Linshang Chemical
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1-(Chloromethyl)-4-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
848670 |
| Chemical Formula | C8H6ClF3 |
| Molar Mass | 194.58 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 184 - 186 °C |
| Melting Point | N/A |
| Density | 1.286 g/cm³ |
| Solubility In Water | Insoluble |
| Vapor Pressure | N/A |
| Flash Point | 67 °C |
| Refractive Index | 1.459 - 1.461 |
As an accredited 1-(Chloromethyl)-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 mL bottle of 1-(chloromethyl)-4-(trifluoromethyl)benzene, well - sealed. |
| Storage | 1-(Chloromethyl)-4-(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and contact with air or moisture, which could potentially lead to decomposition or reactivity issues. |
| Shipping | 1-(Chloromethyl)-4-(trifluoromethyl)benzene is shipped in accordance with chemical transport regulations. Packed securely in appropriate containers, it's transported by methods ensuring safety, avoiding spills and exposure during transit. |
Competitive 1-(Chloromethyl)-4-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-(Chloromethyl)-4-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 1- (chloromethyl) -4- (trifluoromethyl) benzene?
1 - (cyanomethyl) -4 - (trifluoromethyl) benzene, which is a crucial raw material in organic synthesis, has a wide range of applications in many fields.
In the field of medicinal chemistry, it can be used as a key intermediate to assist in the synthesis of a variety of drug molecules with specific biological activities. The unique electronic and spatial effects of cyano and trifluoromethyl groups can significantly affect the interaction between drugs and targets, enhancing the activity, selectivity and metabolic stability of drugs. For example, when developing anti-tumor drugs, such structural modifications can optimize the targeting of drugs to tumor cells and enhance their efficacy in inhibiting tumor growth.
In the field of materials science, 1- (cyanomethyl) -4- (trifluoromethyl) benzene also shows important value. It can participate in the synthesis of polymer materials, giving materials special properties. Such as improving the heat resistance, chemical stability and electrical properties of materials. Taking the preparation of high-performance engineering plastics as an example, the introduction of this structural unit can improve the mechanical properties and chemical corrosion resistance of plastics, making it applicable in high-end fields such as aerospace, electronics and electrical appliances.
In the field of pesticide chemistry, this compound can be used as an important starting material for the synthesis of new pesticides. With its unique chemical structure, the synthesized pesticides may have the advantages of high efficiency, low toxicity, and environmental friendliness, which helps to improve the yield and quality of crops while reducing the negative impact on the environment.
In short, 1- (cyanomethyl) -4- (trifluoromethyl) benzene, with its unique chemical structure, plays an indispensable role in many fields such as medicine, materials, and pesticides, and is of great significance to promote the development of related industries.
In the field of medicinal chemistry, it can be used as a key intermediate to assist in the synthesis of a variety of drug molecules with specific biological activities. The unique electronic and spatial effects of cyano and trifluoromethyl groups can significantly affect the interaction between drugs and targets, enhancing the activity, selectivity and metabolic stability of drugs. For example, when developing anti-tumor drugs, such structural modifications can optimize the targeting of drugs to tumor cells and enhance their efficacy in inhibiting tumor growth.
In the field of materials science, 1- (cyanomethyl) -4- (trifluoromethyl) benzene also shows important value. It can participate in the synthesis of polymer materials, giving materials special properties. Such as improving the heat resistance, chemical stability and electrical properties of materials. Taking the preparation of high-performance engineering plastics as an example, the introduction of this structural unit can improve the mechanical properties and chemical corrosion resistance of plastics, making it applicable in high-end fields such as aerospace, electronics and electrical appliances.
In the field of pesticide chemistry, this compound can be used as an important starting material for the synthesis of new pesticides. With its unique chemical structure, the synthesized pesticides may have the advantages of high efficiency, low toxicity, and environmental friendliness, which helps to improve the yield and quality of crops while reducing the negative impact on the environment.
In short, 1- (cyanomethyl) -4- (trifluoromethyl) benzene, with its unique chemical structure, plays an indispensable role in many fields such as medicine, materials, and pesticides, and is of great significance to promote the development of related industries.
What are the physical properties of 1- (chloromethyl) -4- (trifluoromethyl) benzene?
(Monomethyl) -4 - (trifluoromethyl) benzene, its physical properties are described as follows.
Under normal temperature and pressure, this substance is mostly colorless to light yellow liquid, clear and transparent, and has no impurities visible to the naked eye. Its smell is unique, emitting a special smell similar to aromatic hydrocarbons. Although it is not pungent, it also has a certain degree of recognition, and it can be felt when smelled.
When it comes to the boiling point, it is about within a certain temperature range. This temperature converts it from liquid to gaseous state. The specific value varies slightly due to the measurement conditions, and it hovers roughly within a certain range. The boiling point is related to its phase transformation under different temperature environments, which is of great significance in chemical separation, purification and other processes. The value of the melting point of
is also an important physical property. When the temperature drops to a certain value, the substance solidifies from liquid to solid. This melting point value is relatively stable, providing a key basis for identifying and studying the substance.
Its density is also an inherent property, and compared with common organic solvents, it has a specific density value. Density reflects the mass of a substance per unit volume, and is an indispensable parameter in many application scenarios, such as the preparation of mixed solutions and material balance.
In terms of solubility, (monomethyl) -4 - (trifluoromethyl) benzene is soluble in a variety of organic solvents, such as common ethanol, ether, dichloromethane, etc., in which a uniform and stable solution can be formed. However, its solubility in water is very small. This property is due to the difference between its molecular structure and the polarity of water molecules, which makes it difficult for the two to miscible with each other.
In addition, the vapor pressure of the substance is also a physical property that cannot be ignored. The vapor pressure reflects the partial pressure of the substance in the gas-liquid equilibrium state at a certain temperature. The magnitude of the vapor pressure is closely related to the temperature. When the temperature increases, the vapor pressure increases. This property affects its volatilization rate. During storage and use, it needs to be taken into account to ensure safe and effective application.
Under normal temperature and pressure, this substance is mostly colorless to light yellow liquid, clear and transparent, and has no impurities visible to the naked eye. Its smell is unique, emitting a special smell similar to aromatic hydrocarbons. Although it is not pungent, it also has a certain degree of recognition, and it can be felt when smelled.
When it comes to the boiling point, it is about within a certain temperature range. This temperature converts it from liquid to gaseous state. The specific value varies slightly due to the measurement conditions, and it hovers roughly within a certain range. The boiling point is related to its phase transformation under different temperature environments, which is of great significance in chemical separation, purification and other processes. The value of the melting point of
is also an important physical property. When the temperature drops to a certain value, the substance solidifies from liquid to solid. This melting point value is relatively stable, providing a key basis for identifying and studying the substance.
Its density is also an inherent property, and compared with common organic solvents, it has a specific density value. Density reflects the mass of a substance per unit volume, and is an indispensable parameter in many application scenarios, such as the preparation of mixed solutions and material balance.
In terms of solubility, (monomethyl) -4 - (trifluoromethyl) benzene is soluble in a variety of organic solvents, such as common ethanol, ether, dichloromethane, etc., in which a uniform and stable solution can be formed. However, its solubility in water is very small. This property is due to the difference between its molecular structure and the polarity of water molecules, which makes it difficult for the two to miscible with each other.
In addition, the vapor pressure of the substance is also a physical property that cannot be ignored. The vapor pressure reflects the partial pressure of the substance in the gas-liquid equilibrium state at a certain temperature. The magnitude of the vapor pressure is closely related to the temperature. When the temperature increases, the vapor pressure increases. This property affects its volatilization rate. During storage and use, it needs to be taken into account to ensure safe and effective application.
What are the chemical properties of 1- (chloromethyl) -4- (trifluoromethyl) benzene?
The chemical properties of 1 - (methoxy) -4 - (trifluoromethoxy) benzene are quite unique. In this compound, both methoxy and trifluoromethoxy exert a significant influence on its chemical behavior.
Methoxy group has the effect of electron donator. Because its oxygen atom is rich in electrons, it can transfer the electron cloud density to the benzene ring through the conjugation effect, so that the electron cloud density of the benzene ring increases. In this way, the reactivity of the benzene ring to the electrophilic reagent is enhanced. In the electrophilic substitution reaction, the methoxy group is the ortho and para-site group, which prompts the electrophilic reagent to preferentially attack the ortho and para-site of the benzene ring.
And trifluoromethoxy, due to the extremely high electronegativity of fluorine atoms, presents a strong electron-absorbing effect. It pulls away the electron cloud from the benzene ring, reducing the electron cloud density of the benzene ring, resulting in a decrease in the reactivity of the benzene ring to electrophilic reagents. However, under specific reaction conditions, the electronic effect induced by trifluoromethoxy will also play a role in the selectivity of the reaction check point.
These two groups coexist in the benzene ring and affect each other and restrict each other. The electron-withdrawing of methoxy and trifluoromethoxy makes the distribution of electron clouds in the benzene ring more complex. This makes 1- (methoxy) -4- (trifluoromethoxy) benzene exhibit different properties from single-substituted benzene in many chemical reactions.
In the oxidation reaction, the electron cloud density of the benzene ring is increased due to the methoxy power supplier, which makes it relatively easy to be oxidized. However, the electron-withdrawing effect of the trifluoromethoxy group can slow down the oxidation process to a certain extent. In the nucleophilic substitution reaction, the change of the electron cloud density of the benzene ring affects the difficulty of attacking the nucleophilic reagent and the choice of the check point.
In addition, the physical properties of the compound are also influenced by this digroup, such as melting point, boiling point, solubility, etc., all of which exhibit specific values and laws due to the electronic effects and steric resistance of the groups.
Methoxy group has the effect of electron donator. Because its oxygen atom is rich in electrons, it can transfer the electron cloud density to the benzene ring through the conjugation effect, so that the electron cloud density of the benzene ring increases. In this way, the reactivity of the benzene ring to the electrophilic reagent is enhanced. In the electrophilic substitution reaction, the methoxy group is the ortho and para-site group, which prompts the electrophilic reagent to preferentially attack the ortho and para-site of the benzene ring.
And trifluoromethoxy, due to the extremely high electronegativity of fluorine atoms, presents a strong electron-absorbing effect. It pulls away the electron cloud from the benzene ring, reducing the electron cloud density of the benzene ring, resulting in a decrease in the reactivity of the benzene ring to electrophilic reagents. However, under specific reaction conditions, the electronic effect induced by trifluoromethoxy will also play a role in the selectivity of the reaction check point.
These two groups coexist in the benzene ring and affect each other and restrict each other. The electron-withdrawing of methoxy and trifluoromethoxy makes the distribution of electron clouds in the benzene ring more complex. This makes 1- (methoxy) -4- (trifluoromethoxy) benzene exhibit different properties from single-substituted benzene in many chemical reactions.
In the oxidation reaction, the electron cloud density of the benzene ring is increased due to the methoxy power supplier, which makes it relatively easy to be oxidized. However, the electron-withdrawing effect of the trifluoromethoxy group can slow down the oxidation process to a certain extent. In the nucleophilic substitution reaction, the change of the electron cloud density of the benzene ring affects the difficulty of attacking the nucleophilic reagent and the choice of the check point.
In addition, the physical properties of the compound are also influenced by this digroup, such as melting point, boiling point, solubility, etc., all of which exhibit specific values and laws due to the electronic effects and steric resistance of the groups.
What are the preparation methods of 1- (chloromethyl) -4- (trifluoromethyl) benzene?
The preparation method of 1 - (deuterium methyl) -4 - (trideuterium methyl) benzene has been known in ancient times. The method is mostly based on the ancient books, and after many studies and practices, it can be described in detail today.
One method is based on benzene, supplemented by halogenated deuteromethane. The benzene is first placed in a special kettle. The kettle is preferably cast in copper, and the wall thickness should be moderate so that it can withstand the warm pressure of the reaction. An appropriate amount of catalyst is added to the kettle. This catalyst can be made of metal halide or the like, such as aluminum chloride. The dosage should be accurately measured and proportionally prepared according to the amount of benzene. Then slowly inject halogenated deuterium methane. When injecting, pay attention to the flow rate, and do not make it too fast or too hasty, which will cause the reaction to be disordered. During the reaction, the temperature should be controlled in a specific range, and the temperature in the kettle should be kept at a moderate temperature, about tens of degrees. It should not be too high or too low. If it is too high, it is easy to cause side reactions, and if it is too low, the reaction will be slow and difficult. Under this condition, after several hours of reaction, the crude product of 1 - (deuterium methyl) -4 - (trideuterium methyl) benzene can be obtained. The crude product still contains impurities, and it needs to be purified by distillation. The crude product should be placed in a distiller and separated according to its boiling point.
The second method also uses benzene as the starting material, and first reacts benzene with a specific deuterium substitution reagent. The preparation of this deuterium substitution reagent requires a lot of effort, and it needs to be synthesized by multi-step reaction between deuterium source and specific organic reagent according to the ancient method. The benzene and the obtained deuterium substitution reagent are co-placed in a reaction vessel. The vessel needs to be airtight and able to withstand a certain pressure, preferably glass or ceramic material. During the reaction, specific lighting conditions can be applied to accelerate and orient the reaction. The intensity and duration of light need to be finely adjusted, and strong light and long light or weak light and short light are not suitable. In addition to light, it is also necessary to pay attention to the temperature and pH of the system, and a buffer can be added in time to stabilize the acid and alkali of the system After this reaction process, the product is gradually formed, and then it is extracted and recrystallized to remove impurities to obtain pure 1- (deuterium methyl) -4- (trideuterium methyl) benzene.
The third method is to use a benzene derivative containing a specific group as the raw material. The derivative is first substituted by deuterium to introduce deuterium atoms at a specific position. This substitution reaction requires the selection of suitable deuterium substitution reagents and reaction conditions. The activity of the reagents, the solvent of the reaction, the temperature, and the time need to be carefully considered. After the substitution is completed, the remaining groups are gradually converted into the required deuterium methyl and trideuterium methyl through a series of functional group conversion reactions. There are many steps in this process, and each step requires precise operation. If there is a slight error, all previous efforts will be wasted. Finally, through fine separation and purification methods, high-purity target products can be obtained.
One method is based on benzene, supplemented by halogenated deuteromethane. The benzene is first placed in a special kettle. The kettle is preferably cast in copper, and the wall thickness should be moderate so that it can withstand the warm pressure of the reaction. An appropriate amount of catalyst is added to the kettle. This catalyst can be made of metal halide or the like, such as aluminum chloride. The dosage should be accurately measured and proportionally prepared according to the amount of benzene. Then slowly inject halogenated deuterium methane. When injecting, pay attention to the flow rate, and do not make it too fast or too hasty, which will cause the reaction to be disordered. During the reaction, the temperature should be controlled in a specific range, and the temperature in the kettle should be kept at a moderate temperature, about tens of degrees. It should not be too high or too low. If it is too high, it is easy to cause side reactions, and if it is too low, the reaction will be slow and difficult. Under this condition, after several hours of reaction, the crude product of 1 - (deuterium methyl) -4 - (trideuterium methyl) benzene can be obtained. The crude product still contains impurities, and it needs to be purified by distillation. The crude product should be placed in a distiller and separated according to its boiling point.
The second method also uses benzene as the starting material, and first reacts benzene with a specific deuterium substitution reagent. The preparation of this deuterium substitution reagent requires a lot of effort, and it needs to be synthesized by multi-step reaction between deuterium source and specific organic reagent according to the ancient method. The benzene and the obtained deuterium substitution reagent are co-placed in a reaction vessel. The vessel needs to be airtight and able to withstand a certain pressure, preferably glass or ceramic material. During the reaction, specific lighting conditions can be applied to accelerate and orient the reaction. The intensity and duration of light need to be finely adjusted, and strong light and long light or weak light and short light are not suitable. In addition to light, it is also necessary to pay attention to the temperature and pH of the system, and a buffer can be added in time to stabilize the acid and alkali of the system After this reaction process, the product is gradually formed, and then it is extracted and recrystallized to remove impurities to obtain pure 1- (deuterium methyl) -4- (trideuterium methyl) benzene.
The third method is to use a benzene derivative containing a specific group as the raw material. The derivative is first substituted by deuterium to introduce deuterium atoms at a specific position. This substitution reaction requires the selection of suitable deuterium substitution reagents and reaction conditions. The activity of the reagents, the solvent of the reaction, the temperature, and the time need to be carefully considered. After the substitution is completed, the remaining groups are gradually converted into the required deuterium methyl and trideuterium methyl through a series of functional group conversion reactions. There are many steps in this process, and each step requires precise operation. If there is a slight error, all previous efforts will be wasted. Finally, through fine separation and purification methods, high-purity target products can be obtained.
What are the precautions for using 1- (chloromethyl) -4- (trifluoromethyl) benzene?
(1- (methoxy) -4- (triethoxy) silicon has the following precautions during use:
First, pay attention to its chemical properties. This silicon compound contains specific functional groups, and the methoxy group and the triethoxy group may react under specific conditions. When exposed to water, the ethoxy group is easy to hydrolyze, and the corresponding alcohol and silanol groups are formed, or further condensed to form siloxy bonds, which affects its original performance and expected reaction. If used in a humid environment, moisture-proof measures should be taken in advance to ensure that the reaction system and storage container are dry before use.
Second, pay attention to its storage conditions. It should be stored in a cool, dry and well-ventilated place, away from fire sources and oxidants. Due to its chemical structure, it may react violently with oxidants, causing danger. If the storage temperature is too high, it may cause self-polymerization or other side reactions, resulting in product deterioration.
Third, pay attention to safety protection when using. Wear appropriate protective equipment during operation, such as gloves, goggles and protective clothing. Because it may be irritating to the skin and eyes, if you accidentally touch the skin, you should immediately rinse with a lot of water and seek medical attention if necessary. If it splashes into the eyes, you need to rinse with a lot of water quickly and seek medical attention as soon as possible.
Fourth, the reaction conditions are strictly controlled. When participating in a chemical reaction, conditions such as temperature, reaction time, and proportion of reactants are critical. The temperature is not suitable, the reaction rate or direction is affected, and the desired product purity and yield cannot be achieved. The best reaction conditions need to be determined by experimental exploration according to the specific reaction.
Fifth, pay attention to compatibility with other substances. When mixing with different solvents and additives, know the compatibility in advance. Some solvents may interact with the silicon compound to change its solubility or chemical stability; some additives or impurities may also interfere with its reaction process or final performance.)
First, pay attention to its chemical properties. This silicon compound contains specific functional groups, and the methoxy group and the triethoxy group may react under specific conditions. When exposed to water, the ethoxy group is easy to hydrolyze, and the corresponding alcohol and silanol groups are formed, or further condensed to form siloxy bonds, which affects its original performance and expected reaction. If used in a humid environment, moisture-proof measures should be taken in advance to ensure that the reaction system and storage container are dry before use.
Second, pay attention to its storage conditions. It should be stored in a cool, dry and well-ventilated place, away from fire sources and oxidants. Due to its chemical structure, it may react violently with oxidants, causing danger. If the storage temperature is too high, it may cause self-polymerization or other side reactions, resulting in product deterioration.
Third, pay attention to safety protection when using. Wear appropriate protective equipment during operation, such as gloves, goggles and protective clothing. Because it may be irritating to the skin and eyes, if you accidentally touch the skin, you should immediately rinse with a lot of water and seek medical attention if necessary. If it splashes into the eyes, you need to rinse with a lot of water quickly and seek medical attention as soon as possible.
Fourth, the reaction conditions are strictly controlled. When participating in a chemical reaction, conditions such as temperature, reaction time, and proportion of reactants are critical. The temperature is not suitable, the reaction rate or direction is affected, and the desired product purity and yield cannot be achieved. The best reaction conditions need to be determined by experimental exploration according to the specific reaction.
Fifth, pay attention to compatibility with other substances. When mixing with different solvents and additives, know the compatibility in advance. Some solvents may interact with the silicon compound to change its solubility or chemical stability; some additives or impurities may also interfere with its reaction process or final performance.)
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