Linshang Chemical
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1-Fluoro-3-(Trichloromethyl)Benzene
Linshang Chemical
|
HS Code |
651486 |
| Chemical Formula | C7H4Cl3F |
| Molecular Weight | 215.464 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 197 - 198 °C |
| Density | Approx. 1.49 g/cm³ |
| Vapor Pressure | Low vapor pressure at room temperature |
| Solubility | Insoluble in water, soluble in organic solvents like ethanol, ether |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 1-Fluoro-3-(Trichloromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - fluoro - 3 - (trichloromethyl)benzene: Packed in 5 - liter containers. |
| Storage | 1 - fluoro - 3 - (trichloromethyl)benzene should be stored in a cool, well - ventilated area away from heat sources and ignition points. It should be stored in a tightly sealed container to prevent leakage and vapor release. Keep it separate from oxidizing agents, reducing agents, and incompatible materials to avoid potential chemical reactions. |
| Shipping | 1 - fluoro - 3 - (trichloromethyl)benzene is shipped in sealed, corrosion - resistant containers. Special handling procedures are followed due to its chemical nature, ensuring compliance with safety regulations during transportation. |
Competitive 1-Fluoro-3-(Trichloromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 1-Fluoro-3-(Trichloromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-fluoro-3- (trichloromethyl) benzene?
1-Fluoro-3- (trichloromethyl) benzene is 1-fluoro-3- (trichloromethyl) benzene. The chemical properties of this substance are unique and have a variety of characteristics.
From the perspective of the properties of halogenated aromatics, the fluorine atoms and trichloromethyl atoms on the benzene ring have a great influence on its chemical behavior. Fluorine atoms have strong electronegativity, which can change the electron cloud density distribution of the benzene ring, and make the electron cloud density of the benzene ring o-site and para-site relatively lower. Therefore, the electrophilic substitution reaction activity is lower than that of benzene, and the reaction check point is more inclined to the meta- Trichloromethyl is also an electron-withdrawing group, which strengthens the trend of decreasing electron cloud density of benzene ring, and further affects the activity and regioselectivity of electrophilic substitution reactions.
In nucleophilic substitution reactions, because fluorine atoms are connected to benzene rings, the C-F bond energy is higher, making it relatively difficult for fluorine atoms to be replaced by nucleophilic reagents. However, under certain conditions, such as high temperature, strong base or the presence of a catalytic system, the C-F bond may also break and be replaced by nucleophilic reagents.
Furthermore, the presence of trichloromethyl makes the compound have certain chemical activity. The chlorine atoms in trichloromethyl can undergo substitution and elimination reactions under appropriate conditions. For example, in an alkaline environment, chlorine atoms in trichloromethyl may be gradually replaced by nucleophiles such as hydroxyl groups to form products containing different substituents.
This compound also has certain stability, because the conjugation system of benzene ring provides additional electron delocalization, which enhances the stability of the molecule as a whole. However, due to the influence of fluorine atoms and trichloromethyl, its stability is different from that of benzene, and chemical reactions can occur under certain conditions, showing unique chemical properties. It may have specific uses in fields such as organic synthesis.
From the perspective of the properties of halogenated aromatics, the fluorine atoms and trichloromethyl atoms on the benzene ring have a great influence on its chemical behavior. Fluorine atoms have strong electronegativity, which can change the electron cloud density distribution of the benzene ring, and make the electron cloud density of the benzene ring o-site and para-site relatively lower. Therefore, the electrophilic substitution reaction activity is lower than that of benzene, and the reaction check point is more inclined to the meta- Trichloromethyl is also an electron-withdrawing group, which strengthens the trend of decreasing electron cloud density of benzene ring, and further affects the activity and regioselectivity of electrophilic substitution reactions.
In nucleophilic substitution reactions, because fluorine atoms are connected to benzene rings, the C-F bond energy is higher, making it relatively difficult for fluorine atoms to be replaced by nucleophilic reagents. However, under certain conditions, such as high temperature, strong base or the presence of a catalytic system, the C-F bond may also break and be replaced by nucleophilic reagents.
Furthermore, the presence of trichloromethyl makes the compound have certain chemical activity. The chlorine atoms in trichloromethyl can undergo substitution and elimination reactions under appropriate conditions. For example, in an alkaline environment, chlorine atoms in trichloromethyl may be gradually replaced by nucleophiles such as hydroxyl groups to form products containing different substituents.
This compound also has certain stability, because the conjugation system of benzene ring provides additional electron delocalization, which enhances the stability of the molecule as a whole. However, due to the influence of fluorine atoms and trichloromethyl, its stability is different from that of benzene, and chemical reactions can occur under certain conditions, showing unique chemical properties. It may have specific uses in fields such as organic synthesis.
What are the main uses of 1-fluoro-3- (trichloromethyl) benzene?
1-Fluoro-3- (trichloromethyl) benzene has a wide range of uses. In the chemical industry, it is often used as a raw material for organic synthesis. It can participate in the synthesis of various complex organic compounds through specific reaction paths. In pharmaceutical chemistry, it may play a key intermediate role in the development of new drugs. With its unique chemical structure, it introduces specific functional groups to drug molecules to optimize drug properties, such as enhancing drug activity and stability.
In the field of materials science, 1-fluoro-3- (trichloromethyl) benzene also has important uses. It can be used to prepare materials with special properties, such as some high-performance polymer materials. By incorporating it into the polymer structure, the material can be endowed with properties such as excellent chemical resistance and heat resistance, thus broadening the application scenarios of the material, and can be applied in aerospace, electronic equipment and other fields that require strict material properties.
In addition, in the field of pesticides, it may also be used as a raw material or intermediate for the synthesis of pesticide products with efficient insecticidal and bactericidal effects, providing strong support for the pest control of agricultural production. In short, 1-fluoro-3- (trichloromethyl) benzene plays an indispensable role in many fields due to its unique chemical properties, which is of great significance to promote the development of various related industries.
In the field of materials science, 1-fluoro-3- (trichloromethyl) benzene also has important uses. It can be used to prepare materials with special properties, such as some high-performance polymer materials. By incorporating it into the polymer structure, the material can be endowed with properties such as excellent chemical resistance and heat resistance, thus broadening the application scenarios of the material, and can be applied in aerospace, electronic equipment and other fields that require strict material properties.
In addition, in the field of pesticides, it may also be used as a raw material or intermediate for the synthesis of pesticide products with efficient insecticidal and bactericidal effects, providing strong support for the pest control of agricultural production. In short, 1-fluoro-3- (trichloromethyl) benzene plays an indispensable role in many fields due to its unique chemical properties, which is of great significance to promote the development of various related industries.
What is the preparation method of 1-fluoro-3- (trichloromethyl) benzene?
1-Fluoro-3- (trichloromethyl) benzene is 1-fluoro-3- (trichloromethyl) benzene. The preparation method is as follows:
can be prepared by chlorination of m-fluorotoluene. The radical substitution reaction of m-fluorotoluene and chlorine gas occurs under the condition of light or the presence of initiator. Due to the relatively high electron cloud density of methyl groups, chlorine atoms preferentially replace hydrogen atoms in methyl groups. However, due to factors such as steric hindrance and reaction conditions, under suitable conditions, chlorine atoms can mainly replace hydrogen atoms at the base of methyl to generate 1-fluoro-3-chloromethylbenzene, and then further chlorination, so that the hydrogen atoms on the chlorine methyl are gradually replaced by chlorine atoms, and finally 1-fluoro-3- (trichloromethyl) benzene.
During the reaction process, chlorine needs to be slowly introduced, and the reaction conditions such as reaction temperature and light intensity should be controlled. If the temperature is too high or the chlorine gas is introduced too quickly, side reactions such as excessive chlorination may occur, and polychlorination by-products will be formed, which will affect the yield and purity of the target product.
Another preparation idea is to use m-chlorotrichlorotoluene as raw material, and through nucleophilic substitution reaction, the chlorine atom is replaced by the fluorine atom. Select appropriate nucleophilic reagents, such as potassium fluoride, etc., and carry out the reaction in the presence of appropriate organic solvents and catalysts. The selection of organic solvents is crucial, and it is necessary to ensure that it has good solubility to the reactants and products, and does not have side reactions with the reactants and products. At the same time, it is necessary to control the pH of the reaction system, reaction time and other conditions to improve the selectivity and yield of the reaction, and finally obtain 1-fluoro-3- (trichloromethyl) benzene.
can be prepared by chlorination of m-fluorotoluene. The radical substitution reaction of m-fluorotoluene and chlorine gas occurs under the condition of light or the presence of initiator. Due to the relatively high electron cloud density of methyl groups, chlorine atoms preferentially replace hydrogen atoms in methyl groups. However, due to factors such as steric hindrance and reaction conditions, under suitable conditions, chlorine atoms can mainly replace hydrogen atoms at the base of methyl to generate 1-fluoro-3-chloromethylbenzene, and then further chlorination, so that the hydrogen atoms on the chlorine methyl are gradually replaced by chlorine atoms, and finally 1-fluoro-3- (trichloromethyl) benzene.
During the reaction process, chlorine needs to be slowly introduced, and the reaction conditions such as reaction temperature and light intensity should be controlled. If the temperature is too high or the chlorine gas is introduced too quickly, side reactions such as excessive chlorination may occur, and polychlorination by-products will be formed, which will affect the yield and purity of the target product.
Another preparation idea is to use m-chlorotrichlorotoluene as raw material, and through nucleophilic substitution reaction, the chlorine atom is replaced by the fluorine atom. Select appropriate nucleophilic reagents, such as potassium fluoride, etc., and carry out the reaction in the presence of appropriate organic solvents and catalysts. The selection of organic solvents is crucial, and it is necessary to ensure that it has good solubility to the reactants and products, and does not have side reactions with the reactants and products. At the same time, it is necessary to control the pH of the reaction system, reaction time and other conditions to improve the selectivity and yield of the reaction, and finally obtain 1-fluoro-3- (trichloromethyl) benzene.
What should I pay attention to when storing and transporting 1-fluoro-3- (trichloromethyl) benzene?
1-Fluoro-3- (trichloromethyl) benzene is an organic compound. During storage and transportation, many key matters need to be paid attention to.
One is related to the storage environment. This compound should be stored in a cool and well-ventilated place. Because it is more sensitive to heat, high temperature can easily cause chemical changes and may even cause dangerous reactions. The warehouse temperature should be controlled within an appropriate range, not too high. And it needs to be kept away from fire and heat sources. Open flames and hot topics will threaten its stability.
Second, in terms of packaging requirements. Suitable packaging materials must be used. Packaging that can effectively block external factors should be selected to prevent leakage. The packaging material needs to have good corrosion resistance, because the compound may cause erosion to some materials. The packaging should be sturdy to ensure that it will not be damaged during handling and storage.
Third, about isolation from other substances. Do not mix with oxidants, strong bases and other substances. Oxidants have strong oxidizing properties and may react violently with 1-fluoro-3- (trichloromethyl) benzene; strong bases may chemically react with them, changing their chemical properties. These reactions may pose a safety hazard.
Fourth, the storage area should be well marked. The name, characteristics, hazard level and other key information of the compound are clearly marked, so that the staff can quickly understand its danger and make correct judgments during operation and emergency treatment.
Fifth, during transportation, ensure that the transportation vehicle is in good condition. Vehicles need to have corresponding safety equipment and protective measures to prevent packaging damage and material leakage due to bumps and collisions during transportation. At the same time, transportation personnel should receive professional training, familiar with the characteristics of the compound and emergency treatment methods. In case of emergencies, they can respond quickly and correctly to ensure transportation safety.
One is related to the storage environment. This compound should be stored in a cool and well-ventilated place. Because it is more sensitive to heat, high temperature can easily cause chemical changes and may even cause dangerous reactions. The warehouse temperature should be controlled within an appropriate range, not too high. And it needs to be kept away from fire and heat sources. Open flames and hot topics will threaten its stability.
Second, in terms of packaging requirements. Suitable packaging materials must be used. Packaging that can effectively block external factors should be selected to prevent leakage. The packaging material needs to have good corrosion resistance, because the compound may cause erosion to some materials. The packaging should be sturdy to ensure that it will not be damaged during handling and storage.
Third, about isolation from other substances. Do not mix with oxidants, strong bases and other substances. Oxidants have strong oxidizing properties and may react violently with 1-fluoro-3- (trichloromethyl) benzene; strong bases may chemically react with them, changing their chemical properties. These reactions may pose a safety hazard.
Fourth, the storage area should be well marked. The name, characteristics, hazard level and other key information of the compound are clearly marked, so that the staff can quickly understand its danger and make correct judgments during operation and emergency treatment.
Fifth, during transportation, ensure that the transportation vehicle is in good condition. Vehicles need to have corresponding safety equipment and protective measures to prevent packaging damage and material leakage due to bumps and collisions during transportation. At the same time, transportation personnel should receive professional training, familiar with the characteristics of the compound and emergency treatment methods. In case of emergencies, they can respond quickly and correctly to ensure transportation safety.
What are the effects of 1-fluoro-3- (trichloromethyl) benzene on the environment and human health?
1-Fluoro-3- (trichloromethyl) benzene is also an organic compound. Its impact on the environment and human health cannot be underestimated.
At the environmental end, this substance has a certain stability, is difficult to degrade naturally, and is easy to remain between water and soil. If it flows into rivers, lakes and seas, it may cause water pollution and harm aquatic organisms. After aquatic organisms ingest or come into contact with this substance, their physiological functions may be disrupted, reproduction will be blocked, and even death. In the soil, it may also affect the activity and community structure of soil microorganisms, posing a threat to the balance of soil ecosystems, and then affecting plant growth.
As for personal health, 1-fluoro-3- (trichloromethyl) benzene may be ingested into the human body through breathing, skin contact and diet. Inhalation through the respiratory tract can irritate the respiratory mucosa, causing cough, asthma and other discomfort. If exposed to the skin, it may cause skin allergies, itching, redness and swelling. Once it enters the human body or accumulates in the body, it interferes with the endocrine system, affects the normal secretion and regulation of hormones, and causes reproductive and developmental problems. Long-term exposure to this substance may also damage the function of important organs such as the liver and kidneys, and even increase the risk of cancer. Therefore, the potential harm of 1-fluoro-3- (trichloromethyl) benzene to the environment and human health should be given high priority, and appropriate measures should be taken, such as strict control of emissions and enhanced monitoring, to reduce its negative impact and protect the environment and human health.
At the environmental end, this substance has a certain stability, is difficult to degrade naturally, and is easy to remain between water and soil. If it flows into rivers, lakes and seas, it may cause water pollution and harm aquatic organisms. After aquatic organisms ingest or come into contact with this substance, their physiological functions may be disrupted, reproduction will be blocked, and even death. In the soil, it may also affect the activity and community structure of soil microorganisms, posing a threat to the balance of soil ecosystems, and then affecting plant growth.
As for personal health, 1-fluoro-3- (trichloromethyl) benzene may be ingested into the human body through breathing, skin contact and diet. Inhalation through the respiratory tract can irritate the respiratory mucosa, causing cough, asthma and other discomfort. If exposed to the skin, it may cause skin allergies, itching, redness and swelling. Once it enters the human body or accumulates in the body, it interferes with the endocrine system, affects the normal secretion and regulation of hormones, and causes reproductive and developmental problems. Long-term exposure to this substance may also damage the function of important organs such as the liver and kidneys, and even increase the risk of cancer. Therefore, the potential harm of 1-fluoro-3- (trichloromethyl) benzene to the environment and human health should be given high priority, and appropriate measures should be taken, such as strict control of emissions and enhanced monitoring, to reduce its negative impact and protect the environment and human health.
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