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1-(Chloromethyl)-4-(Methylsulfonyl)Benzene
Linshang Chemical
|
HS Code |
763670 |
| Chemical Formula | C8H9ClO2S |
| Molecular Weight | 204.673 g/mol |
| Appearance | Solid (likely white or off - white powder) |
| Boiling Point | N/A (decomposes before boiling in many cases) |
| Melting Point | 85 - 87 °C |
| Density | N/A (data may be limited) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Flash Point | N/A (data may be scarce) |
| Vapor Pressure | Very low at room temperature |
| Stability | Stable under normal conditions, but reactive towards nucleophiles |
As an accredited 1-(Chloromethyl)-4-(Methylsulfonyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 1-(chloromethyl)-4-(methylsulfonyl)benzene packaged in a sealed container. |
| Storage | 1-(Chloromethyl)-4-(methylsulfonyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent leakage and exposure to air and moisture. Store it separately from incompatible substances such as oxidizing agents, bases, and reactive metals to avoid potential chemical reactions. |
| Shipping | 1-(Chloromethyl)-4-(methylsulfonyl)benzene is shipped in specialized, well - sealed containers. Strict regulations govern its transport due to its chemical nature, ensuring safety during transit to prevent spills and environmental hazards. |
Competitive 1-(Chloromethyl)-4-(Methylsulfonyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 1- (chloromethyl) -4- (methylsulfonyl) benzene?
1 - (cyanomethyl) -4 - (methylsulfonyl) benzene, its main use is quite extensive.
In the field of pharmaceutical synthesis, this compound is often used as a key intermediate. Due to its unique chemical structure, it can participate in a variety of complex reactions and help to construct molecular structures with specific pharmacological activities. For example, in the synthesis of some antibacterial drugs, 1 - (cyanomethyl) -4 - (methylsulfonyl) benzene can be skillfully combined with other chemical groups through a series of carefully designed reaction steps to create drug molecules with strong inhibition or killing ability against specific bacteria.
In the field of materials science, it also has unique functions. With its own structural characteristics, the properties of specific materials can be optimized. For example, in the preparation of some polymer materials, appropriate addition of this compound can effectively improve the stability and mechanical properties of the material. It can interact with the polymer chain, or form chemical bonds, or generate intermolecular forces, thereby adjusting the microstructure of the material and improving the comprehensive properties of the material to meet the strict requirements of material properties in different application scenarios.
In many reactions in organic synthetic chemistry, 1 - (cyanomethyl) - 4 - (methylsulfonyl) benzene with its cyanomethyl and methylsulfonyl groups can be used as a unique reaction check point, participating in nucleophilic substitution, electrophilic addition and other classic organic reactions, providing rich possibilities and effective ways for the synthesis of novel and complex organic compounds, and promoting the continuous development of organic synthetic chemistry.
In the field of pharmaceutical synthesis, this compound is often used as a key intermediate. Due to its unique chemical structure, it can participate in a variety of complex reactions and help to construct molecular structures with specific pharmacological activities. For example, in the synthesis of some antibacterial drugs, 1 - (cyanomethyl) -4 - (methylsulfonyl) benzene can be skillfully combined with other chemical groups through a series of carefully designed reaction steps to create drug molecules with strong inhibition or killing ability against specific bacteria.
In the field of materials science, it also has unique functions. With its own structural characteristics, the properties of specific materials can be optimized. For example, in the preparation of some polymer materials, appropriate addition of this compound can effectively improve the stability and mechanical properties of the material. It can interact with the polymer chain, or form chemical bonds, or generate intermolecular forces, thereby adjusting the microstructure of the material and improving the comprehensive properties of the material to meet the strict requirements of material properties in different application scenarios.
In many reactions in organic synthetic chemistry, 1 - (cyanomethyl) - 4 - (methylsulfonyl) benzene with its cyanomethyl and methylsulfonyl groups can be used as a unique reaction check point, participating in nucleophilic substitution, electrophilic addition and other classic organic reactions, providing rich possibilities and effective ways for the synthesis of novel and complex organic compounds, and promoting the continuous development of organic synthetic chemistry.
What are the physical properties of 1- (chloromethyl) -4- (methylsulfonyl) benzene?
1 - (cyanomethyl) - 4 - (methylsulfonyl) benzene, this is an organic compound with unique physical properties.
Looking at its properties, it is mostly white to light yellow crystalline powder under normal conditions. This form is easy to store and use, and in many chemical reactions, the powder substance can increase the contact area with other reactants, making the reaction more likely to occur.
When it comes to the melting point, it is about a specific temperature range. This melting point characteristic is of great significance for the purification and identification of the substance. By accurately measuring the melting point, its purity can be judged. If the melting point deviates from the standard range, or suggests that impurities are mixed in. In terms of solubility,
has a certain solubility in common organic solvents such as ethanol and acetone, but poor solubility in water. This difference in solubility is a key consideration when separating, purifying and selecting the reaction solvent. For example, when performing certain reactions, according to its solubility, choose the appropriate solvent to ensure the smooth progress of the reaction and achieve the desired effect.
Its density is also an important physical parameter, and the specific density value reflects the compactness of the internal structure of the substance. When it comes to mixing substances or preparing a solution of a specific concentration, density data is indispensable and helps to accurately calculate the dosage.
In addition, the stability of the substance is good under certain conditions, but in the case of strong acids, strong bases or specific high temperature environments, or chemical reactions occur, resulting in structural changes and the formation of new substances. Understanding this stability characteristic, when storing and using, appropriate protective measures can be taken to avoid deterioration of the substance due to improper conditions, to ensure that its performance and use are not affected.
Looking at its properties, it is mostly white to light yellow crystalline powder under normal conditions. This form is easy to store and use, and in many chemical reactions, the powder substance can increase the contact area with other reactants, making the reaction more likely to occur.
When it comes to the melting point, it is about a specific temperature range. This melting point characteristic is of great significance for the purification and identification of the substance. By accurately measuring the melting point, its purity can be judged. If the melting point deviates from the standard range, or suggests that impurities are mixed in. In terms of solubility,
has a certain solubility in common organic solvents such as ethanol and acetone, but poor solubility in water. This difference in solubility is a key consideration when separating, purifying and selecting the reaction solvent. For example, when performing certain reactions, according to its solubility, choose the appropriate solvent to ensure the smooth progress of the reaction and achieve the desired effect.
Its density is also an important physical parameter, and the specific density value reflects the compactness of the internal structure of the substance. When it comes to mixing substances or preparing a solution of a specific concentration, density data is indispensable and helps to accurately calculate the dosage.
In addition, the stability of the substance is good under certain conditions, but in the case of strong acids, strong bases or specific high temperature environments, or chemical reactions occur, resulting in structural changes and the formation of new substances. Understanding this stability characteristic, when storing and using, appropriate protective measures can be taken to avoid deterioration of the substance due to improper conditions, to ensure that its performance and use are not affected.
What are the chemical properties of 1- (chloromethyl) -4- (methylsulfonyl) benzene?
1 - (methoxy) - 4 - (methylsulfonyl) benzene, this is an organic compound. Its chemical properties are interesting and important in the field of organic synthesis.
First of all, its structure is based on a benzene ring. Above the benzene ring, there is a methoxy group at position 1 and a methylsulfonyl group at position 4. Methoxy is formed by connecting a methyl group to an oxygen atom, which has a certain electron-giving effect. Because the oxygen atom is rich in lone pairs of electrons, it can shift the electron cloud in the direction of the benzene ring through the conjugation effect, thereby increasing the electron cloud density of the benzene ring. The methylsulfonyl group at position 4 has a special electronic interaction between the sulfur atom and the oxygen atom. The sulfur atom has an empty d orbital, and the lone pair electrons of the oxygen atom can feed back to the empty d orbital of the sulfur atom, which makes the group have a certain electron-withdrawing property, which will affect the distribution of the electron cloud of the benzene ring, so that the electron cloud density of the benzene ring decreases near position 4.
Looking at its chemical properties, the electron cloud density at different positions on the benzene ring of this compound is different, and the reactivity is also different due to the joint action of the electron-giving methoxy group and the electron-withdrawing methylsulfonyl group. In the electrophilic substitution reaction, the methoxy group acts as an ortho-para-locator, which can guide the electrophilic reagent to preferentially attack the ortho However, since the 4 position has been occupied by the methylsulfonyl group, the electrophilic reagents mainly attack the ortho-position of the methoxy group. In the redox reaction, the sulfur atom in the methylsulfonyl group is in the + 4 valence state, which has a certain degree of reduction and can be oxidized to a higher valence sulfone group by appropriate oxidants. At the same time, the methoxy group is relatively stable, but under certain conditions, such as when encountering strong nucleophiles, the carbon-oxygen bond in the methoxy group may be broken.
In addition, due to its specific chemical properties, the compound can be used as a key intermediate in the field of medicinal chemistry for the synthesis of drug molecules with specific biological activities. In the field of materials science, it may also be used in the preparation of some functional materials due to its unique electronic structure.
First of all, its structure is based on a benzene ring. Above the benzene ring, there is a methoxy group at position 1 and a methylsulfonyl group at position 4. Methoxy is formed by connecting a methyl group to an oxygen atom, which has a certain electron-giving effect. Because the oxygen atom is rich in lone pairs of electrons, it can shift the electron cloud in the direction of the benzene ring through the conjugation effect, thereby increasing the electron cloud density of the benzene ring. The methylsulfonyl group at position 4 has a special electronic interaction between the sulfur atom and the oxygen atom. The sulfur atom has an empty d orbital, and the lone pair electrons of the oxygen atom can feed back to the empty d orbital of the sulfur atom, which makes the group have a certain electron-withdrawing property, which will affect the distribution of the electron cloud of the benzene ring, so that the electron cloud density of the benzene ring decreases near position 4.
Looking at its chemical properties, the electron cloud density at different positions on the benzene ring of this compound is different, and the reactivity is also different due to the joint action of the electron-giving methoxy group and the electron-withdrawing methylsulfonyl group. In the electrophilic substitution reaction, the methoxy group acts as an ortho-para-locator, which can guide the electrophilic reagent to preferentially attack the ortho However, since the 4 position has been occupied by the methylsulfonyl group, the electrophilic reagents mainly attack the ortho-position of the methoxy group. In the redox reaction, the sulfur atom in the methylsulfonyl group is in the + 4 valence state, which has a certain degree of reduction and can be oxidized to a higher valence sulfone group by appropriate oxidants. At the same time, the methoxy group is relatively stable, but under certain conditions, such as when encountering strong nucleophiles, the carbon-oxygen bond in the methoxy group may be broken.
In addition, due to its specific chemical properties, the compound can be used as a key intermediate in the field of medicinal chemistry for the synthesis of drug molecules with specific biological activities. In the field of materials science, it may also be used in the preparation of some functional materials due to its unique electronic structure.
What are the synthesis methods of 1- (chloromethyl) -4- (methylsulfonyl) benzene?
To prepare 1- (cyanomethyl) -4- (methylenesulfonyl) benzene, there are many synthesis methods, and each has its own advantages. Let me come one by one.
First, halogenated benzene is the starting point. Shilling halogenated benzene and cyanomethyl reagents through nucleophilic substitution reaction can obtain 1- (cyanomethyl) halogenated benzene. This step requires attention to the precise control of reaction conditions, such as temperature, amount of base, etc., to avoid the growth of side reactions. Then, 1 - (cyanomethyl) halogenated benzene acts with methylenesulfonyl reagents, and the target product is obtained through metal catalysis or other suitable reaction paths. The advantage of this path is that the raw material is easy to find, but the steps are slightly complicated and require fine operation.
Second, starting from benzaldehyde. Benzaldehyde and cyanogen methyl reagents undergo condensation reaction to obtain styrene derivatives containing cyanogen methyl. Subsequently, through a series of reactions such as oxidation and sulfonylation, the specific position is converted into methylsulfonyl group, and the final product is obtained. In this way, the selectivity of each step of the reaction needs to be careful to ensure the yield and purity.
Third, through the rearrangement or ring expansion reaction of the benzo ring system. Some benzo ring compounds with specific substituents can directly construct the structure of the target product under suitable conditions by rearrangement or ring expansion. Although this approach is well conceived, the reaction conditions are severe, and the structural requirements of the raw materials are quite high.
Fourth, the coupling reaction catalyzed by transition metals is used. Cyanogen-containing methyl halide and methylsulfonyl halide are used as raw materials, and transition metal catalysts, such as palladium and nickel, are used in the presence of ligands. This method is efficient and convenient, but the cost of the catalyst may be considered.
All these synthetic methods have advantages and disadvantages. Experimenters should make careful choices according to their own experimental conditions, availability of raw materials, purity and yield requirements of target products, etc., in order to achieve twice the result with half the effort.
First, halogenated benzene is the starting point. Shilling halogenated benzene and cyanomethyl reagents through nucleophilic substitution reaction can obtain 1- (cyanomethyl) halogenated benzene. This step requires attention to the precise control of reaction conditions, such as temperature, amount of base, etc., to avoid the growth of side reactions. Then, 1 - (cyanomethyl) halogenated benzene acts with methylenesulfonyl reagents, and the target product is obtained through metal catalysis or other suitable reaction paths. The advantage of this path is that the raw material is easy to find, but the steps are slightly complicated and require fine operation.
Second, starting from benzaldehyde. Benzaldehyde and cyanogen methyl reagents undergo condensation reaction to obtain styrene derivatives containing cyanogen methyl. Subsequently, through a series of reactions such as oxidation and sulfonylation, the specific position is converted into methylsulfonyl group, and the final product is obtained. In this way, the selectivity of each step of the reaction needs to be careful to ensure the yield and purity.
Third, through the rearrangement or ring expansion reaction of the benzo ring system. Some benzo ring compounds with specific substituents can directly construct the structure of the target product under suitable conditions by rearrangement or ring expansion. Although this approach is well conceived, the reaction conditions are severe, and the structural requirements of the raw materials are quite high.
Fourth, the coupling reaction catalyzed by transition metals is used. Cyanogen-containing methyl halide and methylsulfonyl halide are used as raw materials, and transition metal catalysts, such as palladium and nickel, are used in the presence of ligands. This method is efficient and convenient, but the cost of the catalyst may be considered.
All these synthetic methods have advantages and disadvantages. Experimenters should make careful choices according to their own experimental conditions, availability of raw materials, purity and yield requirements of target products, etc., in order to achieve twice the result with half the effort.
What are the precautions for storing and transporting 1- (chloromethyl) -4- (methylsulfonyl) benzene?
There are many things to pay attention to when storing and transporting H (1- (cyanomethyl) -4- (methylsulfonyl) pyridine.
The first thing to note is that this substance has a certain chemical activity, and it may cause dangerous chemical reactions when heated or in contact with specific substances. Therefore, when storing, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent reactions caused by excessive temperature. The temperature and humidity of the environment in which it is located need to be strictly controlled. If the humidity is too high, the substance may deteriorate due to moisture, and if the temperature is too high, it may promote decomposition.
Furthermore, due to its chemical properties, the storage place should be stored separately from oxidants, acids, alkalis and other substances, and must not be mixed. This is because the substance may react violently with the above-mentioned substances, endangering safety. For example, if it encounters a strong oxidant, it may cause combustion or even explosion.
During transportation, it should not be sloppy. The packaging must be firm to prevent damage to the package due to bumps and collisions during transportation, and material leakage. The selected packaging material must be able to withstand a certain external impact and do not chemically react with the substance. The transportation vehicle also needs to have corresponding safety equipment, such as fire extinguishers, for emergencies. At the same time, transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods. In case of leakage and other emergencies, they can be disposed of quickly and properly to reduce the harm.
In addition, whether it is storage or transportation, relevant regulations and standards must be strictly followed. Relevant operators should also be professionally trained and familiar with the operation process and safety precautions to ensure the safety of the entire storage and transportation process.
The first thing to note is that this substance has a certain chemical activity, and it may cause dangerous chemical reactions when heated or in contact with specific substances. Therefore, when storing, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent reactions caused by excessive temperature. The temperature and humidity of the environment in which it is located need to be strictly controlled. If the humidity is too high, the substance may deteriorate due to moisture, and if the temperature is too high, it may promote decomposition.
Furthermore, due to its chemical properties, the storage place should be stored separately from oxidants, acids, alkalis and other substances, and must not be mixed. This is because the substance may react violently with the above-mentioned substances, endangering safety. For example, if it encounters a strong oxidant, it may cause combustion or even explosion.
During transportation, it should not be sloppy. The packaging must be firm to prevent damage to the package due to bumps and collisions during transportation, and material leakage. The selected packaging material must be able to withstand a certain external impact and do not chemically react with the substance. The transportation vehicle also needs to have corresponding safety equipment, such as fire extinguishers, for emergencies. At the same time, transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods. In case of leakage and other emergencies, they can be disposed of quickly and properly to reduce the harm.
In addition, whether it is storage or transportation, relevant regulations and standards must be strictly followed. Relevant operators should also be professionally trained and familiar with the operation process and safety precautions to ensure the safety of the entire storage and transportation process.
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