Linshang Chemical
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1-(Chloromethyl)-4-Ethylbenzene
|
HS Code |
272613 |
| Chemical Formula | C9H11Cl |
| Molar Mass | 154.64 g/mol |
| Appearance | Liquid |
| Odor | Typical aromatic odor |
| Density | Approx. 1.04 g/cm³ |
| Boiling Point | Around 201 - 203 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Approx. 75 °C |
As an accredited 1-(Chloromethyl)-4-Ethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(chloromethyl)-4-ethylbenzene packaged in a sealed, corrosion - resistant bottle. |
| Storage | 1-(Chloromethyl)-4-ethylbenzene should be stored in a cool, well - ventilated area, away from heat, sparks, and open flames as it is flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances. Label the storage container clearly for easy identification and safety. |
| Shipping | 1-(Chloromethyl)-4 -ethylbenzene is a chemical. Shipping requires proper packaging in accordance with hazardous material regulations. It must be labeled clearly, and transported by approved carriers following safety protocols to prevent spills and ensure safe delivery. |
Competitive 1-(Chloromethyl)-4-Ethylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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What are the main uses of 1- (chloromethyl) -4-ethylbenzene?
1 - (cyanomethyl) - 4 - ethylbenzene, its main use is not directly recorded in "Tiangong Kaiwu", but it is deduced from the perspective of ancient times and related chemical principles.
In the traditional dyeing and weaving industry, benzene compounds can be used as organic solvents. 1 - (cyanomethyl) - 4 - ethylbenzene has certain solubility and can be used to dissolve natural dyes, such as indigo, etc., to help it better disperse in the dye solution, making the fabric dyeing more uniform and brighter. In ancient times, fabric dyeing was an important industry, and this substance may play a role in improving the quality of dyeing.
Furthermore, in the field of fragrance preparation, the compound has a unique chemical structure or gives it a specific smell. Ancient fragrance production often pursues unique fragrance, 1 - (cyanomethyl) - 4 - ethylbenzene has a pleasant aroma, or can be used as one of the fragrance ingredients, used in the preparation of sachets, incense, etc. At that time, spices were not only used to add aroma, but also used for deworming, health preservation, etc., and were indispensable in aristocratic life and religious ceremonies.
In terms of pharmaceutical processing, ancient medicine has explored the properties of various substances. 1- (Cyanomethyl) -4-ethylbenzene can participate in the processing of some drugs, or as a solvent to assist in the extraction of active ingredients of medicinal materials, or to change the properties of drugs in specific chemical reactions to improve their efficacy. Although there was no modern precise chemical analysis in ancient times, long-term practice may enable craftsmen to discover some of its medicinal auxiliary values.
In the traditional dyeing and weaving industry, benzene compounds can be used as organic solvents. 1 - (cyanomethyl) - 4 - ethylbenzene has certain solubility and can be used to dissolve natural dyes, such as indigo, etc., to help it better disperse in the dye solution, making the fabric dyeing more uniform and brighter. In ancient times, fabric dyeing was an important industry, and this substance may play a role in improving the quality of dyeing.
Furthermore, in the field of fragrance preparation, the compound has a unique chemical structure or gives it a specific smell. Ancient fragrance production often pursues unique fragrance, 1 - (cyanomethyl) - 4 - ethylbenzene has a pleasant aroma, or can be used as one of the fragrance ingredients, used in the preparation of sachets, incense, etc. At that time, spices were not only used to add aroma, but also used for deworming, health preservation, etc., and were indispensable in aristocratic life and religious ceremonies.
In terms of pharmaceutical processing, ancient medicine has explored the properties of various substances. 1- (Cyanomethyl) -4-ethylbenzene can participate in the processing of some drugs, or as a solvent to assist in the extraction of active ingredients of medicinal materials, or to change the properties of drugs in specific chemical reactions to improve their efficacy. Although there was no modern precise chemical analysis in ancient times, long-term practice may enable craftsmen to discover some of its medicinal auxiliary values.
What are the physical properties of 1- (chloromethyl) -4-ethylbenzene?
1 - (methoxy) -4 -ethylbenzene, also known as p-ethylanisole, has the following physical properties:
Looking at its shape, it is a colorless to light yellow transparent liquid under normal conditions, clear and free of impurities, like a clear spring, under light, or slightly shiny.
Smell its taste, with a fragrant smell, unique and pleasant aroma, or sweet like flowers and fruits, or with a touch of woody calm aroma, often used in the field of fragrance blending, adding a unique flavor to many fragrance products.
In terms of its melting point, the melting point is about -43 ° C. At this temperature, the substance gradually solidifies from the liquid state and changes its shape. The boiling point is roughly in the range of 189-191 ° C. When the temperature rises to the boiling point, the liquid will vaporize violently and transform into a gaseous state.
Speaking of density, in a 20 ° C environment, its density is about 0.905-0.915g/cm ³, which is slightly less dense than water. If it is placed in the same container as water, it can be seen that it floats on the water surface.
Looking at its solubility, it has very little solubility in water, just like a stranger who is incompatible with water. However, in organic solvents such as ethanol, ether, and acetone, it exhibits good solubility and can be uniformly mixed with these organic solvents to form a uniform and stable solution. The refractive index of
is about 1.5010 to 1.5040 at 20 ° C. This property makes it refract at a specific angle when light passes through, which may be of some significance for optical research and related applications.
Looking at its shape, it is a colorless to light yellow transparent liquid under normal conditions, clear and free of impurities, like a clear spring, under light, or slightly shiny.
Smell its taste, with a fragrant smell, unique and pleasant aroma, or sweet like flowers and fruits, or with a touch of woody calm aroma, often used in the field of fragrance blending, adding a unique flavor to many fragrance products.
In terms of its melting point, the melting point is about -43 ° C. At this temperature, the substance gradually solidifies from the liquid state and changes its shape. The boiling point is roughly in the range of 189-191 ° C. When the temperature rises to the boiling point, the liquid will vaporize violently and transform into a gaseous state.
Speaking of density, in a 20 ° C environment, its density is about 0.905-0.915g/cm ³, which is slightly less dense than water. If it is placed in the same container as water, it can be seen that it floats on the water surface.
Looking at its solubility, it has very little solubility in water, just like a stranger who is incompatible with water. However, in organic solvents such as ethanol, ether, and acetone, it exhibits good solubility and can be uniformly mixed with these organic solvents to form a uniform and stable solution. The refractive index of
is about 1.5010 to 1.5040 at 20 ° C. This property makes it refract at a specific angle when light passes through, which may be of some significance for optical research and related applications.
What are the chemical properties of 1- (chloromethyl) -4-ethylbenzene?
(1 - (methoxy) - 4 - ethylbenzene is an organic compound with unique chemical properties.)
In this compound, the methoxy group coexists with ethylbenzene structure, giving it special chemical activity. Methoxy is a donator group, which affects the electron cloud density distribution of the benzene ring. With its donator conjugation effect, the electron cloud density of the benzene ring can be increased, especially the electron cloud density of the ortho and para-sites. In this way, the activity of the electrophilic substitution of the benzene ring is increased, and it is easier to react with the electrophilic reagent. For example, in the halogenation reaction, the methoxy group makes the benzene ring more easily replaced by the halogen atom, and the substitution check point is mainly in the ortho and para-sites
In the ethylbenzene part, the ethyl group itself also has a certain electronic effect on the benzene ring. The electron-inducing effect of alkyl groups also increases the electron cloud density of the benzene ring, but the effect is slightly weaker than the conjugation effect of the methoxy group. However, the steric hindrance effect of ethylbenzene cannot be ignored. In chemical reactions, it will affect the position and way of the reagent approaching the benzene ring. For example, in some reactions involving larger volumes of electrophilic reagents, the spatial hindrance caused by ethylbenzene will make the electrophilic reagent more inclined to attack the position with small steric resistance.
In addition, the chemical properties of 1- (methoxy) -4 -ethylbenzene are also affected by the reaction conditions. Under the action of different temperatures, solvents and catalysts, its reactivity and reaction path will change. At high temperatures and with suitable catalysts, the reaction of side chain ethyl may occur, such as the oxidation or dehydrogenation of ethyl; under mild conditions, it is mainly the electrophilic substitution reaction on the benzene ring. In short, this compound is rich in chemical properties and complex, and has important significance and wide application in the field of organic synthesis.
In this compound, the methoxy group coexists with ethylbenzene structure, giving it special chemical activity. Methoxy is a donator group, which affects the electron cloud density distribution of the benzene ring. With its donator conjugation effect, the electron cloud density of the benzene ring can be increased, especially the electron cloud density of the ortho and para-sites. In this way, the activity of the electrophilic substitution of the benzene ring is increased, and it is easier to react with the electrophilic reagent. For example, in the halogenation reaction, the methoxy group makes the benzene ring more easily replaced by the halogen atom, and the substitution check point is mainly in the ortho and para-sites
In the ethylbenzene part, the ethyl group itself also has a certain electronic effect on the benzene ring. The electron-inducing effect of alkyl groups also increases the electron cloud density of the benzene ring, but the effect is slightly weaker than the conjugation effect of the methoxy group. However, the steric hindrance effect of ethylbenzene cannot be ignored. In chemical reactions, it will affect the position and way of the reagent approaching the benzene ring. For example, in some reactions involving larger volumes of electrophilic reagents, the spatial hindrance caused by ethylbenzene will make the electrophilic reagent more inclined to attack the position with small steric resistance.
In addition, the chemical properties of 1- (methoxy) -4 -ethylbenzene are also affected by the reaction conditions. Under the action of different temperatures, solvents and catalysts, its reactivity and reaction path will change. At high temperatures and with suitable catalysts, the reaction of side chain ethyl may occur, such as the oxidation or dehydrogenation of ethyl; under mild conditions, it is mainly the electrophilic substitution reaction on the benzene ring. In short, this compound is rich in chemical properties and complex, and has important significance and wide application in the field of organic synthesis.
What are the synthesis methods of 1- (chloromethyl) -4-ethylbenzene?
To prepare 1 - (methoxy) - 4 - ethylbenzene, the following methods can be used:
First, start with halogenated benzene. Take p-bromotoluene, in anhydrous ether, and stir it with magnesium chips to obtain Grignard's reagent. Then, slowly add methoxy bromoethane, and react with nucleophilic substitution to form 1 - (methoxy) - 4 - ethylbenzene. The key to the reaction lies in the activity of Grignard's reagent and the control of the reaction conditions. The environment of anhydrous and oxygen-free is essential for the smooth reaction.
Second, based on benzene derivatives. Methoxyacetophenone is selected. First, zinc amalgam and concentrated hydrochloric acid are used as agents, and the carbonyl group is reduced by Clemenson to form methylene to obtain 1- (methoxy) -4-ethylbenzene. In this way, the concentration and temperature of hydrochloric acid during the preparation and reaction of zinc amalgam need to be accurately grasped to obtain the yield.
Third, by the method of Fu-gram reaction. Using benzene and methoxyacetyl chloride as materials, under the catalysis of anhydrous aluminum trichloride, the Fu-gram acylation reaction is carried out first to obtain p-methoxyacetophenone. After reduction, such as sodium borohydride or lithium aluminum hydride as a reducing agent, the carbonyl group is reduced to an alcohol hydroxyl group, and then an appropriate dehydrating agent, such as concentrated sulfuric acid or aluminum oxide, is dehydrated to obtain the target product. Among them, the positioning effect of Fu-Ke acylation reaction, the selectivity of reduction reaction and the conditions of dehydration reaction are all factors that affect the formation of the product.
All synthesis methods have advantages and disadvantages. Depending on the ease of availability of raw materials, the level of cost, the difficulty of reaction and the purity of the product, etc., the most suitable way can be selected in the field of organic synthesis to achieve high efficiency and accuracy.
First, start with halogenated benzene. Take p-bromotoluene, in anhydrous ether, and stir it with magnesium chips to obtain Grignard's reagent. Then, slowly add methoxy bromoethane, and react with nucleophilic substitution to form 1 - (methoxy) - 4 - ethylbenzene. The key to the reaction lies in the activity of Grignard's reagent and the control of the reaction conditions. The environment of anhydrous and oxygen-free is essential for the smooth reaction.
Second, based on benzene derivatives. Methoxyacetophenone is selected. First, zinc amalgam and concentrated hydrochloric acid are used as agents, and the carbonyl group is reduced by Clemenson to form methylene to obtain 1- (methoxy) -4-ethylbenzene. In this way, the concentration and temperature of hydrochloric acid during the preparation and reaction of zinc amalgam need to be accurately grasped to obtain the yield.
Third, by the method of Fu-gram reaction. Using benzene and methoxyacetyl chloride as materials, under the catalysis of anhydrous aluminum trichloride, the Fu-gram acylation reaction is carried out first to obtain p-methoxyacetophenone. After reduction, such as sodium borohydride or lithium aluminum hydride as a reducing agent, the carbonyl group is reduced to an alcohol hydroxyl group, and then an appropriate dehydrating agent, such as concentrated sulfuric acid or aluminum oxide, is dehydrated to obtain the target product. Among them, the positioning effect of Fu-Ke acylation reaction, the selectivity of reduction reaction and the conditions of dehydration reaction are all factors that affect the formation of the product.
All synthesis methods have advantages and disadvantages. Depending on the ease of availability of raw materials, the level of cost, the difficulty of reaction and the purity of the product, etc., the most suitable way can be selected in the field of organic synthesis to achieve high efficiency and accuracy.
What are the precautions for using 1- (chloromethyl) -4-ethylbenzene?
For 1 - (cyanomethyl) - 4 - ethylbenzene, all precautions must be kept in mind when using it.
First, this product is toxic. When operating, be sure to be fully armed, wear protective clothing, protective gloves and goggles to prevent it from touching the skin and eyes. If you come into contact inadvertently, rinse with plenty of water immediately and seek medical treatment immediately.
Second, 1 - (cyanomethyl) - 4 - ethylbenzene is flammable, so the use environment must be kept away from fire and heat sources, and fireworks are strictly prohibited. The storage place should also be selected in a cool and well-ventilated place, and should be stored separately from oxidants, acids, etc., and must not be mixed to prevent dangerous chemical reactions.
Third, during use, ventilation conditions must not be ignored. It is necessary to ensure that the operating space is well ventilated. It is best to carry out relevant operations in the fume hood, which can effectively reduce the concentration of its steam in the air and avoid inhaling too much harmful steam, endangering human health.
Fourth, for the use of 1- (cyanomethyl) -4-ethylbenzene, the operator must be specially trained and familiar with its characteristics, uses and emergency treatment methods. When operating, strictly follow the established operating procedures and do not act recklessly.
Fifth, after use, properly dispose of the remaining materials and waste. It must not be discarded at will, and should be treated harmlessly in accordance with relevant regulations to prevent pollution to the environment.
All these precautions are related to personal safety and environmental safety. Those who use 1- (cyanomethyl) -4-ethylbenzene must not be ignored or careless.
First, this product is toxic. When operating, be sure to be fully armed, wear protective clothing, protective gloves and goggles to prevent it from touching the skin and eyes. If you come into contact inadvertently, rinse with plenty of water immediately and seek medical treatment immediately.
Second, 1 - (cyanomethyl) - 4 - ethylbenzene is flammable, so the use environment must be kept away from fire and heat sources, and fireworks are strictly prohibited. The storage place should also be selected in a cool and well-ventilated place, and should be stored separately from oxidants, acids, etc., and must not be mixed to prevent dangerous chemical reactions.
Third, during use, ventilation conditions must not be ignored. It is necessary to ensure that the operating space is well ventilated. It is best to carry out relevant operations in the fume hood, which can effectively reduce the concentration of its steam in the air and avoid inhaling too much harmful steam, endangering human health.
Fourth, for the use of 1- (cyanomethyl) -4-ethylbenzene, the operator must be specially trained and familiar with its characteristics, uses and emergency treatment methods. When operating, strictly follow the established operating procedures and do not act recklessly.
Fifth, after use, properly dispose of the remaining materials and waste. It must not be discarded at will, and should be treated harmlessly in accordance with relevant regulations to prevent pollution to the environment.
All these precautions are related to personal safety and environmental safety. Those who use 1- (cyanomethyl) -4-ethylbenzene must not be ignored or careless.
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