Linshang Chemical
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1-(Dichloromethyl)-2-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
212039 |
| Chemical Formula | C8H5Cl2F3 |
| Molar Mass | 227.026 g/mol |
| Appearance | Liquid (likely) |
| Boiling Point | Data may vary, needs experimental determination |
| Melting Point | Data may vary, needs experimental determination |
| Density | Data may vary, needs experimental determination |
| Solubility In Water | Low solubility (organic nature) |
| Vapor Pressure | Data may vary, needs experimental determination |
| Flash Point | Data may vary, needs experimental determination |
| Logp Octanol Water Partition Coefficient | Data may vary, needs experimental determination |
As an accredited 1-(Dichloromethyl)-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1-(dichloromethyl)-2-(trifluoromethyl)benzene in a sealed, chemical - resistant bottle. |
| Storage | 1-(Dichloromethyl)-2-(trifluoromethyl)benzene should be stored in a cool, well - ventilated area, away from heat and ignition sources. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials due to its chemical nature. Store separately from oxidizing agents, reducing agents, and other incompatible substances to prevent potential reactions. |
| Shipping | 1-(Dichloromethyl)-2-(trifluoromethyl)benzene is shipped in accordance with chemical transportation regulations. It's typically in sealed, specialized containers to prevent leakage and ensure safe transit, following all relevant safety protocols. |
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What are the main uses of 1- (dichloromethyl) -2- (trifluoromethyl) benzene?
(1) The main uses of dimethyl and (2) trimethylsilicon are related to many fields of chemical industry.
Dimethylsilicon plays a pivotal role in the preparation of silicone materials. It is often used as a key raw material for synthetic silicone oil, silicone rubber, etc. Taking silicone oil as an example, in the field of industrial lubrication, silicone oil has excellent lubricating properties due to the unique chemical structure endowed by dimethyl silicon, which can effectively reduce the friction loss between mechanical components and improve the efficiency and service life of machinery. In the electronics industry, silicone oil can be used as a potting material for electronic components. With the good insulation and thermal stability brought by dimethyl silicon, it escorts the stable operation of electronic equipment.
In the synthesis of silicone rubber, dimethylsilicon is also indispensable. Silicone rubber exhibits excellent high temperature resistance, low temperature resistance and weather resistance due to the structural characteristics of dimethylsilicon. In the aerospace field, silicone rubber seals are synthesized from dimethylsilicon-containing components, which can adapt to extreme temperature environments, ensure that all parts of the aircraft are well sealed, and maintain flight safety and stability.
Trimethylsilicon has made extraordinary contributions to the field of organic synthetic chemistry. It is often used as a protective group to protect certain functional groups in organic molecules. In the synthesis of complex organic compounds, some functional groups are prone to side reactions under reaction conditions. At this time, trimethylsilicon can selectively combine with specific functional groups to protect them. After the other reaction steps are completed, the trimethylsilicon protecting group is removed under mild conditions to restore the activity of the functional group, so as to achieve the precise synthesis of the target compound.
In drug development, the protective group strategy of trimethylsilicon is widely used. Many drug molecules have complex structures, and the synthesis process requires multiple steps. Trimethylsilicon helps protect specific functional groups, ensuring that the reaction proceeds according to the expected path, improving the yield and purity of drug synthesis, and providing key technical support for new drug development.
Dimethylsilicon plays a pivotal role in the preparation of silicone materials. It is often used as a key raw material for synthetic silicone oil, silicone rubber, etc. Taking silicone oil as an example, in the field of industrial lubrication, silicone oil has excellent lubricating properties due to the unique chemical structure endowed by dimethyl silicon, which can effectively reduce the friction loss between mechanical components and improve the efficiency and service life of machinery. In the electronics industry, silicone oil can be used as a potting material for electronic components. With the good insulation and thermal stability brought by dimethyl silicon, it escorts the stable operation of electronic equipment.
In the synthesis of silicone rubber, dimethylsilicon is also indispensable. Silicone rubber exhibits excellent high temperature resistance, low temperature resistance and weather resistance due to the structural characteristics of dimethylsilicon. In the aerospace field, silicone rubber seals are synthesized from dimethylsilicon-containing components, which can adapt to extreme temperature environments, ensure that all parts of the aircraft are well sealed, and maintain flight safety and stability.
Trimethylsilicon has made extraordinary contributions to the field of organic synthetic chemistry. It is often used as a protective group to protect certain functional groups in organic molecules. In the synthesis of complex organic compounds, some functional groups are prone to side reactions under reaction conditions. At this time, trimethylsilicon can selectively combine with specific functional groups to protect them. After the other reaction steps are completed, the trimethylsilicon protecting group is removed under mild conditions to restore the activity of the functional group, so as to achieve the precise synthesis of the target compound.
In drug development, the protective group strategy of trimethylsilicon is widely used. Many drug molecules have complex structures, and the synthesis process requires multiple steps. Trimethylsilicon helps protect specific functional groups, ensuring that the reaction proceeds according to the expected path, improving the yield and purity of drug synthesis, and providing key technical support for new drug development.
What are the physical properties of 1- (dichloromethyl) -2- (trifluoromethyl) benzene?
(1) The physical properties of dimethyl and (2) trimethylsilicon are as follows:
Dimethylsilicon contains dimethyl groups in its molecules. Under normal conditions, it is mostly liquid, which has a certain degree of stability. Its boiling phase is not high, because the molecular force is not high. This is due to the characteristic of dimethyl, which is non-toxic, so that the molecular properties of dimethyl silicon are weak, and the Vander force of the molecule is also small. Therefore, when adding silicon, it is easy to overcome the molecular force, and it is reduced by the liquid.
Furthermore, the density of dimethyl silicon is usually smaller than that of water, so it can float on the water surface. In terms of solubility, due to its own non-solubility, it is easily soluble in non-soluble properties such as hexane and toluene. It is soluble in water. This follows the principle of similar dissolution.
As far as trimethylsilicon is concerned, it contains trimethylsilica atoms. Physical dimethylsilica has a common problem, and it is also common in liquid and liquid. The boiling time is also not high, and the molecular force is not very high. The non-resistance of trimethyl group is more than that of dimethyl group, resulting in weaker molecular resistance of trimethylsilica, smaller molecular van der force, and lower boiling time.
The density is also smaller than that of water, and it can float on the water surface. In terms of solubility, it is also soluble in non-soluble and soluble in water. And trimethylsilicon, due to its special properties, often exhibits special activities in chemical reactions, and is often used in synthetic and other fields. It is often used as a support group or a specific chemical reaction. This is due to its physical density.
Dimethylsilicon contains dimethyl groups in its molecules. Under normal conditions, it is mostly liquid, which has a certain degree of stability. Its boiling phase is not high, because the molecular force is not high. This is due to the characteristic of dimethyl, which is non-toxic, so that the molecular properties of dimethyl silicon are weak, and the Vander force of the molecule is also small. Therefore, when adding silicon, it is easy to overcome the molecular force, and it is reduced by the liquid.
Furthermore, the density of dimethyl silicon is usually smaller than that of water, so it can float on the water surface. In terms of solubility, due to its own non-solubility, it is easily soluble in non-soluble properties such as hexane and toluene. It is soluble in water. This follows the principle of similar dissolution.
As far as trimethylsilicon is concerned, it contains trimethylsilica atoms. Physical dimethylsilica has a common problem, and it is also common in liquid and liquid. The boiling time is also not high, and the molecular force is not very high. The non-resistance of trimethyl group is more than that of dimethyl group, resulting in weaker molecular resistance of trimethylsilica, smaller molecular van der force, and lower boiling time.
The density is also smaller than that of water, and it can float on the water surface. In terms of solubility, it is also soluble in non-soluble and soluble in water. And trimethylsilicon, due to its special properties, often exhibits special activities in chemical reactions, and is often used in synthetic and other fields. It is often used as a support group or a specific chemical reaction. This is due to its physical density.
Is 1- (dichloromethyl) -2- (trifluoromethyl) benzene chemically stable?
Whether the chemical properties of Ximing (1- (dimethyl) -2- (trimethyl) ether are stable or not, its molecular structure and related reaction mechanism need to be investigated in detail.
The chemical bond properties in the molecule of this ether compound are very important. The substituents of dimethyl and trimethyl have an impact on the electron cloud distribution and spatial structure of the molecule. From the perspective of electronic effects, methyl groups are electron donor groups, which can increase the electron cloud density around the ether bond. This change has a significant impact on its chemical stability.
Under normal conditions, ether compounds have a certain chemical activity due to the isolation of oxygen atoms. However, in this compound, the electron donor action of methyl groups may change its reactivity. Spatial steric hindrance is also a key consideration. The presence of dimethyl and trimethyl groups crowds the space around the molecule. This steric hindrance effect can prevent the reactants from approaching the ether bond, which in turn affects the difficulty of participating in the chemical reaction.
In common chemical reaction environments, such as room temperature and pressure without strong oxidants, strong acids and bases, due to the electronic effect and steric hindrance caused by methyl groups, (1- (dimethyl) -2- (trimethyl) ether) may exhibit relatively high chemical stability. Due to the change of electron cloud distribution and spatial hindrance, it is difficult for general nucleophiles and electrophiles to approach the ether bond, so it is not easy to initiate reactions such as ether bond fracture.
However, under special conditions such as high temperature, strong oxidation or strong acid and strong base, its stability may be destroyed. High temperature can provide enough energy to overcome the reaction energy barrier, strong acid and strong base or strong oxidant can react with molecules in a special way, such as acid-catalyzed ether bond fracture, or oxidation reaction changes its molecular structure, resulting in loss of chemical stability.
In summary, (1- (dimethyl) -2- (trimethyl) ether) is chemically stable under conventional mild conditions, but it is not stable under special harsh conditions.
The chemical bond properties in the molecule of this ether compound are very important. The substituents of dimethyl and trimethyl have an impact on the electron cloud distribution and spatial structure of the molecule. From the perspective of electronic effects, methyl groups are electron donor groups, which can increase the electron cloud density around the ether bond. This change has a significant impact on its chemical stability.
Under normal conditions, ether compounds have a certain chemical activity due to the isolation of oxygen atoms. However, in this compound, the electron donor action of methyl groups may change its reactivity. Spatial steric hindrance is also a key consideration. The presence of dimethyl and trimethyl groups crowds the space around the molecule. This steric hindrance effect can prevent the reactants from approaching the ether bond, which in turn affects the difficulty of participating in the chemical reaction.
In common chemical reaction environments, such as room temperature and pressure without strong oxidants, strong acids and bases, due to the electronic effect and steric hindrance caused by methyl groups, (1- (dimethyl) -2- (trimethyl) ether) may exhibit relatively high chemical stability. Due to the change of electron cloud distribution and spatial hindrance, it is difficult for general nucleophiles and electrophiles to approach the ether bond, so it is not easy to initiate reactions such as ether bond fracture.
However, under special conditions such as high temperature, strong oxidation or strong acid and strong base, its stability may be destroyed. High temperature can provide enough energy to overcome the reaction energy barrier, strong acid and strong base or strong oxidant can react with molecules in a special way, such as acid-catalyzed ether bond fracture, or oxidation reaction changes its molecular structure, resulting in loss of chemical stability.
In summary, (1- (dimethyl) -2- (trimethyl) ether) is chemically stable under conventional mild conditions, but it is not stable under special harsh conditions.
What are the synthesis methods of 1- (dichloromethyl) -2- (trifluoromethyl) benzene?
To prepare 1 - (diethylamino) -2 - (triethylamino) benzene, the following methods can be used:
First, benzene is used as the starting material. First, benzene and halogenated ethane are catalyzed by Louis acid (such as aluminum trichloride), and the Fu-gram alkylation reaction is carried out to obtain ethylbenzene. Ethylbenzene is then nitrified, and the nitro group is introduced to generate nitroethylbenzene. After that, the nitro group is reduced to an amino group with a suitable reducing agent (such as iron and hydrochloric acid) to obtain ethylaniline. Next, the reaction of ethaniline and halogenated ethane under basic conditions, the hydrogen on the amino group is gradually replaced by ethyl group. After controlling the reaction conditions and the proportion of the material, the product in which the amino group in the target product is replaced by different numbers of ethyl groups can be obtained. After separation and purification, 1- (diethylamino) -2- (triethylamino) benzene is obtained.
Second, starting from aniline. Aniline first reacts with halogenated ethane, and the control conditions make the hydrogen of the amino group in the aniline gradually replaced by ethyl group to generate aniline derivatives with different alkylation degrees. Then, guided by a suitable positioning group, nitro is introduced at a specific position in the phenyl ring through nitration reaction. Nitro is then reduced to amino group, and finally through further alkylation reaction, the synthesis of the target product is achieved. This process requires fine regulation of the reaction conditions to ensure the accuracy of the nitro introduction position and the controllability of the degree of alkylation.
Third, halogenated benzene is used as the raw material. Halogenated benzene first reacts with ethylamine in the presence of suitable metal catalysts (such as palladium catalysts) and ligands, and ethylamino is introduced into the benzene ring. After controlling the reaction process, halogenated benzene derivatives with different ethylamino substitutions can be obtained. Then through the subsequent halogenation reaction, a new halogen atom is introduced at a suitable position in the benzene ring, and then reacts with ethylamine to achieve further alkylation of the amino group, and finally synthesizes 1- (diethylamino) -2 - (triethylamino) benzene. This route relies on an efficient catalytic system to promote the smooth progress of amination and subsequent reactions.
All these methods have their own advantages and disadvantages. In actual synthesis, it is necessary to comprehensively weigh factors such as the availability of raw materials, cost, difficulty of reaction conditions, and purity requirements of the product to choose the appropriate method.
First, benzene is used as the starting material. First, benzene and halogenated ethane are catalyzed by Louis acid (such as aluminum trichloride), and the Fu-gram alkylation reaction is carried out to obtain ethylbenzene. Ethylbenzene is then nitrified, and the nitro group is introduced to generate nitroethylbenzene. After that, the nitro group is reduced to an amino group with a suitable reducing agent (such as iron and hydrochloric acid) to obtain ethylaniline. Next, the reaction of ethaniline and halogenated ethane under basic conditions, the hydrogen on the amino group is gradually replaced by ethyl group. After controlling the reaction conditions and the proportion of the material, the product in which the amino group in the target product is replaced by different numbers of ethyl groups can be obtained. After separation and purification, 1- (diethylamino) -2- (triethylamino) benzene is obtained.
Second, starting from aniline. Aniline first reacts with halogenated ethane, and the control conditions make the hydrogen of the amino group in the aniline gradually replaced by ethyl group to generate aniline derivatives with different alkylation degrees. Then, guided by a suitable positioning group, nitro is introduced at a specific position in the phenyl ring through nitration reaction. Nitro is then reduced to amino group, and finally through further alkylation reaction, the synthesis of the target product is achieved. This process requires fine regulation of the reaction conditions to ensure the accuracy of the nitro introduction position and the controllability of the degree of alkylation.
Third, halogenated benzene is used as the raw material. Halogenated benzene first reacts with ethylamine in the presence of suitable metal catalysts (such as palladium catalysts) and ligands, and ethylamino is introduced into the benzene ring. After controlling the reaction process, halogenated benzene derivatives with different ethylamino substitutions can be obtained. Then through the subsequent halogenation reaction, a new halogen atom is introduced at a suitable position in the benzene ring, and then reacts with ethylamine to achieve further alkylation of the amino group, and finally synthesizes 1- (diethylamino) -2 - (triethylamino) benzene. This route relies on an efficient catalytic system to promote the smooth progress of amination and subsequent reactions.
All these methods have their own advantages and disadvantages. In actual synthesis, it is necessary to comprehensively weigh factors such as the availability of raw materials, cost, difficulty of reaction conditions, and purity requirements of the product to choose the appropriate method.
What are the precautions for 1- (dichloromethyl) -2- (trifluoromethyl) benzene during storage and transportation?
When storing and transporting dimethyl and trimethyl silica, there are various things that should be paid attention to.
The first one to bear the brunt is its flammability. Both are flammable and are very easy to explode in case of open flames and hot topics. Therefore, in the storage place, be sure to keep away from fire and heat sources, and strictly prohibit smoking. And should be placed in a cool and ventilated warehouse, the warehouse temperature should not be too high. When transporting, avoid heat, and transport vehicles should be equipped with the corresponding variety and quantity of fire-fighting equipment.
Secondly, its volatility should not be underestimated. Dimethyl and trimethyl silica are volatile, and the volatile gas will form an explosive mixture and spread in the air. Therefore, the storage container must be well sealed to prevent volatilization and leakage. During transportation, it is also necessary to ensure that the container is not damaged and there is no risk of leakage. In the event of a leak, do not take it lightly. Quickly evacuate personnel from the leak-contaminated area to a safe area, isolate them, and strictly restrict access. Emergency personnel should wear self-contained positive pressure breathing apparatus and anti-static overalls to cut off the source of leakage as much as possible to prevent it from flowing into restricted spaces such as sewers and drainage ditches.
Furthermore, these two are also harmful to the human body. Its vapor or fog is irritating to the eyes, mucous membranes and upper respiratory tract, and irritating to the skin. Therefore, during the operation, the operator must undergo special training and strictly abide by the operating procedures. Operators are advised to wear self-priming filter gas masks (half masks), chemical safety glasses, anti-static overalls, and rubber oil-resistant gloves.
When storing and transporting dimethyl and trimethyl silica, due attention should be paid to their flammability, volatility, and harmful properties, and caution should be taken to ensure the safety of the process.
The first one to bear the brunt is its flammability. Both are flammable and are very easy to explode in case of open flames and hot topics. Therefore, in the storage place, be sure to keep away from fire and heat sources, and strictly prohibit smoking. And should be placed in a cool and ventilated warehouse, the warehouse temperature should not be too high. When transporting, avoid heat, and transport vehicles should be equipped with the corresponding variety and quantity of fire-fighting equipment.
Secondly, its volatility should not be underestimated. Dimethyl and trimethyl silica are volatile, and the volatile gas will form an explosive mixture and spread in the air. Therefore, the storage container must be well sealed to prevent volatilization and leakage. During transportation, it is also necessary to ensure that the container is not damaged and there is no risk of leakage. In the event of a leak, do not take it lightly. Quickly evacuate personnel from the leak-contaminated area to a safe area, isolate them, and strictly restrict access. Emergency personnel should wear self-contained positive pressure breathing apparatus and anti-static overalls to cut off the source of leakage as much as possible to prevent it from flowing into restricted spaces such as sewers and drainage ditches.
Furthermore, these two are also harmful to the human body. Its vapor or fog is irritating to the eyes, mucous membranes and upper respiratory tract, and irritating to the skin. Therefore, during the operation, the operator must undergo special training and strictly abide by the operating procedures. Operators are advised to wear self-priming filter gas masks (half masks), chemical safety glasses, anti-static overalls, and rubber oil-resistant gloves.
When storing and transporting dimethyl and trimethyl silica, due attention should be paid to their flammability, volatility, and harmful properties, and caution should be taken to ensure the safety of the process.
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