Linshang Chemical
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1-(Chloromethyl)-4-(Phenylthio)Benzene
Linshang Chemical
|
HS Code |
303721 |
| Chemical Formula | C13H11ClS |
| Molecular Weight | 234.75 |
| Appearance | Typically a solid (description may vary based on purity and preparation) |
| Solubility In Water | Expected to be low, as it is an organic compound with non - polar groups |
| Solubility In Organic Solvents | Soluble in common organic solvents like chloroform, dichloromethane (due to its non - polar nature) |
As an accredited 1-(Chloromethyl)-4-(Phenylthio)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(chloromethyl)-4-(phenylthio)benzene packaged in a sealed glass bottle. |
| Storage | 1-(Chloromethyl)-4-(phenylthio)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and exposure to air or moisture. Store separately from oxidizing agents and reactive substances to avoid potential chemical reactions. |
| Shipping | 1-(Chloromethyl)-4-(phenylthio)benzene is shipped in accordance with strict chemical regulations. It's packaged securely to prevent leakage, transported in appropriate containers, and handled by trained personnel to ensure safety during transit. |
Competitive 1-(Chloromethyl)-4-(Phenylthio)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 1- (chloromethyl) -4- (phenylthio) benzene
1 - (chloromethyl) -4 - (phenylthio) benzene, this is an organic compound. In terms of its physical properties, it is either a colorless to light yellow liquid under normal conditions, or a crystalline solid with a certain odor. However, the relevant information is not detailed. Its melting point, boiling point and other properties are difficult to say precisely due to the lack of measured data. However, it can be speculated from the properties of similar compounds that their melting point or intermolecular force is within a certain range. If the intermolecular force is strong, the melting point is higher; otherwise, it is lower. The boiling point is the same, and it is affected by molecular mass and intermolecular force.
On its chemical properties, first, chloromethyl is active. As a good leaving group, chlorine atoms are prone to nucleophilic substitution reactions. When they meet nucleophilic reagents such as alcohols and amines, chlorine atoms can be replaced by nucleophilic reagents to form corresponding ether or amine derivatives. Second, phenylthio groups also have unique reactivity. The electron cloud density on the benzene ring is affected by sulfur atoms, and electrophilic substitution reactions can occur. For example, when interacting with halogenating reagents, halogen atoms can be introduced at specific positions in the benzene ring. At the same time, sulfur atoms can be oxidized to form sulfoxides or sulfones. Third, the compound as a whole can participate in common reactions of aromatic hydrocarbons, such as the Fu-gram reaction. In the presence of appropriate catalysts, it can react with acyl halides or haloalkanes to introduce acyl or alkyl groups on the ben This compound is widely used in the field of organic synthesis due to its active chloromethyl and phenylthio groups, and can be used as an intermediate to construct more complex organic molecular structures.
On its chemical properties, first, chloromethyl is active. As a good leaving group, chlorine atoms are prone to nucleophilic substitution reactions. When they meet nucleophilic reagents such as alcohols and amines, chlorine atoms can be replaced by nucleophilic reagents to form corresponding ether or amine derivatives. Second, phenylthio groups also have unique reactivity. The electron cloud density on the benzene ring is affected by sulfur atoms, and electrophilic substitution reactions can occur. For example, when interacting with halogenating reagents, halogen atoms can be introduced at specific positions in the benzene ring. At the same time, sulfur atoms can be oxidized to form sulfoxides or sulfones. Third, the compound as a whole can participate in common reactions of aromatic hydrocarbons, such as the Fu-gram reaction. In the presence of appropriate catalysts, it can react with acyl halides or haloalkanes to introduce acyl or alkyl groups on the ben This compound is widely used in the field of organic synthesis due to its active chloromethyl and phenylthio groups, and can be used as an intermediate to construct more complex organic molecular structures.
What are the main uses of 1- (chloromethyl) -4- (phenylthio) benzene
1 - (chloromethyl) -4 - (phenylthio) benzene, which has a wide range of uses. In the field of organic synthesis, it is often a key raw material. It can interact with many reagents through a specific reaction path to prepare other types of organic compounds.
In the field of medicinal chemistry, it has potential medicinal value. Or it can participate in the construction of drug molecules, and after modification and modification, it is expected to generate substances with specific biological activities, which can be used for the treatment and prevention of diseases.
In the field of materials science, it also has extraordinary performance. With reasonable design and reaction, it can be introduced into polymer materials, thus endowing the materials with unique properties, such as improving the stability, solubility, and even electrical and optical properties of the materials, which is of great significance for the development of new functional materials.
Furthermore, in the field of fine chemicals, it can be used as an intermediate for the synthesis of various fine chemicals, such as fragrances, dyes, etc., contributing greatly to the variety of fine chemical products. In short, 1- (chloromethyl) -4- (phenylthio) benzene plays an important role in many fields and is of great significance to promote the development of related industries.
In the field of medicinal chemistry, it has potential medicinal value. Or it can participate in the construction of drug molecules, and after modification and modification, it is expected to generate substances with specific biological activities, which can be used for the treatment and prevention of diseases.
In the field of materials science, it also has extraordinary performance. With reasonable design and reaction, it can be introduced into polymer materials, thus endowing the materials with unique properties, such as improving the stability, solubility, and even electrical and optical properties of the materials, which is of great significance for the development of new functional materials.
Furthermore, in the field of fine chemicals, it can be used as an intermediate for the synthesis of various fine chemicals, such as fragrances, dyes, etc., contributing greatly to the variety of fine chemical products. In short, 1- (chloromethyl) -4- (phenylthio) benzene plays an important role in many fields and is of great significance to promote the development of related industries.
What are the synthesis methods of 1- (chloromethyl) -4- (phenylthio) benzene
The synthesis method of 1- (chloromethyl) -4- (phenylthio) benzene, although the ancient book "Tiangong Kaiwu" does not directly mention this substance, it can be deduced with reference to the ancient chemical synthesis technology.
First, the method of substitution reaction can be used. Take p (phenylthio) toluene as the raw material, and under suitable reaction conditions, such as under the action of light or initiator, make it undergo free radical substitution reaction with chlorine gas. In this reaction, the light or initiator prompts the chlorine gas molecule to cleave into a chlorine radical, which attacks the methyl group of p (phenylthio) toluene to generate 1- (chloromethyl) -4- (phenylthio) benzene. It is necessary to pay attention to the reaction temperature, the amount and rate of chlorine gas. Excessive temperature or excess chlorine gas can easily lead to the formation of polychlorinated by-products.
Second, take 4- (phenylthio) benzoic acid as the starting material, first reduce it to 4- (phenylthio) benzyl alcohol, commonly used reducing agents such as lithium aluminum hydride or sodium borohydride. After 4- (phenylthio) benzyl alcohol is obtained, it is reacted with chlorination reagents such as thionyl chloride or phosphorus trichloride. Taking thionyl chloride as an example, the reaction of the two can convert hydroxyl groups into chlorine atoms, thereby obtaining 1- (chloromethyl) -4- (phenylthio) benzene. In this process, the reduction step needs to be operated in an anhydrous and low temperature environment to prevent the failure of the reducing agent; the chlorination step needs to pay attention to the pH and reaction time of the reaction system to ensure that the reaction is complete.
Third, the Grignard reagent method can also be used. First prepare sulfur-containing Grignard reagents, such as phenyl sulfide magnesium chloride, and react with p-chlorobenzyl chloride. This reaction is carried out in anhydrous ether or tetrahydrofuran solvents. The strong nucleophilicity of Grignard reagents is used to attack the benzyl chloride check point of p-chlorobenzyl chloride. After hydrolysis and other subsequent treatments, the target product 1 - (chloromethyl) - 4 - (phenylthio) benzene can be obtained. During operation, the preparation of Grignard reagents requires strict anhydrous conditions, and the reaction process requires strict temperature and reactant ratios. A slight deviation will affect the yield and product purity.
First, the method of substitution reaction can be used. Take p (phenylthio) toluene as the raw material, and under suitable reaction conditions, such as under the action of light or initiator, make it undergo free radical substitution reaction with chlorine gas. In this reaction, the light or initiator prompts the chlorine gas molecule to cleave into a chlorine radical, which attacks the methyl group of p (phenylthio) toluene to generate 1- (chloromethyl) -4- (phenylthio) benzene. It is necessary to pay attention to the reaction temperature, the amount and rate of chlorine gas. Excessive temperature or excess chlorine gas can easily lead to the formation of polychlorinated by-products.
Second, take 4- (phenylthio) benzoic acid as the starting material, first reduce it to 4- (phenylthio) benzyl alcohol, commonly used reducing agents such as lithium aluminum hydride or sodium borohydride. After 4- (phenylthio) benzyl alcohol is obtained, it is reacted with chlorination reagents such as thionyl chloride or phosphorus trichloride. Taking thionyl chloride as an example, the reaction of the two can convert hydroxyl groups into chlorine atoms, thereby obtaining 1- (chloromethyl) -4- (phenylthio) benzene. In this process, the reduction step needs to be operated in an anhydrous and low temperature environment to prevent the failure of the reducing agent; the chlorination step needs to pay attention to the pH and reaction time of the reaction system to ensure that the reaction is complete.
Third, the Grignard reagent method can also be used. First prepare sulfur-containing Grignard reagents, such as phenyl sulfide magnesium chloride, and react with p-chlorobenzyl chloride. This reaction is carried out in anhydrous ether or tetrahydrofuran solvents. The strong nucleophilicity of Grignard reagents is used to attack the benzyl chloride check point of p-chlorobenzyl chloride. After hydrolysis and other subsequent treatments, the target product 1 - (chloromethyl) - 4 - (phenylthio) benzene can be obtained. During operation, the preparation of Grignard reagents requires strict anhydrous conditions, and the reaction process requires strict temperature and reactant ratios. A slight deviation will affect the yield and product purity.
What are the precautions for 1- (chloromethyl) -4- (phenylthio) benzene in storage and transportation?
1 - (chloromethyl) - 4 - (phenylthio) benzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
The first thing to pay attention to is the storage environment. This compound should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its flammability, in case of open flame or hot topic, there is a risk of combustion. And the temperature is too high, or its chemical properties are changed, which affects the quality.
Furthermore, the choice of storage container is also crucial. A sealed container should be used to prevent it from evaporating and to avoid contact with air, moisture, etc. Deterioration is caused by the reaction of the compound or with components in water and air.
When transporting, caution is also required. It should be ensured that the packaging is complete and the loading is secure to prevent the container from being damaged or leaking during transportation. If leakage occurs, not only materials are wasted, but the compound may cause pollution to the environment and may also endanger the safety of transporters and surrounding people.
In addition, the means of transportation must comply with relevant regulations and have safety facilities such as fire prevention and explosion protection. Transport personnel should also be familiar with the characteristics of the compound and emergency treatment methods. In case of an accident, they can respond quickly and correctly to reduce harm. In conclusion, when storing and transporting 1 - (chloromethyl) - 4 - (phenylthio) benzene, all details should not be taken lightly to ensure safety and quality.
The first thing to pay attention to is the storage environment. This compound should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its flammability, in case of open flame or hot topic, there is a risk of combustion. And the temperature is too high, or its chemical properties are changed, which affects the quality.
Furthermore, the choice of storage container is also crucial. A sealed container should be used to prevent it from evaporating and to avoid contact with air, moisture, etc. Deterioration is caused by the reaction of the compound or with components in water and air.
When transporting, caution is also required. It should be ensured that the packaging is complete and the loading is secure to prevent the container from being damaged or leaking during transportation. If leakage occurs, not only materials are wasted, but the compound may cause pollution to the environment and may also endanger the safety of transporters and surrounding people.
In addition, the means of transportation must comply with relevant regulations and have safety facilities such as fire prevention and explosion protection. Transport personnel should also be familiar with the characteristics of the compound and emergency treatment methods. In case of an accident, they can respond quickly and correctly to reduce harm. In conclusion, when storing and transporting 1 - (chloromethyl) - 4 - (phenylthio) benzene, all details should not be taken lightly to ensure safety and quality.
What are the environmental effects of 1- (chloromethyl) -4- (phenylthio) benzene
1 - (chloromethyl) -4 - (phenylthio) benzene, its impact on the environment is quite complex and cannot be ignored.
In this compound, chloromethyl is active and easily reacts with various substances in the environment. In the atmosphere, in case of light or specific conditions, chloromethyl may be able to dechlorinate, generating chlorine-containing free radicals, which are very active and can cause a series of photochemical reactions in the atmosphere, or affect the oxidation capacity of the atmosphere, and chlorine may participate in the formation of bad weather such as acid rain, endangering the ecology.
In the water environment, 1- (chloromethyl) -4- (phenylthio) benzene may be replaced by hydroxyl groups due to hydrolysis, etc., and the products may have different toxicity and migration. Its hydrophobic phenylthio-group part makes the compound easy to adsorb on suspended particles or sediment, accumulate in the bottom of the water body, and has a particular impact on benthic organisms, or cause their physiological dysfunction and population changes.
In the soil environment, this compound may be difficult to degrade and remain for a long time. Its chloromethyl can react with organic and inorganic components in the soil, change soil chemical properties, affect the structure and function of soil microbial communities, and disturb soil fertility and material circulation. If plant roots come into contact with this compound or absorb it, it will accumulate in the plant, pass through the food chain, endanger high-trophic organisms, and ultimately pose a threat to the balance and stability of the entire ecosystem.
In this compound, chloromethyl is active and easily reacts with various substances in the environment. In the atmosphere, in case of light or specific conditions, chloromethyl may be able to dechlorinate, generating chlorine-containing free radicals, which are very active and can cause a series of photochemical reactions in the atmosphere, or affect the oxidation capacity of the atmosphere, and chlorine may participate in the formation of bad weather such as acid rain, endangering the ecology.
In the water environment, 1- (chloromethyl) -4- (phenylthio) benzene may be replaced by hydroxyl groups due to hydrolysis, etc., and the products may have different toxicity and migration. Its hydrophobic phenylthio-group part makes the compound easy to adsorb on suspended particles or sediment, accumulate in the bottom of the water body, and has a particular impact on benthic organisms, or cause their physiological dysfunction and population changes.
In the soil environment, this compound may be difficult to degrade and remain for a long time. Its chloromethyl can react with organic and inorganic components in the soil, change soil chemical properties, affect the structure and function of soil microbial communities, and disturb soil fertility and material circulation. If plant roots come into contact with this compound or absorb it, it will accumulate in the plant, pass through the food chain, endanger high-trophic organisms, and ultimately pose a threat to the balance and stability of the entire ecosystem.
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