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1-(Chloromethyl)-4-Fluoro-2-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
994688 |
| Chemical Formula | C8H5ClF4 |
| Molecular Weight | 212.57 |
| Appearance | Liquid (usually) |
| Boiling Point | Data needed |
| Melting Point | Data needed |
| Density | Data needed |
| Solubility | Data needed |
| Vapor Pressure | Data needed |
| Flash Point | Data needed |
| Refractive Index | Data needed |
As an accredited 1-(Chloromethyl)-4-Fluoro-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(chloromethyl)-4-fluoro-2-(trifluoromethyl)benzene in a sealed chemical - grade bottle. |
| Storage | 1-(Chloromethyl)-4-fluoro-2-(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to air or moisture, which could potentially lead to decomposition or reaction. |
| Shipping | 1-(Chloromethyl)-4-fluoro-2-(trifluoromethyl)benzene is shipped in sealed, corrosion - resistant containers. Compliance with hazardous chemical shipping regulations is ensured, with proper labeling and handling to prevent spills during transit. |
Competitive 1-(Chloromethyl)-4-Fluoro-2-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-(Chloromethyl)-4-Fluoro-2-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1- (chloromethyl) -4-fluoro-2- (trifluoromethyl) benzene?
1 - (cyanomethyl) -4 -chloro-2 - (trichloromethyl) pyridine is a crucial intermediate in organic synthesis. It has a wide range of uses and plays a pivotal role in the fields of medicine and pesticides.
In the field of medicine, using this as a raw material, through exquisite chemical reactions, many drugs with specific pharmacological activities can be synthesized. For example, in the preparation of some antibacterial drugs, 1- (cyanomethyl) -4-chloro-2- (trichloromethyl) pyridine participates in the key steps. Its unique chemical structure endows the drug with excellent antibacterial properties, which helps the drug to accurately act on pathogens, inhibit their growth and reproduction, and protect human health.
In the field of pesticides, this compound is even more brilliant. Based on it, through careful research and development and preparation, high-efficiency pesticides can be prepared. Such pesticides can effectively kill a variety of crop pests due to their special chemical properties. After pests come into contact with or ingest pesticides containing this ingredient, their physiological functions are disturbed, and the nervous system and digestive system are damaged, thus achieving the purpose of protecting crops and improving yield and quality.
Furthermore, in some cutting-edge research in materials science, 1- (cyanomethyl) -4-chloro-2- (trichloromethyl) pyridine is also occasionally used. Scientists use its unique reactivity to modify the surface of materials, improve the physical and chemical properties of materials, such as enhancing the stability and corrosion resistance of materials, and open up new paths for the development and application of new materials.
In the field of medicine, using this as a raw material, through exquisite chemical reactions, many drugs with specific pharmacological activities can be synthesized. For example, in the preparation of some antibacterial drugs, 1- (cyanomethyl) -4-chloro-2- (trichloromethyl) pyridine participates in the key steps. Its unique chemical structure endows the drug with excellent antibacterial properties, which helps the drug to accurately act on pathogens, inhibit their growth and reproduction, and protect human health.
In the field of pesticides, this compound is even more brilliant. Based on it, through careful research and development and preparation, high-efficiency pesticides can be prepared. Such pesticides can effectively kill a variety of crop pests due to their special chemical properties. After pests come into contact with or ingest pesticides containing this ingredient, their physiological functions are disturbed, and the nervous system and digestive system are damaged, thus achieving the purpose of protecting crops and improving yield and quality.
Furthermore, in some cutting-edge research in materials science, 1- (cyanomethyl) -4-chloro-2- (trichloromethyl) pyridine is also occasionally used. Scientists use its unique reactivity to modify the surface of materials, improve the physical and chemical properties of materials, such as enhancing the stability and corrosion resistance of materials, and open up new paths for the development and application of new materials.
What are the physical properties of 1- (chloromethyl) -4-fluoro-2- (trifluoromethyl) benzene?
1 - (cyanomethyl) -4 -bromo-2 - (tribromomethyl) naphthalene, is a kind of organic compound. Its physical properties have the following characteristics:
Looking at its appearance, it may be a crystalline solid under normal conditions. Due to the strong intermolecular forces of such compounds, they tend to form a regularly arranged lattice structure.
Regarding its melting point, due to the presence of many halogen atoms in the molecule, the intermolecular forces increase, so the melting point is relatively high. The presence of bromine atoms and cyano groups, tribromomethyl groups, etc. enhances the van der Waals force between molecules, so that higher energy is required to destroy the lattice and turn it from a solid state to a liquid state.
As for the boiling point, it is also quite high due to the large intermolecular force. In the liquid state, to overcome the attractive force between molecules to turn it into a gaseous state, more energy input is required, and the boiling point is increased.
In terms of solubility, the compound is difficult to dissolve in water. This is because water is a polar solvent, and the polarity of the 1- (cyanomethyl) -4-bromo-2- (tribromomethyl) naphthalene molecule is weak. Although the cyanyl group in the molecule has a certain polarity, the existence of a large number of haloalkyl groups makes the non-polar characteristics of the whole molecule prominent. According to the principle of "similar miscibility", its solubility in water is very small. However, in organic solvents, such as benzene, toluene, dichloromethane, etc., because of their similar polarity to organic solvents, their solubility is relatively good.
In addition, the density of this compound may be higher than that of water, and the weight per unit volume increases due to the heavy atom bromine contained in the molecule.
The physical properties of this compound are determined by its molecular structure, which is of great significance for its applications in organic synthesis, materials science and other fields.
Looking at its appearance, it may be a crystalline solid under normal conditions. Due to the strong intermolecular forces of such compounds, they tend to form a regularly arranged lattice structure.
Regarding its melting point, due to the presence of many halogen atoms in the molecule, the intermolecular forces increase, so the melting point is relatively high. The presence of bromine atoms and cyano groups, tribromomethyl groups, etc. enhances the van der Waals force between molecules, so that higher energy is required to destroy the lattice and turn it from a solid state to a liquid state.
As for the boiling point, it is also quite high due to the large intermolecular force. In the liquid state, to overcome the attractive force between molecules to turn it into a gaseous state, more energy input is required, and the boiling point is increased.
In terms of solubility, the compound is difficult to dissolve in water. This is because water is a polar solvent, and the polarity of the 1- (cyanomethyl) -4-bromo-2- (tribromomethyl) naphthalene molecule is weak. Although the cyanyl group in the molecule has a certain polarity, the existence of a large number of haloalkyl groups makes the non-polar characteristics of the whole molecule prominent. According to the principle of "similar miscibility", its solubility in water is very small. However, in organic solvents, such as benzene, toluene, dichloromethane, etc., because of their similar polarity to organic solvents, their solubility is relatively good.
In addition, the density of this compound may be higher than that of water, and the weight per unit volume increases due to the heavy atom bromine contained in the molecule.
The physical properties of this compound are determined by its molecular structure, which is of great significance for its applications in organic synthesis, materials science and other fields.
What are the chemical properties of 1- (chloromethyl) -4-fluoro-2- (trifluoromethyl) benzene?
The chemical properties of 1-% (cyanomethyl) -4-cyano-2- (tricyanomethyl) benzene are quite unique. In this compound, the presence of cyanyl groups endows it with specific activity. Cyanyl groups are functional groups with strong electron-absorbing properties. Multiple cyanyl groups coexist in the same molecular structure and interact with each other, resulting in the substance exhibiting unique chemical behaviors.
In terms of reactivity, the electron cloud distribution in the molecule is significantly changed due to the strong electron-absorbing effect of cyanyl groups. The electron cloud density on the aromatic ring decreases, making it difficult for electrophilic substitution reactions to occur. On the contrary, nucleophilic substitution reactions are promoted by the electronic effects produced by cyanyl groups. For example, if there is a nucleophilic reagent, it may attack the carbon atoms attached to the cyanyl group and initiate a substitution reaction. This is because the electron cloud density of the carbon atom is relatively low, making it more vulnerable to the attack of the nucleophilic reagent.
Furthermore, the stability of this compound is also affected by the cyanyl group. Although the interaction between cyanyl groups can enhance the stability of the molecule, under certain conditions, in the case of strong acids, strong bases or high temperature environments, the cyanyl group may undergo hydrolysis, alcoholysis and other reactions, resulting in molecular structure changes. In the hydrolysis reaction, the cyanyl group is gradually converted into functional groups such as carboxyl groups or amide groups, which in turn causes major changes in the chemical properties of the compound.
From the perspective of physical properties, the presence of multiple cyanos increases the force between molecules, or causes its melting point and boiling point to rise. At the same time, its solubility will also vary due to the combined effect of hydrophilicity and hydrophobicity of cyanos. It may have a certain solubility in organic solvents, while its solubility in water is relatively limited, which is closely related to the characteristics of cyanos.
In terms of reactivity, the electron cloud distribution in the molecule is significantly changed due to the strong electron-absorbing effect of cyanyl groups. The electron cloud density on the aromatic ring decreases, making it difficult for electrophilic substitution reactions to occur. On the contrary, nucleophilic substitution reactions are promoted by the electronic effects produced by cyanyl groups. For example, if there is a nucleophilic reagent, it may attack the carbon atoms attached to the cyanyl group and initiate a substitution reaction. This is because the electron cloud density of the carbon atom is relatively low, making it more vulnerable to the attack of the nucleophilic reagent.
Furthermore, the stability of this compound is also affected by the cyanyl group. Although the interaction between cyanyl groups can enhance the stability of the molecule, under certain conditions, in the case of strong acids, strong bases or high temperature environments, the cyanyl group may undergo hydrolysis, alcoholysis and other reactions, resulting in molecular structure changes. In the hydrolysis reaction, the cyanyl group is gradually converted into functional groups such as carboxyl groups or amide groups, which in turn causes major changes in the chemical properties of the compound.
From the perspective of physical properties, the presence of multiple cyanos increases the force between molecules, or causes its melting point and boiling point to rise. At the same time, its solubility will also vary due to the combined effect of hydrophilicity and hydrophobicity of cyanos. It may have a certain solubility in organic solvents, while its solubility in water is relatively limited, which is closely related to the characteristics of cyanos.
What are the synthesis methods of 1- (chloromethyl) -4-fluoro-2- (trifluoromethyl) benzene?
To prepare 1 - (cyanomethyl) - 4 - chloro - 2 - (trichloromethyl) pyridine, there are various ways to synthesize it, and this is the way for you.
First, it can be gradually converted by pyridine derivatives. With a suitable pyridine starting material, chlorine atoms are introduced at a specific position first, and this step can be achieved by electrophilic substitution reaction. Select a suitable chlorine substitution reagent, such as chlorine gas or chlorine-containing compounds, and under appropriate reaction conditions, such as temperature and catalyst, the chlorine atoms fall precisely in the fourth position of the pyridine ring. Then, try to introduce cyanomethyl and trichloromethyl. The introduction of cyanomethyl group can be connected to the first position of the pyridine ring through the nucleophilic substitution reaction of halogenated alkanes with cyanides such as sodium cyanide. The introduction of trichloromethyl group can use a specific trichloromethylation agent to successfully add trichloromethyl group to the second position of the pyridine ring in an appropriate reaction environment.
Second, the strategy of constructing the pyridine ring can also be started. Chain compounds containing cyanomethyl group, chlorine atom and trichloromethyl group and other related substituents are first prepared, and then they are synthesized as the target pyridine compound through intramolecular cyclization reaction. This path requires fine design of the structure of the chain compound to ensure the smooth progress of the cyclization reaction. In the cyclization process, the reaction conditions, such as pH, temperature, etc., should be properly controlled to improve the yield and selectivity of the target product.
Third, there is still a way of thinking, which is based on the existing pyridine analogues, through the method of functional group conversion. For example, if there are pyridine compounds with similar substituents but need further modification, their specific functional groups can be reacted. For example, a substituent is chemically converted into a desired group such as cyanomethyl or trichloromethyl. This process requires in-depth understanding of the reactivity and conversion conditions of various functional groups, and careful selection of appropriate reagents and reaction steps to achieve efficient synthesis.
First, it can be gradually converted by pyridine derivatives. With a suitable pyridine starting material, chlorine atoms are introduced at a specific position first, and this step can be achieved by electrophilic substitution reaction. Select a suitable chlorine substitution reagent, such as chlorine gas or chlorine-containing compounds, and under appropriate reaction conditions, such as temperature and catalyst, the chlorine atoms fall precisely in the fourth position of the pyridine ring. Then, try to introduce cyanomethyl and trichloromethyl. The introduction of cyanomethyl group can be connected to the first position of the pyridine ring through the nucleophilic substitution reaction of halogenated alkanes with cyanides such as sodium cyanide. The introduction of trichloromethyl group can use a specific trichloromethylation agent to successfully add trichloromethyl group to the second position of the pyridine ring in an appropriate reaction environment.
Second, the strategy of constructing the pyridine ring can also be started. Chain compounds containing cyanomethyl group, chlorine atom and trichloromethyl group and other related substituents are first prepared, and then they are synthesized as the target pyridine compound through intramolecular cyclization reaction. This path requires fine design of the structure of the chain compound to ensure the smooth progress of the cyclization reaction. In the cyclization process, the reaction conditions, such as pH, temperature, etc., should be properly controlled to improve the yield and selectivity of the target product.
Third, there is still a way of thinking, which is based on the existing pyridine analogues, through the method of functional group conversion. For example, if there are pyridine compounds with similar substituents but need further modification, their specific functional groups can be reacted. For example, a substituent is chemically converted into a desired group such as cyanomethyl or trichloromethyl. This process requires in-depth understanding of the reactivity and conversion conditions of various functional groups, and careful selection of appropriate reagents and reaction steps to achieve efficient synthesis.
What should be paid attention to when storing and transporting 1- (chloromethyl) -4-fluoro-2- (trifluoromethyl) benzene?
When storing and transporting (cyanomethyl) -4-cyanomethyl-2-tricyanomethyl) benzene-like compounds, all people should pay attention.
First safety protection. These compounds are toxic and dangerous, and operators must wear complete protective equipment, such as protective clothing, gloves, goggles and gas masks, to prevent contact with the skin, eyes, or inhalation of their volatile gases, causing damage to the body.
This is the storage condition. Store in a cool, dry and well-ventilated place, away from fire and heat sources. Due to their nature or instability, high temperature, humidity or light may cause them to deteriorate or cause dangerous reactions. It needs to be stored separately from oxidizing agents, acids, alkalis, etc., and must not be mixed to prevent chemical reactions.
Further transportation specifications. When transporting, appropriate transportation tools and packaging materials must be selected in accordance with relevant regulations. Packaging must be tight to ensure that there is no risk of leakage. During transportation, close attention should be paid to environmental factors such as temperature and humidity to avoid severe vibration and collision to prevent package damage and compound leakage.
It is also necessary to pay attention to label warnings. On storage containers and transportation vehicles, there should be clear and prominent labels indicating the characteristics, hazards and emergency treatment methods of compounds, so that contacts can be seen at a glance. In case of emergencies, correct measures can be taken quickly.
All of these are things that must be paid attention to when storing and transporting (cyanomethyl) -4-cyanomethyl-2 - (tricyanomethyl) benzene and other compounds. A little negligence can lead to catastrophe, endangering life and environmental safety.
First safety protection. These compounds are toxic and dangerous, and operators must wear complete protective equipment, such as protective clothing, gloves, goggles and gas masks, to prevent contact with the skin, eyes, or inhalation of their volatile gases, causing damage to the body.
This is the storage condition. Store in a cool, dry and well-ventilated place, away from fire and heat sources. Due to their nature or instability, high temperature, humidity or light may cause them to deteriorate or cause dangerous reactions. It needs to be stored separately from oxidizing agents, acids, alkalis, etc., and must not be mixed to prevent chemical reactions.
Further transportation specifications. When transporting, appropriate transportation tools and packaging materials must be selected in accordance with relevant regulations. Packaging must be tight to ensure that there is no risk of leakage. During transportation, close attention should be paid to environmental factors such as temperature and humidity to avoid severe vibration and collision to prevent package damage and compound leakage.
It is also necessary to pay attention to label warnings. On storage containers and transportation vehicles, there should be clear and prominent labels indicating the characteristics, hazards and emergency treatment methods of compounds, so that contacts can be seen at a glance. In case of emergencies, correct measures can be taken quickly.
All of these are things that must be paid attention to when storing and transporting (cyanomethyl) -4-cyanomethyl-2 - (tricyanomethyl) benzene and other compounds. A little negligence can lead to catastrophe, endangering life and environmental safety.
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