Linshang Chemical
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1-Iodo-2,3-Dichloro-5-Methylbenzene
Linshang Chemical
|
HS Code |
875500 |
| Chemical Formula | C7H5Cl2I |
| Molar Mass | 287.925 g/mol |
| Appearance | Solid (usually) |
| Physical State At Room Temp | Solid |
| Melting Point | N/A (specify if known) |
| Boiling Point | N/A (specify if known) |
| Density | N/A (specify if known) |
| Solubility In Water | Low (organic compounds like this are often hydrophobic) |
| Solubility In Organic Solvents | Soluble in common organic solvents (e.g., ethanol, ether) |
| Odor | Typically has an odor characteristic of halogen - containing organic compounds |
As an accredited 1-Iodo-2,3-Dichloro-5-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 1 - iodo - 2,3 - dichloro - 5 - methylbenzene packaged in a sealed glass bottle. |
| Storage | 1 - iodo - 2,3 - dichloro - 5 - methylbenzene should be stored in a cool, dry, well - ventilated area away from sources of heat, ignition, and direct sunlight. Keep it in a tightly sealed container to prevent leakage and vapor release. Store it separately from oxidizing agents, acids, and bases to avoid potential chemical reactions. Follow local safety regulations for storage. |
| Shipping | 1 - iodo - 2,3 - dichloro - 5 - methylbenzene is shipped in accordance with hazardous chemical regulations. Packed in well - sealed, corrosion - resistant containers, transported by approved carriers, ensuring safety during transit. |
Competitive 1-Iodo-2,3-Dichloro-5-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 1-Iodo-2,3-Dichloro-5-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-iodine-2,3-dichloro-5-methylbenzene?
2,3-Dibromo-5-methylfuran is an organic compound with the following chemical properties:
1. ** Electrophilic Substitution Reaction **: Its furan ring is rich in electrons and has high reactivity to electrophilic reagents. For example, under certain conditions, it can undergo electrophilic substitution with bromine, and bromine atoms will selectively replace hydrogen atoms at positions with higher electron cloud density on the furan ring. Because methyl is a power supply group, it will increase the electron cloud density of the adjacent and para-position of the carbon connected to it, so electrophilic substitution is more likely to occur at these positions.
2. ** Addition Reaction **: The carbon-carbon double bond in the molecule can be added. Taking addition with hydrogen as an example, in the presence of suitable catalysts such as palladium carbon, the carbon-carbon double bond can undergo an addition reaction with hydrogen, and the double bond can be converted into a single bond to generate saturated furan derivatives. If the conditions are appropriate, it can also be added with halogens, hydrogen halides and other electrophilic reagents. If added with hydrogen chloride, chlorine atoms will be added to double-bonded carbon atoms with less hydrogen.
3. ** Oxidation reaction **: Can be acted by oxidants. In case of mild oxidants, carbon atoms on the furan ring may be oxidized to form corresponding oxidation products. Oxygen-containing functional groups such as aldehyde groups and carboxyl groups may appear in the products. If the oxidizing agent is strong and the conditions are severe, the furan ring may be destroyed, and complex reactions such as ring opening may occur.
4. ** Methyl-related reactions **: The methyl group at the 5-position can undergo some specific reactions. For example, in the presence of light or initiators, the hydrogen atoms on the methyl group can be replaced by halogen atoms to form halogenated methylfuran derivatives. The generated halogenated products can further undergo nucleophilic substitution reactions with nucleophiles and introduce other functional groups.
1. ** Electrophilic Substitution Reaction **: Its furan ring is rich in electrons and has high reactivity to electrophilic reagents. For example, under certain conditions, it can undergo electrophilic substitution with bromine, and bromine atoms will selectively replace hydrogen atoms at positions with higher electron cloud density on the furan ring. Because methyl is a power supply group, it will increase the electron cloud density of the adjacent and para-position of the carbon connected to it, so electrophilic substitution is more likely to occur at these positions.
2. ** Addition Reaction **: The carbon-carbon double bond in the molecule can be added. Taking addition with hydrogen as an example, in the presence of suitable catalysts such as palladium carbon, the carbon-carbon double bond can undergo an addition reaction with hydrogen, and the double bond can be converted into a single bond to generate saturated furan derivatives. If the conditions are appropriate, it can also be added with halogens, hydrogen halides and other electrophilic reagents. If added with hydrogen chloride, chlorine atoms will be added to double-bonded carbon atoms with less hydrogen.
3. ** Oxidation reaction **: Can be acted by oxidants. In case of mild oxidants, carbon atoms on the furan ring may be oxidized to form corresponding oxidation products. Oxygen-containing functional groups such as aldehyde groups and carboxyl groups may appear in the products. If the oxidizing agent is strong and the conditions are severe, the furan ring may be destroyed, and complex reactions such as ring opening may occur.
4. ** Methyl-related reactions **: The methyl group at the 5-position can undergo some specific reactions. For example, in the presence of light or initiators, the hydrogen atoms on the methyl group can be replaced by halogen atoms to form halogenated methylfuran derivatives. The generated halogenated products can further undergo nucleophilic substitution reactions with nucleophiles and introduce other functional groups.
What are the physical properties of 1-iodine-2,3-dichloro-5-methylbenzene?
2,3-Dibromo-5-methylfuran is a colorless to light yellow liquid with a special odor. It is volatile, with a relative density of about 1.96 (water = 1), a boiling point of 190-192 ° C, insoluble in water, and miscible in most organic solvents such as ethanol, ether, and chloroform.
This substance is very important in the chemical industry and is used as a key intermediate in organic synthesis. Due to the presence of bromine atoms and methyl and furan rings in the molecule, it is endowed with unique reactivity. Bromine atoms are active and can react with many nucleophilic reagents through nucleophilic substitution reactions to form new carbon-heteroatomic bonds, laying the foundation for the construction of complex organic molecules.
However, it also poses certain dangers. Its vapor and air can form an explosive mixture, which can cause combustion and explosion in case of open flame and high heat energy. It can react strongly with oxidants. The decomposition of hot topics emits toxic gases. When operating, it is necessary to strictly follow safety procedures and conduct it in a well-ventilated environment. Avoid contact with open flames and hot topics. Operators should wear suitable protective equipment to prevent vapor inhalation, skin contact and eye contact.
This substance is very important in the chemical industry and is used as a key intermediate in organic synthesis. Due to the presence of bromine atoms and methyl and furan rings in the molecule, it is endowed with unique reactivity. Bromine atoms are active and can react with many nucleophilic reagents through nucleophilic substitution reactions to form new carbon-heteroatomic bonds, laying the foundation for the construction of complex organic molecules.
However, it also poses certain dangers. Its vapor and air can form an explosive mixture, which can cause combustion and explosion in case of open flame and high heat energy. It can react strongly with oxidants. The decomposition of hot topics emits toxic gases. When operating, it is necessary to strictly follow safety procedures and conduct it in a well-ventilated environment. Avoid contact with open flames and hot topics. Operators should wear suitable protective equipment to prevent vapor inhalation, skin contact and eye contact.
What are the common synthesis methods of 1-iodine-2,3-dichloro-5-methylbenzene?
The common synthesis methods of dibromo-5-methylfuran are as follows:
Using furan as the starting material
1. ** Halogenation reaction **:
-furan is first halogenated with bromine. In a suitable solvent (such as dichloromethane), at low temperature (such as about\ (0 ^ {\ circ} C\)) slowly dropwise addition of bromine dichloromethane solution, the 2-position and 5-position of furan are prone to electrophilic substitution reactions, resulting in a mixture of 2-bromofuran and 5-bromofuran. This is because the furan ring has a certain aromaticity, the electron cloud density is relatively high, and it is easy to be attacked by electrophilic reagents.
- The reaction equation can be expressed as:\ (C_4H_4O + Br_2\ xrightarrow [] {CH_2Cl_2, 0 ^ {\ circ} C} C_4H_3BrO + HBr\), and the generated 2-bromofuran and 5-bromofuran can be separated by distillation and other methods.
2. ** Methylation Reaction **:
- Methylation reaction is carried out with 5-bromofuran as raw material. The Grignard reagent method can be used to first react magnesium chips with halomethane (such as iodomethane\ (CH_3I\)) in anhydrous ether to prepare methyl Grignard reagent\ (CH_3MgI\).
- Then 5-bromofuran is added dropwise to a system containing methyl Grignard reagent and reacted at an appropriate temperature (e.g. reflux temperature) to generate 5-methylfuran. This reaction takes advantage of the strong nucleophilicity of Grignard reagents to attack the carbon where the bromine atom of 5-bromofuran is located, and a substitution reaction occurs, and the bromine atom is replaced by methyl.
- The reaction equation is:\ (C_4H_3BrO + CH_3MgI\ xrightarrow [] {Et_2O, reflux} C_5H_6O + MgBrI\)
3. ** Re-halogenation **:
- 5-methylfuran is halogenated with bromine again. Under suitable reaction conditions, such as light or in the presence of an initiator, control the amount of bromine to halogenate 5-methylfuran at the 2-position to produce dibromo-5-methylfuran. For example, under light conditions, 5-methylfuran reacts with an appropriate amount of bromine in carbon tetrachloride solution.
- The reaction equation is:\ (C_5H_6O + Br_2\ xrightarrow [] {CCl_4, h\ nu} C_5H_4Br_2O + HBr\)
with other furan-containing structural compounds as raw materials
1. ** Starting from methylfuran-containing derivatives **:
- If a suitable methylfuran-containing derivative is available and its 2-position has a replaceable active group (such as hydroxy, amino, etc.), the reactive group can be converted into a bromine atom by a halogenating reagent (such as phosphorus tribromide\ (PBr_3\), a mixed system of hydrobromic acid and concentrated sulfuric acid, etc.) to obtain dibromo-5-methylfuran.
- For example, if 2-hydroxy-5-methylfuran is used as a raw material and reacts with phosphorus tribromide, the hydroxy group is replaced by a bromine atom. The reaction equation is:\ (C_5H_6O_2 + PBr_3\ longrightarrow C_5H_4Br_2O + H_3PO_3\)
2. ** Construct a furan ring by cyclization reaction and introduce a substituent **:
- Using a 1,4-dicarbonyl compound with a bromine and methyl-containing reagent in the presence of an acidic catalyst (such as p-toluenesulfonic acid) Cyclization occurs to construct a furan ring and introduce methyl and bromine atoms simultaneously.
- For example, 1,4-pentanedione and methyl magnesium bromide (which can be prepared from methyl bromide and magnesium) catalyzed by p-toluenesulfonic acid first undergo a series of reactions such as nucleophilic addition, and finally cyclize to form the precursor of dibromo-5-methylfuran, and then undergo appropriate oxidation or dehydration to obtain the target product. Such reactions are complex and require precise control of reaction conditions to improve yield and selectivity.
Using furan as the starting material
1. ** Halogenation reaction **:
-furan is first halogenated with bromine. In a suitable solvent (such as dichloromethane), at low temperature (such as about\ (0 ^ {\ circ} C\)) slowly dropwise addition of bromine dichloromethane solution, the 2-position and 5-position of furan are prone to electrophilic substitution reactions, resulting in a mixture of 2-bromofuran and 5-bromofuran. This is because the furan ring has a certain aromaticity, the electron cloud density is relatively high, and it is easy to be attacked by electrophilic reagents.
- The reaction equation can be expressed as:\ (C_4H_4O + Br_2\ xrightarrow [] {CH_2Cl_2, 0 ^ {\ circ} C} C_4H_3BrO + HBr\), and the generated 2-bromofuran and 5-bromofuran can be separated by distillation and other methods.
2. ** Methylation Reaction **:
- Methylation reaction is carried out with 5-bromofuran as raw material. The Grignard reagent method can be used to first react magnesium chips with halomethane (such as iodomethane\ (CH_3I\)) in anhydrous ether to prepare methyl Grignard reagent\ (CH_3MgI\).
- Then 5-bromofuran is added dropwise to a system containing methyl Grignard reagent and reacted at an appropriate temperature (e.g. reflux temperature) to generate 5-methylfuran. This reaction takes advantage of the strong nucleophilicity of Grignard reagents to attack the carbon where the bromine atom of 5-bromofuran is located, and a substitution reaction occurs, and the bromine atom is replaced by methyl.
- The reaction equation is:\ (C_4H_3BrO + CH_3MgI\ xrightarrow [] {Et_2O, reflux} C_5H_6O + MgBrI\)
3. ** Re-halogenation **:
- 5-methylfuran is halogenated with bromine again. Under suitable reaction conditions, such as light or in the presence of an initiator, control the amount of bromine to halogenate 5-methylfuran at the 2-position to produce dibromo-5-methylfuran. For example, under light conditions, 5-methylfuran reacts with an appropriate amount of bromine in carbon tetrachloride solution.
- The reaction equation is:\ (C_5H_6O + Br_2\ xrightarrow [] {CCl_4, h\ nu} C_5H_4Br_2O + HBr\)
with other furan-containing structural compounds as raw materials
1. ** Starting from methylfuran-containing derivatives **:
- If a suitable methylfuran-containing derivative is available and its 2-position has a replaceable active group (such as hydroxy, amino, etc.), the reactive group can be converted into a bromine atom by a halogenating reagent (such as phosphorus tribromide\ (PBr_3\), a mixed system of hydrobromic acid and concentrated sulfuric acid, etc.) to obtain dibromo-5-methylfuran.
- For example, if 2-hydroxy-5-methylfuran is used as a raw material and reacts with phosphorus tribromide, the hydroxy group is replaced by a bromine atom. The reaction equation is:\ (C_5H_6O_2 + PBr_3\ longrightarrow C_5H_4Br_2O + H_3PO_3\)
2. ** Construct a furan ring by cyclization reaction and introduce a substituent **:
- Using a 1,4-dicarbonyl compound with a bromine and methyl-containing reagent in the presence of an acidic catalyst (such as p-toluenesulfonic acid) Cyclization occurs to construct a furan ring and introduce methyl and bromine atoms simultaneously.
- For example, 1,4-pentanedione and methyl magnesium bromide (which can be prepared from methyl bromide and magnesium) catalyzed by p-toluenesulfonic acid first undergo a series of reactions such as nucleophilic addition, and finally cyclize to form the precursor of dibromo-5-methylfuran, and then undergo appropriate oxidation or dehydration to obtain the target product. Such reactions are complex and require precise control of reaction conditions to improve yield and selectivity.
In what fields is 1-iodine-2,3-dichloro-5-methylbenzene used?
2,3-Dioxo-5-methylfuran is used in many fields. In the field of medicine, it is a key intermediate for drug synthesis. In the preparation of many antibacterial and antiviral drugs, 2,3-dioxo-5-methylfuran is often used as the starting material. Through a series of chemical transformations, complex molecular structures with specific pharmacological activities are constructed to escort human health.
In the field of materials science, it can participate in the synthesis of high-performance polymer materials. By ingeniously designing the polymerization reaction, the 2,3-dioxy-5-methylfuran structural unit is introduced into the main chain or side chain of the polymer, which can significantly improve the properties of the material, such as improving the thermal stability, mechanical strength and flexibility of the material, so as to meet the strict requirements of different engineering scenarios on material properties.
In the field of organic synthetic chemistry, 2,3-dioxy-5-methylfuran is often used as a key building block in organic synthesis due to its unique molecular structure and reactivity. Chemists use it to participate in various chemical reactions, such as cyclization reactions, addition reactions, etc., to synthesize complex and novel organic compounds, which greatly enrich the types of organic compounds and inject new vitality into the development of organic chemistry.
In the field of fragrance industry, 2,3-dioxy-5-methylfuran also has outstanding performance. Because of its unique odor characteristics, it can be used to prepare a variety of flavors and fragrances after preparation, adding unique aroma to food, cosmetics and other industries, and enhancing the sensory quality and market competitiveness of products.
In the field of materials science, it can participate in the synthesis of high-performance polymer materials. By ingeniously designing the polymerization reaction, the 2,3-dioxy-5-methylfuran structural unit is introduced into the main chain or side chain of the polymer, which can significantly improve the properties of the material, such as improving the thermal stability, mechanical strength and flexibility of the material, so as to meet the strict requirements of different engineering scenarios on material properties.
In the field of organic synthetic chemistry, 2,3-dioxy-5-methylfuran is often used as a key building block in organic synthesis due to its unique molecular structure and reactivity. Chemists use it to participate in various chemical reactions, such as cyclization reactions, addition reactions, etc., to synthesize complex and novel organic compounds, which greatly enrich the types of organic compounds and inject new vitality into the development of organic chemistry.
In the field of fragrance industry, 2,3-dioxy-5-methylfuran also has outstanding performance. Because of its unique odor characteristics, it can be used to prepare a variety of flavors and fragrances after preparation, adding unique aroma to food, cosmetics and other industries, and enhancing the sensory quality and market competitiveness of products.
What are the precautions in the preparation of 1-iodine-2,3-dichloro-5-methylbenzene?
In the process of baking "2,3-dioxy-5-methylfuran", many matters need to be paid attention to.
The selection of starting materials is crucial. The selected raw materials for 2,3-dioxy-5-methylfuran must be of high purity, excellent quality, and a little impurities, which may cause the reaction to be skewed and the product to be impure. And the storage of raw materials also needs to be cautious. It should be placed in a cool, dry and well-ventilated place to avoid excessive contact with air and moisture and prevent it from deteriorating.
The reaction conditions should be controlled and not be lost. In terms of temperature, different stages have appropriate temperatures. Too fast or too slow heating, too high or too low temperature all affect the reaction rate and product formation. If the temperature is slightly higher at a specific stage, it may cause frequent side reactions and reduce the yield of the product; if the temperature is slightly lower, the reaction will be delayed and the efficiency will be low. The same is true for pressure, and proper pressure is the guarantee for the smooth progress of the reaction. Improper pressure may cause the direction of the reaction to change, or cause the state of the reactants to be abnormal, which is unfavorable to the advancement of the reaction.
The use of catalysts requires a lot of skill. Selecting a suitable catalyst can greatly increase the reaction rate and selectivity of the product. However, the amount of catalyst must be accurate, too much or the reaction will be out of control, and too little will cause the catalytic effect to be poor. And the activity of the catalyst is easily affected by external factors, such as impurities, temperature, etc., so it is necessary to pay attention to the change of its activity Use modern analytical methods, such as chromatography, spectroscopy, etc., to observe the reaction process and product formation in real time. If any abnormalities are found, such as the proportion of the product does not match expectations and impurities increase, the reaction conditions can be adjusted in time to ensure that the reaction proceeds according to plan.
Post-processing can not be ignored. After the reaction is completed, the separation and purification of the product are complicated and critical. Choose appropriate separation methods, such as distillation, extraction, etc., to remove impurities and improve the purity of the product. During the purification operation, pay attention to mild conditions to avoid product loss or deterioration.
The above things are interlinked in the baking process of 2,3-dioxy-5-methylfuran, all of which are related to the quality and yield of the product. Fine treatment and rigorous operation are required.
The selection of starting materials is crucial. The selected raw materials for 2,3-dioxy-5-methylfuran must be of high purity, excellent quality, and a little impurities, which may cause the reaction to be skewed and the product to be impure. And the storage of raw materials also needs to be cautious. It should be placed in a cool, dry and well-ventilated place to avoid excessive contact with air and moisture and prevent it from deteriorating.
The reaction conditions should be controlled and not be lost. In terms of temperature, different stages have appropriate temperatures. Too fast or too slow heating, too high or too low temperature all affect the reaction rate and product formation. If the temperature is slightly higher at a specific stage, it may cause frequent side reactions and reduce the yield of the product; if the temperature is slightly lower, the reaction will be delayed and the efficiency will be low. The same is true for pressure, and proper pressure is the guarantee for the smooth progress of the reaction. Improper pressure may cause the direction of the reaction to change, or cause the state of the reactants to be abnormal, which is unfavorable to the advancement of the reaction.
The use of catalysts requires a lot of skill. Selecting a suitable catalyst can greatly increase the reaction rate and selectivity of the product. However, the amount of catalyst must be accurate, too much or the reaction will be out of control, and too little will cause the catalytic effect to be poor. And the activity of the catalyst is easily affected by external factors, such as impurities, temperature, etc., so it is necessary to pay attention to the change of its activity Use modern analytical methods, such as chromatography, spectroscopy, etc., to observe the reaction process and product formation in real time. If any abnormalities are found, such as the proportion of the product does not match expectations and impurities increase, the reaction conditions can be adjusted in time to ensure that the reaction proceeds according to plan.
Post-processing can not be ignored. After the reaction is completed, the separation and purification of the product are complicated and critical. Choose appropriate separation methods, such as distillation, extraction, etc., to remove impurities and improve the purity of the product. During the purification operation, pay attention to mild conditions to avoid product loss or deterioration.
The above things are interlinked in the baking process of 2,3-dioxy-5-methylfuran, all of which are related to the quality and yield of the product. Fine treatment and rigorous operation are required.
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