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1-(Chloromethyl)-4-[(Trifluoromethyl)Sulfanyl]Benzene
Linshang Chemical
|
HS Code |
568295 |
| Chemical Formula | C8H6ClF3S |
| Molecular Weight | 230.646 g/mol |
| Solubility In Water | Insoluble (organic compound, non - polar groups) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Stability | Stable under normal conditions, but reactive with strong oxidizing agents |
As an accredited 1-(Chloromethyl)-4-[(Trifluoromethyl)Sulfanyl]Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1-(chloromethyl)-4-[(trifluoromethyl)sulfanyl]benzene in sealed chemical - grade packaging. |
| Storage | 1-(Chloromethyl)-4-[(trifluoromethyl)sulfanyl]benzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. It should be kept in a tightly - sealed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances like oxidizing agents, bases, and reactive metals to prevent potential reactions. |
| Shipping | 1-(Chloromethyl)-4-[(trifluoromethyl)sulfanyl]benzene is shipped in specialized, well - sealed containers. Due to its chemical nature, it follows strict regulations for safe transportation, ensuring proper handling to prevent any risks. |
Competitive 1-(Chloromethyl)-4-[(Trifluoromethyl)Sulfanyl]Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the main use of 1- (chloromethyl) -4- [ (trifluoromethyl) thioalkyl] benzene?
(1- (Cyanomethyl) -4- [ (trifluoromethyl) sulfonyl] benzene, the main use of this substance is in the field of pharmaceutical and pesticide creation.
It plays a crucial role in the creation of medicine. Due to its special chemical structure, it endows it with excellent biological activity and pharmacological properties. For example, it can be used as a key intermediate to synthesize drugs with specific curative effects. With its structural properties, it can precisely act on specific biological targets in the human body and play a significant role in the treatment of diseases. Or it can regulate human physiology and fight various diseases, such as inflammation and tumors. It is like a cornerstone in the construction of drug molecules, laying the foundation for the development of new and efficient drugs.
In the field of pesticide creation, it also has extraordinary value. It can be manufactured into pesticide products with high insecticidal, bactericidal or herbicidal properties. Its structure can give pesticides a unique mechanism of action, which can specifically act on the specific physiological processes of pests, pathogens or weeds. Or interfere with its metabolism, or destroy its cell structure, so as to achieve good control effect. And compared with traditional pesticides, such pesticides based on this compound are more environmentally friendly and efficient, with less impact on the ecological environment, and can effectively ensure the yield and quality of crops, contributing to the sustainable development of agriculture.)
It plays a crucial role in the creation of medicine. Due to its special chemical structure, it endows it with excellent biological activity and pharmacological properties. For example, it can be used as a key intermediate to synthesize drugs with specific curative effects. With its structural properties, it can precisely act on specific biological targets in the human body and play a significant role in the treatment of diseases. Or it can regulate human physiology and fight various diseases, such as inflammation and tumors. It is like a cornerstone in the construction of drug molecules, laying the foundation for the development of new and efficient drugs.
In the field of pesticide creation, it also has extraordinary value. It can be manufactured into pesticide products with high insecticidal, bactericidal or herbicidal properties. Its structure can give pesticides a unique mechanism of action, which can specifically act on the specific physiological processes of pests, pathogens or weeds. Or interfere with its metabolism, or destroy its cell structure, so as to achieve good control effect. And compared with traditional pesticides, such pesticides based on this compound are more environmentally friendly and efficient, with less impact on the ecological environment, and can effectively ensure the yield and quality of crops, contributing to the sustainable development of agriculture.)
What are the physical properties of 1- (chloromethyl) -4- [ (trifluoromethyl) thioalkyl] benzene
(1) The properties of this substance are related to its structure. To clarify its properties, first check its structure. 1 - (cyanomethyl) -4- [ (trifluoromethyl) pyridyl] benzene is composed of carbon, hydrogen, nitrogen, and fluorine elements connected in a specific formula to form its framework.
(2) Its physical properties, first of all, the melting boiling point. Due to the force between molecules, it has a certain melting point. The groups in the molecule interact with each other, so that the melting boiling point is different from other substances. Among them, the role of cyanomethyl, trifluoromethyl, benzene ring, and pyridyl group cannot be ignored. Cyanomethyl has a certain polarity and can increase the intermolecular force; the electronegativity of the fluorine of the trifluoromethyl gene is strong, which makes the molecular charge distribution uneven and also affects the intermolecular action, which makes its melting and boiling point have a specific value.
(3) Solubility is also an important physical property. In organic solvents, because it contains non-polar parts such as benzene rings, it can be soluble in some non-polar or weakly polar organic solvents, such as toluene, chloroform, etc. However, the polarity of the cyanyl group also makes it soluble in polar solvents. This is due to the principle of similarity and compatibility. The polar part of the molecule interacts with the polar solvent, and the non-polar part interacts with the non-polar solvent.
(4) In terms of appearance, it is usually solid or liquid, depending on its specific conditions. If the molecules are arranged in an orderly manner and the force is strong, they are mostly solid; if the interaction between molecules is weak and the movement is free, it may be liquid. And its color is often affected by impurities and the conjugate system of molecular structure. When it is pure, it may be colorless and transparent. If there are impurities or the conjugate system causes changes in light absorption, the color may be different.
(5) In terms of density, it is determined by its molecular mass and the way of molecular accumulation. The mass of each atom adds the mass of the molecule, and the density of molecules in crystals or liquids is different. Molecular structures are regular and tightly packed, and the density is larger; otherwise, it is smaller.
(2) Its physical properties, first of all, the melting boiling point. Due to the force between molecules, it has a certain melting point. The groups in the molecule interact with each other, so that the melting boiling point is different from other substances. Among them, the role of cyanomethyl, trifluoromethyl, benzene ring, and pyridyl group cannot be ignored. Cyanomethyl has a certain polarity and can increase the intermolecular force; the electronegativity of the fluorine of the trifluoromethyl gene is strong, which makes the molecular charge distribution uneven and also affects the intermolecular action, which makes its melting and boiling point have a specific value.
(3) Solubility is also an important physical property. In organic solvents, because it contains non-polar parts such as benzene rings, it can be soluble in some non-polar or weakly polar organic solvents, such as toluene, chloroform, etc. However, the polarity of the cyanyl group also makes it soluble in polar solvents. This is due to the principle of similarity and compatibility. The polar part of the molecule interacts with the polar solvent, and the non-polar part interacts with the non-polar solvent.
(4) In terms of appearance, it is usually solid or liquid, depending on its specific conditions. If the molecules are arranged in an orderly manner and the force is strong, they are mostly solid; if the interaction between molecules is weak and the movement is free, it may be liquid. And its color is often affected by impurities and the conjugate system of molecular structure. When it is pure, it may be colorless and transparent. If there are impurities or the conjugate system causes changes in light absorption, the color may be different.
(5) In terms of density, it is determined by its molecular mass and the way of molecular accumulation. The mass of each atom adds the mass of the molecule, and the density of molecules in crystals or liquids is different. Molecular structures are regular and tightly packed, and the density is larger; otherwise, it is smaller.
What are the chemical properties of 1- (chloromethyl) -4- [ (trifluoromethyl) thioalkyl] benzene?
The chemical properties of (alkylphenyl) -4- [ (trifluorophenyl) sulfonyl] naphthalene are quite unique.
In this compound, the alkylphenyl part is connected to the phenyl group, giving it a certain lipid solubility and aromaticity. The presence of alkyl groups makes the molecule flexible, which can affect its solubility and intermolecular forces in different solvents. The conjugate system of phenyl groups not only enhances the stability of the compound, but also endows it with special optical and electronic properties, which may have potential applications in the fields of photochemistry and electron conduction.
Furthermore, the introduction of 4- [ (trifluorophenyl) sulfonyl] naphthalene part, trifluoroalkyl, due to its strong electronegativity and unique electronic effects, greatly changes the polarity and lipophilicity of molecules. Trifluoroalkyl can enhance the interaction between molecules and biological targets, and is often used in pharmaceutical chemistry to improve the activity and metabolic stability of drug molecules. The presence of sulfonyl groups increases the water solubility of molecules, and its sulfur atoms can act as potential hydrogen bond receptors or donors, affecting the crystal structure and biological activity of molecules. Naphthalene rings provide a larger conjugation plane, further enhancing the stability and electron delocalization ability of molecules, and also contribute significantly to the optical and electrical properties of molecules.
In summary, this compound combines the properties of a variety of special groups, and its chemical properties are rich, which may have broad application prospects in many fields such as materials science and drug development.
In this compound, the alkylphenyl part is connected to the phenyl group, giving it a certain lipid solubility and aromaticity. The presence of alkyl groups makes the molecule flexible, which can affect its solubility and intermolecular forces in different solvents. The conjugate system of phenyl groups not only enhances the stability of the compound, but also endows it with special optical and electronic properties, which may have potential applications in the fields of photochemistry and electron conduction.
Furthermore, the introduction of 4- [ (trifluorophenyl) sulfonyl] naphthalene part, trifluoroalkyl, due to its strong electronegativity and unique electronic effects, greatly changes the polarity and lipophilicity of molecules. Trifluoroalkyl can enhance the interaction between molecules and biological targets, and is often used in pharmaceutical chemistry to improve the activity and metabolic stability of drug molecules. The presence of sulfonyl groups increases the water solubility of molecules, and its sulfur atoms can act as potential hydrogen bond receptors or donors, affecting the crystal structure and biological activity of molecules. Naphthalene rings provide a larger conjugation plane, further enhancing the stability and electron delocalization ability of molecules, and also contribute significantly to the optical and electrical properties of molecules.
In summary, this compound combines the properties of a variety of special groups, and its chemical properties are rich, which may have broad application prospects in many fields such as materials science and drug development.
What are the synthesis methods of 1- (chloromethyl) -4- [ (trifluoromethyl) thioalkyl] benzene?
To prepare 1- (cyanomethyl) -4- [ (trifluoromethyl) pyridyl] benzene, the following methods can be followed:
First, the nucleophilic substitution reaction of halogenated benzene with reagents containing cyanomethyl and trifluoromethyl pyridyl is carried out. First take halogenated benzene, add a base such as potassium carbonate to a suitable solvent such as N, N-dimethylformamide, add a base such as potassium carbonate, heat up to a certain extent, and then slowly add a halogenated reagent containing cyanomethyl and trifluoromethyl pyridyl, and continue to stir the reaction for several times. This process requires attention to the control of reaction temperature and time. If the temperature is too high or side reactions are caused, the reaction will be slow if it is too low. After the reaction is completed, the product is purified by extraction, column chromatography, etc.
Second, a metal-catalyzed coupling reaction is used. Phenylboronic acid derivatives and halides containing cyanomethyl and trifluoromethyl pyridyl groups are used as raw materials, and the reaction is carried out in an alkaline environment in the presence of metal catalysts and ligands such as palladium. Commonly used bases such as sodium carbonate, and the solvent can be selected from a mixture of toluene and water. React in a nitrogen-protected atmosphere, when heated and stirred for several times. The selection of metal catalysts and ligands is the key, and their activity and selectivity affect the yield and purity of the reaction. After the reaction, the pure product is obtained by extraction, distillation, etc.
Third, through the step-by-step construction method. Cyanomethyl groups are first introduced into the benzene ring in a suitable reaction, and benzene and haloacetonitrile can be used to undergo Fu-gram alkylation under the catalysis of Lewis acid. Then, in another reaction step, trifluoromethyl pyridyl groups are connected to the benzene ring under specific reaction conditions. This process requires fine design of the reaction sequence and conditions, and the purification after each step is also indispensable to remove impurities and prevent them from affecting the subsequent reaction.
All these various production methods have their own advantages and disadvantages. The choice needs to be weighed according to factors such as raw material availability, cost, and reaction conditions, and the reaction conditions are carefully controlled to achieve the ideal yield and purity.
First, the nucleophilic substitution reaction of halogenated benzene with reagents containing cyanomethyl and trifluoromethyl pyridyl is carried out. First take halogenated benzene, add a base such as potassium carbonate to a suitable solvent such as N, N-dimethylformamide, add a base such as potassium carbonate, heat up to a certain extent, and then slowly add a halogenated reagent containing cyanomethyl and trifluoromethyl pyridyl, and continue to stir the reaction for several times. This process requires attention to the control of reaction temperature and time. If the temperature is too high or side reactions are caused, the reaction will be slow if it is too low. After the reaction is completed, the product is purified by extraction, column chromatography, etc.
Second, a metal-catalyzed coupling reaction is used. Phenylboronic acid derivatives and halides containing cyanomethyl and trifluoromethyl pyridyl groups are used as raw materials, and the reaction is carried out in an alkaline environment in the presence of metal catalysts and ligands such as palladium. Commonly used bases such as sodium carbonate, and the solvent can be selected from a mixture of toluene and water. React in a nitrogen-protected atmosphere, when heated and stirred for several times. The selection of metal catalysts and ligands is the key, and their activity and selectivity affect the yield and purity of the reaction. After the reaction, the pure product is obtained by extraction, distillation, etc.
Third, through the step-by-step construction method. Cyanomethyl groups are first introduced into the benzene ring in a suitable reaction, and benzene and haloacetonitrile can be used to undergo Fu-gram alkylation under the catalysis of Lewis acid. Then, in another reaction step, trifluoromethyl pyridyl groups are connected to the benzene ring under specific reaction conditions. This process requires fine design of the reaction sequence and conditions, and the purification after each step is also indispensable to remove impurities and prevent them from affecting the subsequent reaction.
All these various production methods have their own advantages and disadvantages. The choice needs to be weighed according to factors such as raw material availability, cost, and reaction conditions, and the reaction conditions are carefully controlled to achieve the ideal yield and purity.
What are the precautions for using 1- (chloromethyl) -4- [ (trifluoromethyl) thioalkyl] benzene?
During the use of 1-% (cyanomethyl) -4- [ (trifluoromethyl) sulfonyl] benzene, the following things should be paid attention to:
First, it is related to toxicity and safety. This substance contains cyanyl groups, and many cyanyl compounds are toxic. During operation, protective measures must be strictly implemented. Be sure to wear protective clothing, protective gloves and goggles to prevent skin contact and eye splashing. At the same time, it is necessary to ensure that the operation is carried out in a well-ventilated place. It is best to operate in a fume hood to avoid inhalation of volatile gases. If you are inadvertently exposed, rinse with plenty of water immediately and seek medical attention quickly.
Second, pay attention to chemical stability and reactivity. The trifluoromethyl sulfonyl group and cyanomethyl group in this substance may participate in a variety of chemical reactions. When using, avoid contact with strong oxidizing agents, strong acids, strong bases and other substances, because it may cause violent reactions and even lead to dangerous conditions. Before conducting a new chemical reaction, be sure to understand the reaction characteristics and latent risks of the substance in detail, and determine the appropriate reaction conditions and operating procedures by consulting relevant literature or conducting pre-experiments.
Third, pay attention to storage conditions. Store it in a cool, dry and well-ventilated place, away from fire and heat sources. Because it may be sensitive to factors such as air, humidity or light, it needs to be sealed and stored to prevent it from absorbing moisture or photochemical reactions and deteriorating, which will affect the use effect and lead to deviations in experiments or production.
Fourth, the use and measurement should be accurate. In view of the fact that the substance may be expensive and the reaction requires accurate dosage, during the use process, appropriate measuring tools and tools should be used to ensure that the dosage is accurate, not only to avoid incomplete reactions due to insufficient dosage, but also to prevent waste and subsequent processing problems caused by excessive dosage.
First, it is related to toxicity and safety. This substance contains cyanyl groups, and many cyanyl compounds are toxic. During operation, protective measures must be strictly implemented. Be sure to wear protective clothing, protective gloves and goggles to prevent skin contact and eye splashing. At the same time, it is necessary to ensure that the operation is carried out in a well-ventilated place. It is best to operate in a fume hood to avoid inhalation of volatile gases. If you are inadvertently exposed, rinse with plenty of water immediately and seek medical attention quickly.
Second, pay attention to chemical stability and reactivity. The trifluoromethyl sulfonyl group and cyanomethyl group in this substance may participate in a variety of chemical reactions. When using, avoid contact with strong oxidizing agents, strong acids, strong bases and other substances, because it may cause violent reactions and even lead to dangerous conditions. Before conducting a new chemical reaction, be sure to understand the reaction characteristics and latent risks of the substance in detail, and determine the appropriate reaction conditions and operating procedures by consulting relevant literature or conducting pre-experiments.
Third, pay attention to storage conditions. Store it in a cool, dry and well-ventilated place, away from fire and heat sources. Because it may be sensitive to factors such as air, humidity or light, it needs to be sealed and stored to prevent it from absorbing moisture or photochemical reactions and deteriorating, which will affect the use effect and lead to deviations in experiments or production.
Fourth, the use and measurement should be accurate. In view of the fact that the substance may be expensive and the reaction requires accurate dosage, during the use process, appropriate measuring tools and tools should be used to ensure that the dosage is accurate, not only to avoid incomplete reactions due to insufficient dosage, but also to prevent waste and subsequent processing problems caused by excessive dosage.
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