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1-Iodo-2,3-Dichloro-5-(Tert-Butyl)Benzene
Linshang Chemical
|
HS Code |
649581 |
| Chemical Formula | C10H11Cl2I |
| Molar Mass | 345.904 g/mol |
| Appearance | Solid (predicted) |
| Boiling Point | Estimated around 300 - 320 °C |
| Melting Point | No data (needs experimental determination) |
| Density | No data (estimated based on similar compounds: around 1.7 - 1.9 g/cm³) |
| Solubility In Water | Insoluble (hydrophobic aromatic compound) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Vapor Pressure | Very low at room temperature |
| Stability | Stable under normal conditions, but can react with strong oxidizing and reducing agents |
As an accredited 1-Iodo-2,3-Dichloro-5-(Tert-Butyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 1 - iodo - 2,3 - dichloro - 5 - (tert - butyl)benzene in a sealed glass bottle. |
| Storage | 1 - iodo - 2,3 - dichloro - 5 - (tert - butyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent evaporation and exposure to air or moisture, which could potentially lead to decomposition. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions. |
| Shipping | 1 - iodo - 2,3 - dichloro - 5 - (tert - butyl)benzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, with proper labeling for safe transportation. |
Competitive 1-Iodo-2,3-Dichloro-5-(Tert-Butyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 1-iodo-2,3-dichloro-5- (tert-butyl) benzene?
1 - iodo - 2,3 - dichloro - 5 - (tert - butyl) benzene is an organic compound with unique chemical properties. It is rich in properties due to its iodine, chlorine and tert-butyl groups.
First, halogen atoms (iodine and chlorine) endow this compound with activity. Iodine atoms are easily attacked and left by nucleophiles in nucleophilic substitution reactions due to their large atomic radius and relatively weak C-I bonds, opening the door to new chemical bond formation. For example, in the reaction with sodium alcohol, iodine can be replaced by alkoxy groups to form corresponding ethers. Although the C-Cl bond is stronger than the C-I bond, the chlorine atom can also participate in nucleophilic substitution under appropriate conditions, such as high temperature and the presence of catalysts, like the reaction with ammonia, chlorine can be replaced with amino groups.
Secondly, the conjugation system of the benzene ring endows the compound with stability, and at the same time allows it to undergo electrophilic substitution reaction. Since the electron cloud density of the benzene ring is affected by iodine, chlorine and tert-butyl, the electrophilic reagents are more inclined to attack specific positions. Tert-butyl is the power supply group, which makes the electron cloud density of the benzene ring o and para-position relatively high, and the electrophilic reagents are easy to attack these positions; while the halogen atom is the electron-absorbing group, which For example, when reacting with mixed acids of nitric acid and sulfuric acid, the nitro group will mainly replace the tert-butyl ortho and para-sites on the benzene ring.
Furthermore, the presence of tert-butyl affects the physical and chemical properties of the compound. Its large volume produces a steric hindrance effect. In chemical reactions, it will hinder the reagent from approaching a specific position in the benzene ring, affecting the reaction rate and selectivity. In space, restricting the tight accumulation between molecules affects the melting point and boiling point of the compound, usually making its melting boiling point lower than that of the non-bulky tert-butyl analogs. In conclusion, 1-iodo-2,3-dichloro-5- (tert-butyl) benzene exhibits rich chemical reactivity and unique physical properties due to the interaction of iodine, chlorine, tert-butyl and benzene ring, and has potential application value in organic synthesis, materials science and other fields.
First, halogen atoms (iodine and chlorine) endow this compound with activity. Iodine atoms are easily attacked and left by nucleophiles in nucleophilic substitution reactions due to their large atomic radius and relatively weak C-I bonds, opening the door to new chemical bond formation. For example, in the reaction with sodium alcohol, iodine can be replaced by alkoxy groups to form corresponding ethers. Although the C-Cl bond is stronger than the C-I bond, the chlorine atom can also participate in nucleophilic substitution under appropriate conditions, such as high temperature and the presence of catalysts, like the reaction with ammonia, chlorine can be replaced with amino groups.
Secondly, the conjugation system of the benzene ring endows the compound with stability, and at the same time allows it to undergo electrophilic substitution reaction. Since the electron cloud density of the benzene ring is affected by iodine, chlorine and tert-butyl, the electrophilic reagents are more inclined to attack specific positions. Tert-butyl is the power supply group, which makes the electron cloud density of the benzene ring o and para-position relatively high, and the electrophilic reagents are easy to attack these positions; while the halogen atom is the electron-absorbing group, which For example, when reacting with mixed acids of nitric acid and sulfuric acid, the nitro group will mainly replace the tert-butyl ortho and para-sites on the benzene ring.
Furthermore, the presence of tert-butyl affects the physical and chemical properties of the compound. Its large volume produces a steric hindrance effect. In chemical reactions, it will hinder the reagent from approaching a specific position in the benzene ring, affecting the reaction rate and selectivity. In space, restricting the tight accumulation between molecules affects the melting point and boiling point of the compound, usually making its melting boiling point lower than that of the non-bulky tert-butyl analogs. In conclusion, 1-iodo-2,3-dichloro-5- (tert-butyl) benzene exhibits rich chemical reactivity and unique physical properties due to the interaction of iodine, chlorine, tert-butyl and benzene ring, and has potential application value in organic synthesis, materials science and other fields.
What are the common synthesis methods for 1-iodo-2,3-dichloro-5- (tert-butyl) benzene?
1-Iodo-2,3-dichloro-5- (tert-butyl) benzene is an organic compound. There are several common methods for synthesis.
First, 2,3-dichloro-5- (tert-butyl) aniline is used as the starting material. The aniline is first reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. The diazonium salt is active and then reacts with potassium iodide, and the diazonium group is replaced by an iodine atom to obtain 1-iodo-2,3-dichloro-5- (tert-butyl) benzene. In this process, the diazotization reaction needs to be strictly controlled at temperature to prevent the decomposition of diazonium salts, which will cause the reaction to go out of control and reduce the yield.
Second, 2,3-dichloro-5- (tert-butyl) benzoic acid is used as the starting material. First, it is converted into the corresponding acid chloride, which is often used to react with sulfoxide chloride to obtain an acid chloride. After the Rosemond reduction reaction, palladium-barium sulfate is used as the catalyst to reduce the acid chloride to an aldehyde. Then, the aldehyde reacts with the iodoform reagent, and finally the target product can be obtained. This route is a little complicated, and the reaction conditions of each step need to be precisely controlled. For example, when Rosemond is reduced, the activity of the catalyst has a great influence on the reaction. If the activity is too high, it is easy to over-reduce, resulting in impure products.
Third, a suitable halogenated benzene derivative is used as the raw material. The tert-butyl group is introduced through the Fu-gram alkylation reaction, and then the chlorine atom and the iodine atom are introduced in sequence through the halogenation reaction. The Fu-gram alkylation reaction requires an anhydrous environment, and the selection of suitable catalysts and reaction solvents can improve the selectivity and yield of the reaction. During the halogenation reaction, the reaction conditions such as temperature and light have a significant impact on the location and quantity of halogen atoms introduced.
The synthesis of 1-iodo-2,3-dichloro-5- (tert-butyl) benzene has various advantages and disadvantages. In actual synthesis, the appropriate synthesis path should be carefully selected according to factors such as raw material availability, cost, reaction conditions and product purity requirements.
First, 2,3-dichloro-5- (tert-butyl) aniline is used as the starting material. The aniline is first reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. The diazonium salt is active and then reacts with potassium iodide, and the diazonium group is replaced by an iodine atom to obtain 1-iodo-2,3-dichloro-5- (tert-butyl) benzene. In this process, the diazotization reaction needs to be strictly controlled at temperature to prevent the decomposition of diazonium salts, which will cause the reaction to go out of control and reduce the yield.
Second, 2,3-dichloro-5- (tert-butyl) benzoic acid is used as the starting material. First, it is converted into the corresponding acid chloride, which is often used to react with sulfoxide chloride to obtain an acid chloride. After the Rosemond reduction reaction, palladium-barium sulfate is used as the catalyst to reduce the acid chloride to an aldehyde. Then, the aldehyde reacts with the iodoform reagent, and finally the target product can be obtained. This route is a little complicated, and the reaction conditions of each step need to be precisely controlled. For example, when Rosemond is reduced, the activity of the catalyst has a great influence on the reaction. If the activity is too high, it is easy to over-reduce, resulting in impure products.
Third, a suitable halogenated benzene derivative is used as the raw material. The tert-butyl group is introduced through the Fu-gram alkylation reaction, and then the chlorine atom and the iodine atom are introduced in sequence through the halogenation reaction. The Fu-gram alkylation reaction requires an anhydrous environment, and the selection of suitable catalysts and reaction solvents can improve the selectivity and yield of the reaction. During the halogenation reaction, the reaction conditions such as temperature and light have a significant impact on the location and quantity of halogen atoms introduced.
The synthesis of 1-iodo-2,3-dichloro-5- (tert-butyl) benzene has various advantages and disadvantages. In actual synthesis, the appropriate synthesis path should be carefully selected according to factors such as raw material availability, cost, reaction conditions and product purity requirements.
In what fields is 1-iodo-2,3-dichloro-5- (tert-butyl) benzene used?
1 - iodo - 2,3 - dichloro - 5 - (tert - butyl) benzene is an organic compound that has applications in many fields.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to its structure containing halogen atoms and tert-butyl, halogen atoms can participate in nucleophilic substitution reactions, and tert-butyl atoms can affect the spatial structure and electron cloud distribution of molecules. By means of nucleophilic substitution, coupling reactions, etc., chemists can use 1-iodo-2,3-dichloro-5- (tert-butyl) benzene as the starting material to construct more complex organic molecular structures, synthesize drug molecules with specific biological activities, or prepare materials with unique properties.
In the field of materials science, the compound also has potential uses. Its structural properties may endow materials with novel electrical, optical or thermal properties. For example, introducing it into the structure of polymer materials may change the solubility, crystallinity and stability of materials, and then be used to prepare special-purpose plastics, coatings or electronic materials to improve the specific properties of materials to meet different application needs.
In the field of medicinal chemistry, this compound may be used as a lead compound for drug development due to its unique chemical structure. Researchers can explore the interaction between the compound and biological targets by modifying and optimizing its structure, hoping to find drug candidates with high activity, high selectivity and low toxicity, providing a possible direction and basis for the creation of new drugs.
In addition, in organometallic chemistry, 1-iodo-2,3-dichloro-5- (tert-butyl) benzene can be used as a ligand precursor to coordinate with metal centers to form organometallic complexes. Such complexes may exhibit unique catalytic activity and selectivity in catalytic reactions, providing powerful tools for efficient organic synthesis reactions.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to its structure containing halogen atoms and tert-butyl, halogen atoms can participate in nucleophilic substitution reactions, and tert-butyl atoms can affect the spatial structure and electron cloud distribution of molecules. By means of nucleophilic substitution, coupling reactions, etc., chemists can use 1-iodo-2,3-dichloro-5- (tert-butyl) benzene as the starting material to construct more complex organic molecular structures, synthesize drug molecules with specific biological activities, or prepare materials with unique properties.
In the field of materials science, the compound also has potential uses. Its structural properties may endow materials with novel electrical, optical or thermal properties. For example, introducing it into the structure of polymer materials may change the solubility, crystallinity and stability of materials, and then be used to prepare special-purpose plastics, coatings or electronic materials to improve the specific properties of materials to meet different application needs.
In the field of medicinal chemistry, this compound may be used as a lead compound for drug development due to its unique chemical structure. Researchers can explore the interaction between the compound and biological targets by modifying and optimizing its structure, hoping to find drug candidates with high activity, high selectivity and low toxicity, providing a possible direction and basis for the creation of new drugs.
In addition, in organometallic chemistry, 1-iodo-2,3-dichloro-5- (tert-butyl) benzene can be used as a ligand precursor to coordinate with metal centers to form organometallic complexes. Such complexes may exhibit unique catalytic activity and selectivity in catalytic reactions, providing powerful tools for efficient organic synthesis reactions.
What are the physical properties of 1-iodo-2,3-dichloro-5- (tert-butyl) benzene?
1-Iodo-2,3-dichloro-5- (tert-butyl) benzene is an organic compound with unique physical properties. It is mostly liquid or solid at room temperature, depending on the intermolecular force and the relative molecular mass.
Looking at its appearance, the pure material may be a colorless to light yellow liquid or solid, but it actually contains impurities or has different colors.
Discusses the melting point and boiling point, the presence of iodine, chlorine atoms and tert-butyl groups in the molecule, and increases the intermolecular force. Iodine atoms have a large electron cloud, which can enhance the dispersion force; chlorine atoms have a large electronegativity, which can generate dipole-dipole interactions; tert-butyl is a large alkyl group, which increases the steric resistance and dispersion force of molecules. Therefore, its melting point and boiling point are higher than those of simple benzene derivatives, and the specific values vary depending on the exact structure and purity.
The density of this compound is greater than that of water, because its relative molecular weight is larger, and the halogen atom is heavy, and the molecules are tightly packed.
In terms of solubility, it is a non-polar or weakly polar organic compound. According to the principle of "similar phase dissolution", it is easily soluble in non-polar or weakly polar organic solvents, such as benzene, toluene, dichloromethane, etc., and has very little solubility in water. Because water is a strongly polar molecule, the intermolecular force between water and the compound is weak and difficult to miscible.
In addition, its volatility is low. Due to the strong intermolecular force, the molecule needs more energy to break away from the liquid surface, so it evaporates slowly at room temperature.
In conclusion, the physical properties of 1-iodo-2,3-dichloro-5- (tert-butyl) benzene are significantly affected by atoms and groups in the molecular structure, and understanding their properties is extremely important for related chemical research and applications.
Looking at its appearance, the pure material may be a colorless to light yellow liquid or solid, but it actually contains impurities or has different colors.
Discusses the melting point and boiling point, the presence of iodine, chlorine atoms and tert-butyl groups in the molecule, and increases the intermolecular force. Iodine atoms have a large electron cloud, which can enhance the dispersion force; chlorine atoms have a large electronegativity, which can generate dipole-dipole interactions; tert-butyl is a large alkyl group, which increases the steric resistance and dispersion force of molecules. Therefore, its melting point and boiling point are higher than those of simple benzene derivatives, and the specific values vary depending on the exact structure and purity.
The density of this compound is greater than that of water, because its relative molecular weight is larger, and the halogen atom is heavy, and the molecules are tightly packed.
In terms of solubility, it is a non-polar or weakly polar organic compound. According to the principle of "similar phase dissolution", it is easily soluble in non-polar or weakly polar organic solvents, such as benzene, toluene, dichloromethane, etc., and has very little solubility in water. Because water is a strongly polar molecule, the intermolecular force between water and the compound is weak and difficult to miscible.
In addition, its volatility is low. Due to the strong intermolecular force, the molecule needs more energy to break away from the liquid surface, so it evaporates slowly at room temperature.
In conclusion, the physical properties of 1-iodo-2,3-dichloro-5- (tert-butyl) benzene are significantly affected by atoms and groups in the molecular structure, and understanding their properties is extremely important for related chemical research and applications.
What are the storage conditions for 1-iodo-2,3-dichloro-5- (tert-butyl) benzene?
1 - iodo - 2, 3 - dichloro - 5 - (tert - butyl) benzene is an organic compound, and the conditions for its existence are quite important, which is related to its stability and quality.
This compound should be placed in a cool and dry place. In a cool place, it should be prevented from increasing molecular activity due to high temperature, triggering decomposition or deterioration. Under high temperature, molecular motion intensifies, chemical bonds are easily broken, resulting in changes in its chemical structure and loss of its original properties. A dry environment is also indispensable. Edge water can be used as a medium for many chemical reactions. If the compound encounters water or undergoes adverse reactions such as hydrolysis, its purity and properties will be affected.
And it should be placed in a dark place. Light contains energy, or causes the compound molecules to absorb light energy and jump to the excited state, triggering photochemical reactions, causing the compound to decompose or convert into other substances.
At the same time, the compound needs to be sealed and stored. Sealing can prevent it from contacting with gases such as oxygen and carbon dioxide in the air. Oxygen is oxidizing, or oxidizes the compound; carbon dioxide or reacts with some groups in the compound, causing its properties to change.
In addition, it needs to be kept away from fire and heat sources. Because it is an organic compound, it is mostly flammable, encountering open flames or hot topics, or causing combustion or even explosion, endangering safety.
To preserve 1-iodo-2,3-dichloro-5- (tert-butyl) benzene, it needs to be cool, dry, protected from light, sealed, and away from sources of ignition, so that its properties can be kept stable for subsequent use.
This compound should be placed in a cool and dry place. In a cool place, it should be prevented from increasing molecular activity due to high temperature, triggering decomposition or deterioration. Under high temperature, molecular motion intensifies, chemical bonds are easily broken, resulting in changes in its chemical structure and loss of its original properties. A dry environment is also indispensable. Edge water can be used as a medium for many chemical reactions. If the compound encounters water or undergoes adverse reactions such as hydrolysis, its purity and properties will be affected.
And it should be placed in a dark place. Light contains energy, or causes the compound molecules to absorb light energy and jump to the excited state, triggering photochemical reactions, causing the compound to decompose or convert into other substances.
At the same time, the compound needs to be sealed and stored. Sealing can prevent it from contacting with gases such as oxygen and carbon dioxide in the air. Oxygen is oxidizing, or oxidizes the compound; carbon dioxide or reacts with some groups in the compound, causing its properties to change.
In addition, it needs to be kept away from fire and heat sources. Because it is an organic compound, it is mostly flammable, encountering open flames or hot topics, or causing combustion or even explosion, endangering safety.
To preserve 1-iodo-2,3-dichloro-5- (tert-butyl) benzene, it needs to be cool, dry, protected from light, sealed, and away from sources of ignition, so that its properties can be kept stable for subsequent use.
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