surface properties of materials to make them more suitable for specific application scenarios, such as in the fields of electronic device packaging materials and high-performance coatings.
In the field of organic synthesis, this is a key intermediate. For example, in fragrance synthesis, it can be converted into fragrant and rich fragrance components through specific chemical reactions. Because the compound has a unique chemical structure, after ingenious modification, it can endow fragrances with different aroma characteristics, which can be used in the preparation of various perfumes and fragrances to increase the layering and uniqueness of its aroma.
It also plays an important role in medicinal chemistry. In the synthesis of many drugs, this is the starting material or key intermediate. Its structure can provide specific chemical groups for drug molecules, which can help to enhance the activity of drugs, improve their solubility, or adjust the metabolic properties of drugs in the body, thereby improving the efficacy and safety of drugs.
In the field of materials science, 1- (hydroxymethyl) -4- (1,1-dimethylethyl) benzene is also used. In the preparation process of some polymer materials, it can be introduced as a functional monomer to give the material special properties. For example, to enhance the heat resistance and chemical corrosion resistance of materials, or to adjust the surface properties of materials to make them more suitable for specific application scenarios, such as in the fields of electronic device packaging materials and high-performance coatings.
What are the physical properties of 1- (chloromethyl) -4- (1,1-dimethylethyl) benzene?
(1 - (methoxy) -4 - (1,1 - dimethylethyl) benzene, also known as p-tert-butyl anisole, has the following physical properties:
This substance is a colorless liquid at room temperature, and it is clear and transparent when viewed. It has a special aromatic odor, which is unique and obvious, and is easier to detect. Its boiling point is in a specific range, between 164 and 166 degrees Celsius. At this temperature, the substance will change from liquid to gaseous. The melting point is relatively low, at -62 degrees Celsius. When the temperature drops to this point and below, it will solidify from liquid to solid.
The density of p-tert-butyl anisole is less than that of water, about 0.86g/cm ³. If mixed with water, it will float on the water surface. At the same time, it is insoluble in water, but it can be miscible with most organic solvents such as ethanol and ether in any ratio, which is determined by its molecular structure characteristics.
This substance has a certain degree of volatility and will gradually evaporate in the air, emitting its unique odor. And its vapor is heavier than air and can spread to a considerable distance at a lower place. In case of open flame and high heat energy, it will cause combustion and explosion, which poses a certain safety risk.)
This substance is a colorless liquid at room temperature, and it is clear and transparent when viewed. It has a special aromatic odor, which is unique and obvious, and is easier to detect. Its boiling point is in a specific range, between 164 and 166 degrees Celsius. At this temperature, the substance will change from liquid to gaseous. The melting point is relatively low, at -62 degrees Celsius. When the temperature drops to this point and below, it will solidify from liquid to solid.
The density of p-tert-butyl anisole is less than that of water, about 0.86g/cm ³. If mixed with water, it will float on the water surface. At the same time, it is insoluble in water, but it can be miscible with most organic solvents such as ethanol and ether in any ratio, which is determined by its molecular structure characteristics.
This substance has a certain degree of volatility and will gradually evaporate in the air, emitting its unique odor. And its vapor is heavier than air and can spread to a considerable distance at a lower place. In case of open flame and high heat energy, it will cause combustion and explosion, which poses a certain safety risk.)
What are the chemical properties of 1- (chloromethyl) -4- (1,1-dimethylethyl) benzene?
1 - (methoxy) - 4 - (1,1 - dimethylethyl) benzene, also known as p-tert-butyl anisole, is an organic compound. Its physical and chemical properties are unique and it is widely used in many fields.
Discussing the physical properties, the substance is a colorless to light yellow liquid under normal conditions, with a special aromatic odor. Boiling point is about 197 - 198 ° C, melting point - 61 ° C, density is about 0.86 g/cm ³, insoluble in water, but miscible with organic solvents such as ethanol and ether.
In terms of chemical properties, first, due to the presence of benzene rings, it has the characteristics of aromatic hydrocarbons, and electrophilic substitution reactions can occur. For example, when reacted with a halogenating agent under appropriate conditions, the halogen atom will replace the hydrogen atom on the benzene ring; when reacted with the mixed acid of concentrated sulfuric acid and concentrated nitric acid, nitro substitution products can be formed. Second, the methoxy group is a donator group, which has an impact on the distribution of electron clouds in the benzene ring, increasing the density of electron clouds in the ortho and para-sites of the benzene ring, and the electrophilic substitution reaction is more likely to occur in the ortho and para-sites. Third, 1,1-dimethylethyl (tert-butyl) is relatively stable and does not react easily under normal conditions, but under the action of strong oxidants or specific high temperatures, high pressures and catalysts, its carbon-carbon bonds may break. Fourth, the compound has certain oxidation resistance. Due to the donator effect of the methoxy group, it can capture free radicals In the fragrance industry, this compound can be used to prepare flavors due to its unique aroma. In the field of organic synthesis, it is an important intermediate and can prepare a variety of drugs, pesticides and other fine chemicals through a series of reactions. Due to its antioxidant properties, it is also used as an antioxidant in the food, oil and other industries to delay the rancidity of oils and oxidative deterioration of foods.
Discussing the physical properties, the substance is a colorless to light yellow liquid under normal conditions, with a special aromatic odor. Boiling point is about 197 - 198 ° C, melting point - 61 ° C, density is about 0.86 g/cm ³, insoluble in water, but miscible with organic solvents such as ethanol and ether.
In terms of chemical properties, first, due to the presence of benzene rings, it has the characteristics of aromatic hydrocarbons, and electrophilic substitution reactions can occur. For example, when reacted with a halogenating agent under appropriate conditions, the halogen atom will replace the hydrogen atom on the benzene ring; when reacted with the mixed acid of concentrated sulfuric acid and concentrated nitric acid, nitro substitution products can be formed. Second, the methoxy group is a donator group, which has an impact on the distribution of electron clouds in the benzene ring, increasing the density of electron clouds in the ortho and para-sites of the benzene ring, and the electrophilic substitution reaction is more likely to occur in the ortho and para-sites. Third, 1,1-dimethylethyl (tert-butyl) is relatively stable and does not react easily under normal conditions, but under the action of strong oxidants or specific high temperatures, high pressures and catalysts, its carbon-carbon bonds may break. Fourth, the compound has certain oxidation resistance. Due to the donator effect of the methoxy group, it can capture free radicals In the fragrance industry, this compound can be used to prepare flavors due to its unique aroma. In the field of organic synthesis, it is an important intermediate and can prepare a variety of drugs, pesticides and other fine chemicals through a series of reactions. Due to its antioxidant properties, it is also used as an antioxidant in the food, oil and other industries to delay the rancidity of oils and oxidative deterioration of foods.
What are the preparation methods of 1- (chloromethyl) -4- (1,1-dimethylethyl) benzene?
To prepare 1- (cyanomethyl) -4- (1,1-dimethethyl) benzene, the following methods can be used:
First, p-tert-butyltoluene is used as the starting material. First, it is heated with N-bromosuccinimide (NBS) in an appropriate solvent such as carbon tetrachloride in the presence of an initiator such as benzoyl peroxide. The benzyl hydrogen of p-tert-butyltoluene is highly active due to the influence of benzene ring and tert-butyl group. NBS can selectively replace the benzyl hydrogen to generate p-tert-butylbenzyl bromide. In this step, attention should be paid to controlling the reaction temperature and the amount of NBS to avoid the formation of polybrominated products. Afterwards, p-tert-butyl benzyl bromide is reacted with sodium cyanide or potassium cyanide in a polar aprotic solvent such as dimethyl sulfoxide (DMSO). The bromine atom of bromobenzyl is highly reactive, and the cyanogen ion can replace the bromine atom to obtain 1- (cyanomethyl) -4- (1,1-dimethyl ethyl) benzene. This reaction needs to be carried out in an anhydrous environment to prevent the hydrolysis of sodium cyanide or potassium cyanide.
Second, you can start from p-tert-butyl benzoic acid. First, p-tert-butyl benzoic acid and methanol are esterified under the catalysis of concentrated sulfuric acid to form methyl p-tert-butyl benzoate. During the reaction, it needs to be heated and appropriate equipment such as a water Then, using strong reducing agents such as lithium aluminum hydride (LiAlH), methyl p-tert-butylbenzoate is reduced to p-tert-butylbenzyl alcohol in anhydrous ether or tetrahydrofuran solvents. This step needs to be carried out at low temperature and in a strictly anhydrous environment, because lithium aluminum hydride reacts violently with water. Finally, p-tert-butylbenzyl alcohol reacts with hydrobromic acid or phosphorus tribromide, and the hydroxyl group is replaced by a bromine atom to form p-tert-butylbenzyl bromide, which is then reacted with sodium cyanide or potassium cyanide according to the above method, and the target product can also be obtained.
Third, tert-butylbenzene and acrylonitrile are used as raw materials, and the Fourier-gram reaction is carried out The benzene ring electron cloud density of tert-butylbenzene is high, and acrylonitrile forms a carbon-cation intermediate under the action of aluminum trichloride, and then undergoes an electrophilic substitution reaction with tert-butylbenzene to generate 1- (cyanomethyl) -4- (1,1 -dimethyl ethyl) benzene. The reaction needs to start under anhydrous and low temperature conditions, and gradually heat up. At the same time, attention should be paid to controlling the amount of aluminum trichloride and the reaction time to prevent side reactions from occurring.
First, p-tert-butyltoluene is used as the starting material. First, it is heated with N-bromosuccinimide (NBS) in an appropriate solvent such as carbon tetrachloride in the presence of an initiator such as benzoyl peroxide. The benzyl hydrogen of p-tert-butyltoluene is highly active due to the influence of benzene ring and tert-butyl group. NBS can selectively replace the benzyl hydrogen to generate p-tert-butylbenzyl bromide. In this step, attention should be paid to controlling the reaction temperature and the amount of NBS to avoid the formation of polybrominated products. Afterwards, p-tert-butyl benzyl bromide is reacted with sodium cyanide or potassium cyanide in a polar aprotic solvent such as dimethyl sulfoxide (DMSO). The bromine atom of bromobenzyl is highly reactive, and the cyanogen ion can replace the bromine atom to obtain 1- (cyanomethyl) -4- (1,1-dimethyl ethyl) benzene. This reaction needs to be carried out in an anhydrous environment to prevent the hydrolysis of sodium cyanide or potassium cyanide.
Second, you can start from p-tert-butyl benzoic acid. First, p-tert-butyl benzoic acid and methanol are esterified under the catalysis of concentrated sulfuric acid to form methyl p-tert-butyl benzoate. During the reaction, it needs to be heated and appropriate equipment such as a water Then, using strong reducing agents such as lithium aluminum hydride (LiAlH), methyl p-tert-butylbenzoate is reduced to p-tert-butylbenzyl alcohol in anhydrous ether or tetrahydrofuran solvents. This step needs to be carried out at low temperature and in a strictly anhydrous environment, because lithium aluminum hydride reacts violently with water. Finally, p-tert-butylbenzyl alcohol reacts with hydrobromic acid or phosphorus tribromide, and the hydroxyl group is replaced by a bromine atom to form p-tert-butylbenzyl bromide, which is then reacted with sodium cyanide or potassium cyanide according to the above method, and the target product can also be obtained.
Third, tert-butylbenzene and acrylonitrile are used as raw materials, and the Fourier-gram reaction is carried out The benzene ring electron cloud density of tert-butylbenzene is high, and acrylonitrile forms a carbon-cation intermediate under the action of aluminum trichloride, and then undergoes an electrophilic substitution reaction with tert-butylbenzene to generate 1- (cyanomethyl) -4- (1,1 -dimethyl ethyl) benzene. The reaction needs to start under anhydrous and low temperature conditions, and gradually heat up. At the same time, attention should be paid to controlling the amount of aluminum trichloride and the reaction time to prevent side reactions from occurring.
What are the precautions for using 1- (chloromethyl) -4- (1,1-dimethylethyl) benzene?
1 - (cyanomethyl) - 4 - (1,1 - dimethylethyl) benzene, this is an organic compound. During use, many things should be paid attention to:
First, safety protection is essential. This compound may be toxic and irritating to some extent. Be sure to wear suitable protective equipment during operation, such as protective gloves, goggles and gas masks, to prevent skin contact, eye splashing and inhalation of its volatile gases, to avoid damage to the body.
Second, storage conditions should not be ignored. Store it in a cool, well-ventilated place, away from fire and heat sources. Because it is mostly flammable substances, in case of open flames and hot topics, it is easy to cause combustion and explosion. Therefore, the storage environment must be kept away from the fire source, and the temperature should not be too high. At the same time, ensure that the ventilation in the storage area is smooth to prevent gas accumulation.
Third, the ventilation conditions in the use place must be good. Whether it is used in a laboratory or an industrial production environment, it should be equipped with high-efficiency ventilation facilities to discharge volatile gases in time to reduce the concentration of harmful substances in the air and reduce the risk of inhalation by operators.
Fourth, the operating specifications should not be underestimated. Conduct experiments or production in strict accordance with the established operating procedures to avoid compound leakage and splashing due to improper operation. After use, properly dispose of the remaining substances and waste, and do not discard them at will. Dispose of them in accordance with relevant environmental protection regulations to prevent pollution of the environment.
Fifth, it is essential to be familiar with emergency treatment methods. In the event of an accident such as leakage, contact or inhalation, correct emergency measures should be taken immediately. If it comes into contact with the skin, quickly rinse with a large amount of flowing water; if it comes into contact with the eyes, immediately rinse with flowing water or normal saline and seek medical attention; if inhaled, quickly transfer to a fresh place of air to keep the respiratory tract unobstructed, and perform artificial respiration and seek medical attention if necessary. Operators need to be familiar with such emergency treatment procedures so that they can respond in time when an accident occurs.
First, safety protection is essential. This compound may be toxic and irritating to some extent. Be sure to wear suitable protective equipment during operation, such as protective gloves, goggles and gas masks, to prevent skin contact, eye splashing and inhalation of its volatile gases, to avoid damage to the body.
Second, storage conditions should not be ignored. Store it in a cool, well-ventilated place, away from fire and heat sources. Because it is mostly flammable substances, in case of open flames and hot topics, it is easy to cause combustion and explosion. Therefore, the storage environment must be kept away from the fire source, and the temperature should not be too high. At the same time, ensure that the ventilation in the storage area is smooth to prevent gas accumulation.
Third, the ventilation conditions in the use place must be good. Whether it is used in a laboratory or an industrial production environment, it should be equipped with high-efficiency ventilation facilities to discharge volatile gases in time to reduce the concentration of harmful substances in the air and reduce the risk of inhalation by operators.
Fourth, the operating specifications should not be underestimated. Conduct experiments or production in strict accordance with the established operating procedures to avoid compound leakage and splashing due to improper operation. After use, properly dispose of the remaining substances and waste, and do not discard them at will. Dispose of them in accordance with relevant environmental protection regulations to prevent pollution of the environment.
Fifth, it is essential to be familiar with emergency treatment methods. In the event of an accident such as leakage, contact or inhalation, correct emergency measures should be taken immediately. If it comes into contact with the skin, quickly rinse with a large amount of flowing water; if it comes into contact with the eyes, immediately rinse with flowing water or normal saline and seek medical attention; if inhaled, quickly transfer to a fresh place of air to keep the respiratory tract unobstructed, and perform artificial respiration and seek medical attention if necessary. Operators need to be familiar with such emergency treatment procedures so that they can respond in time when an accident occurs.
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