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1-(Chloromethyl)-4-Ethenylbenzene
Linshang Chemical
|
HS Code |
287581 |
| Chemical Formula | C9H9Cl |
| Molar Mass | 152.62 g/mol |
| Appearance | Colorless to yellow - liquid |
| Odor | Pungent |
| Boiling Point | 204 - 206 °C |
| Density | 1.07 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 78 °C |
| Stability | Stable under normal conditions, but reactive towards nucleophiles |
As an accredited 1-(Chloromethyl)-4-Ethenylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1-(chloromethyl)-4-ethenylbenzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 1-(Chloromethyl)-4-ethenylbenzene should be stored in a cool, dry, well - ventilated area away from heat sources, ignition sources, and oxidizing agents. Keep it in a tightly - sealed container to prevent leakage and exposure to air or moisture. Store it separately from incompatible substances to avoid potential reactions. Follow local safety regulations for proper storage. |
| Shipping | 1-(Chloromethyl)-4-ethenylbenzene is shipped in well - sealed, corrosion - resistant containers. It's transported under strict safety protocols due to its chemical nature, ensuring compliance with regulations to prevent spills and environmental harm. |
Competitive 1-(Chloromethyl)-4-Ethenylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 1- (chloromethyl) -4-vinylbenzene?
1 - (cyanomethyl) -4 -ethylfuranyl ether, its main use is quite extensive.
In the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of many specific drugs. Due to its unique chemical structure, it has the potential to interact with specific targets in organisms. With a carefully designed synthesis route, it can be ingeniously integrated into the molecular structure of the drug, thereby regulating the activity, selectivity and pharmacokinetic properties of the drug. For example, some innovative drug research and development for specific diseases, 1- (cyanomethyl) -4-ethylfuranyl ether is converted through a series of chemical reactions to become an active ingredient with precise therapeutic effect, providing a strong material basis for the treatment of difficult diseases.
In the field of materials science, it also shows important value. It can be used as a functional monomer to participate in the polymerization of polymer materials. The resulting polymer materials have excellent thermal stability, mechanical properties or special optical and electrical properties due to the introduction of this special structural unit. These properties make such materials useful in high-end fields such as electronic devices and aerospace. For example, when preparing high-performance insulating materials, the addition of 1- (cyanomethyl) -4-ethylfuranyl ether can significantly improve the insulation properties and temperature resistance of the materials, meeting the strict requirements of related fields.
In the field of organic synthetic chemistry, as a multifunctional reagent, it provides an effective way to construct complex organic molecular structures. Organic chemists can use its active functional groups to expand and modify the molecular framework through various classical organic reactions, such as nucleophilic substitution and addition reactions, to synthesize organic compounds with novel structures and unique properties, injecting new vitality into the development of organic synthetic chemistry.
In the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of many specific drugs. Due to its unique chemical structure, it has the potential to interact with specific targets in organisms. With a carefully designed synthesis route, it can be ingeniously integrated into the molecular structure of the drug, thereby regulating the activity, selectivity and pharmacokinetic properties of the drug. For example, some innovative drug research and development for specific diseases, 1- (cyanomethyl) -4-ethylfuranyl ether is converted through a series of chemical reactions to become an active ingredient with precise therapeutic effect, providing a strong material basis for the treatment of difficult diseases.
In the field of materials science, it also shows important value. It can be used as a functional monomer to participate in the polymerization of polymer materials. The resulting polymer materials have excellent thermal stability, mechanical properties or special optical and electrical properties due to the introduction of this special structural unit. These properties make such materials useful in high-end fields such as electronic devices and aerospace. For example, when preparing high-performance insulating materials, the addition of 1- (cyanomethyl) -4-ethylfuranyl ether can significantly improve the insulation properties and temperature resistance of the materials, meeting the strict requirements of related fields.
In the field of organic synthetic chemistry, as a multifunctional reagent, it provides an effective way to construct complex organic molecular structures. Organic chemists can use its active functional groups to expand and modify the molecular framework through various classical organic reactions, such as nucleophilic substitution and addition reactions, to synthesize organic compounds with novel structures and unique properties, injecting new vitality into the development of organic synthetic chemistry.
What are the physical properties of 1- (chloromethyl) -4-vinylbenzene?
(1- (Cyanomethyl) -4 -ethylfuranyl ether is an organic compound, and its physical properties are as follows:
Under normal conditions, it is either a colorless to light yellow liquid with a clear texture or a solid state, which is related to its molecular structure and intermolecular forces. The way atoms are connected to each other and the spatial arrangement of atoms in the molecule results in differences in intermolecular forces, which in turn affect the aggregation state of substances.
Smell, or have a special smell, but the specific characteristics of the smell depend on the characteristics of the functional groups in its chemical structure. Cyanomethyl and the functional groups contained in ethylfuranyl ether, or have unique effects on olfactory receptors, triggering specific odor perception.
When it comes to boiling point, due to the interactions between molecules such as van der Waals forces and hydrogen bonds, it requires specific energy to overcome these forces and realize the transition from liquid to gaseous state. Factors such as the relative mass and polarity of molecules have a great influence on the boiling point. The intermolecular forces determined by the polarity and molecular mass of this compound give it a specific boiling point value.
Melting point is related to the lattice structure and molecular arrangement. In the solid state, molecules are arranged into lattices according to specific laws. When the temperature rises, the lattice vibration intensifies. When it reaches a certain degree, the lattice disintegrates and the substance melts. The lattice stability formed by the molecular structure and interaction of this compound determines its melting point.
In terms of solubility, according to the principle of similarity solubility, its solubility in organic solvents is better. Because its molecular structure is similar to that of organic solvents, the intermolecular forces can match each other, which is conducive to dissolution. However, its solubility in water is poor, because its structure is not highly hydrophilic, and the interaction with water molecules is weak.
Density is also an important physical property, depending on the molecular mass and the degree of molecular packing compactness. If the molecular mass is large and the packing is tight, the density is relatively high; otherwise, it is low. The molecular structure and aggregation method of this compound determine the specific value of its density.)
Under normal conditions, it is either a colorless to light yellow liquid with a clear texture or a solid state, which is related to its molecular structure and intermolecular forces. The way atoms are connected to each other and the spatial arrangement of atoms in the molecule results in differences in intermolecular forces, which in turn affect the aggregation state of substances.
Smell, or have a special smell, but the specific characteristics of the smell depend on the characteristics of the functional groups in its chemical structure. Cyanomethyl and the functional groups contained in ethylfuranyl ether, or have unique effects on olfactory receptors, triggering specific odor perception.
When it comes to boiling point, due to the interactions between molecules such as van der Waals forces and hydrogen bonds, it requires specific energy to overcome these forces and realize the transition from liquid to gaseous state. Factors such as the relative mass and polarity of molecules have a great influence on the boiling point. The intermolecular forces determined by the polarity and molecular mass of this compound give it a specific boiling point value.
Melting point is related to the lattice structure and molecular arrangement. In the solid state, molecules are arranged into lattices according to specific laws. When the temperature rises, the lattice vibration intensifies. When it reaches a certain degree, the lattice disintegrates and the substance melts. The lattice stability formed by the molecular structure and interaction of this compound determines its melting point.
In terms of solubility, according to the principle of similarity solubility, its solubility in organic solvents is better. Because its molecular structure is similar to that of organic solvents, the intermolecular forces can match each other, which is conducive to dissolution. However, its solubility in water is poor, because its structure is not highly hydrophilic, and the interaction with water molecules is weak.
Density is also an important physical property, depending on the molecular mass and the degree of molecular packing compactness. If the molecular mass is large and the packing is tight, the density is relatively high; otherwise, it is low. The molecular structure and aggregation method of this compound determine the specific value of its density.)
What are the chemical properties of 1- (chloromethyl) -4-vinylbenzene?
(The chemical properties of 1- (methoxy) -4 -ethoxybenzoyl groups are like the mysteries hidden in the microscopic world, and need to be carefully explored.)
In this compound, methoxy and ethoxy are both characteristic substituents. Methoxy, which is formed by connecting methyl groups to oxygen atoms, has a high electron cloud density and has an electron-giving effect. On the benzene ring, it can affect the electron cloud distribution of the benzene ring through conjugation and induction effects. As a result, the electron cloud density of the benzene ring can be increased, especially at the adjacent and para-sites, which in turn increases the electrophilic substitution activity of the benzene ring.
The ethoxy group has a slightly more complex structure than the methoxy group, but it is also an electron donor group. Its influence on the electron cloud distribution of the benzene ring is similar to that of the methoxy group, but the degree may be different. The two coexist on the benzene ring, and they cooperate and restrict each other.
From the perspective of spatial structure, the steric hindrance between methoxy and ethoxy groups also affects the chemical properties of the compound. Larger steric hindrance may prevent some reagents from approaching the benzene ring, which affects the selectivity and activity of the reaction.
In chemical reactions, this compound can participate in many nucleophilic substitution reactions due to the presence of benzoyl groups. The carbonyl group of benzoyl group has strong electronegativity, which can make carbonyl carbon partially positive and vulnerable to nucleophilic attack. In addition, the regulation of methoxy and ethoxy groups on the electron cloud of the benzene ring may change the electrophilicity of carbonyl carbon, which in turn affects the reaction rate and product formation.
And because of the presence of benzene ring, typical reactions of aromatic hydrocarbons can occur, such as halogenation, nitrification, sulfonation and other electrophilic substitution reactions. The localization effect of methoxy and ethoxy groups will guide the reaction to mainly occur at specific positions of the benzene ring, showing unique chemical activities and reaction laws.
In this compound, methoxy and ethoxy are both characteristic substituents. Methoxy, which is formed by connecting methyl groups to oxygen atoms, has a high electron cloud density and has an electron-giving effect. On the benzene ring, it can affect the electron cloud distribution of the benzene ring through conjugation and induction effects. As a result, the electron cloud density of the benzene ring can be increased, especially at the adjacent and para-sites, which in turn increases the electrophilic substitution activity of the benzene ring.
The ethoxy group has a slightly more complex structure than the methoxy group, but it is also an electron donor group. Its influence on the electron cloud distribution of the benzene ring is similar to that of the methoxy group, but the degree may be different. The two coexist on the benzene ring, and they cooperate and restrict each other.
From the perspective of spatial structure, the steric hindrance between methoxy and ethoxy groups also affects the chemical properties of the compound. Larger steric hindrance may prevent some reagents from approaching the benzene ring, which affects the selectivity and activity of the reaction.
In chemical reactions, this compound can participate in many nucleophilic substitution reactions due to the presence of benzoyl groups. The carbonyl group of benzoyl group has strong electronegativity, which can make carbonyl carbon partially positive and vulnerable to nucleophilic attack. In addition, the regulation of methoxy and ethoxy groups on the electron cloud of the benzene ring may change the electrophilicity of carbonyl carbon, which in turn affects the reaction rate and product formation.
And because of the presence of benzene ring, typical reactions of aromatic hydrocarbons can occur, such as halogenation, nitrification, sulfonation and other electrophilic substitution reactions. The localization effect of methoxy and ethoxy groups will guide the reaction to mainly occur at specific positions of the benzene ring, showing unique chemical activities and reaction laws.
What are the applications of 1- (chloromethyl) -4-vinylbenzene in synthesis?
1 - (methoxy) -4 -ethylbenzyl is commonly used in many organic synthesis reactions in synthesis. Its methoxy and ethylbenzyl structures endow the compound with unique reactivity and properties.
In nucleophilic substitution reactions, methoxy groups, as the power supply group, can increase the electron cloud density of the benzene ring, making the benzene ring ortho and para-sites more vulnerable to nucleophilic attack. For example, halogenated hydrocarbons can undergo nucleophilic substitution with 1 - (methoxy) -4 -ethylbenzyl under basic conditions, thereby introducing new functional groups and expanding the structural diversity of the compound.
In the oxidation reaction, the ethylbenzyl part can be moderately oxidized, for example, by a specific oxidant, the hydrogen on the benzyl carbon can be gradually oxidized to convert into different oxidation state functional groups such as alcohol, aldehyde and even carboxylic acid, which lays the foundation for the subsequent synthesis of complex structure compounds.
In electrophilic substitution reactions such as the Friedel-Crafts reaction, the methoxy group of 1- (methoxy) -4-ethylbenzyl makes the benzene ring more nucleophilic, and it is easy to react with electrophilic reagents. New substituents are introduced at specific positions of the benzene ring, and then various organic molecules with specific structures and functions are constructed. It is of great significance in the fields of medicinal chemistry and materials science. The structural properties of this group make it a key building block for building complex organic molecules in the field of organic synthetic chemistry, enabling chemists to synthesize compounds with unique properties and uses.
In nucleophilic substitution reactions, methoxy groups, as the power supply group, can increase the electron cloud density of the benzene ring, making the benzene ring ortho and para-sites more vulnerable to nucleophilic attack. For example, halogenated hydrocarbons can undergo nucleophilic substitution with 1 - (methoxy) -4 -ethylbenzyl under basic conditions, thereby introducing new functional groups and expanding the structural diversity of the compound.
In the oxidation reaction, the ethylbenzyl part can be moderately oxidized, for example, by a specific oxidant, the hydrogen on the benzyl carbon can be gradually oxidized to convert into different oxidation state functional groups such as alcohol, aldehyde and even carboxylic acid, which lays the foundation for the subsequent synthesis of complex structure compounds.
In electrophilic substitution reactions such as the Friedel-Crafts reaction, the methoxy group of 1- (methoxy) -4-ethylbenzyl makes the benzene ring more nucleophilic, and it is easy to react with electrophilic reagents. New substituents are introduced at specific positions of the benzene ring, and then various organic molecules with specific structures and functions are constructed. It is of great significance in the fields of medicinal chemistry and materials science. The structural properties of this group make it a key building block for building complex organic molecules in the field of organic synthetic chemistry, enabling chemists to synthesize compounds with unique properties and uses.
What is the preparation method of 1- (chloromethyl) -4-vinylbenzene?
To prepare 1 - (cyanomethyl) -4 -ethylbenzonitrile, the following ancient methods can be used.
First take an appropriate amount of raw materials, such as compounds containing cyanide groups and halogenated hydrocarbons with ethyl groups. With the activity of halogenated hydrocarbons, nucleophilic substitution reactions can occur with cyanyl compounds containing active groups.
In a clean reactor, put an appropriate amount of organic solvent, such as dimethylformamide (DMF), this solvent has good solubility and stability, which can promote the reaction. The temperature of the reactor is adjusted to a suitable range, between about 60 and 80 degrees Celsius. The precise control of temperature has a great impact on the reaction process and product yield.
Then, slowly add a catalyst amount of alkali, such as potassium carbonate. The role of alkali is to promote the nucleophilicity of cyanyl compounds and accelerate the reaction rate. As halogenated hydrocarbons are slowly dripped into the reaction system, the reaction gradually unfolds. This process requires close observation of reaction phenomena, such as changes in solution color, precipitation formation, etc.
When the reaction continues for several times, when the reaction tends to be complete, the reaction process is monitored by thin-layer chromatography (TLC) to confirm that the raw materials are exhausted and the amount of product generated is as expected. Then, the reaction mixture is cooled to room temperature, poured into an appropriate amount of water, and the product is extracted with an organic solvent, such as dichloromethane, for multiple extractions, so that the product is enriched in the organic phase.
After extraction, the organic phase is dried with anhydrous sodium sulfate to remove the moisture. Subsequently, the organic solvent is removed by reduced pressure distillation to obtain the crude product. The crude product is further purified by column chromatography, and suitable silica gel and eluent are selected. According to the difference in the adsorption and desorption capacity of the product and impurities on the silica gel, the product can be purified, and finally the pure 1- (cyanomethyl) -4-ethylbenzonitrile can be obtained. The whole process needs to be handled with caution and strict procedures to obtain ideal results.
First take an appropriate amount of raw materials, such as compounds containing cyanide groups and halogenated hydrocarbons with ethyl groups. With the activity of halogenated hydrocarbons, nucleophilic substitution reactions can occur with cyanyl compounds containing active groups.
In a clean reactor, put an appropriate amount of organic solvent, such as dimethylformamide (DMF), this solvent has good solubility and stability, which can promote the reaction. The temperature of the reactor is adjusted to a suitable range, between about 60 and 80 degrees Celsius. The precise control of temperature has a great impact on the reaction process and product yield.
Then, slowly add a catalyst amount of alkali, such as potassium carbonate. The role of alkali is to promote the nucleophilicity of cyanyl compounds and accelerate the reaction rate. As halogenated hydrocarbons are slowly dripped into the reaction system, the reaction gradually unfolds. This process requires close observation of reaction phenomena, such as changes in solution color, precipitation formation, etc.
When the reaction continues for several times, when the reaction tends to be complete, the reaction process is monitored by thin-layer chromatography (TLC) to confirm that the raw materials are exhausted and the amount of product generated is as expected. Then, the reaction mixture is cooled to room temperature, poured into an appropriate amount of water, and the product is extracted with an organic solvent, such as dichloromethane, for multiple extractions, so that the product is enriched in the organic phase.
After extraction, the organic phase is dried with anhydrous sodium sulfate to remove the moisture. Subsequently, the organic solvent is removed by reduced pressure distillation to obtain the crude product. The crude product is further purified by column chromatography, and suitable silica gel and eluent are selected. According to the difference in the adsorption and desorption capacity of the product and impurities on the silica gel, the product can be purified, and finally the pure 1- (cyanomethyl) -4-ethylbenzonitrile can be obtained. The whole process needs to be handled with caution and strict procedures to obtain ideal results.
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