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1-(Chloromethyl)-4-Methyl-Benzene
Linshang Chemical
|
HS Code |
323501 |
| Chemical Formula | C8H9Cl |
| Molar Mass | 140.61 g/mol |
| Appearance | Colorless to light yellow liquid |
| Odor | Pungent odor |
| Density | 1.069 g/cm³ at 20 °C |
| Boiling Point | 195 - 197 °C |
| Melting Point | -32 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
| Flash Point | 73 °C |
| Vapor Pressure | 0.13 kPa at 20 °C |
As an accredited 1-(Chloromethyl)-4-Methyl-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle of 1-(chloromethyl)-4 - methyl - benzene, tightly sealed. |
| Storage | 1-(Chloromethyl)-4 - methyl - benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources due to its flammability risk. Keep it in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents, bases, and reactive chemicals to avoid potential hazardous reactions. Use appropriate storage cabinets designed for chemicals. |
| Shipping | 1-(Chloromethyl)-4 -methyl -benzene is a chemical. Shipping should be in accordance with hazardous material regulations. Use properly labeled, sealed containers, transported by approved carriers to prevent leakage and ensure safety during transit. |
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What are the main uses of 1- (chloromethyl) -4-methylbenzene?
1- (cyanomethyl) -4-methylpyridine, which is a very important compound in the field of organic chemistry. Its main uses are as follows:
First of all, in the field of pharmaceutical synthesis, its position is pivotal. Gain 1- (cyanomethyl) -4-methylpyridine can be used as a key intermediate for the preparation of many drugs. For example, some drug molecules with specific physiological activities need to be introduced into specific structural fragments by 1- (cyanomethyl) -4-methylpyridine in the synthesis path, and then the corresponding pharmacological effects of the drug are imparted. Through ingenious chemical reactions, using the special structure of this compound, the core structure of drug molecules can be precisely constructed, laying the foundation for the development of drugs for the treatment of various diseases.
Secondly, in the field of materials science, it also shows unique value. It can be used as a raw material for the synthesis of specific functional materials. By virtue of its own chemical properties, it can react with other substances to prepare materials with special properties. For example, some materials with good optical and electrical properties, 1- (cyanomethyl) -4-methylpyridine can have a significant impact on the molecular structure and properties of the material, so that it can meet the special needs of materials in fields such as electronic devices and optical instruments.
Furthermore, in the field of organic synthesis chemistry, it is an important reaction substrate. Because its structure contains cyanomethyl and methyl pyridine groups, both groups have unique reactivity. It can participate in a variety of organic reactions, such as nucleophilic substitution reactions, addition reactions, etc. Chemists can ingeniously design reaction conditions according to reaction requirements, so that 1- (cyanomethyl) -4-methyl pyridine reacts with different reagents, thereby constructing organic compounds with diverse structures, which greatly enriches the types of organic compounds and promotes the development of organic synthesis chemistry.
First of all, in the field of pharmaceutical synthesis, its position is pivotal. Gain 1- (cyanomethyl) -4-methylpyridine can be used as a key intermediate for the preparation of many drugs. For example, some drug molecules with specific physiological activities need to be introduced into specific structural fragments by 1- (cyanomethyl) -4-methylpyridine in the synthesis path, and then the corresponding pharmacological effects of the drug are imparted. Through ingenious chemical reactions, using the special structure of this compound, the core structure of drug molecules can be precisely constructed, laying the foundation for the development of drugs for the treatment of various diseases.
Secondly, in the field of materials science, it also shows unique value. It can be used as a raw material for the synthesis of specific functional materials. By virtue of its own chemical properties, it can react with other substances to prepare materials with special properties. For example, some materials with good optical and electrical properties, 1- (cyanomethyl) -4-methylpyridine can have a significant impact on the molecular structure and properties of the material, so that it can meet the special needs of materials in fields such as electronic devices and optical instruments.
Furthermore, in the field of organic synthesis chemistry, it is an important reaction substrate. Because its structure contains cyanomethyl and methyl pyridine groups, both groups have unique reactivity. It can participate in a variety of organic reactions, such as nucleophilic substitution reactions, addition reactions, etc. Chemists can ingeniously design reaction conditions according to reaction requirements, so that 1- (cyanomethyl) -4-methyl pyridine reacts with different reagents, thereby constructing organic compounds with diverse structures, which greatly enriches the types of organic compounds and promotes the development of organic synthesis chemistry.
What are the physical properties of 1- (chloromethyl) -4-methylbenzene?
1 - (cyanomethyl) - 4 -methylpyridine is an organic compound, and its physical properties are particularly important. Here is an ancient saying.
Looking at its physical state, under room temperature, it is often colorless to light yellow liquid, like a clear spring, clear and transparent, without the disturbance of variegated colors. Looking at it gives people a sense of tranquility.
Smell its smell, it has a special smell. Although it is not rich and fragrant, it is also unique and highly recognizable, lingering between the noses, giving people a distinct sensory impression.
On its boiling point, it is about a certain temperature range. This temperature makes it gradually transform from liquid to gaseous state. If the heat is appropriate, the boiling of water and the rise of bubbles will change its state. The nature of this boiling point is related to its state transition in different temperature environments.
As for the melting point, it is also a specific value. When the temperature drops to this point, it slowly solidifies from the liquid state, such as winter water, which turns into ice when cold, and the change of shape is demarcated by this melting point.
In addition, its solubility can be dissolved in some organic solvents, such as fish in water, and the phase is seamless. However, its solubility in water is relatively limited, like oil and water, and it is difficult to completely mix. This difference in solubility makes it different in different solvent systems.
And its density is different from that of water, or light or heavy. This characteristic determines the upper and lower position relationship when it coexists with water and other substances. In many chemical operations and practical applications, this is one of the key considerations.
The physical properties of this 1- (cyanomethyl) -4-methylpyridine are useful in various fields such as chemical research and industrial production. They are all indispensable references. Only by understanding their properties can they be used effectively for various purposes.
Looking at its physical state, under room temperature, it is often colorless to light yellow liquid, like a clear spring, clear and transparent, without the disturbance of variegated colors. Looking at it gives people a sense of tranquility.
Smell its smell, it has a special smell. Although it is not rich and fragrant, it is also unique and highly recognizable, lingering between the noses, giving people a distinct sensory impression.
On its boiling point, it is about a certain temperature range. This temperature makes it gradually transform from liquid to gaseous state. If the heat is appropriate, the boiling of water and the rise of bubbles will change its state. The nature of this boiling point is related to its state transition in different temperature environments.
As for the melting point, it is also a specific value. When the temperature drops to this point, it slowly solidifies from the liquid state, such as winter water, which turns into ice when cold, and the change of shape is demarcated by this melting point.
In addition, its solubility can be dissolved in some organic solvents, such as fish in water, and the phase is seamless. However, its solubility in water is relatively limited, like oil and water, and it is difficult to completely mix. This difference in solubility makes it different in different solvent systems.
And its density is different from that of water, or light or heavy. This characteristic determines the upper and lower position relationship when it coexists with water and other substances. In many chemical operations and practical applications, this is one of the key considerations.
The physical properties of this 1- (cyanomethyl) -4-methylpyridine are useful in various fields such as chemical research and industrial production. They are all indispensable references. Only by understanding their properties can they be used effectively for various purposes.
What are the chemical properties of 1- (chloromethyl) -4-methylbenzene?
The chemical properties of (1- (methoxy) -4 -methylbenzene are as follows:)
This substance is an organic compound with specific chemical activity. In its structure, the benzene ring is a stable conjugated system, which has a great influence on the chemical properties. Methoxy and methyl are used as benzene ring substituents to change the electron cloud distribution of the benzene ring, and the left and right reaction activity and check point selectivity.
As for the electrophilic substitution reaction, methoxy is the power supply group, which increases the electron cloud density of the benzene ring o and para-position, and is more likely to react with electrophilic reagents. The electrophilic substitution mostly occurs in the methoxy o o and para-position. For example, in the halogenation reaction, halogenating agents such as chlorine and bromine are easy to introduce halogen atoms into the methoxy ortho and para-sites; in the nitration reaction, the nitro group also tends to enter the methoxy ortho and para-sites.
methyl is also a power supply group, which has an impact on the benzene ring electron cloud. Although the power supply is weaker than the methoxy group, it also increases the electron cloud density of the benzene ring, enhancing the electrophilic substitution activity of the benzene ring. And the presence of methyl increases the spatial resistance of the benzene ring ortho-site slightly, which has a certain effect on the attack direction of the electrophilic reagent.
In the oxidation reaction, the side chain methyl can be oxidized to a carboxyl group under the action of a suitable oxidant such as acidic potassium permanganate to generate 1-
When reacting with metal-organic reagents, the benzene ring in this compound can be used as an electrophilic reagent, and nucleophilic substitution reaction occurs with metal-containing reagents such as Grignard reagent to realize the construction of carbon-carbon bonds and synthesize more complex organic compounds.
The chemical properties of this compound are jointly determined by the benzene ring and the substituted methoxy group and methyl group. These properties are of great significance in the fields of organic synthesis, medicinal chemistry, etc., and help to design and synthesize target compounds.
This substance is an organic compound with specific chemical activity. In its structure, the benzene ring is a stable conjugated system, which has a great influence on the chemical properties. Methoxy and methyl are used as benzene ring substituents to change the electron cloud distribution of the benzene ring, and the left and right reaction activity and check point selectivity.
As for the electrophilic substitution reaction, methoxy is the power supply group, which increases the electron cloud density of the benzene ring o and para-position, and is more likely to react with electrophilic reagents. The electrophilic substitution mostly occurs in the methoxy o o and para-position. For example, in the halogenation reaction, halogenating agents such as chlorine and bromine are easy to introduce halogen atoms into the methoxy ortho and para-sites; in the nitration reaction, the nitro group also tends to enter the methoxy ortho and para-sites.
methyl is also a power supply group, which has an impact on the benzene ring electron cloud. Although the power supply is weaker than the methoxy group, it also increases the electron cloud density of the benzene ring, enhancing the electrophilic substitution activity of the benzene ring. And the presence of methyl increases the spatial resistance of the benzene ring ortho-site slightly, which has a certain effect on the attack direction of the electrophilic reagent.
In the oxidation reaction, the side chain methyl can be oxidized to a carboxyl group under the action of a suitable oxidant such as acidic potassium permanganate to generate 1-
When reacting with metal-organic reagents, the benzene ring in this compound can be used as an electrophilic reagent, and nucleophilic substitution reaction occurs with metal-containing reagents such as Grignard reagent to realize the construction of carbon-carbon bonds and synthesize more complex organic compounds.
The chemical properties of this compound are jointly determined by the benzene ring and the substituted methoxy group and methyl group. These properties are of great significance in the fields of organic synthesis, medicinal chemistry, etc., and help to design and synthesize target compounds.
What are the applications of 1- (chloromethyl) -4-methylbenzene in synthesis?
(1 - (methoxy) - 4 - methylbenzene has many applications in synthesis, which is an important research content in the field of organic chemistry. The following will describe its common applications in detail.)
First, in the field of drug synthesis, this compound is often a key intermediate. Due to its unique chemical structure, it can participate in a series of reactions to build a drug-active molecular skeleton. For example, in the synthesis path of many anti-cancer drugs, 1 - (methoxy) - 4 - methylbenzene is halogenated, introduced into halogen atoms, and then coupled with nitrogen-containing heterocyclic compounds. Drug molecules with specific anti-cancer activities can be obtained through multi-step reactions. This is because the methoxy group and methyl group on the benzene ring of the compound can adjust the molecular electron cloud density, affect the reactivity and selectivity, and help to construct structures that meet the needs of drug targets.
Second, it also has significant applications in materials science. It can be introduced into the main chain or side chain of polymer materials through polymerization. For example, it is copolymerized with ethylene monomers to prepare functional polymer materials. The prepared materials exhibit special physical and chemical properties due to the presence of methoxy groups and methyl groups, such as changing the solubility, thermal stability and optical properties of the material. In the field of optoelectronic materials, polymers synthesized on this basis may have good charge transport properties, and are expected to be applied to devices such as organic Light Emitting Diodes (OLEDs) and solar cells to improve their performance.
Third, there are also many figures in the field of fragrance synthesis. Because it has a special aromatic odor, and can be further adjusted by chemical modification. For example, through oxidation, esterification and other reactions, fragrance compounds with unique aromas are prepared. 1 - (methoxy) - 4 - methylbenzene is oxidized to form corresponding phenols, and then esterified with acid anhydrides to obtain fragrances with elegant floral aroma, which can be used to prepare perfumes, cosmetics and food fragrances to meet different fragrance needs.
First, in the field of drug synthesis, this compound is often a key intermediate. Due to its unique chemical structure, it can participate in a series of reactions to build a drug-active molecular skeleton. For example, in the synthesis path of many anti-cancer drugs, 1 - (methoxy) - 4 - methylbenzene is halogenated, introduced into halogen atoms, and then coupled with nitrogen-containing heterocyclic compounds. Drug molecules with specific anti-cancer activities can be obtained through multi-step reactions. This is because the methoxy group and methyl group on the benzene ring of the compound can adjust the molecular electron cloud density, affect the reactivity and selectivity, and help to construct structures that meet the needs of drug targets.
Second, it also has significant applications in materials science. It can be introduced into the main chain or side chain of polymer materials through polymerization. For example, it is copolymerized with ethylene monomers to prepare functional polymer materials. The prepared materials exhibit special physical and chemical properties due to the presence of methoxy groups and methyl groups, such as changing the solubility, thermal stability and optical properties of the material. In the field of optoelectronic materials, polymers synthesized on this basis may have good charge transport properties, and are expected to be applied to devices such as organic Light Emitting Diodes (OLEDs) and solar cells to improve their performance.
Third, there are also many figures in the field of fragrance synthesis. Because it has a special aromatic odor, and can be further adjusted by chemical modification. For example, through oxidation, esterification and other reactions, fragrance compounds with unique aromas are prepared. 1 - (methoxy) - 4 - methylbenzene is oxidized to form corresponding phenols, and then esterified with acid anhydrides to obtain fragrances with elegant floral aroma, which can be used to prepare perfumes, cosmetics and food fragrances to meet different fragrance needs.
What are the preparation methods of 1- (chloromethyl) -4-methylbenzene?
The preparation method of 1- (cyanomethyl) -4 -methylbenzene is as follows:
First, p-toluenitrile is used as the starting material. The p-toluenitrile is reacted with halogenated methane (such as chloromethane) under alkaline conditions and in the presence of a phase transfer catalyst. First, the basic substance (such as sodium hydroxide) is prepared into an aqueous solution of appropriate concentration, added to the reaction vessel, and then the phase transfer catalyst (such as quaternary ammonium salt) is added. After stirring, the halogenated methane is slowly added dropwise. At the same time, the p-toluenitrile is dissolved in a suitable organic solvent (such as N, N-dimethylformamide), and slowly added to the reaction system Control the reaction temperature within a certain range (e.g. 40-60 ° C) and react for several hours. After the reaction is completed, the product is extracted with an organic solvent, washed with water, dried, and separated from 1- (cyanomethyl) -4-methylbenzene by distillation and other means. The raw materials of this method are relatively easy to obtain, and the reaction conditions are relatively mild, but the choice and amount of phase transfer catalyst have a great influence on the reaction yield.
Second, p-methyl benzyl chloride and sodium cyanide are used as raw materials. In a suitable organic solvent (such as a mixed solvent of ethanol and water), p-methyl benzyl chloride is mixed with sodium cyanide. Sodium cyanide is first dissolved in some solvents, and then p-methyl benzyl chloride is slowly added dropwise. During the reaction, the temperature needs to be controlled (such as about 50 ° C) and stirred continuously. Because sodium cyanide is highly toxic, it is necessary to strictly follow safety procedures during operation. After the reaction is completed, the same post-processing steps such as extraction, washing, drying and distillation are carried out to obtain the target product. The reaction steps of this method are relatively simple, but the use of sodium cyanide requires high attention to safety, and the post-processing process should ensure that the residual cyanide is completely removed.
Third, it can be passed by the Grignard reagent method. Grignard reagent is prepared by p-methyl bromobenzene, magnesium chips are placed in a dry reaction bottle, a small amount of initiator (such as iodine) is added, and then an anhydrous ether solution of p-methyl bromobenzene is slowly added dropwise. After initiating the reaction, it is continuously added dropwise to obtain p-methyl phenyl magnesium bromide. After that, chloroacetonitrile is added to this Grignard reagent, and it is reacted at a low temperature (such as 0-10 ° C). After the reaction is completed, post-treatment operations such as hydrolysis are carried out, and finally 1- (cyanomethyl) -4-methyl benzene can be obtained. This method requires harsh reaction conditions and requires an anhydrous and oxygen-free environment,
First, p-toluenitrile is used as the starting material. The p-toluenitrile is reacted with halogenated methane (such as chloromethane) under alkaline conditions and in the presence of a phase transfer catalyst. First, the basic substance (such as sodium hydroxide) is prepared into an aqueous solution of appropriate concentration, added to the reaction vessel, and then the phase transfer catalyst (such as quaternary ammonium salt) is added. After stirring, the halogenated methane is slowly added dropwise. At the same time, the p-toluenitrile is dissolved in a suitable organic solvent (such as N, N-dimethylformamide), and slowly added to the reaction system Control the reaction temperature within a certain range (e.g. 40-60 ° C) and react for several hours. After the reaction is completed, the product is extracted with an organic solvent, washed with water, dried, and separated from 1- (cyanomethyl) -4-methylbenzene by distillation and other means. The raw materials of this method are relatively easy to obtain, and the reaction conditions are relatively mild, but the choice and amount of phase transfer catalyst have a great influence on the reaction yield.
Second, p-methyl benzyl chloride and sodium cyanide are used as raw materials. In a suitable organic solvent (such as a mixed solvent of ethanol and water), p-methyl benzyl chloride is mixed with sodium cyanide. Sodium cyanide is first dissolved in some solvents, and then p-methyl benzyl chloride is slowly added dropwise. During the reaction, the temperature needs to be controlled (such as about 50 ° C) and stirred continuously. Because sodium cyanide is highly toxic, it is necessary to strictly follow safety procedures during operation. After the reaction is completed, the same post-processing steps such as extraction, washing, drying and distillation are carried out to obtain the target product. The reaction steps of this method are relatively simple, but the use of sodium cyanide requires high attention to safety, and the post-processing process should ensure that the residual cyanide is completely removed.
Third, it can be passed by the Grignard reagent method. Grignard reagent is prepared by p-methyl bromobenzene, magnesium chips are placed in a dry reaction bottle, a small amount of initiator (such as iodine) is added, and then an anhydrous ether solution of p-methyl bromobenzene is slowly added dropwise. After initiating the reaction, it is continuously added dropwise to obtain p-methyl phenyl magnesium bromide. After that, chloroacetonitrile is added to this Grignard reagent, and it is reacted at a low temperature (such as 0-10 ° C). After the reaction is completed, post-treatment operations such as hydrolysis are carried out, and finally 1- (cyanomethyl) -4-methyl benzene can be obtained. This method requires harsh reaction conditions and requires an anhydrous and oxygen-free environment,
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