Linshang Chemical
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1-(Chloromethyl)-4-Fluoro-2-Methoxybenzene
Linshang Chemical
|
HS Code |
614689 |
| Chemical Formula | C8H8ClFO |
| Molecular Weight | 174.6 |
| Appearance | Typically a colorless to light - yellow liquid |
| Boiling Point | Data may vary, around 200 - 220°C (estimated) |
| Density | Data may vary, estimated around 1.2 - 1.3 g/cm³ |
| Solubility | Soluble in organic solvents like dichloromethane, ethyl acetate |
| Vapor Pressure | Low vapor pressure at room temperature |
| Flash Point | Data may vary, estimated flammable range flash point |
| Stability | Stable under normal conditions, but reactive towards strong oxidizing agents |
As an accredited 1-(Chloromethyl)-4-Fluoro-2-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(chloromethyl)-4-fluoro-2-methoxybenzene in a sealed, labeled chemical - grade bottle. |
| Storage | 1-(Chloromethyl)-4-fluoro-2-methoxybenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It should be placed in a tightly - sealed container to prevent leakage and exposure to air and moisture. Keep it separate from oxidizing agents and reactive substances to avoid potential chemical reactions. Store it at a recommended temperature range, typically around room temperature, but consult safety data sheets for precise storage details. |
| Shipping | 1-(Chloromethyl)-4-fluoro-2-methoxybenzene is shipped in accordance with strict chemical regulations. Packed in suitable containers, it's transported by approved carriers, ensuring safety during transit. |
Competitive 1-(Chloromethyl)-4-Fluoro-2-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the physical properties of 1- (chloromethyl) -4-fluoro-2-methoxybenzene?
The physical properties of (1- (cyanomethyl) -4 -cyano- 2 -methoxyphenyl) benzene are studied. The shape of this compound is often solid, and its melting is very important for the first time. Therefore, its melting depends on a specific temperature, which is due to the combined action of molecular forces, crystalline factors, etc.
and solubility. It exhibits good solubility in solutions such as dichloromethane and chloroform, as well as in non-molecular solutions such as acetonitrile and N, N-dimethylformamide. The molecule of this compound contains an organic group, and the above-mentioned dissolution can form an even-even interaction, etc., so it is soluble. However, in water, its solubility is very small, because the water molecule is weak, and the water-forming ability of the chemical compound is weak, and its non-organic part is large, resulting in a hydrophobic effect and dissolution in water.
Furthermore, its density is also an important physical property. The precise quantity can be obtained with a specific value of its density. This value reflects the density of the molecule, the weight of the molecule and the empty phase. The structure, mesh and arrangement of the atoms in the molecule together determine its density characteristics.
In addition, the refractive index of the chemical compound also has a specific value. The refractive index is the ratio of the propagation rate of light in the compound to the propagation rate in vacuum, reflecting the refractive ability of light. This property is closely related to the distribution of molecular sub-clouds and the rate of transformation, etc., and can be used as one of the test indicators for the determination of compounds. Therefore, such physical properties are important for in-depth understanding of the properties of (1- (cyanomethyl) -4-cyano- 2-methoxyphenyl) benzene, as well as for chemical synthesis, materials science, and other fields.
and solubility. It exhibits good solubility in solutions such as dichloromethane and chloroform, as well as in non-molecular solutions such as acetonitrile and N, N-dimethylformamide. The molecule of this compound contains an organic group, and the above-mentioned dissolution can form an even-even interaction, etc., so it is soluble. However, in water, its solubility is very small, because the water molecule is weak, and the water-forming ability of the chemical compound is weak, and its non-organic part is large, resulting in a hydrophobic effect and dissolution in water.
Furthermore, its density is also an important physical property. The precise quantity can be obtained with a specific value of its density. This value reflects the density of the molecule, the weight of the molecule and the empty phase. The structure, mesh and arrangement of the atoms in the molecule together determine its density characteristics.
In addition, the refractive index of the chemical compound also has a specific value. The refractive index is the ratio of the propagation rate of light in the compound to the propagation rate in vacuum, reflecting the refractive ability of light. This property is closely related to the distribution of molecular sub-clouds and the rate of transformation, etc., and can be used as one of the test indicators for the determination of compounds. Therefore, such physical properties are important for in-depth understanding of the properties of (1- (cyanomethyl) -4-cyano- 2-methoxyphenyl) benzene, as well as for chemical synthesis, materials science, and other fields.
What are the chemical properties of 1- (chloromethyl) -4-fluoro-2-methoxybenzene?
1 - (cyanomethyl) - 4 - cyano2 - methoxybenzyl has the following chemical properties:
In this compound, both cyanomethyl and cyanyl groups have high reactivity. Cyanyl groups are strong electron-absorbing groups, which can reduce the electron cloud density of the carbon atoms connected to them, thereby enhancing the polarity of the molecule. In this compound, cyanyl groups can participate in many reactions, such as hydrolysis reactions. Under appropriate conditions, cyanyl groups can be hydrolyzed and converted into carboxyl groups. This process is like a delicate chemical change, just like the transformation of all things in nature. Nucleophilic addition reactions can also occur. Due to the electron cloud distribution characteristics of carbon-nitrogen bonds in cyanyl groups, they are vulnerable to attack by nucleophilic reagents, and combine with various nucleophilic reagents to open new chemical connections.
And methoxy is the power supply sub-group, which can increase the electron cloud density of the benzene ring through the conjugation effect, making the benzene ring more prone to electrophilic substitution reactions. Above the benzene ring, electrophilic reagents tend to attack the methoxy o-ortho and para-sites, which is due to the positioning and guiding effect of the power supply conjugation effect. For example, during the halogenation reaction, halogen atoms are easily introduced in the methoxy-ortho and para-sites, as if the methoxy group indicates a specific binding check
Furthermore, the carbon-carbon bond of the benzyl group in the molecule can be broken under specific conditions and participate in free radical reactions. For example, under the action of light or initiators, the carbon-carbon bond of benzyl is homogenized to produce free radicals, which in turn triggers a series of free radical chain reactions, which can become a prairie fire and generate rich chemical changes. The multiple chemical properties of this compound make it like a shining star in the field of organic synthesis, with broad application potential and research value. It can be used as a key intermediate to participate in the synthesis of various organic compounds with special structures and functions.
In this compound, both cyanomethyl and cyanyl groups have high reactivity. Cyanyl groups are strong electron-absorbing groups, which can reduce the electron cloud density of the carbon atoms connected to them, thereby enhancing the polarity of the molecule. In this compound, cyanyl groups can participate in many reactions, such as hydrolysis reactions. Under appropriate conditions, cyanyl groups can be hydrolyzed and converted into carboxyl groups. This process is like a delicate chemical change, just like the transformation of all things in nature. Nucleophilic addition reactions can also occur. Due to the electron cloud distribution characteristics of carbon-nitrogen bonds in cyanyl groups, they are vulnerable to attack by nucleophilic reagents, and combine with various nucleophilic reagents to open new chemical connections.
And methoxy is the power supply sub-group, which can increase the electron cloud density of the benzene ring through the conjugation effect, making the benzene ring more prone to electrophilic substitution reactions. Above the benzene ring, electrophilic reagents tend to attack the methoxy o-ortho and para-sites, which is due to the positioning and guiding effect of the power supply conjugation effect. For example, during the halogenation reaction, halogen atoms are easily introduced in the methoxy-ortho and para-sites, as if the methoxy group indicates a specific binding check
Furthermore, the carbon-carbon bond of the benzyl group in the molecule can be broken under specific conditions and participate in free radical reactions. For example, under the action of light or initiators, the carbon-carbon bond of benzyl is homogenized to produce free radicals, which in turn triggers a series of free radical chain reactions, which can become a prairie fire and generate rich chemical changes. The multiple chemical properties of this compound make it like a shining star in the field of organic synthesis, with broad application potential and research value. It can be used as a key intermediate to participate in the synthesis of various organic compounds with special structures and functions.
What are the main uses of 1- (chloromethyl) -4-fluoro-2-methoxybenzene?
(1 - (cyanomethyl) - 4 - cyano - 2 - methoxybenzyl) This substance has a wide range of uses and is of great significance in many fields.
In the field of medicinal chemistry, it is a key intermediate in organic synthesis. With its special chemical structure, complex drug molecules can be constructed through a series of chemical reactions. For example, it can participate in the introduction of specific active groups and help develop specific drugs for certain diseases. By rationally designing the reaction route and using it as the starting material, the chemical structure and activity of the product can be precisely regulated, providing key support for the development of innovative drugs.
In the field of materials science, it also plays a crucial role. It can be used as a monomer or additive for the synthesis of polymer materials with special properties. When participating in the polymerization reaction as a monomer, it can endow the polymer materials with unique electrical, optical or mechanical properties. For example, synthesizing polymer materials with good electrical conductivity or fluorescence properties can be used to prepare advanced materials such as organic Light Emitting Diodes (OLEDs) and sensors, thereby promoting technological innovation in the field of materials science.
In pesticide chemistry, (1- (cyanomethyl) - 4-cyano- 2-methoxybenzyl) also has application value. It can be used to create new pesticides, with its chemical activity to inhibit or kill specific pests or pathogens, providing more efficient and environmentally friendly solutions for agricultural pest control and promoting sustainable development of agriculture.
In summary, (1- (cyanomethyl) -4-cyano- 2-methoxybenzyl) plays an irreplaceable role in many fields such as medicine, materials, and pesticides, providing an important material basis for the development and progress of related fields.
In the field of medicinal chemistry, it is a key intermediate in organic synthesis. With its special chemical structure, complex drug molecules can be constructed through a series of chemical reactions. For example, it can participate in the introduction of specific active groups and help develop specific drugs for certain diseases. By rationally designing the reaction route and using it as the starting material, the chemical structure and activity of the product can be precisely regulated, providing key support for the development of innovative drugs.
In the field of materials science, it also plays a crucial role. It can be used as a monomer or additive for the synthesis of polymer materials with special properties. When participating in the polymerization reaction as a monomer, it can endow the polymer materials with unique electrical, optical or mechanical properties. For example, synthesizing polymer materials with good electrical conductivity or fluorescence properties can be used to prepare advanced materials such as organic Light Emitting Diodes (OLEDs) and sensors, thereby promoting technological innovation in the field of materials science.
In pesticide chemistry, (1- (cyanomethyl) - 4-cyano- 2-methoxybenzyl) also has application value. It can be used to create new pesticides, with its chemical activity to inhibit or kill specific pests or pathogens, providing more efficient and environmentally friendly solutions for agricultural pest control and promoting sustainable development of agriculture.
In summary, (1- (cyanomethyl) -4-cyano- 2-methoxybenzyl) plays an irreplaceable role in many fields such as medicine, materials, and pesticides, providing an important material basis for the development and progress of related fields.
What are the synthesis methods of 1- (chloromethyl) -4-fluoro-2-methoxybenzene?
To prepare 1 - (methoxy) - 4 - bromo - 2 - methoxybenzene, there are many methods for its synthesis, which are described in detail below.
First, phenols can be started. First, take the corresponding phenols, use halogenated reagents, such as bromine, etc., under suitable reaction conditions, perform a halogenation reaction, which can introduce bromine atoms at specific positions in the phenol ring. Subsequently, methylating reagents, such as dimethyl sulfate, etc., react with phenolic hydroxyl groups in an alkaline environment to form methoxy groups, so as to achieve the synthesis of the target product. In this approach, the halogenation step needs to pay attention to the selectivity of the reaction check point to ensure that the bromine atom is introduced into the desired position; the methylation step should pay attention to the amount of reagent and the reaction conditions to avoid excessive methylation.
Second, halogenated aromatics are used as raw materials. First, the halogenated aromatics are reacted with methoxylating reagents, such as sodium methoxide, in a suitable solvent and temperature to introduce methoxy groups. After that, other positions on the benzene ring are modified as appropriate. If another methoxy group needs to be introduced, methylation methods can be used again; if bromine atoms are introduced, they can be achieved through a suitable bromination reaction. This method requires precise control of the reaction conditions of each step to ensure that the reaction proceeds in the desired direction, and attention should be paid to the influence of different substituents on the subsequent reaction activity and selectivity.
Third, with the help of the reaction of aryl boric acid or borate esters. First prepare aryl boric acid or borate esters containing specific substituents, and then couple with halogenated hydrocarbons under palladium catalysis and other conditions, which can introduce methoxy or bromine atoms. This method has relatively mild reaction conditions and good selectivity, but the choice and dosage of catalysts, reaction solvents and other factors have a great impact on the success or failure of the reaction. And the preparation of aryl boric acid or borate esters also requires fine operation to obtain high-purity raw materials.
First, phenols can be started. First, take the corresponding phenols, use halogenated reagents, such as bromine, etc., under suitable reaction conditions, perform a halogenation reaction, which can introduce bromine atoms at specific positions in the phenol ring. Subsequently, methylating reagents, such as dimethyl sulfate, etc., react with phenolic hydroxyl groups in an alkaline environment to form methoxy groups, so as to achieve the synthesis of the target product. In this approach, the halogenation step needs to pay attention to the selectivity of the reaction check point to ensure that the bromine atom is introduced into the desired position; the methylation step should pay attention to the amount of reagent and the reaction conditions to avoid excessive methylation.
Second, halogenated aromatics are used as raw materials. First, the halogenated aromatics are reacted with methoxylating reagents, such as sodium methoxide, in a suitable solvent and temperature to introduce methoxy groups. After that, other positions on the benzene ring are modified as appropriate. If another methoxy group needs to be introduced, methylation methods can be used again; if bromine atoms are introduced, they can be achieved through a suitable bromination reaction. This method requires precise control of the reaction conditions of each step to ensure that the reaction proceeds in the desired direction, and attention should be paid to the influence of different substituents on the subsequent reaction activity and selectivity.
Third, with the help of the reaction of aryl boric acid or borate esters. First prepare aryl boric acid or borate esters containing specific substituents, and then couple with halogenated hydrocarbons under palladium catalysis and other conditions, which can introduce methoxy or bromine atoms. This method has relatively mild reaction conditions and good selectivity, but the choice and dosage of catalysts, reaction solvents and other factors have a great impact on the success or failure of the reaction. And the preparation of aryl boric acid or borate esters also requires fine operation to obtain high-purity raw materials.
What should be paid attention to when storing and transporting 1- (chloromethyl) -4-fluoro-2-methoxybenzene?
1 - (cyanomethyl) - 4 - cyanogen - 2 - methoxyphenylacetonitrile, this is a chemical substance. During storage and transportation, many matters need to be paid attention to.
Bear the brunt, when storing, it must be found in a cool, dry and well-ventilated place. Due to its chemical properties, if it is wet or high temperature, it may cause chemical reactions, cause material deterioration, or even cause danger. For example, excessive moisture, or cause its hydrolysis, affecting quality and stability.
Furthermore, keep away from fire and heat sources. This substance may be flammable or may react with heat. Open flames or hot topics can easily induce combustion or even explosion. If there is a source of fire around, a spark or a little spark may ignite, causing unimaginable consequences.
And it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Because of its chemical activity, it comes into contact with different types of chemicals, or reacts violently. If it encounters an oxidizing agent, or an oxidation reaction occurs, a large amount of energy is released, causing a sudden rise in temperature and causing danger.
When transporting, the packaging must be tight. Make sure that there is no risk of leakage of the substance during handling. The packaging material must be able to withstand a certain external force and do not react with the substance.
Transportation vehicles should also be properly selected and equipped with fire and explosion-proof safety devices. During transportation, drivers should drive cautiously to avoid bumps and collisions to prevent material leakage caused by damaged packaging. If leakage unfortunately occurs, it needs to be dealt with in a timely manner to prevent harm to the environment and people. In short, the storage and transportation of 1 - (cyanomethyl) - 4 - cyanogen - 2 - methoxyphenylacetonitrile must be carried out in accordance with safety standards.
Bear the brunt, when storing, it must be found in a cool, dry and well-ventilated place. Due to its chemical properties, if it is wet or high temperature, it may cause chemical reactions, cause material deterioration, or even cause danger. For example, excessive moisture, or cause its hydrolysis, affecting quality and stability.
Furthermore, keep away from fire and heat sources. This substance may be flammable or may react with heat. Open flames or hot topics can easily induce combustion or even explosion. If there is a source of fire around, a spark or a little spark may ignite, causing unimaginable consequences.
And it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Because of its chemical activity, it comes into contact with different types of chemicals, or reacts violently. If it encounters an oxidizing agent, or an oxidation reaction occurs, a large amount of energy is released, causing a sudden rise in temperature and causing danger.
When transporting, the packaging must be tight. Make sure that there is no risk of leakage of the substance during handling. The packaging material must be able to withstand a certain external force and do not react with the substance.
Transportation vehicles should also be properly selected and equipped with fire and explosion-proof safety devices. During transportation, drivers should drive cautiously to avoid bumps and collisions to prevent material leakage caused by damaged packaging. If leakage unfortunately occurs, it needs to be dealt with in a timely manner to prevent harm to the environment and people. In short, the storage and transportation of 1 - (cyanomethyl) - 4 - cyanogen - 2 - methoxyphenylacetonitrile must be carried out in accordance with safety standards.
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