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1-(Chloromethyl)-4-Nitrobenzene
Linshang Chemical
|
HS Code |
847629 |
| Chemical Formula | C7H6ClNO2 |
| Molar Mass | 171.58 g/mol |
| Appearance | Yellow - solid |
| Melting Point | 44 - 48 °C |
| Boiling Point | 242 - 244 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like benzene, toluene |
| Density | 1.32 g/cm³ |
| Flash Point | 121.7 °C |
| Odor | Pungent odor |
| Hazard Class | Toxic, Corrosive |
As an accredited 1-(Chloromethyl)-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(chloromethyl)-4 -nitrobenzene packaged in a sealed, labeled chemical bottle. |
| Storage | 1-(Chloromethyl)-4-nitrobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition points. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances like oxidizing agents and bases to prevent reactions. This helps maintain its stability and ensure safety. |
| Shipping | 1-(Chloromethyl)-4-nitrobenzene is a hazardous chemical. It must be shipped in accordance with strict regulations. Use proper packaging to prevent leakage, and clearly label the package with hazard warnings for safe transportation. |
Competitive 1-(Chloromethyl)-4-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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What are the main uses of 1- (chloromethyl) -4-nitrobenzene?
1- (cyanomethyl) -4-pyridylnaphthalene has a wide range of main uses. In the field of pharmaceutical research and development, this compound has great potential. Its unique structure may be compatible with specific biological targets, so it can lay the foundation for the creation of new drugs.
In the development of anticancer drugs, 1- (cyanomethyl) -4-pyridylnaphthalene may inhibit the proliferation and induce apoptosis of cancer cells by interfering with specific signaling pathways. The growth and division of cancer cells depend on the regulation of many signaling pathways. This compound may be able to precisely act on key links, such as inhibiting the activity of some cancer-promoting proteins and inhibiting the abnormal proliferation of cancer cells.
In the development of anti-infective drugs, it should not be underestimated. The survival and reproduction of microorganisms require specific metabolic pathways and molecular mechanisms. 1- (cyanomethyl) -4-pyridylnaphthalene may be able to destroy the key metabolic processes of microorganisms with its special structure, or hinder its adhesion and invasion with host cells, so as to achieve anti-infective effects.
And in the field of materials science, it also has applications. Because it has certain physical and chemical properties, it can be used to prepare functional materials. For example, it can be introduced into polymer materials to impart special optical, electrical or mechanical properties to the materials. It may affect the molecular arrangement and interaction of materials, so that materials exhibit unique characteristics to meet the needs of different application scenarios, such as in photoelectric materials, sensor materials, etc.
Furthermore, in organic synthetic chemistry, 1- (cyanomethyl) -4-pyridyl naphthalene can be used as an important synthetic intermediate. Chemists can use various chemical modifications and reactions to construct more complex and diverse organic molecular structures, which contribute to the development of organic synthetic chemistry and facilitate the creation and exploration of new organic compounds.
In the development of anticancer drugs, 1- (cyanomethyl) -4-pyridylnaphthalene may inhibit the proliferation and induce apoptosis of cancer cells by interfering with specific signaling pathways. The growth and division of cancer cells depend on the regulation of many signaling pathways. This compound may be able to precisely act on key links, such as inhibiting the activity of some cancer-promoting proteins and inhibiting the abnormal proliferation of cancer cells.
In the development of anti-infective drugs, it should not be underestimated. The survival and reproduction of microorganisms require specific metabolic pathways and molecular mechanisms. 1- (cyanomethyl) -4-pyridylnaphthalene may be able to destroy the key metabolic processes of microorganisms with its special structure, or hinder its adhesion and invasion with host cells, so as to achieve anti-infective effects.
And in the field of materials science, it also has applications. Because it has certain physical and chemical properties, it can be used to prepare functional materials. For example, it can be introduced into polymer materials to impart special optical, electrical or mechanical properties to the materials. It may affect the molecular arrangement and interaction of materials, so that materials exhibit unique characteristics to meet the needs of different application scenarios, such as in photoelectric materials, sensor materials, etc.
Furthermore, in organic synthetic chemistry, 1- (cyanomethyl) -4-pyridyl naphthalene can be used as an important synthetic intermediate. Chemists can use various chemical modifications and reactions to construct more complex and diverse organic molecular structures, which contribute to the development of organic synthetic chemistry and facilitate the creation and exploration of new organic compounds.
What are the physical properties of 1- (chloromethyl) -4-nitrobenzene?
1 - (cyanomethyl) -4 -pyridyl naphthalene is also an organic compound. Its physical properties are quite characteristic, and this is described in detail by you.
Looking at its appearance, under normal temperature and pressure, it is mostly a crystalline solid state, with a fine texture, like frost and snow. The color is white and pure, or slightly yellowish, which may be related to the presence or absence of impurities.
As for the melting point, after fine determination, it is about a certain temperature range. This temperature limit is quite critical, which can be used to distinguish the purity. When heated to this range, the substance gradually melts from the solid state to the liquid state, and the transformation witnesses the manifestation of the material's characteristics.
Solubility is also an important physical property. In organic solvents, such as ethanol, dichloromethane, etc., its solubility is acceptable. Ethanol is a common organic solvent with both hydrophilic hydroxyl groups and lipophilic ethyl groups in its molecular structure, and 1- (cyanomethyl) -4-pyridyl naphthalene is in it. By virtue of the interaction force between molecules, it partially dissolves to form a uniform mixed system. However, in water, due to the significant hydrophobic characteristics of its molecular structure, its solubility is poor, and it is difficult to blend with water molecules affinity. It is mostly suspended or settled in the bottom with solid particles.
Furthermore, its density also has a certain value, which is lighter or heavier than that of water, which is related to the arrangement of its molecular weight and spatial structure. The determination of density is of great significance in many fields such as chemical applications, separation and purification.
In addition, the volatility of this substance is weak, and very little volatilization escapes into the air at room temperature. This characteristic makes it highly stable under general storage and use conditions, and can reduce losses and safety hazards caused by volatilization.
In summary, the physical properties of 1- (cyanomethyl) -4-pyridyl naphthalene are key considerations in organic synthesis, drug development and other fields. In-depth investigation of it can provide a solid foundation for the development of related fields.
Looking at its appearance, under normal temperature and pressure, it is mostly a crystalline solid state, with a fine texture, like frost and snow. The color is white and pure, or slightly yellowish, which may be related to the presence or absence of impurities.
As for the melting point, after fine determination, it is about a certain temperature range. This temperature limit is quite critical, which can be used to distinguish the purity. When heated to this range, the substance gradually melts from the solid state to the liquid state, and the transformation witnesses the manifestation of the material's characteristics.
Solubility is also an important physical property. In organic solvents, such as ethanol, dichloromethane, etc., its solubility is acceptable. Ethanol is a common organic solvent with both hydrophilic hydroxyl groups and lipophilic ethyl groups in its molecular structure, and 1- (cyanomethyl) -4-pyridyl naphthalene is in it. By virtue of the interaction force between molecules, it partially dissolves to form a uniform mixed system. However, in water, due to the significant hydrophobic characteristics of its molecular structure, its solubility is poor, and it is difficult to blend with water molecules affinity. It is mostly suspended or settled in the bottom with solid particles.
Furthermore, its density also has a certain value, which is lighter or heavier than that of water, which is related to the arrangement of its molecular weight and spatial structure. The determination of density is of great significance in many fields such as chemical applications, separation and purification.
In addition, the volatility of this substance is weak, and very little volatilization escapes into the air at room temperature. This characteristic makes it highly stable under general storage and use conditions, and can reduce losses and safety hazards caused by volatilization.
In summary, the physical properties of 1- (cyanomethyl) -4-pyridyl naphthalene are key considerations in organic synthesis, drug development and other fields. In-depth investigation of it can provide a solid foundation for the development of related fields.
What are the chemical properties of 1- (chloromethyl) -4-nitrobenzene?
The chemical properties of 1 - (cyanomethyl) -4 -pyridylquinoline are as follows:
This compound contains the structure of cyanomethyl and pyridylquinoline, and the cyanyl group in the cyanomethyl group has higher reactivity. The electron cloud density of carbon and nitrogen in the cyanyl group is high, which is vulnerable to attack by electrophilic reagents, and can undergo hydrolysis reaction. Under acidic conditions, cyanyl groups are gradually hydrolyzed to carboxylic groups, which are first converted to amides, and then carboxylic acids; under basic conditions, it can also be hydrolyzed, but the reaction mechanism is slightly different from acidic conditions.
Furthermore, cyanomethyl can participate in nucleophilic Because of its strong electron-absorbing cyanyl group, the carbon atom connected to it is partially positively charged. In case of suitable nucleophiles, such as alkoxides, amines, etc., the nucleophilic part of the nucleophilic reagent will attack the carbon atom, replace the cyanyl group or react with the cyanyl group.
And the pyridyl quinoline part, the pyridine ring and the quinoline ring are both aromatic and highly stable. However, the nitrogen atom of the pyridine ring has lone pairs of electrons and is alkaline to a certain extent, which can react with acids to form pyridine salts.
In addition, the hydrogen atom on the pyridine ring and the quinoline ring can undergo electrophilic substitution reactions due to the influence of the distribution of electron clouds on For example, under appropriate catalyst and reaction conditions, halogenation, nitrification, sulfonation and other reactions can occur. The substitution position is affected by the localization effect of the substituent on the ring, and the nitrogen atom of the pyridine ring is the meta-localization group. The electron cloud density distribution at different positions in the quinoline ring is different, which also affects the check point of the electrophilic substitution reaction.
Due to its unique structure, this compound may have important uses in organic synthesis, pharmaceutical chemistry and other fields. Its chemical properties lay the foundation for related research and applications.
This compound contains the structure of cyanomethyl and pyridylquinoline, and the cyanyl group in the cyanomethyl group has higher reactivity. The electron cloud density of carbon and nitrogen in the cyanyl group is high, which is vulnerable to attack by electrophilic reagents, and can undergo hydrolysis reaction. Under acidic conditions, cyanyl groups are gradually hydrolyzed to carboxylic groups, which are first converted to amides, and then carboxylic acids; under basic conditions, it can also be hydrolyzed, but the reaction mechanism is slightly different from acidic conditions.
Furthermore, cyanomethyl can participate in nucleophilic Because of its strong electron-absorbing cyanyl group, the carbon atom connected to it is partially positively charged. In case of suitable nucleophiles, such as alkoxides, amines, etc., the nucleophilic part of the nucleophilic reagent will attack the carbon atom, replace the cyanyl group or react with the cyanyl group.
And the pyridyl quinoline part, the pyridine ring and the quinoline ring are both aromatic and highly stable. However, the nitrogen atom of the pyridine ring has lone pairs of electrons and is alkaline to a certain extent, which can react with acids to form pyridine salts.
In addition, the hydrogen atom on the pyridine ring and the quinoline ring can undergo electrophilic substitution reactions due to the influence of the distribution of electron clouds on For example, under appropriate catalyst and reaction conditions, halogenation, nitrification, sulfonation and other reactions can occur. The substitution position is affected by the localization effect of the substituent on the ring, and the nitrogen atom of the pyridine ring is the meta-localization group. The electron cloud density distribution at different positions in the quinoline ring is different, which also affects the check point of the electrophilic substitution reaction.
Due to its unique structure, this compound may have important uses in organic synthesis, pharmaceutical chemistry and other fields. Its chemical properties lay the foundation for related research and applications.
What is the preparation method of 1- (chloromethyl) -4-nitrobenzene?
To prepare 1 - (methoxy) - 4 - benzylbenzene, you can follow the following ancient method.
First take an appropriate amount of benzene and put it in a clean kettle. With an appropriate device, slowly introduce bromine, and add an appropriate amount of iron powder to the system as a catalyst. At this time, benzene and bromine undergoes a substitution reaction to generate bromobenzene. The key to the reaction lies in the appropriate control of temperature. It should not be too high or too low. If it is too high, side reactions will increase, and if it is too low, the reaction will be slow.
After obtaining bromobenzene, take another container, add magnesium chips and an appropriate amount of anhydrous ether to make an environment of Grignard reagent. Then the prepared bromobenzene is slowly dripped into it to form the Grignard reagent of bromobenzene. This process needs to ensure that the system is anhydrous and oxygen-free, because both water and oxygen can cause Grignard's reagent to fail.
At the same time, methoxy benzyl halide is prepared. Take benzyl alcohol and act with an appropriate halogenating agent (such as sulfoxide chloride, etc.) to convert the hydroxyl group into a halogen atom, and then react with sodium methoxide to introduce a methoxy group to obtain a methoxy benzyl halide.
Then, the methoxy benzyl halide is added to the system containing the bromobenzene Grignard reagent The nucleophilic substitution reaction occurs between the two. The carbon negative ions in the Grignard reagent attack the carbon connected to the halogen atom of the methoxy benzyl halide, and the halogen atom leaves, thus forming the prototype of 1- (methoxy) -4-benzylbenzene.
After the reaction is completed, the reaction mixture is carefully treated with an appropriate acid solution to dissolve and separate impurities such as magnesium salts. After distillation, extraction, recrystallization and other purification methods, the unreacted raw materials and by-products can be removed to obtain pure 1- (methoxy) -4-benzylbenzene.
This preparation method, although the steps are complex, each step complements each other, and careful operation is required to obtain it smoothly.
First take an appropriate amount of benzene and put it in a clean kettle. With an appropriate device, slowly introduce bromine, and add an appropriate amount of iron powder to the system as a catalyst. At this time, benzene and bromine undergoes a substitution reaction to generate bromobenzene. The key to the reaction lies in the appropriate control of temperature. It should not be too high or too low. If it is too high, side reactions will increase, and if it is too low, the reaction will be slow.
After obtaining bromobenzene, take another container, add magnesium chips and an appropriate amount of anhydrous ether to make an environment of Grignard reagent. Then the prepared bromobenzene is slowly dripped into it to form the Grignard reagent of bromobenzene. This process needs to ensure that the system is anhydrous and oxygen-free, because both water and oxygen can cause Grignard's reagent to fail.
At the same time, methoxy benzyl halide is prepared. Take benzyl alcohol and act with an appropriate halogenating agent (such as sulfoxide chloride, etc.) to convert the hydroxyl group into a halogen atom, and then react with sodium methoxide to introduce a methoxy group to obtain a methoxy benzyl halide.
Then, the methoxy benzyl halide is added to the system containing the bromobenzene Grignard reagent The nucleophilic substitution reaction occurs between the two. The carbon negative ions in the Grignard reagent attack the carbon connected to the halogen atom of the methoxy benzyl halide, and the halogen atom leaves, thus forming the prototype of 1- (methoxy) -4-benzylbenzene.
After the reaction is completed, the reaction mixture is carefully treated with an appropriate acid solution to dissolve and separate impurities such as magnesium salts. After distillation, extraction, recrystallization and other purification methods, the unreacted raw materials and by-products can be removed to obtain pure 1- (methoxy) -4-benzylbenzene.
This preparation method, although the steps are complex, each step complements each other, and careful operation is required to obtain it smoothly.
What are the precautions for using 1- (chloromethyl) -4-nitrobenzene?
1 - (Cyanomethyl) - 4 -carbonylquinoline should be paid attention to the following items during the application process:
First, it is related to safety protection. This compound may have certain toxicity and irritation, and comprehensive protective measures must be taken when it comes into contact. Such as wearing protective clothing, gloves, protective glasses and masks to prevent skin, eyes and respiratory tract damage. After the operation, the contact area should be rinsed with a lot of water in time. If it is accidentally contacted, emergency treatment should be carried out quickly according to the specific situation, and emergency medical treatment should be taken if necessary.
Second, about the operating environment. It needs to be operated in a well-ventilated place to avoid the accumulation of volatile gases from the compound in a limited space and reduce the risk of poisoning. If conditions permit, it is best to operate in the fume hood to ensure that harmful gases can be discharged in time.
Third, it involves storage conditions. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. It needs to be stored separately from oxidants, acids, alkalis, etc., and mixed storage should be avoided to prevent dangerous chemical reactions. At the same time, the storage area should be equipped with suitable containment materials to deal with possible leakage conditions.
Fourth, for the dosage. Strictly control the dosage in accordance with the experimental or production requirements to avoid overuse. Excessive use will not only cause material waste, but may also make subsequent reactions difficult to control and even cause safety accidents.
Fifth, pay attention to compatibility taboos. Before mixing with other compounds, it is necessary to clarify whether there are compatibility taboos between the two. Some substances may react violently with it, generating gas, heat, and even causing serious consequences such as explosion. Therefore, it is necessary to consult relevant information in detail or conduct pre-experiments before use.
First, it is related to safety protection. This compound may have certain toxicity and irritation, and comprehensive protective measures must be taken when it comes into contact. Such as wearing protective clothing, gloves, protective glasses and masks to prevent skin, eyes and respiratory tract damage. After the operation, the contact area should be rinsed with a lot of water in time. If it is accidentally contacted, emergency treatment should be carried out quickly according to the specific situation, and emergency medical treatment should be taken if necessary.
Second, about the operating environment. It needs to be operated in a well-ventilated place to avoid the accumulation of volatile gases from the compound in a limited space and reduce the risk of poisoning. If conditions permit, it is best to operate in the fume hood to ensure that harmful gases can be discharged in time.
Third, it involves storage conditions. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. It needs to be stored separately from oxidants, acids, alkalis, etc., and mixed storage should be avoided to prevent dangerous chemical reactions. At the same time, the storage area should be equipped with suitable containment materials to deal with possible leakage conditions.
Fourth, for the dosage. Strictly control the dosage in accordance with the experimental or production requirements to avoid overuse. Excessive use will not only cause material waste, but may also make subsequent reactions difficult to control and even cause safety accidents.
Fifth, pay attention to compatibility taboos. Before mixing with other compounds, it is necessary to clarify whether there are compatibility taboos between the two. Some substances may react violently with it, generating gas, heat, and even causing serious consequences such as explosion. Therefore, it is necessary to consult relevant information in detail or conduct pre-experiments before use.
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