Linshang Chemical
PRODUCTS
1-Fluoro-4-Chlorobenzene
Linshang Chemical
|
HS Code |
916028 |
| Chemical Formula | C6H4ClF |
| Molar Mass | 128.547 g/mol |
| Appearance | Colorless liquid |
| Boiling Point | 117 - 118 °C |
| Melting Point | -48 °C |
| Density | 1.192 g/mL at 25 °C |
| Solubility In Water | Insoluble |
| Vapor Pressure | 3.97 kPa at 25 °C |
| Flash Point | 17 °C |
| Refractive Index | 1.4770 (20 °C) |
As an accredited 1-Fluoro-4-Chlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle of 1 - fluoro - 4 - chlorobenzene, tightly sealed for chemical storage. |
| Storage | 1 - Fluoro - 4 - chlorobenzene should be stored in a cool, well - ventilated area away from heat sources and open flames. It should be kept in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive substances. Adhere to local safety regulations, and ensure the storage area has proper spill - containment measures. |
| Shipping | 1 - fluoro - 4 - chlorobenzene is shipped in sealed, corrosion - resistant containers. Compliance with strict hazardous chemical regulations is ensured. Shipment is carefully monitored to prevent leakage during transit. |
Competitive 1-Fluoro-4-Chlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 1-Fluoro-4-Chlorobenzene in China?
As a trusted 1-Fluoro-4-Chlorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Fluoro-4-Chlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 1-fluoro-4-chlorobenzene?
1-Fluoro-4-chlorobenzene is also an organic compound. Its physical properties are unique, let me come one by one.
Looking at its shape, under room temperature and pressure, 1-fluoro-4-chlorobenzene is a colorless to light yellow transparent liquid, clear and clear, like a spring stream, pure and free of impurities.
Smell its smell, it has a fragrant smell, but this fragrance is not like the richness of spring flowers, but the special fragrance of chemical substances. Although it has a fragrance, it also hides a warning and should not be approached wantonly.
In terms of its melting and boiling point, the melting point is -35 ° C, just like the cold of winter, when the temperature drops slightly, it can be condensed into a solid state; the boiling point reaches 117-119 ° C, and it needs to be moderately heated before it can be turned into a gaseous state and show its other form.
When it comes to density, its value is about 1.22 g/cm ³, which is heavier than water. If it is placed with water, it will be like a stone entering water and sinking to the bottom.
In terms of solubility, 1-fluoro-4-chlorobenzene is insoluble in water, and the two are like two distinct streams, which are difficult to blend; but they can be miscible with most organic solvents such as ethanol and ether, just like when friends meet and blend with each other, and can show different chemical wonders in the embrace of organic solvents.
Its vapor pressure also has characteristics. At a specific temperature, a certain vapor pressure will be generated, which is a manifestation of its molecular activity and is related to its existence in the gas phase.
In addition, the vapor density of 1-fluoro-4-chlorobenzene is higher than that of air. If it escapes into the air, it will sink like heavy fog, close to the ground, and easy to accumulate in low places. This characteristic is particularly important when using and storing.
Looking at its shape, under room temperature and pressure, 1-fluoro-4-chlorobenzene is a colorless to light yellow transparent liquid, clear and clear, like a spring stream, pure and free of impurities.
Smell its smell, it has a fragrant smell, but this fragrance is not like the richness of spring flowers, but the special fragrance of chemical substances. Although it has a fragrance, it also hides a warning and should not be approached wantonly.
In terms of its melting and boiling point, the melting point is -35 ° C, just like the cold of winter, when the temperature drops slightly, it can be condensed into a solid state; the boiling point reaches 117-119 ° C, and it needs to be moderately heated before it can be turned into a gaseous state and show its other form.
When it comes to density, its value is about 1.22 g/cm ³, which is heavier than water. If it is placed with water, it will be like a stone entering water and sinking to the bottom.
In terms of solubility, 1-fluoro-4-chlorobenzene is insoluble in water, and the two are like two distinct streams, which are difficult to blend; but they can be miscible with most organic solvents such as ethanol and ether, just like when friends meet and blend with each other, and can show different chemical wonders in the embrace of organic solvents.
Its vapor pressure also has characteristics. At a specific temperature, a certain vapor pressure will be generated, which is a manifestation of its molecular activity and is related to its existence in the gas phase.
In addition, the vapor density of 1-fluoro-4-chlorobenzene is higher than that of air. If it escapes into the air, it will sink like heavy fog, close to the ground, and easy to accumulate in low places. This characteristic is particularly important when using and storing.
What are the chemical properties of 1-fluoro-4-chlorobenzene?
1 - fluoro - 4 - chlorobenzene is an organic compound with unique chemical properties. Let me tell you one by one.
In this compound, both the chlorine atom and the fluorine atom are halogen atoms. Due to the electron-absorbing induction effect of the halogen atom, the electron cloud density of the benzene ring is reduced, so the electrophilic substitution activity of the benzene ring is weakened. When the electrophilic substitution reaction occurs, the halogen atom is an adjacent and para-site group, and the new substituent is more into its adjacent and para-sites. For example, in the halogenation reaction, if the iron bromide is used as the catalyst to react with bromine, the bromine atom will mainly replace the hydrogen atom of the adjacent and para-site of the chlorine and fluorine atom to form the corresponding hal
1-fluoro-4-chlorobenzene fluorine atoms and chlorine atoms can undergo substitution reactions. Under suitable nucleophilic reagents and reaction conditions, fluorine atoms can be replaced by nucleophilic reagents. If heated with sodium alcohol, fluorine atoms may be replaced by alkoxy groups to form compounds containing ether bonds. Similarly, chlorine atoms can also participate in similar substitution reactions, but because the activity of fluorine atoms is slightly different from that of chlorine atoms, the reaction conditions may be slightly different.
This compound can also participate in metal-organic reactions. For example, when reacted with magnesium, Grignard reagents can be formed. The generated Grignard reagent has strong nucleophilic properties and can react with a variety of electrophilic reagents, such as aldose and ketone, to form new carbon-carbon bonds, thereby synthesizing organic compounds with more complex structures.
In addition, 1-fluoro-4-chlorobenzene has certain stability and can exist stably at room temperature and pressure. However, in case of high temperature, open flame or strong oxidant, there may be a risk of reaction, and caution should be used when using and storing. Its chemical properties are diverse, making it widely used in the field of organic synthesis. It can be used as an intermediate for the preparation of drugs, pesticides, dyes and other organic compounds.
In this compound, both the chlorine atom and the fluorine atom are halogen atoms. Due to the electron-absorbing induction effect of the halogen atom, the electron cloud density of the benzene ring is reduced, so the electrophilic substitution activity of the benzene ring is weakened. When the electrophilic substitution reaction occurs, the halogen atom is an adjacent and para-site group, and the new substituent is more into its adjacent and para-sites. For example, in the halogenation reaction, if the iron bromide is used as the catalyst to react with bromine, the bromine atom will mainly replace the hydrogen atom of the adjacent and para-site of the chlorine and fluorine atom to form the corresponding hal
1-fluoro-4-chlorobenzene fluorine atoms and chlorine atoms can undergo substitution reactions. Under suitable nucleophilic reagents and reaction conditions, fluorine atoms can be replaced by nucleophilic reagents. If heated with sodium alcohol, fluorine atoms may be replaced by alkoxy groups to form compounds containing ether bonds. Similarly, chlorine atoms can also participate in similar substitution reactions, but because the activity of fluorine atoms is slightly different from that of chlorine atoms, the reaction conditions may be slightly different.
This compound can also participate in metal-organic reactions. For example, when reacted with magnesium, Grignard reagents can be formed. The generated Grignard reagent has strong nucleophilic properties and can react with a variety of electrophilic reagents, such as aldose and ketone, to form new carbon-carbon bonds, thereby synthesizing organic compounds with more complex structures.
In addition, 1-fluoro-4-chlorobenzene has certain stability and can exist stably at room temperature and pressure. However, in case of high temperature, open flame or strong oxidant, there may be a risk of reaction, and caution should be used when using and storing. Its chemical properties are diverse, making it widely used in the field of organic synthesis. It can be used as an intermediate for the preparation of drugs, pesticides, dyes and other organic compounds.
What are the main uses of 1-fluoro-4-chlorobenzene?
1-Fluoro-4-chlorobenzene is 1-fluoro-4-chlorobenzene, also known as p-chlorofluorobenzene. This substance has a wide range of uses and plays a key role in many fields.
First, in the field of pharmaceutical synthesis, it is an important organic synthesis intermediate. The preparation of many drugs uses 1-fluoro-4-chlorobenzene as the starting material and is converted into compounds with specific pharmacological activities through a series of chemical reactions. For example, in the synthesis of some antibacterial drugs, nervous system drugs, etc., 1-fluoro-4-chlorobenzene can introduce key fluorine atoms and chlorine atoms, which have a profound impact on the biological activity, fat solubility and metabolic stability of drug molecules. With the unique electronic and spatial effects of these two atoms, the interaction between drugs and targets can be optimized and the efficacy of drugs can be improved.
Second, in the field of pesticides, 1-fluoro-4-chlorobenzene also plays an important role. It can be used to synthesize a variety of high-efficiency pesticides, such as insecticides, fungicides, etc. The pesticides it participates in the synthesis have the characteristics of high efficiency, low toxicity and environmental friendliness. Due to the presence of fluorine-containing and chlorine-containing structures, the effect of pesticides on pests or bacteria can be enhanced, while reducing the residue in the environment and reducing the adverse impact on the ecological environment.
Third, in the field of materials science, 1-fluoro-4-chlorobenzene can be used to prepare high-performance polymer materials. By polymerizing with other monomers, the polymer can give special properties, such as improving the heat resistance, chemical stability and mechanical properties of the polymer. The obtained materials can be used in aerospace, electronics and other fields that require strict material properties.
In summary, 1-fluoro-4-chlorobenzene has important uses in the fields of medicine, pesticides, and materials science, and is of great significance in promoting the development of these fields.
First, in the field of pharmaceutical synthesis, it is an important organic synthesis intermediate. The preparation of many drugs uses 1-fluoro-4-chlorobenzene as the starting material and is converted into compounds with specific pharmacological activities through a series of chemical reactions. For example, in the synthesis of some antibacterial drugs, nervous system drugs, etc., 1-fluoro-4-chlorobenzene can introduce key fluorine atoms and chlorine atoms, which have a profound impact on the biological activity, fat solubility and metabolic stability of drug molecules. With the unique electronic and spatial effects of these two atoms, the interaction between drugs and targets can be optimized and the efficacy of drugs can be improved.
Second, in the field of pesticides, 1-fluoro-4-chlorobenzene also plays an important role. It can be used to synthesize a variety of high-efficiency pesticides, such as insecticides, fungicides, etc. The pesticides it participates in the synthesis have the characteristics of high efficiency, low toxicity and environmental friendliness. Due to the presence of fluorine-containing and chlorine-containing structures, the effect of pesticides on pests or bacteria can be enhanced, while reducing the residue in the environment and reducing the adverse impact on the ecological environment.
Third, in the field of materials science, 1-fluoro-4-chlorobenzene can be used to prepare high-performance polymer materials. By polymerizing with other monomers, the polymer can give special properties, such as improving the heat resistance, chemical stability and mechanical properties of the polymer. The obtained materials can be used in aerospace, electronics and other fields that require strict material properties.
In summary, 1-fluoro-4-chlorobenzene has important uses in the fields of medicine, pesticides, and materials science, and is of great significance in promoting the development of these fields.
What are 1-fluoro-4-chlorobenzene synthesis methods?
1-Fluoro-4-chlorobenzene is also an organic compound. There are many opinions on the synthesis method. The above numbers are as follows.
First, p-chloroaniline is used as the beginning, and it can be obtained by diazotization and Himan reaction. First, p-chloroaniline is co-diazotized with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. Then it interacts with fluoroboronic acid to obtain a diazonium salt of fluoroboronic acid. Then it is decomposed by heating and nitrogen escapes, resulting in 1-fluoro-4-chlorobenzene. There are many steps in this way, but the conditions are easier to control and the product purity is also good.
Second, p-chlorophenol is used as the raw material and reacts with fluorination reagents If potassium fluoride is used as a fluorinating agent, a phase transfer catalyst is added to an appropriate organic solvent to heat up the reaction. In this case, the organic solvent must have good solubility to the reactants and a suitable boiling point. The phase transfer catalyst can promote ion transfer and increase the reaction rate. The raw material of this method is easy to obtain, but the activity of potassium fluoride is limited, or a higher temperature and a longer time are required.
Third, benzene is used as the initial material, and it is chlorinated, nitrified, reduced, diazotized and fluorinated. First, benzene and chlorine are chlorinated under the catalyst to obtain chlorobenzene. Next, chlorobenzene is nitrified with mixed acids to obtain p-chloronitrobenzene. Reduced with iron powder or sodium sulfide to form p-chloroaniline. Then by diazotization and Seaman reaction, the target product is obtained. This path is long and there are many intermediate products, but the raw material benzene is cheap and easy to obtain, which may have advantages in industrial production.
Synthesis of 1-fluoro-4-chlorobenzene has advantages and disadvantages, and the practical application needs to be weighed according to factors such as raw material availability, cost, and product purity.
First, p-chloroaniline is used as the beginning, and it can be obtained by diazotization and Himan reaction. First, p-chloroaniline is co-diazotized with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. Then it interacts with fluoroboronic acid to obtain a diazonium salt of fluoroboronic acid. Then it is decomposed by heating and nitrogen escapes, resulting in 1-fluoro-4-chlorobenzene. There are many steps in this way, but the conditions are easier to control and the product purity is also good.
Second, p-chlorophenol is used as the raw material and reacts with fluorination reagents If potassium fluoride is used as a fluorinating agent, a phase transfer catalyst is added to an appropriate organic solvent to heat up the reaction. In this case, the organic solvent must have good solubility to the reactants and a suitable boiling point. The phase transfer catalyst can promote ion transfer and increase the reaction rate. The raw material of this method is easy to obtain, but the activity of potassium fluoride is limited, or a higher temperature and a longer time are required.
Third, benzene is used as the initial material, and it is chlorinated, nitrified, reduced, diazotized and fluorinated. First, benzene and chlorine are chlorinated under the catalyst to obtain chlorobenzene. Next, chlorobenzene is nitrified with mixed acids to obtain p-chloronitrobenzene. Reduced with iron powder or sodium sulfide to form p-chloroaniline. Then by diazotization and Seaman reaction, the target product is obtained. This path is long and there are many intermediate products, but the raw material benzene is cheap and easy to obtain, which may have advantages in industrial production.
Synthesis of 1-fluoro-4-chlorobenzene has advantages and disadvantages, and the practical application needs to be weighed according to factors such as raw material availability, cost, and product purity.
What do 1-fluoro-4-chlorobenzene need to pay attention to when storing and transporting?
1-Fluoro-4-chlorobenzene, Chinese name 1-fluoro-4-chlorobenzene, this substance should be stored and transported, and many matters should be paid attention to.
First words storage. First, must choose a cool and well ventilated place for storage. Because the heat of this substance is prone to danger, the temperature is too high or cause chemical reactions, or even explosions. Second, the storage place must be away from fire and heat sources. These two can cause the material to burn, which can lead to disaster. Third, it should be stored separately from oxidants, food chemicals, etc., and must not be mixed. Because of its chemical activity, it can be mixed with other substances or react violently. Fourth, the warehouse should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. In case of an accident, it can be responded to in time to reduce losses. And the storage container should also be well sealed to prevent leakage.
As for transportation, there are also many precautions. When transporting, the vehicle must be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. During driving, drivers and escorts must always be vigilant and must not leave their posts without authorization. Transportation vehicles should follow the prescribed route and do not stop in residential areas and densely populated areas. When loading and unloading, light loading and light unloading are required. It is strictly forbidden to drop, heavy pressure and friction to avoid damage to the packaging and cause material leakage. During transportation, ensure that the container does not leak, collapse, fall or damage.
All of these should be taken into account when storing and transporting 1-fluoro-4-chlorobenzene. They must not be taken lightly and must be operated in strict accordance with regulations to ensure safety.
First words storage. First, must choose a cool and well ventilated place for storage. Because the heat of this substance is prone to danger, the temperature is too high or cause chemical reactions, or even explosions. Second, the storage place must be away from fire and heat sources. These two can cause the material to burn, which can lead to disaster. Third, it should be stored separately from oxidants, food chemicals, etc., and must not be mixed. Because of its chemical activity, it can be mixed with other substances or react violently. Fourth, the warehouse should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. In case of an accident, it can be responded to in time to reduce losses. And the storage container should also be well sealed to prevent leakage.
As for transportation, there are also many precautions. When transporting, the vehicle must be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. During driving, drivers and escorts must always be vigilant and must not leave their posts without authorization. Transportation vehicles should follow the prescribed route and do not stop in residential areas and densely populated areas. When loading and unloading, light loading and light unloading are required. It is strictly forbidden to drop, heavy pressure and friction to avoid damage to the packaging and cause material leakage. During transportation, ensure that the container does not leak, collapse, fall or damage.
All of these should be taken into account when storing and transporting 1-fluoro-4-chlorobenzene. They must not be taken lightly and must be operated in strict accordance with regulations to ensure safety.
Scan to WhatsApp
