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1-(Chloromethyl)-4-(Phenylsulfanyl)Benzene
Linshang Chemical
|
HS Code |
899924 |
| Chemical Formula | C13H11ClS |
| Molar Mass | 234.749 g/mol |
| Appearance | Typically a solid |
| Physical State At Room Temp | Solid |
| Boiling Point | Estimated high boiling point due to aromatic structure |
| Solubility In Water | Low solubility in water (hydrophobic due to non - polar groups) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Odor | May have an unpleasant, pungent odor |
As an accredited 1-(Chloromethyl)-4-(Phenylsulfanyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(chloromethyl)-4-(phenylsulfanyl)benzene in sealed chemical - grade packaging. |
| Storage | 1-(Chloromethyl)-4-(phenylsulfanyl)benzene should be stored in a cool, dry, well - ventilated area, away from sources of heat and ignition. Keep it in a tightly sealed container, preferably made of corrosion - resistant material. Store it separately from oxidizing agents, strong acids, and bases to prevent chemical reactions. Avoid exposure to moisture which could potentially initiate decomposition. |
| Shipping | 1-(Chloromethyl)-4-(phenylsulfanyl)benzene is shipped in sealed, corrosion - resistant containers. Compliance with chemical transportation regulations is ensured, with proper labeling indicating its nature for safe handling during transit. |
Competitive 1-(Chloromethyl)-4-(Phenylsulfanyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 1- (chloromethyl) -4- (phenylsulfanyl) benzene?
1- (chloromethyl) -4- (phenylthio) benzene, this is an organic compound with unique chemical properties. It contains chloromethyl and phenylthio groups, which give the compound a variety of activities.
Let's talk about chloromethyl first, chlorine atoms have high activity and are prone to substitution reactions. In the case of nucleophiles, chlorine atoms are easily replaced, which can be used to introduce different functional groups. If the nucleophilic reagent is an alcohol, under suitable conditions, the chlorine atom will be replaced by alkoxy groups to form ether compounds; if the nucleophilic reagent is an amine, nitrogen-containing derivatives will be formed. This property makes 1- (chloromethyl) -4- (phenylthio) benzene an important intermediate in organic synthesis, assisting chemists in constructing complex organic molecular structures.
Looking at the benzenthio group again, the electron cloud distribution of sulfur atoms is special, giving benzenthio groups a certain nucleophilicity. Although its nucleophilicity is not as good as that of common nucleophilic reagents, it can participate in nucleophilic substitution or addition reactions in specific reactions. At the same time, the benzene ring conjugation system stabilizes the benzenthio group, and affects the electron cloud distribution of compounds, so that the electron cloud density of the adjacent and para-sites of the benzene ring changes, which affects the substitution reaction activity and position selectivity on the benzene ring. For example, when electrophilic substitution is carried out, the benzenthio group makes the reaction more likely to occur in its adjacent and para-sites.
In addition, the overall structure of 1- (chloromethyl) -4- The molecule contains aromatic rings, which make it stable and hydrophobic, and has good solubility in organic solvents. It can participate in various solution-phase organic reactions. Due to the existence of chloromethyl and phenylthio groups, the compound can participate in various reactions such as oxidation and reduction, providing rich possibilities for organic synthesis.
Let's talk about chloromethyl first, chlorine atoms have high activity and are prone to substitution reactions. In the case of nucleophiles, chlorine atoms are easily replaced, which can be used to introduce different functional groups. If the nucleophilic reagent is an alcohol, under suitable conditions, the chlorine atom will be replaced by alkoxy groups to form ether compounds; if the nucleophilic reagent is an amine, nitrogen-containing derivatives will be formed. This property makes 1- (chloromethyl) -4- (phenylthio) benzene an important intermediate in organic synthesis, assisting chemists in constructing complex organic molecular structures.
Looking at the benzenthio group again, the electron cloud distribution of sulfur atoms is special, giving benzenthio groups a certain nucleophilicity. Although its nucleophilicity is not as good as that of common nucleophilic reagents, it can participate in nucleophilic substitution or addition reactions in specific reactions. At the same time, the benzene ring conjugation system stabilizes the benzenthio group, and affects the electron cloud distribution of compounds, so that the electron cloud density of the adjacent and para-sites of the benzene ring changes, which affects the substitution reaction activity and position selectivity on the benzene ring. For example, when electrophilic substitution is carried out, the benzenthio group makes the reaction more likely to occur in its adjacent and para-sites.
In addition, the overall structure of 1- (chloromethyl) -4- The molecule contains aromatic rings, which make it stable and hydrophobic, and has good solubility in organic solvents. It can participate in various solution-phase organic reactions. Due to the existence of chloromethyl and phenylthio groups, the compound can participate in various reactions such as oxidation and reduction, providing rich possibilities for organic synthesis.
What are the common synthesis methods of 1- (chloromethyl) -4- (phenylsulfanyl) benzene?
1 - (chloromethyl) - 4 - (phenylthio) benzene, the method of synthesis, often using phenylthiophenol and p-chloromethylchlorobenzene as raw materials, with an appropriate base, in a suitable solvent reaction.
First take an appropriate amount of phenylthiophenol, put it in a clean reactor, and add an appropriate amount of alkali, such as potassium carbonate. The base can promote the reaction, so that the sulfur atom of phenylthiophenol is more nucleophilic. Then slowly add the solution of p-chloromethylchlorobenzene, and the solvent used can be selected as N, N-dimethylformamide (DMF). This solvent can make the reactants miscible and has no adverse interference with the reaction.
When reacting, it is necessary to control the temperature, generally at a moderate temperature, such as between 50 and 80 degrees Celsius. If the temperature is too low, the reaction will be slow; if the temperature is too high, it may cause side reactions to breed. During the reaction process, continue to stir to make the reactants fully contact and accelerate the reaction rate. After several hours of reaction, after the reaction is completed, the conventional separation and purification methods, such as extraction, column chromatography, etc. remove impurities, and obtain a pure 1 - (chloromethyl) -4 - (phenylthio) benzene product.
There are also other ways to synthesize this compound, such as first thio-modifying the benzene ring, and then introducing chloromethyl. However, in comparison, the direct reaction of thiophenol and p-chloromethyl chlorobenzene is more simple and efficient, so it is a common method for synthesizing 1- (chloromethyl) -4- (phenylthio) benzene.
First take an appropriate amount of phenylthiophenol, put it in a clean reactor, and add an appropriate amount of alkali, such as potassium carbonate. The base can promote the reaction, so that the sulfur atom of phenylthiophenol is more nucleophilic. Then slowly add the solution of p-chloromethylchlorobenzene, and the solvent used can be selected as N, N-dimethylformamide (DMF). This solvent can make the reactants miscible and has no adverse interference with the reaction.
When reacting, it is necessary to control the temperature, generally at a moderate temperature, such as between 50 and 80 degrees Celsius. If the temperature is too low, the reaction will be slow; if the temperature is too high, it may cause side reactions to breed. During the reaction process, continue to stir to make the reactants fully contact and accelerate the reaction rate. After several hours of reaction, after the reaction is completed, the conventional separation and purification methods, such as extraction, column chromatography, etc. remove impurities, and obtain a pure 1 - (chloromethyl) -4 - (phenylthio) benzene product.
There are also other ways to synthesize this compound, such as first thio-modifying the benzene ring, and then introducing chloromethyl. However, in comparison, the direct reaction of thiophenol and p-chloromethyl chlorobenzene is more simple and efficient, so it is a common method for synthesizing 1- (chloromethyl) -4- (phenylthio) benzene.
In what fields is 1- (chloromethyl) -4- (phenylsulfanyl) benzene used?
1- (chloromethyl) -4- (phenylthio) benzene, this compound is useful in many fields.
In the field of medicinal chemistry, it can be used as a key intermediate. Due to the characteristics of chloromethyl and phenylthio groups in the structure, it can participate in a variety of chemical reactions and help to construct complex drug molecular structures. Through appropriate reactions, specific functional groups can be introduced to endow drugs with unique physiological activities. For example, when developing new antibacterial and antiviral drugs, this can be used as a starting material and transformed in a series, or lead compounds with excellent activity can be obtained.
It also has a place in the field of materials science. Because of its special chemical structure, it can be used to prepare special polymer materials. For example, by polymerizing with other monomers, its structural units are introduced into the polymer chain, which can endow the material with unique electrical, optical or mechanical properties, such as improving the conductivity and fluorescence properties of the material, or enhancing the strength and flexibility of the material, and then applied to electronic devices, optical display materials, etc.
In the field of organic synthesis, 1- (chloromethyl) -4- (phenylthio) benzene is an extremely useful synthetic block. Chemists can design and implement various organic synthesis routes by virtue of its nucleophilic substitution activity of chloromethyl and the stability of phenylthio. For example, by introducing different groups through nucleophilic substitution reactions, rich organic compounds are constructed, which contribute to the development of organic synthetic chemistry and help to create novel organic molecules with special properties.
In the field of medicinal chemistry, it can be used as a key intermediate. Due to the characteristics of chloromethyl and phenylthio groups in the structure, it can participate in a variety of chemical reactions and help to construct complex drug molecular structures. Through appropriate reactions, specific functional groups can be introduced to endow drugs with unique physiological activities. For example, when developing new antibacterial and antiviral drugs, this can be used as a starting material and transformed in a series, or lead compounds with excellent activity can be obtained.
It also has a place in the field of materials science. Because of its special chemical structure, it can be used to prepare special polymer materials. For example, by polymerizing with other monomers, its structural units are introduced into the polymer chain, which can endow the material with unique electrical, optical or mechanical properties, such as improving the conductivity and fluorescence properties of the material, or enhancing the strength and flexibility of the material, and then applied to electronic devices, optical display materials, etc.
In the field of organic synthesis, 1- (chloromethyl) -4- (phenylthio) benzene is an extremely useful synthetic block. Chemists can design and implement various organic synthesis routes by virtue of its nucleophilic substitution activity of chloromethyl and the stability of phenylthio. For example, by introducing different groups through nucleophilic substitution reactions, rich organic compounds are constructed, which contribute to the development of organic synthetic chemistry and help to create novel organic molecules with special properties.
What are the physical properties of 1- (chloromethyl) -4- (phenylsulfanyl) benzene?
1- (chloromethyl) -4- (phenylthio) benzene, this is an organic compound. Looking at its physical properties, under normal conditions, it is either a colorless to light yellow liquid or a crystalline solid, depending on the specific environmental conditions. Its melting and boiling point is critical, with a melting point of about [X] ° C and a boiling point of about [X] ° C. This compound exhibits good solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc., which can be miscible with it, but its solubility in water is extremely low, due to the molecular structure of the compound, which makes it hydrophobic.
Looking at its appearance, if it is a liquid, it is clear and transparent, or slightly colored; if it is a solid, it is mostly crystalline, crystalline or regular, or irregular. Smell it, or it has a special smell, which may be irritating, but not extremely strong.
In terms of density, it is about [X] g/cm ³, which is similar to the density of common organic solvents. Because it is volatile to a certain extent, it will slowly evaporate in the air, so it needs to be properly sealed when stored to prevent its escape. In addition, its refractive index is also a specific value, about [X], which is of great significance when identifying and analyzing this compound.
Looking at its appearance, if it is a liquid, it is clear and transparent, or slightly colored; if it is a solid, it is mostly crystalline, crystalline or regular, or irregular. Smell it, or it has a special smell, which may be irritating, but not extremely strong.
In terms of density, it is about [X] g/cm ³, which is similar to the density of common organic solvents. Because it is volatile to a certain extent, it will slowly evaporate in the air, so it needs to be properly sealed when stored to prevent its escape. In addition, its refractive index is also a specific value, about [X], which is of great significance when identifying and analyzing this compound.
What is the market outlook for 1- (chloromethyl) -4- (phenylsulfanyl) benzene?
1 - (chloromethyl) - 4 - (phenylthio) benzene, the current market prospect of this substance can be viewed from the following points.
First of all, its use, this compound is often a key intermediate in organic synthesis. In the field of medicine, with its specific chemical structure, it can be used to create new drugs. Today, the pharmaceutical industry is eager for new drugs with specific effects, constantly seeking novel compounds to develop drugs for difficult diseases. Therefore, if new drugs can be successfully developed on the basis of this compound, the market prospect will be vast.
Furthermore, in the field of materials science, it also has potential application value. With the development of high-tech, the demand for materials with special properties is increasing day by day. 1 - (chloromethyl) - 4 - (phenylthio) benzene may be converted into materials with unique properties through specific reactions, such as photovoltaic materials. The photovoltaic industry is in the ascendant, and the demand for new materials is continuous, which undoubtedly provides a broad market space for this compound.
However, it is also necessary to face up to the challenges it faces. The process of synthesizing this compound may have technical difficulties. If the production process is complicated and costly, it will inevitably limit its large-scale production and marketing activities. In addition, if the synthesis process of compounds is not environmentally friendly, it will also set up many obstacles for its market expansion.
But overall, 1- (chloromethyl) -4- (phenylthio) benzene, with its potential applications in the fields of medicine and materials, will be able to overcome technical difficulties and comply with environmental protection requirements, and will be able to find a place in the market, with promising prospects.
First of all, its use, this compound is often a key intermediate in organic synthesis. In the field of medicine, with its specific chemical structure, it can be used to create new drugs. Today, the pharmaceutical industry is eager for new drugs with specific effects, constantly seeking novel compounds to develop drugs for difficult diseases. Therefore, if new drugs can be successfully developed on the basis of this compound, the market prospect will be vast.
Furthermore, in the field of materials science, it also has potential application value. With the development of high-tech, the demand for materials with special properties is increasing day by day. 1 - (chloromethyl) - 4 - (phenylthio) benzene may be converted into materials with unique properties through specific reactions, such as photovoltaic materials. The photovoltaic industry is in the ascendant, and the demand for new materials is continuous, which undoubtedly provides a broad market space for this compound.
However, it is also necessary to face up to the challenges it faces. The process of synthesizing this compound may have technical difficulties. If the production process is complicated and costly, it will inevitably limit its large-scale production and marketing activities. In addition, if the synthesis process of compounds is not environmentally friendly, it will also set up many obstacles for its market expansion.
But overall, 1- (chloromethyl) -4- (phenylthio) benzene, with its potential applications in the fields of medicine and materials, will be able to overcome technical difficulties and comply with environmental protection requirements, and will be able to find a place in the market, with promising prospects.
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