Linshang Chemical
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1-Fluoro-4-(Trichloromethyl)Benzene
Linshang Chemical
|
HS Code |
647971 |
| Chemical Formula | C7H4Cl3F |
| Molecular Weight | 215.46 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 207 - 209 °C |
| Density | 1.484 g/cm³ at 25 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Flash Point | 87 °C |
| Odor | Characteristic aromatic odor |
As an accredited 1-Fluoro-4-(Trichloromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - fluoro - 4 - (trichloromethyl)benzene packaged in 500 - mL bottles, one per pack. |
| Storage | 1 - fluoro - 4 - (trichloromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from sources of heat and ignition. Keep it in a tightly - sealed container to prevent leakage. Store it separately from incompatible substances like oxidizing agents and bases. This helps maintain its stability and reduces the risk of dangerous reactions. |
| Shipping | 1 - fluoro - 4 - (trichloromethyl)benzene is shipped in specialized, well - sealed containers. Compliance with strict chemical shipping regulations is ensured to prevent leaks and risks during transportation, with proper labeling for safety. |
Competitive 1-Fluoro-4-(Trichloromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 1-Fluoro-4-(Trichloromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-fluoro-4- (trichloromethyl) benzene?
1 - fluoro - 4 - (trichloromethyl) benzene is an organic compound with unique properties and is related to many fields of chemistry.
When it comes to physical properties, this compound is mostly liquid at room temperature, has a certain volatility, and has a special odor. Because its molecular structure contains fluorine atoms and trichloromethyl, its density is different from that of common hydrocarbons, which is higher than that of water. And its solubility is special. It has good solubility in organic solvents such as ethanol and ether, but poor solubility in water. Due to the large difference between molecular polarity and water.
Chemical properties, its fluorophenyl ring structure is stable, but trichloromethyl has higher activity. The compound can undergo nucleophilic substitution reaction. Because the chlorine atom in trichloromethyl has strong electron absorption, its carbon positive electricity is enhanced, and it is vulnerable to attack by nucleophilic reagents. Nucleophilic reagents such as sodium alcohol and amines can react with chlorine atoms of trichloromethyl to form new compounds. And under appropriate conditions, aromatic electrophilic substitution can occur. Although fluorine atoms are ortho-para-sites, due to the strong electron-absorbing effect of trichloromethyl, the reaction mainly occurs in the para-position of fluorine atoms. For example, bromine reactions catalyzed by iron bromide can introduce bromine atoms in the para-position. In addition, under the action of a specific catalyst, a reduction reaction can occur, and trichloromethyl can be reduced to other groups, such as methyl or hydroxymethyl, etc. This process often requires suitable reaction conditions and reducing agents, such as metal hydrides.
When it comes to physical properties, this compound is mostly liquid at room temperature, has a certain volatility, and has a special odor. Because its molecular structure contains fluorine atoms and trichloromethyl, its density is different from that of common hydrocarbons, which is higher than that of water. And its solubility is special. It has good solubility in organic solvents such as ethanol and ether, but poor solubility in water. Due to the large difference between molecular polarity and water.
Chemical properties, its fluorophenyl ring structure is stable, but trichloromethyl has higher activity. The compound can undergo nucleophilic substitution reaction. Because the chlorine atom in trichloromethyl has strong electron absorption, its carbon positive electricity is enhanced, and it is vulnerable to attack by nucleophilic reagents. Nucleophilic reagents such as sodium alcohol and amines can react with chlorine atoms of trichloromethyl to form new compounds. And under appropriate conditions, aromatic electrophilic substitution can occur. Although fluorine atoms are ortho-para-sites, due to the strong electron-absorbing effect of trichloromethyl, the reaction mainly occurs in the para-position of fluorine atoms. For example, bromine reactions catalyzed by iron bromide can introduce bromine atoms in the para-position. In addition, under the action of a specific catalyst, a reduction reaction can occur, and trichloromethyl can be reduced to other groups, such as methyl or hydroxymethyl, etc. This process often requires suitable reaction conditions and reducing agents, such as metal hydrides.
What are the main uses of 1-fluoro-4- (trichloromethyl) benzene?
1-Fluoro-4- (trichloromethyl) benzene is 1-fluoro-4- (trichloromethyl) benzene, which has a wide range of uses.
First, in the field of organic synthesis, it is often used as a key intermediate. Due to the unique activity of fluorine atoms and trichloromethyl in its molecular structure, it can participate in many chemical reactions. For example, in nucleophilic substitution reactions, fluorine atoms can be replaced by other nucleophiles to form new carbon-heteroatomic bonds, thereby synthesizing organic compounds with specific structures and functions. Like some fluorine-containing pharmaceutical intermediates, it is often used as a starting material and prepared through multi-step reactions.
Second, it also has important uses in materials science. From this raw material, polymer materials with unique properties can be synthesized. After the conversion of trichloromethyl through a specific reaction, the polymer material is endowed with characteristics such as excellent chemical resistance and thermal stability. For example, the synthesis of some high-performance engineering plastics, after the introduction of this structural unit, the material properties are significantly improved, and it is used in aerospace, automobile manufacturing and other fields that require strict material properties.
Third, in the agricultural field, it can be used as an important raw material for the synthesis of pesticides. Through reasonable structural modification and reaction, pesticide products with high insecticidal, bactericidal or herbicidal activities are prepared. Its fluorine and chlorine-containing structure helps to enhance the biological activity and affinity of pesticides to specific targets, improve drug efficacy, and reduce adverse effects on the environment.
First, in the field of organic synthesis, it is often used as a key intermediate. Due to the unique activity of fluorine atoms and trichloromethyl in its molecular structure, it can participate in many chemical reactions. For example, in nucleophilic substitution reactions, fluorine atoms can be replaced by other nucleophiles to form new carbon-heteroatomic bonds, thereby synthesizing organic compounds with specific structures and functions. Like some fluorine-containing pharmaceutical intermediates, it is often used as a starting material and prepared through multi-step reactions.
Second, it also has important uses in materials science. From this raw material, polymer materials with unique properties can be synthesized. After the conversion of trichloromethyl through a specific reaction, the polymer material is endowed with characteristics such as excellent chemical resistance and thermal stability. For example, the synthesis of some high-performance engineering plastics, after the introduction of this structural unit, the material properties are significantly improved, and it is used in aerospace, automobile manufacturing and other fields that require strict material properties.
Third, in the agricultural field, it can be used as an important raw material for the synthesis of pesticides. Through reasonable structural modification and reaction, pesticide products with high insecticidal, bactericidal or herbicidal activities are prepared. Its fluorine and chlorine-containing structure helps to enhance the biological activity and affinity of pesticides to specific targets, improve drug efficacy, and reduce adverse effects on the environment.
What is the preparation method of 1-fluoro-4- (trichloromethyl) benzene?
1-Fluoro-4- (trichloromethyl) benzene, the preparation method often follows several paths.
First, the electrophilic substitution reaction of aromatic hydrocarbons can be used. Using p-chlorotoluene as raw material, under specific reaction conditions, it interacts with a fluorinating agent. This fluorinating agent can be selected such as potassium fluoride. In a suitable organic solvent, heat and stir to make it fluorinate. Organic solvents, such as dimethyl sulfoxide (DMSO), can dissolve the reactants and promote the reaction. During the reaction, the control of temperature is very critical, usually in a certain high temperature range, the reaction can occur smoothly, but it should not be too high to prevent side reactions.
Second, it can be started from p-fluorotoluene. First, the methyl group is chlorinated with an appropriate chlorination reagent, such as chlorine, in the presence of light or initiator. The chlorination process needs to be carefully controlled, because the chlorination of methyl groups can be carried out step by step. To obtain the product of trichloromethyl, the amount of chlorine gas, the reaction time and temperature must be adjusted. After the successful introduction of trichloromethyl, 1-fluoro-4- (trichloromethyl) benzene can be obtained.
Third, it is also possible to prepare it by the Grignard reagent method. First prepare the Grignard reagent containing fluorine, and then react with the halogenated hydrocarbon containing trichloromethyl or the corresponding carbonyl compound. In this process, the preparation of Grignard reagent needs to be carried out under severe conditions of anhydrous and anaerobic to ensure its activity and stability. Subsequent reactions with another reactant also require precise control of reaction conditions, such as temperature, solvent and ratio of reactants, to obtain the target product.
There are various methods for preparing 1-fluoro-4- (trichloromethyl) benzene, but each method has its own advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as the availability of raw materials, cost, and difficulty in controlling reaction conditions to choose the best method.
First, the electrophilic substitution reaction of aromatic hydrocarbons can be used. Using p-chlorotoluene as raw material, under specific reaction conditions, it interacts with a fluorinating agent. This fluorinating agent can be selected such as potassium fluoride. In a suitable organic solvent, heat and stir to make it fluorinate. Organic solvents, such as dimethyl sulfoxide (DMSO), can dissolve the reactants and promote the reaction. During the reaction, the control of temperature is very critical, usually in a certain high temperature range, the reaction can occur smoothly, but it should not be too high to prevent side reactions.
Second, it can be started from p-fluorotoluene. First, the methyl group is chlorinated with an appropriate chlorination reagent, such as chlorine, in the presence of light or initiator. The chlorination process needs to be carefully controlled, because the chlorination of methyl groups can be carried out step by step. To obtain the product of trichloromethyl, the amount of chlorine gas, the reaction time and temperature must be adjusted. After the successful introduction of trichloromethyl, 1-fluoro-4- (trichloromethyl) benzene can be obtained.
Third, it is also possible to prepare it by the Grignard reagent method. First prepare the Grignard reagent containing fluorine, and then react with the halogenated hydrocarbon containing trichloromethyl or the corresponding carbonyl compound. In this process, the preparation of Grignard reagent needs to be carried out under severe conditions of anhydrous and anaerobic to ensure its activity and stability. Subsequent reactions with another reactant also require precise control of reaction conditions, such as temperature, solvent and ratio of reactants, to obtain the target product.
There are various methods for preparing 1-fluoro-4- (trichloromethyl) benzene, but each method has its own advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as the availability of raw materials, cost, and difficulty in controlling reaction conditions to choose the best method.
What should I pay attention to when storing and transporting 1-fluoro-4- (trichloromethyl) benzene?
1 - fluoro - 4 - (trichloromethyl) benzene, this is an organic compound. When storing and transporting, many aspects need to be paid attention to.
First talk about storage. This substance should be placed in a cool and ventilated warehouse. Due to high temperature, it may cause chemical reactions or even cause danger. The temperature of the warehouse should be strictly controlled, not too high, to prevent the properties of the compound from changing. And keep away from fire and heat sources. Open flames and hot topics may cause combustion, explosion and other accidents. At the same time, it should be stored separately from oxidants and food chemicals, and must not be mixed. Because of its active chemical properties, contact with oxidants, etc., or react violently, endangering safety. The warehouse should also be equipped with suitable materials to contain leaks in case of leakage, which can be dealt with in time to avoid greater harm.
As for transportation. Make sure that the packaging is complete and safely loaded before transportation. If the packaging is damaged, the compound or leakage during transportation will pollute the environment and endanger personnel. During transportation, make sure that the container does not leak, collapse, fall or damage. The speed should not be too fast to avoid violent vibration such as sudden braking, resulting in damage to the packaging. Transportation vehicles should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. In the event of an accident on the way, it can be responded to in time. And when transporting, drive according to the specified route, do not stop in densely populated areas, residential areas, etc., in case of leakage, causing serious harm to many people.
First talk about storage. This substance should be placed in a cool and ventilated warehouse. Due to high temperature, it may cause chemical reactions or even cause danger. The temperature of the warehouse should be strictly controlled, not too high, to prevent the properties of the compound from changing. And keep away from fire and heat sources. Open flames and hot topics may cause combustion, explosion and other accidents. At the same time, it should be stored separately from oxidants and food chemicals, and must not be mixed. Because of its active chemical properties, contact with oxidants, etc., or react violently, endangering safety. The warehouse should also be equipped with suitable materials to contain leaks in case of leakage, which can be dealt with in time to avoid greater harm.
As for transportation. Make sure that the packaging is complete and safely loaded before transportation. If the packaging is damaged, the compound or leakage during transportation will pollute the environment and endanger personnel. During transportation, make sure that the container does not leak, collapse, fall or damage. The speed should not be too fast to avoid violent vibration such as sudden braking, resulting in damage to the packaging. Transportation vehicles should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. In the event of an accident on the way, it can be responded to in time. And when transporting, drive according to the specified route, do not stop in densely populated areas, residential areas, etc., in case of leakage, causing serious harm to many people.
What are the effects of 1-fluoro-4- (trichloromethyl) benzene on the environment and human health?
The effects of 1-fluoro-4- (trichloromethyl) benzene on the environment and human health are particularly important to the world. The properties of this substance can cause pollution to the environment, and it is also harmful to human health.
At one end of the environment, 1-fluoro-4- (trichloromethyl) benzene is quite stable and difficult to degrade naturally, so it accumulates in the environment. It can enter the soil, causing soil quality deterioration and disturbing the growth of plants. The root system of the plant touches this substance, or creates obstacles, causing slow growth and even death. And it is easy to evaporate, enter the atmosphere, or react with other substances, forming secondary pollutants, damaging air quality and affecting the climate. Its entry into water bodies, sewage sources, harming aquatic organisms. Or cause abnormalities in aquatic organisms, breaking the balance of aquatic ecology.
As for human health, 1-fluoro-4- (trichloromethyl) benzene may enter the human body through respiration, diet, and skin contact. Exposure to this substance for a long time may damage the human viscera. Such as hurting the liver and kidneys, these two are important officials of detoxification and metabolism for the human body, and being invaded will cause metabolic disorders in the body. And this substance may be carcinogenic, increasing the risk of cancer in people, especially lung and liver cancers. Or disturbing the human body's endocrine, disrupting hormone balance, and causing reproductive and developmental diseases. Weak groups such as children and pregnant women are more vulnerable to it, hindering the development of children and endangering the safety of the fetus.
Because 1-fluoro-4- (trichloromethyl) benzene is harmful to the environment and human health, it is important to prevent its spillage and reduce its ecological and human risks.
At one end of the environment, 1-fluoro-4- (trichloromethyl) benzene is quite stable and difficult to degrade naturally, so it accumulates in the environment. It can enter the soil, causing soil quality deterioration and disturbing the growth of plants. The root system of the plant touches this substance, or creates obstacles, causing slow growth and even death. And it is easy to evaporate, enter the atmosphere, or react with other substances, forming secondary pollutants, damaging air quality and affecting the climate. Its entry into water bodies, sewage sources, harming aquatic organisms. Or cause abnormalities in aquatic organisms, breaking the balance of aquatic ecology.
As for human health, 1-fluoro-4- (trichloromethyl) benzene may enter the human body through respiration, diet, and skin contact. Exposure to this substance for a long time may damage the human viscera. Such as hurting the liver and kidneys, these two are important officials of detoxification and metabolism for the human body, and being invaded will cause metabolic disorders in the body. And this substance may be carcinogenic, increasing the risk of cancer in people, especially lung and liver cancers. Or disturbing the human body's endocrine, disrupting hormone balance, and causing reproductive and developmental diseases. Weak groups such as children and pregnant women are more vulnerable to it, hindering the development of children and endangering the safety of the fetus.
Because 1-fluoro-4- (trichloromethyl) benzene is harmful to the environment and human health, it is important to prevent its spillage and reduce its ecological and human risks.
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