Linshang Chemical
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1-(Chloromethyl)-4-(Trifluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
395610 |
| Chemical Formula | C8H6ClF3O |
| Molecular Weight | 210.58 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 180 - 185°C |
| Density | Approx. 1.35 - 1.45 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Vapor Pressure | Low vapor pressure at room temperature |
| Flash Point | Approx. 70 - 80°C |
| Refractive Index | Typically around 1.44 - 1.46 |
As an accredited 1-(Chloromethyl)-4-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle packaging for 1-(chloromethyl)-4-(trifluoromethoxy)benzene. |
| Storage | 1-(Chloromethyl)-4-(trifluoromethoxy)benzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly - sealed container to prevent leakage and exposure to air or moisture. Store it separately from oxidizing agents and reactive substances to avoid potential chemical reactions. |
| Shipping | 1-(Chloromethyl)-4-(trifluoromethoxy)benzene is shipped in accordance with strict chemical transport regulations. Packed in suitable containers, it's transported by carriers trained in handling such hazardous chemicals to ensure safe delivery. |
Competitive 1-(Chloromethyl)-4-(Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-(Chloromethyl)-4-(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1- (chloromethyl) -4- (trifluoromethoxy) benzene?
1 - (cyanomethyl) -4 - (trifluoromethoxy) benzene, this compound has important uses in many fields.
In the field of pharmaceutical synthesis, it is often used as a key intermediate. The special structure of cyanomethyl and trifluoromethoxy in molecules endows it with unique chemical activities and physical properties. Cyanomethyl can participate in various chemical reactions, such as nucleophilic substitution, addition, etc., laying the foundation for the construction of complex drug molecular structures; the strong electron absorption of trifluoromethoxy can regulate the electron cloud distribution of molecules, significantly affect the interaction between drugs and targets, and enhance the biological activity, lipophilicity and metabolic stability of drugs. For example, when developing some anti-tumor drugs, the introduction of this structural fragment can optimize the affinity and selectivity of the drug to specific tumor cell targets, and improve the therapeutic effect.
In the field of materials science, it also has value that cannot be ignored. Due to the existence of trifluoromethoxy, the surface properties of the material can be improved, such as enhancing the corrosion resistance, weather resistance and low surface energy characteristics of the material. When preparing high-performance coatings, plastics and other materials, the introduction of compounds containing this structure as additives or monomers can endow the material with excellent chemical stability and self-cleaning properties. For example, the use of polymers containing this structure to prepare outdoor architectural coatings can make the coating resist harsh environmental erosion for a long time and maintain good appearance and protection.
In the field of organic synthetic chemistry, 1- (cyanomethyl) -4- (trifluoromethoxy) benzene is an important synthetic building block. With its activity checking point, it can be derived through various organic reactions, such as halogenation reactions, coupling reactions, etc., Rich organic compounds are derived, providing a variety of options for organic synthetic chemists to explore the structure and properties of new compounds, and promoting the development of organic synthetic chemistry.
In the field of pharmaceutical synthesis, it is often used as a key intermediate. The special structure of cyanomethyl and trifluoromethoxy in molecules endows it with unique chemical activities and physical properties. Cyanomethyl can participate in various chemical reactions, such as nucleophilic substitution, addition, etc., laying the foundation for the construction of complex drug molecular structures; the strong electron absorption of trifluoromethoxy can regulate the electron cloud distribution of molecules, significantly affect the interaction between drugs and targets, and enhance the biological activity, lipophilicity and metabolic stability of drugs. For example, when developing some anti-tumor drugs, the introduction of this structural fragment can optimize the affinity and selectivity of the drug to specific tumor cell targets, and improve the therapeutic effect.
In the field of materials science, it also has value that cannot be ignored. Due to the existence of trifluoromethoxy, the surface properties of the material can be improved, such as enhancing the corrosion resistance, weather resistance and low surface energy characteristics of the material. When preparing high-performance coatings, plastics and other materials, the introduction of compounds containing this structure as additives or monomers can endow the material with excellent chemical stability and self-cleaning properties. For example, the use of polymers containing this structure to prepare outdoor architectural coatings can make the coating resist harsh environmental erosion for a long time and maintain good appearance and protection.
In the field of organic synthetic chemistry, 1- (cyanomethyl) -4- (trifluoromethoxy) benzene is an important synthetic building block. With its activity checking point, it can be derived through various organic reactions, such as halogenation reactions, coupling reactions, etc., Rich organic compounds are derived, providing a variety of options for organic synthetic chemists to explore the structure and properties of new compounds, and promoting the development of organic synthetic chemistry.
What are the physical properties of 1- (chloromethyl) -4- (trifluoromethoxy) benzene?
(Monomethylamino) -4- (trifluoromethoxy) benzene, its physical properties are as follows:
This substance is either a solid state at room temperature, or a viscous liquid, depending on its specific structure and molecular interactions. The values of its melting point and boiling point depend on the arrangement and interaction of the atoms in the molecule, as well as the size of the intermolecular forces.
When it comes to color, pure or colorless and transparent, but if it contains some impurities, or a light yellow color. Its smell may have a special aromatic aroma, or a slightly irritating taste, all due to the characteristics of functional groups contained in the molecular structure.
In terms of solubility, due to the hydrophilicity of (monomethylamino) and the hydrophobicity of (trifluoromethoxy) benzene, the solubility in water may be limited, but it is more soluble in organic solvents such as ethanol, ether, and chloroform. This characteristic is derived from the principle of "similarity and dissolution". The molecular structure of organic solvents is similar to that of the substance, and the force applied to each other is conducive to dissolution.
Furthermore, the density of the substance may be different from that of water, depending on the mass of its molecules and the degree of accumulation. Or greater than the density of water, it sinks underwater; or less than the density of water, it floats on water.
Its refractive index is also one of the important physical properties, which can reflect the strength of the material's refractive ability to light, and is related to the distribution of electron clouds and the degree of molecular arrangement order. In optical instruments or related analytical applications, this property may be important.
This substance is either a solid state at room temperature, or a viscous liquid, depending on its specific structure and molecular interactions. The values of its melting point and boiling point depend on the arrangement and interaction of the atoms in the molecule, as well as the size of the intermolecular forces.
When it comes to color, pure or colorless and transparent, but if it contains some impurities, or a light yellow color. Its smell may have a special aromatic aroma, or a slightly irritating taste, all due to the characteristics of functional groups contained in the molecular structure.
In terms of solubility, due to the hydrophilicity of (monomethylamino) and the hydrophobicity of (trifluoromethoxy) benzene, the solubility in water may be limited, but it is more soluble in organic solvents such as ethanol, ether, and chloroform. This characteristic is derived from the principle of "similarity and dissolution". The molecular structure of organic solvents is similar to that of the substance, and the force applied to each other is conducive to dissolution.
Furthermore, the density of the substance may be different from that of water, depending on the mass of its molecules and the degree of accumulation. Or greater than the density of water, it sinks underwater; or less than the density of water, it floats on water.
Its refractive index is also one of the important physical properties, which can reflect the strength of the material's refractive ability to light, and is related to the distribution of electron clouds and the degree of molecular arrangement order. In optical instruments or related analytical applications, this property may be important.
What are the chemical properties of 1- (chloromethyl) -4- (trifluoromethoxy) benzene?
(1) The properties of this substance
1- (methoxy) -4- (trifluoromethoxy) benzene are organic compounds. Its physical and chemical properties are quite unique, and it is often used as a key raw material or intermediate in the field of organic synthesis.
(2) Physical properties
Looking at its physical properties, at room temperature, it is mostly a colorless to yellowish liquid with a light and specific taste. Its boiling point, melting point and density vary depending on the characteristics of the groups in the molecule. The introduction of methoxy and trifluoromethoxy groups changes the intermolecular forces, and the boiling point is about a specific range. The density is also different from that of ordinary benzene compounds, and it has a certain volatility.
(3) Chemical Properties
1. ** Electrophilic Substitution **: Above the benzene ring, the electron cloud distribution is uneven due to the methoxy group as the power supply group and the trifluoromethoxy group as the electron-withdrawing group. The electron cloud density of the ortho and para-methoxy groups is high, so the electrophilic reagents are easy to attack the neighbor and para-position of the methoxy group, and substitution reactions occur, such as halogenation, nitrification, sulfonation, etc., which can introduce a variety of functional groups and expand the possibility of their derivation.
2. ** Stability **: The trifluoromethoxy group has strong electronegativity, which makes the carbon-oxygen bond connected to it relatively stable and not easy to break. However, under specific strong acid, strong base or high temperature conditions, the molecular structure may change, and its stability is also affected by the environment.
3. ** Reactivity **: Overall, the synergy of 1- (methoxy) -4- (trifluoromethoxy) benzene groups has moderate reactivity. It is neither extremely active and difficult to control the reaction, nor inert and difficult to participate in the reaction. In many organic reactions, different reaction paths and products can be exhibited according to the reaction conditions and the added reagents.
1- (methoxy) -4- (trifluoromethoxy) benzene are organic compounds. Its physical and chemical properties are quite unique, and it is often used as a key raw material or intermediate in the field of organic synthesis.
(2) Physical properties
Looking at its physical properties, at room temperature, it is mostly a colorless to yellowish liquid with a light and specific taste. Its boiling point, melting point and density vary depending on the characteristics of the groups in the molecule. The introduction of methoxy and trifluoromethoxy groups changes the intermolecular forces, and the boiling point is about a specific range. The density is also different from that of ordinary benzene compounds, and it has a certain volatility.
(3) Chemical Properties
1. ** Electrophilic Substitution **: Above the benzene ring, the electron cloud distribution is uneven due to the methoxy group as the power supply group and the trifluoromethoxy group as the electron-withdrawing group. The electron cloud density of the ortho and para-methoxy groups is high, so the electrophilic reagents are easy to attack the neighbor and para-position of the methoxy group, and substitution reactions occur, such as halogenation, nitrification, sulfonation, etc., which can introduce a variety of functional groups and expand the possibility of their derivation.
2. ** Stability **: The trifluoromethoxy group has strong electronegativity, which makes the carbon-oxygen bond connected to it relatively stable and not easy to break. However, under specific strong acid, strong base or high temperature conditions, the molecular structure may change, and its stability is also affected by the environment.
3. ** Reactivity **: Overall, the synergy of 1- (methoxy) -4- (trifluoromethoxy) benzene groups has moderate reactivity. It is neither extremely active and difficult to control the reaction, nor inert and difficult to participate in the reaction. In many organic reactions, different reaction paths and products can be exhibited according to the reaction conditions and the added reagents.
What are the synthesis methods of 1- (chloromethyl) -4- (trifluoromethoxy) benzene?
The synthesis method of 1- (cyanomethyl) -4- (trifluoromethoxy) benzene has been known for a long time. There are many methods, each with its own advantages. Let me tell you one by one.
First, it can be started from halogenated benzene. With halogenated benzene as the starting material, under specific reaction conditions, nucleophilic substitution reaction occurs with cyanomethyl-containing reagents. This step requires careful regulation of reaction temperature, pressure, type and dosage of catalyst. The obtained intermediate is then reacted with the reagent containing trifluoromethoxy group, and after several steps of conversion, the final product is obtained. The key to this path lies in the precise control of the nucleophilic substitution reaction. The halogen activity of halogenated benzene and the nucleophilicity of the reagent have a profound impact on the reaction process and yield.
Second, based on the benzene ring, the trifluoromethoxy group is introduced first. By suitable reactions, benzene can interact with reagents containing trifluoromethoxy to generate benzene derivatives containing trifluoromethoxy. Then, try to introduce cyanomethyl. In this process, the reaction conditions for the introduction of trifluoromethoxy are very important, and appropriate solvents, bases and reaction temperatures need to be selected to ensure the selectivity and yield of the reaction. The subsequent steps of introducing cyanomethyl groups also need to optimize the reaction parameters according to the specific situation.
Third, other benzene derivatives are also used as starters. Cyanomethyl and trifluoromethoxy are gradually introduced through the transformation and modification of their specific functional groups. This method requires in-depth understanding of the structure and properties of the starting derivatives, ingenious design of reaction routes, and the use of various organic reactions, such as oxidation, reduction, substitution, addition, etc., to achieve the orderly transformation of functional groups and achieve the synthesis goal.
All these synthesis methods require fine operation, insight into the reaction mechanism, and consideration of the influence of various factors to efficiently prepare 1- (cyanomethyl) -4- (trifluoromethoxy) benzene.
First, it can be started from halogenated benzene. With halogenated benzene as the starting material, under specific reaction conditions, nucleophilic substitution reaction occurs with cyanomethyl-containing reagents. This step requires careful regulation of reaction temperature, pressure, type and dosage of catalyst. The obtained intermediate is then reacted with the reagent containing trifluoromethoxy group, and after several steps of conversion, the final product is obtained. The key to this path lies in the precise control of the nucleophilic substitution reaction. The halogen activity of halogenated benzene and the nucleophilicity of the reagent have a profound impact on the reaction process and yield.
Second, based on the benzene ring, the trifluoromethoxy group is introduced first. By suitable reactions, benzene can interact with reagents containing trifluoromethoxy to generate benzene derivatives containing trifluoromethoxy. Then, try to introduce cyanomethyl. In this process, the reaction conditions for the introduction of trifluoromethoxy are very important, and appropriate solvents, bases and reaction temperatures need to be selected to ensure the selectivity and yield of the reaction. The subsequent steps of introducing cyanomethyl groups also need to optimize the reaction parameters according to the specific situation.
Third, other benzene derivatives are also used as starters. Cyanomethyl and trifluoromethoxy are gradually introduced through the transformation and modification of their specific functional groups. This method requires in-depth understanding of the structure and properties of the starting derivatives, ingenious design of reaction routes, and the use of various organic reactions, such as oxidation, reduction, substitution, addition, etc., to achieve the orderly transformation of functional groups and achieve the synthesis goal.
All these synthesis methods require fine operation, insight into the reaction mechanism, and consideration of the influence of various factors to efficiently prepare 1- (cyanomethyl) -4- (trifluoromethoxy) benzene.
What are the precautions for using 1- (chloromethyl) -4- (trifluoromethoxy) benzene?
When using 1 - (cyanomethyl) -4 - (trifluoromethoxy) benzene, pay attention to various matters. This substance has certain chemical activity, and the first safety protection should be taken when operating. Appropriate protective equipment, such as protective clothing, gloves, goggles, etc., should be worn to prevent it from coming into contact with the skin and eyes and causing damage. Because of its toxicity and irritation, if you accidentally touch it, rinse it with plenty of water as soon as possible and seek medical treatment.
In addition, this substance is also exquisite in storage. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent it from changing its chemical properties due to heat or even causing danger. And it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed to avoid chemical reactions.
During use, accurate dosage control is the key. Improper dosage, or cause the reaction to go out of control, will not only affect the results of the experiment or production, but also pose a safety hazard. Therefore, before operation, it is necessary to accurately measure according to the requirements of the experiment or production.
At the same time, the relevant reaction environment cannot be ignored. Temperature, pressure, pH and other conditions can affect the reaction of 1- (cyanomethyl) -4- (trifluoromethoxy) benzene. The reaction environment must be strictly regulated according to the established process requirements to ensure the smooth progress of the reaction.
In addition, the operation site should be equipped with corresponding emergency treatment equipment and materials, such as fire extinguishers, adsorbents, etc. In the event of an emergency such as leakage, emergency treatment can be carried out quickly to contain the spread of hazards.
In general, when using 1- (cyanomethyl) -4- (trifluoromethoxy) benzene, it is necessary to be careful, consider all factors carefully, and strictly abide by the operating procedures, so as to ensure safety and achieve the desired effect.
In addition, this substance is also exquisite in storage. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent it from changing its chemical properties due to heat or even causing danger. And it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed to avoid chemical reactions.
During use, accurate dosage control is the key. Improper dosage, or cause the reaction to go out of control, will not only affect the results of the experiment or production, but also pose a safety hazard. Therefore, before operation, it is necessary to accurately measure according to the requirements of the experiment or production.
At the same time, the relevant reaction environment cannot be ignored. Temperature, pressure, pH and other conditions can affect the reaction of 1- (cyanomethyl) -4- (trifluoromethoxy) benzene. The reaction environment must be strictly regulated according to the established process requirements to ensure the smooth progress of the reaction.
In addition, the operation site should be equipped with corresponding emergency treatment equipment and materials, such as fire extinguishers, adsorbents, etc. In the event of an emergency such as leakage, emergency treatment can be carried out quickly to contain the spread of hazards.
In general, when using 1- (cyanomethyl) -4- (trifluoromethoxy) benzene, it is necessary to be careful, consider all factors carefully, and strictly abide by the operating procedures, so as to ensure safety and achieve the desired effect.
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