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1-Tert-Butyl-4-(Chloromethyl)Benzene
Linshang Chemical
|
HS Code |
994665 |
| Name | 1-Tert-Butyl-4-(Chloromethyl)Benzene |
| Molecular Formula | C11H15Cl |
| Molecular Weight | 182.69 |
| Appearance | Liquid (usually) |
| Boiling Point | Approximately 224 - 226 °C |
| Density | Around 0.98 g/cm³ |
| Solubility | Insoluble in water, soluble in organic solvents like ethanol, ether |
| Flash Point | Probably around 87 °C |
| Vapor Pressure | Low at room temperature |
| Logp | Estimated to be relatively high, indicating lipophilicity |
As an accredited 1-Tert-Butyl-4-(Chloromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - tert - butyl - 4 - (chloromethyl)benzene: 500g in a sealed, corrosion - resistant chemical bottle. |
| Storage | 1 - tert - butyl - 4 - (chloromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage and vapor release. It is best stored in a dedicated chemical storage cabinet, clearly labeled, in accordance with local safety regulations to ensure safe handling and storage. |
| Shipping | 1 - tert - butyl - 4 - (chloromethyl)benzene is shipped in accordance with chemical transport regulations. It's packaged securely in suitable containers to prevent leakage during transit, ensuring safe delivery. |
Competitive 1-Tert-Butyl-4-(Chloromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 1-Tert-Butyl-4-(Chloromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-tert-butyl-4- (chloromethyl) benzene?
1-tert-butyl-4- (chloromethyl) benzene, this is an organic compound with interesting chemical properties.
First of all, its chloromethyl part has high reactivity. Due to the strong electronegativity of chlorine atoms, the carbon-chlorine bond electron cloud is biased towards chlorine, which makes chloromethyl carbons partially positively charged and vulnerable to nucleophilic attack. It is a nucleophilic substitution reaction that can occur. If it reacts with sodium alcohol, the chlorine atom is replaced by an alkoxy group to form a corresponding ether compound; when it reacts with sodium cyanide, the chlorine is replaced by a cyanide group, and the product can be hydrolyzed to obtain a carboxylic acid.
Furthermore, the phenyl ring of this compound also has unique properties. The phenyl ring has a conjugated system and is rich in electr However, due to the fact that both tert-butyl and chloromethyl are ortho-para-sites, electrophilic reagents often attack the ortho-sites and para-sites of benzene rings. For example, under the catalysis of Lewis acid, it can undergo halogenation reactions with halogenating agents, and Fu-gram acylation reactions with acyl halides.
In addition, although its tert-butyl is relatively stable, under certain conditions, such as strong acidity or high temperature environment, reactions such as carbon positive ion rearrangement may occur. However, such reaction conditions are more harsh. In short, 1-tert-butyl-4- (chloromethyl) benzene exhibits a variety of chemical properties due to the characteristics of different parts of its structure, and is widely used in the field of organic synthesis.
First of all, its chloromethyl part has high reactivity. Due to the strong electronegativity of chlorine atoms, the carbon-chlorine bond electron cloud is biased towards chlorine, which makes chloromethyl carbons partially positively charged and vulnerable to nucleophilic attack. It is a nucleophilic substitution reaction that can occur. If it reacts with sodium alcohol, the chlorine atom is replaced by an alkoxy group to form a corresponding ether compound; when it reacts with sodium cyanide, the chlorine is replaced by a cyanide group, and the product can be hydrolyzed to obtain a carboxylic acid.
Furthermore, the phenyl ring of this compound also has unique properties. The phenyl ring has a conjugated system and is rich in electr However, due to the fact that both tert-butyl and chloromethyl are ortho-para-sites, electrophilic reagents often attack the ortho-sites and para-sites of benzene rings. For example, under the catalysis of Lewis acid, it can undergo halogenation reactions with halogenating agents, and Fu-gram acylation reactions with acyl halides.
In addition, although its tert-butyl is relatively stable, under certain conditions, such as strong acidity or high temperature environment, reactions such as carbon positive ion rearrangement may occur. However, such reaction conditions are more harsh. In short, 1-tert-butyl-4- (chloromethyl) benzene exhibits a variety of chemical properties due to the characteristics of different parts of its structure, and is widely used in the field of organic synthesis.
What are the main uses of 1-tert-butyl-4- (chloromethyl) benzene?
1-tert-butyl-4- (chloromethyl) benzene has a wide range of uses and is a key intermediate in the field of organic synthesis.
The cover can undergo many reactions due to its active chloromethyl group, such as nucleophilic substitution. When it encounters alcohols, the chlorine atom in the chloromethyl group is easily replaced by the oxygen atom of the alcohol to form ether substances, which are essential for the synthesis of fine chemical products, such as the preparation of fragrances and pharmaceutical intermediates.
Furthermore, by reacting with nitrogen-containing nucleophiles, nitrogen-containing organic compounds can be obtained. Such compounds often show unique biological activities in the field of pesticide creation and can be used as basic raw materials for the research and development of insecticides and fungicides.
In the field of materials science, 1-tert-butyl-4- (chloromethyl) benzene is also useful. After a specific polymerization reaction, its structure can be introduced into the main chain or side chain of polymer materials to improve material properties, such as enhancing the affinity of materials with specific substances, so that it can be used in the field of separation membrane materials to selectively separate specific components from the mixed system.
In addition, in the preparation of surfactants, its active chloromethyl can participate in the reaction and build a surfactant with a unique structure, endowing the product with properties such as good emulsification and dispersion, and is widely used in daily chemical, petroleum extraction and other industries.
The cover can undergo many reactions due to its active chloromethyl group, such as nucleophilic substitution. When it encounters alcohols, the chlorine atom in the chloromethyl group is easily replaced by the oxygen atom of the alcohol to form ether substances, which are essential for the synthesis of fine chemical products, such as the preparation of fragrances and pharmaceutical intermediates.
Furthermore, by reacting with nitrogen-containing nucleophiles, nitrogen-containing organic compounds can be obtained. Such compounds often show unique biological activities in the field of pesticide creation and can be used as basic raw materials for the research and development of insecticides and fungicides.
In the field of materials science, 1-tert-butyl-4- (chloromethyl) benzene is also useful. After a specific polymerization reaction, its structure can be introduced into the main chain or side chain of polymer materials to improve material properties, such as enhancing the affinity of materials with specific substances, so that it can be used in the field of separation membrane materials to selectively separate specific components from the mixed system.
In addition, in the preparation of surfactants, its active chloromethyl can participate in the reaction and build a surfactant with a unique structure, endowing the product with properties such as good emulsification and dispersion, and is widely used in daily chemical, petroleum extraction and other industries.
What are the synthesis methods of 1-tert-butyl-4- (chloromethyl) benzene?
The synthesis method of 1-tert-butyl-4- (chloromethyl) benzene is described in the past books, and there are some numbers.
First, 4-tert-butyl benzyl alcohol is used as the starting material to interact with the chlorination reagent. For example, select thionyl chloride, add 4-tert-butyl benzyl alcohol to a suitable reaction vessel, and then slowly add thionyl chloride dropwise, and add an appropriate amount of catalyst, such as pyridine. At a specific temperature, usually between room temperature and moderate heating, it can fully react. In this reaction process, the chlorine atom of the thionyl chloride replaces the alcohol hydroxyl group, thereby generating 1-tert-butyl-4- (chloromethyl) benzene. After the reaction is completed, the product is purified by distillation, extraction, etc.
Second, 4-tert-butyltoluene is used as the raw material. First, the methyl is halogenated by halogenation reaction. Usually N-chlorosuccinimide (NCS) is used as a halogenating agent, and a small amount of initiator, such as benzoyl peroxide, is added to inert solvents such as carbon tetrachloride. Under light or heating conditions, the chlorine atom in the NCS will selectively replace the benzyl hydrogen of 4-tert-butyltoluene to generate 1-tert-butyl-4- (chloromethyl) benzene. After the reaction is completed, the pure product is obtained by means of silica gel column chromatography.
Third, using benzene and tert-butyl chloride as the starting material, 4-tert-butyl benzene was first prepared by Fu-gram alkylation reaction. In the reactor, benzene and an appropriate amount of anhydrous aluminum trichloride were added, and tert-butyl chloride was slowly added dropwise at low temperature. In this process, anhydrous aluminum trichloride was used as a catalyst to promote the electrophilic substitution reaction between tert-butyl positive ions and benzene to generate 4-tert-butyl benzene. Then, by a method similar to the above-mentioned 4-tert-butyl toluene halogenation, the benzyl position of 4-tert-butyl benzene was introduced into chloromethyl Finally, through a series of separation and purification operations, the target product was obtained.
First, 4-tert-butyl benzyl alcohol is used as the starting material to interact with the chlorination reagent. For example, select thionyl chloride, add 4-tert-butyl benzyl alcohol to a suitable reaction vessel, and then slowly add thionyl chloride dropwise, and add an appropriate amount of catalyst, such as pyridine. At a specific temperature, usually between room temperature and moderate heating, it can fully react. In this reaction process, the chlorine atom of the thionyl chloride replaces the alcohol hydroxyl group, thereby generating 1-tert-butyl-4- (chloromethyl) benzene. After the reaction is completed, the product is purified by distillation, extraction, etc.
Second, 4-tert-butyltoluene is used as the raw material. First, the methyl is halogenated by halogenation reaction. Usually N-chlorosuccinimide (NCS) is used as a halogenating agent, and a small amount of initiator, such as benzoyl peroxide, is added to inert solvents such as carbon tetrachloride. Under light or heating conditions, the chlorine atom in the NCS will selectively replace the benzyl hydrogen of 4-tert-butyltoluene to generate 1-tert-butyl-4- (chloromethyl) benzene. After the reaction is completed, the pure product is obtained by means of silica gel column chromatography.
Third, using benzene and tert-butyl chloride as the starting material, 4-tert-butyl benzene was first prepared by Fu-gram alkylation reaction. In the reactor, benzene and an appropriate amount of anhydrous aluminum trichloride were added, and tert-butyl chloride was slowly added dropwise at low temperature. In this process, anhydrous aluminum trichloride was used as a catalyst to promote the electrophilic substitution reaction between tert-butyl positive ions and benzene to generate 4-tert-butyl benzene. Then, by a method similar to the above-mentioned 4-tert-butyl toluene halogenation, the benzyl position of 4-tert-butyl benzene was introduced into chloromethyl Finally, through a series of separation and purification operations, the target product was obtained.
What are the precautions for storing and transporting 1-tert-butyl-4- (chloromethyl) benzene?
1-tert-butyl-4- (chloromethyl) benzene is also an organic compound. When storing and transporting, there are several precautions that need to be taken with care.
Bearing the brunt, because of its certain chemical activity, it is easy to cause danger when exposed to heat or open flames. Therefore, the storage place should be a cool and ventilated place, and away from fire and heat sources. The warehouse temperature should not be too high to prevent the compound from decomposing due to heat or causing other chemical reactions.
Furthermore, this substance may be harmful to the human body. Contact with the skin, eyes, or inhalation of its volatile gas can cause discomfort or even damage. When transporting and storing, operators must wear appropriate protective equipment, such as protective clothing, gloves and goggles, to ensure their own safety.
Because of its active chemical properties, storage should avoid mixing with oxidants, strong bases and other substances. Oxidants may cause the compound to oxidize, and contact with strong bases may also cause uncontrollable chemical reactions, causing fire, explosion and other hazards.
During transportation, the packaging must be firm to ensure that there is no risk of leakage. The transportation means selected should also comply with relevant regulations, and close attention should be paid during transportation to prevent package damage caused by impact and vibration. In the unfortunate event of a leak, it should be dealt with immediately according to the emergency plan, evacuate personnel, strictly prohibit fire from approaching, and use appropriate materials to absorb or collect leaks to prevent environmental pollution and cause safety accidents.
In summary, 1-tert-butyl-4- (chloromethyl) benzene must be stored and transported in strict accordance with regulations, paying attention to environmental conditions, personnel protection, item mixing, and packaging and transportation to ensure safety and avoid accidents.
Bearing the brunt, because of its certain chemical activity, it is easy to cause danger when exposed to heat or open flames. Therefore, the storage place should be a cool and ventilated place, and away from fire and heat sources. The warehouse temperature should not be too high to prevent the compound from decomposing due to heat or causing other chemical reactions.
Furthermore, this substance may be harmful to the human body. Contact with the skin, eyes, or inhalation of its volatile gas can cause discomfort or even damage. When transporting and storing, operators must wear appropriate protective equipment, such as protective clothing, gloves and goggles, to ensure their own safety.
Because of its active chemical properties, storage should avoid mixing with oxidants, strong bases and other substances. Oxidants may cause the compound to oxidize, and contact with strong bases may also cause uncontrollable chemical reactions, causing fire, explosion and other hazards.
During transportation, the packaging must be firm to ensure that there is no risk of leakage. The transportation means selected should also comply with relevant regulations, and close attention should be paid during transportation to prevent package damage caused by impact and vibration. In the unfortunate event of a leak, it should be dealt with immediately according to the emergency plan, evacuate personnel, strictly prohibit fire from approaching, and use appropriate materials to absorb or collect leaks to prevent environmental pollution and cause safety accidents.
In summary, 1-tert-butyl-4- (chloromethyl) benzene must be stored and transported in strict accordance with regulations, paying attention to environmental conditions, personnel protection, item mixing, and packaging and transportation to ensure safety and avoid accidents.
What are the effects of 1-tert-butyl-4- (chloromethyl) benzene on the environment and human health?
1-tert-butyl-4- (chloromethyl) benzene, this is an organic compound. Its impact on the environment and human health cannot be underestimated.
First, the impact on the environment. If it enters the natural environment, in the soil, it may affect the normal activities of soil microorganisms due to its own chemical properties. Soil microorganisms are of great significance to soil fertility and material circulation, and their activities are disturbed or cause soil ecological imbalance. Inflow into water bodies, because it is insoluble in water, may adhere to the surface of aquatic organisms, and then be ingested by organisms. In aquatic ecosystems, it is transmitted and enriched through the food chain, or affects many aquatic organisms. For example, it may interfere with the physiological functions of fish, resulting in decreased fertility and abnormal growth and development. And its chemical structure is stable, difficult to degrade naturally, and will exist in the environment for a long time, accumulating over time, and the harm will increase.
Re-discussion on the impact on human health. Inhaled through the respiratory tract, this compound may irritate the respiratory mucosa, causing coughing, asthma, and even cause respiratory inflammation. If exposed to the skin, it may be irritating, causing redness, swelling, itching, and allergies to the skin. Eating it by mistake is even more harmful, entering the digestive system, or damaging the gastrointestinal mucosa, causing symptoms such as nausea, vomiting, and abdominal pain. In the long run, according to relevant studies, it is speculated that because of its chloromethyl and other functional groups, or potential carcinogenicity, long-term exposure or increased risk of cancer. And because of its chemical properties, or interfere with the human endocrine system, affect the normal secretion and regulation of hormones,
In summary, 1-tert-butyl-4- (chloromethyl) benzene poses many potential threats to the environment and human health, and extra caution is required during production, use, and disposal to prevent it from escaping into the environment and endangering ecological and human well-being.
First, the impact on the environment. If it enters the natural environment, in the soil, it may affect the normal activities of soil microorganisms due to its own chemical properties. Soil microorganisms are of great significance to soil fertility and material circulation, and their activities are disturbed or cause soil ecological imbalance. Inflow into water bodies, because it is insoluble in water, may adhere to the surface of aquatic organisms, and then be ingested by organisms. In aquatic ecosystems, it is transmitted and enriched through the food chain, or affects many aquatic organisms. For example, it may interfere with the physiological functions of fish, resulting in decreased fertility and abnormal growth and development. And its chemical structure is stable, difficult to degrade naturally, and will exist in the environment for a long time, accumulating over time, and the harm will increase.
Re-discussion on the impact on human health. Inhaled through the respiratory tract, this compound may irritate the respiratory mucosa, causing coughing, asthma, and even cause respiratory inflammation. If exposed to the skin, it may be irritating, causing redness, swelling, itching, and allergies to the skin. Eating it by mistake is even more harmful, entering the digestive system, or damaging the gastrointestinal mucosa, causing symptoms such as nausea, vomiting, and abdominal pain. In the long run, according to relevant studies, it is speculated that because of its chloromethyl and other functional groups, or potential carcinogenicity, long-term exposure or increased risk of cancer. And because of its chemical properties, or interfere with the human endocrine system, affect the normal secretion and regulation of hormones,
In summary, 1-tert-butyl-4- (chloromethyl) benzene poses many potential threats to the environment and human health, and extra caution is required during production, use, and disposal to prevent it from escaping into the environment and endangering ecological and human well-being.
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