Linshang Chemical
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1-Tert-Butyl-5-Chloro-2-Methoxy-4-Nitrobenzene
Linshang Chemical
|
HS Code |
964618 |
| Chemical Formula | C11H14ClNO3 |
| Molecular Weight | 243.686 g/mol |
| Solubility In Water | Expected to be low (due to non - polar aromatic and alkyl groups) |
| Solubility In Organic Solvents | Likely soluble in common organic solvents like ethanol, acetone, dichloromethane |
| Vapor Pressure | Expected to be low (due to relatively large molecular size and lack of volatile functional groups) |
As an accredited 1-Tert-Butyl-5-Chloro-2-Methoxy-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 1 - tert - butyl - 5 - chloro - 2 - methoxy - 4 - nitrobenzene in a sealed, labeled bottle. |
| Storage | 1 - tert - butyl - 5 - chloro - 2 - methoxy - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent moisture absorption and evaporation. It should be separated from incompatible substances to avoid potential chemical reactions. |
| Shipping | 1 - tert - butyl - 5 - chloro - 2 - methoxy - 4 - nitrobenzene is shipped in sealed, corrosion - resistant containers. Packaging adheres to chemical transport regulations, ensuring secure transit to prevent spills and maintain product integrity. |
Competitive 1-Tert-Butyl-5-Chloro-2-Methoxy-4-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 1-Tert-Butyl-5-Chloro-2-Methoxy-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene?
1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene is an organic compound with unique chemical properties. Its molecules contain tert-butyl, chlorine atom, methoxy group and nitro group, and the interaction of various groups endows the compound with diverse properties.
Stability first. Because tert-butyl is a large alkyl group, it has a steric resistance effect and can stabilize the benzene ring structure to a certain extent. However, nitro is a strong electron-absorbing group, which will reduce the electron cloud density of the benzene ring and weaken the stability of the benzene ring. The methoxy group is an electron-supplying group, which can partially cancel the electron-withdrawing effect of the nitro group, but overall, the influence of the nitro group is still significant, resulting in poor stability of the compound and easy to react under specific conditions.
Let's talk about the reactivity. In view of the strong electron-absorbing effect of nitro groups, the electron cloud density of the benzene ring decreases, and the electrophilic substitution reaction activity decreases. For example, when performing electrophilic substitution reactions such as the Fu-G reaction, compared with benzene or alkylbenzene, the reaction conditions are more severe and the reaction rate is slower. However, due to the uneven distribution of electron cloud density on the benzene ring, a specific location will become an activity check point for the attack of nucleophiles, which is conducive to nucleophil For example, the carbon atom attached to the chlorine atom is more susceptible to attack by nucleophiles due to the influence of nitro electron absorption, and nucleophilic substitution occurs, and the chlorine atom can be replaced by other groups.
In terms of solubility, the compound contains methoxy groups and has a certain polarity. At the same time, the hydrocarbon group part in the molecule makes it have a certain lipid solubility. Therefore, it has a certain solubility in some polar organic solvents such as ethanol and acetone, and it also has a certain solubility in non-polar solvents such as n-hexane, but the solubility in water is extremely low. Because the polarity of the water molecule is quite different from the overall polarity of the compound, and there is no group that is conducive to forming hydrogen bonds with water.
In addition, the compound may have a certain degree of In case of a reducing agent, the nitro group may be reduced to form other groups such as amino groups, which will undergo chemical transformation.
In summary, the interaction of each group in the 1-tert-butyl-5-chloro-2-methoxy-4-nitrophenyl molecule has unique chemical properties. These properties need to be fully considered when applied in fields such as organic synthesis.
Stability first. Because tert-butyl is a large alkyl group, it has a steric resistance effect and can stabilize the benzene ring structure to a certain extent. However, nitro is a strong electron-absorbing group, which will reduce the electron cloud density of the benzene ring and weaken the stability of the benzene ring. The methoxy group is an electron-supplying group, which can partially cancel the electron-withdrawing effect of the nitro group, but overall, the influence of the nitro group is still significant, resulting in poor stability of the compound and easy to react under specific conditions.
Let's talk about the reactivity. In view of the strong electron-absorbing effect of nitro groups, the electron cloud density of the benzene ring decreases, and the electrophilic substitution reaction activity decreases. For example, when performing electrophilic substitution reactions such as the Fu-G reaction, compared with benzene or alkylbenzene, the reaction conditions are more severe and the reaction rate is slower. However, due to the uneven distribution of electron cloud density on the benzene ring, a specific location will become an activity check point for the attack of nucleophiles, which is conducive to nucleophil For example, the carbon atom attached to the chlorine atom is more susceptible to attack by nucleophiles due to the influence of nitro electron absorption, and nucleophilic substitution occurs, and the chlorine atom can be replaced by other groups.
In terms of solubility, the compound contains methoxy groups and has a certain polarity. At the same time, the hydrocarbon group part in the molecule makes it have a certain lipid solubility. Therefore, it has a certain solubility in some polar organic solvents such as ethanol and acetone, and it also has a certain solubility in non-polar solvents such as n-hexane, but the solubility in water is extremely low. Because the polarity of the water molecule is quite different from the overall polarity of the compound, and there is no group that is conducive to forming hydrogen bonds with water.
In addition, the compound may have a certain degree of In case of a reducing agent, the nitro group may be reduced to form other groups such as amino groups, which will undergo chemical transformation.
In summary, the interaction of each group in the 1-tert-butyl-5-chloro-2-methoxy-4-nitrophenyl molecule has unique chemical properties. These properties need to be fully considered when applied in fields such as organic synthesis.
What are the common synthetic methods of 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene?
The common synthesis methods of 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene have attracted much attention in the field of organic synthesis. The synthesis paths are diverse, each has its own advantages and disadvantages, and needs to be carefully selected according to the actual situation.
First, it can be started from suitable benzene derivatives. For example, using 1-tert-butyl-2-methoxybenzene as raw material, nitro is introduced through nitration reaction. This step of the reaction is often carried out under suitable temperature conditions with a mixed acid of concentrated nitric acid and concentrated sulfuric acid as nitrifying reagent. The nitric acid in the mixed acid provides nitro positive ions to attack the benzene ring. After electrophilic substitution, nitro is introduced at a specific position in the benzene ring to generate 1-tert-butyl-2-methoxy-4-nitrobenzene.
Then, the obtained product is chlorinated. Usually chlorine gas or chlorine-containing reagents, such as N-chlorosuccinimide (NCS), are used to achieve chlorination on the benzene ring under the action of light or initiator, and then the target product 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene is obtained.
Another approach is to start from 1-tert-butyl-4-nitrobenzene. It is first chlorinated with chlorination reagents to obtain 1-tert-butyl-5-chloro-4-nitrobenzene, and then methoxylated into methoxy groups. The methoxylation process involves the reaction of alkoxylating reagents such as sodium methoxide in appropriate solvents to achieve the synthesis of 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene.
Or, with 1-tert-butyl-5-chlorobenzene as the starting material, methoxylation is first followed by nitration, and the preparation of the target product can also be achieved. These many synthetic methods require consideration of the control of reaction conditions, the choice of reagents, and the trade-off between yield and purity to obtain the ideal synthetic effect.
First, it can be started from suitable benzene derivatives. For example, using 1-tert-butyl-2-methoxybenzene as raw material, nitro is introduced through nitration reaction. This step of the reaction is often carried out under suitable temperature conditions with a mixed acid of concentrated nitric acid and concentrated sulfuric acid as nitrifying reagent. The nitric acid in the mixed acid provides nitro positive ions to attack the benzene ring. After electrophilic substitution, nitro is introduced at a specific position in the benzene ring to generate 1-tert-butyl-2-methoxy-4-nitrobenzene.
Then, the obtained product is chlorinated. Usually chlorine gas or chlorine-containing reagents, such as N-chlorosuccinimide (NCS), are used to achieve chlorination on the benzene ring under the action of light or initiator, and then the target product 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene is obtained.
Another approach is to start from 1-tert-butyl-4-nitrobenzene. It is first chlorinated with chlorination reagents to obtain 1-tert-butyl-5-chloro-4-nitrobenzene, and then methoxylated into methoxy groups. The methoxylation process involves the reaction of alkoxylating reagents such as sodium methoxide in appropriate solvents to achieve the synthesis of 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene.
Or, with 1-tert-butyl-5-chlorobenzene as the starting material, methoxylation is first followed by nitration, and the preparation of the target product can also be achieved. These many synthetic methods require consideration of the control of reaction conditions, the choice of reagents, and the trade-off between yield and purity to obtain the ideal synthetic effect.
In what areas is 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene applied?
1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene is widely used in the field of chemical synthesis. In the field of organic synthesis, it is often an important intermediary. Because of its specific chemical structure, it can be converted into other valuable compounds through many chemical reactions.
In the field of pharmaceutical chemistry, or as a starting material for the creation of new drugs. By modifying the structure of this compound, molecules with specific pharmacological activities may be developed, which can be used to fight various diseases.
In the field of materials science, or its effectiveness may be demonstrated. Through appropriate synthesis methods, it may be able to be integrated into polymer materials to endow the materials with different properties, such as improving the stability and optical properties of the materials.
In addition, in dye chemistry, this compound may act as a precursor to the preparation of special dyes. Because of its chlorine, nitro and other functional groups, the prepared dyes may have unique color and dyeing properties.
In summary, 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene has potential application value in many fields such as chemicals, pharmaceuticals, materials and dyes, and is indeed a class of organic compounds worthy of further investigation.
In the field of pharmaceutical chemistry, or as a starting material for the creation of new drugs. By modifying the structure of this compound, molecules with specific pharmacological activities may be developed, which can be used to fight various diseases.
In the field of materials science, or its effectiveness may be demonstrated. Through appropriate synthesis methods, it may be able to be integrated into polymer materials to endow the materials with different properties, such as improving the stability and optical properties of the materials.
In addition, in dye chemistry, this compound may act as a precursor to the preparation of special dyes. Because of its chlorine, nitro and other functional groups, the prepared dyes may have unique color and dyeing properties.
In summary, 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene has potential application value in many fields such as chemicals, pharmaceuticals, materials and dyes, and is indeed a class of organic compounds worthy of further investigation.
What are the physical properties of 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene?
1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene is one of the organic compounds. Its physical properties are particularly important, and it is related to the application and characteristics of this compound.
Looking at its properties, it mostly shows a solid state under normal conditions, which is caused by intermolecular forces. Its melting point is also a key physical property. It has been experimentally determined that the melting point is in a specific temperature range. This value is crucial for identifying and purifying the compound. Different compounds have different melting points, so that they can be separated from the mixture.
Furthermore, the boiling point is also a consideration. Although the exact value of its boiling point varies slightly according to the experimental conditions, it is generally within a certain range. The boiling point reflects the volatility of a compound. The boiling point characteristic of this compound is of great significance in separation operations such as distillation.
In terms of solubility, 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene has a certain solubility in organic solvents such as ethanol and ether. Due to its molecular structure containing hydrophobic groups, its solubility in water is poor. This solubility characteristic can be used to select suitable solvents in the process of organic synthesis and extraction to achieve the purpose of separation and reaction.
Its density is also one of the physical properties. Compared with water, the relative density can help to judge its distribution in the liquid-liquid system. If the density is greater than that of water, it is in the lower layer when delaminating; otherwise, it is in the upper layer. This property is very useful in practical operations, such as liquid separation processes.
In addition, the color state of this compound is often colorless to light yellow, and this appearance characteristic can be used as the basis for preliminary identification. However, it should be noted that the color state may vary slightly due to the presence of impurities.
The physical properties of 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene, such as melting point, boiling point, solubility, density, and color state, are all crucial to its research, application, and treatment, and are important considerations in the field of organic chemistry.
Looking at its properties, it mostly shows a solid state under normal conditions, which is caused by intermolecular forces. Its melting point is also a key physical property. It has been experimentally determined that the melting point is in a specific temperature range. This value is crucial for identifying and purifying the compound. Different compounds have different melting points, so that they can be separated from the mixture.
Furthermore, the boiling point is also a consideration. Although the exact value of its boiling point varies slightly according to the experimental conditions, it is generally within a certain range. The boiling point reflects the volatility of a compound. The boiling point characteristic of this compound is of great significance in separation operations such as distillation.
In terms of solubility, 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene has a certain solubility in organic solvents such as ethanol and ether. Due to its molecular structure containing hydrophobic groups, its solubility in water is poor. This solubility characteristic can be used to select suitable solvents in the process of organic synthesis and extraction to achieve the purpose of separation and reaction.
Its density is also one of the physical properties. Compared with water, the relative density can help to judge its distribution in the liquid-liquid system. If the density is greater than that of water, it is in the lower layer when delaminating; otherwise, it is in the upper layer. This property is very useful in practical operations, such as liquid separation processes.
In addition, the color state of this compound is often colorless to light yellow, and this appearance characteristic can be used as the basis for preliminary identification. However, it should be noted that the color state may vary slightly due to the presence of impurities.
The physical properties of 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene, such as melting point, boiling point, solubility, density, and color state, are all crucial to its research, application, and treatment, and are important considerations in the field of organic chemistry.
What are the precautions in the preparation of 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene?
When preparing 1-tert-butyl-5-chloro-2-methoxy-4-nitrobenzene, many precautions need to be kept in mind.
The selection and treatment of raw materials is crucial. The purity of the raw materials used must be guaranteed, and impurities will seriously interfere with the reaction process and product purity. For example, tert-butyl reagents, chlorine-containing raw materials, methoxy-introducing reagents, and nitrogenation reagents must be strictly controlled. If the purity of the raw materials is not good, the subsequent separation and purification work will be difficult.
The reaction conditions cannot be ignored. Precise control of temperature is particularly important, and different reaction stages have different temperature requirements. If the temperature of the tert-butylation reaction is too high, it may lead to an increase in side reactions and the formation of unnecessary tert-butylation by-products; if the temperature is too low, the reaction rate will be slow and time-consuming. During the nitroylation reaction, the temperature is not properly controlled, and polynitro substitutions may be produced, which affects the formation of the target product. The reaction pressure also needs attention. Some reactions can only be carried out efficiently under specific pressures. The pressure deviation is too large, and the reaction is difficult to achieve the desired effect.
The choice of solvent is crucial. It not only needs to be able to dissolve the raw materials and products well, but also needs to have no negative effects on the reaction. For example, in the nucleophilic substitution reaction step, the selected solvent needs to be conducive to the activity of the nucleophilic test agent. If the solvent interacts with the nucleophilic reagent to reduce its activity, the reaction will not be able to proceed smoothly. At the same time, the physical properties such as boiling point and volatility of the solvent also need to be considered for subsequent product separation.
Monitoring during the reaction process is indispensable. Real-time monitoring of the reaction process by means of thin-layer chromatography (TLC) and gas chromatography (GC) can keep abreast of the degree of reaction progress. If the reaction is found to deviate from expectations, the reaction conditions can be adjusted in time, such as adding raw materials, changing temperature, etc., to avoid excessive or incomplete reaction, resulting in waste of raw materials and impure products.
Separation and purification stage should also not be taken lightly. After the reaction, the product is often mixed with impurities such as unreacted raw materials, by-products and solvents. It is extremely important to choose a suitable separation method. During extraction, the appropriate extractant should be selected according to the solubility difference between the product and the impurities in different solvents to ensure the effective separation of the product. When column chromatography separates, the appropriate adsorbent and eluent should be selected according to the polarity difference between the product and the impurities to achieve efficient separation.
In addition, safety issues run through. Many reaction reagents are toxic, corrosive or flammable and explosive, such as nitrogenation reagents, which are highly oxidizing and toxic. Safety procedures must be strictly followed during operation, wearing protective equipment, and carried out in a well-ventilated environment to prevent safety accidents.
The selection and treatment of raw materials is crucial. The purity of the raw materials used must be guaranteed, and impurities will seriously interfere with the reaction process and product purity. For example, tert-butyl reagents, chlorine-containing raw materials, methoxy-introducing reagents, and nitrogenation reagents must be strictly controlled. If the purity of the raw materials is not good, the subsequent separation and purification work will be difficult.
The reaction conditions cannot be ignored. Precise control of temperature is particularly important, and different reaction stages have different temperature requirements. If the temperature of the tert-butylation reaction is too high, it may lead to an increase in side reactions and the formation of unnecessary tert-butylation by-products; if the temperature is too low, the reaction rate will be slow and time-consuming. During the nitroylation reaction, the temperature is not properly controlled, and polynitro substitutions may be produced, which affects the formation of the target product. The reaction pressure also needs attention. Some reactions can only be carried out efficiently under specific pressures. The pressure deviation is too large, and the reaction is difficult to achieve the desired effect.
The choice of solvent is crucial. It not only needs to be able to dissolve the raw materials and products well, but also needs to have no negative effects on the reaction. For example, in the nucleophilic substitution reaction step, the selected solvent needs to be conducive to the activity of the nucleophilic test agent. If the solvent interacts with the nucleophilic reagent to reduce its activity, the reaction will not be able to proceed smoothly. At the same time, the physical properties such as boiling point and volatility of the solvent also need to be considered for subsequent product separation.
Monitoring during the reaction process is indispensable. Real-time monitoring of the reaction process by means of thin-layer chromatography (TLC) and gas chromatography (GC) can keep abreast of the degree of reaction progress. If the reaction is found to deviate from expectations, the reaction conditions can be adjusted in time, such as adding raw materials, changing temperature, etc., to avoid excessive or incomplete reaction, resulting in waste of raw materials and impure products.
Separation and purification stage should also not be taken lightly. After the reaction, the product is often mixed with impurities such as unreacted raw materials, by-products and solvents. It is extremely important to choose a suitable separation method. During extraction, the appropriate extractant should be selected according to the solubility difference between the product and the impurities in different solvents to ensure the effective separation of the product. When column chromatography separates, the appropriate adsorbent and eluent should be selected according to the polarity difference between the product and the impurities to achieve efficient separation.
In addition, safety issues run through. Many reaction reagents are toxic, corrosive or flammable and explosive, such as nitrogenation reagents, which are highly oxidizing and toxic. Safety procedures must be strictly followed during operation, wearing protective equipment, and carried out in a well-ventilated environment to prevent safety accidents.
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