Linshang Chemical
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2,3-Dichloro-4-Fluoronitrobenzene
Linshang Chemical
|
HS Code |
258739 |
| Chemical Formula | C6H2Cl2FNO2 |
| Molar Mass | 208.0 g/mol |
| Appearance | yellow - to - brown solid |
| Boiling Point | 247 - 249 °C |
| Melting Point | 34 - 38 °C |
| Density | 1.598 g/cm³ |
| Solubility In Water | insoluble |
| Solubility In Organic Solvents | soluble in many organic solvents like ethanol, acetone |
| Vapor Pressure | low vapor pressure |
| Flash Point | 109.8 °C |
| Stability | stable under normal conditions but reactive with strong oxidizing agents |
As an accredited 2,3-Dichloro-4-Fluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 25 - kg drum packaging for 2,3 - dichloro - 4 - fluoronitrobenzene chemical. |
| Storage | 2,3 - dichloro - 4 - fluoronitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat, flames, and oxidizing agents. Store in a tightly closed container, preferably made of corrosion - resistant materials. Avoid storing near incompatible substances to prevent potential reactions. Regularly check storage conditions to ensure product integrity. |
| Shipping | 2,3 - dichloro - 4 - fluoronitrobenzene is a chemical. It should be shipped in properly sealed containers, compliant with hazardous materials regulations, ensuring safety during transit to prevent leakage and potential hazards. |
Competitive 2,3-Dichloro-4-Fluoronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2,3-Dichloro-4-Fluoronitrobenzene in China?
As a trusted 2,3-Dichloro-4-Fluoronitrobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2,3-Dichloro-4-Fluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2,3-dichloro-4-fluoronitrobenzene?
2% 2C3-dihydro-4-methoxyphenylnaphthalene, although this substance is not detailed in Tiangong Kaiwu, it has important uses in the field of medicine and chemical industry.
In the field of medicine, it can be a key raw material for the creation of drugs. Due to its unique chemical structure, it can exhibit effects on specific biological targets, and then participate in the development of drugs for the treatment of various diseases. Taking some neurological disease drugs as an example, 2% 2C3-dihydro-4-methoxyphenylnaphthalene can be integrated into drug molecules through delicate design and transformation to help it act precisely on nerve cells, or regulate the transmission of neurotransmitters, or repair damaged nerve tissue, bringing hope for recovery to patients.
In the field of chemical industry, it also has outstanding performance. It can be used as an important intermediate for the synthesis of special materials. In the synthesis of polymer materials, the introduction of this structure can endow the material with unique physical and chemical properties. For example, to improve the stability and heat resistance of the material, so that it can still maintain good performance in high temperature or complex environments, and has great application potential in fields such as aerospace and electronics that require strict material properties. Or in fine chemical products, such as high-end coatings, fragrances, etc., its participation in the synthesis can endow the product with unique quality and characteristics and enhance the market competitiveness of the product.
It can be seen that although the use of 2% 2C3-dihydro-4-methoxyphenylnaphthalene was not clearly recorded in the ancient book "Tiangong Kaiwu", today, with its unique chemical properties, it plays a key role in many aspects of medicine and chemical industry, and contributes to human life and scientific and technological progress.
In the field of medicine, it can be a key raw material for the creation of drugs. Due to its unique chemical structure, it can exhibit effects on specific biological targets, and then participate in the development of drugs for the treatment of various diseases. Taking some neurological disease drugs as an example, 2% 2C3-dihydro-4-methoxyphenylnaphthalene can be integrated into drug molecules through delicate design and transformation to help it act precisely on nerve cells, or regulate the transmission of neurotransmitters, or repair damaged nerve tissue, bringing hope for recovery to patients.
In the field of chemical industry, it also has outstanding performance. It can be used as an important intermediate for the synthesis of special materials. In the synthesis of polymer materials, the introduction of this structure can endow the material with unique physical and chemical properties. For example, to improve the stability and heat resistance of the material, so that it can still maintain good performance in high temperature or complex environments, and has great application potential in fields such as aerospace and electronics that require strict material properties. Or in fine chemical products, such as high-end coatings, fragrances, etc., its participation in the synthesis can endow the product with unique quality and characteristics and enhance the market competitiveness of the product.
It can be seen that although the use of 2% 2C3-dihydro-4-methoxyphenylnaphthalene was not clearly recorded in the ancient book "Tiangong Kaiwu", today, with its unique chemical properties, it plays a key role in many aspects of medicine and chemical industry, and contributes to human life and scientific and technological progress.
What are the synthesis methods of 2,3-dichloro-4-fluoronitrobenzene?
To prepare 2,3-difluoro-4-cyanobenzyl, the method is as follows:
First, start with the compound containing cyanobenzyl group and benzyl group, and introduce fluorine atoms through halogenation reaction. First, take a suitable benzyl derivative, such as p-cyanobenzyl chloride, place it in a reactor, dissolve it in an appropriate amount of organic solvent, such as dichloromethane, at low temperature and in the presence of a catalyst, pass a fluorine-containing halogenation reagent, such as a mixture of hydrogen fluoride and antimony trifluoride, control the reaction temperature and time, so that the benzyl group is selectively halogenated ortho-to generate 2-fluoro-4-cyanobenzyl intermediate, and then introduce another fluorine atom under similar conditions to obtain the target product. This process requires fine regulation of the reaction conditions. Due to the high activity of fluorine atoms, improper operation is easy to cause polyhalogenation or side reactions.
Second, the cyanyl and benzyl structures are constructed with fluoroaromatic hydrocarbons as starting materials. Take 2,3-difluorotoluene, first convert the methyl group into a carboxyl group through oxidation reaction, and use potassium permanganate or potassium dichromate as an oxidant to react with an appropriate solvent and acid-base conditions to obtain 2,3-difluorobenzoic acid. Then the carboxyl group is converted into an acyl chloride, treated with sulfoxide chloride, and then nucleophilic substitution reaction occurs with cyanide reagents, such as cuprous cyanide, under the action of a suitable temperature and catalyst, and a cyano group is introduced to obtain 2,3-difluoro-4-cyanobenzyl. There are many steps in this path, but the reaction in each step is relatively mild and easy to control.
Third, it is synthesized by coupling reactions such as Suzuki coupling. First prepare fluorine-containing aromatic hydrocarbon borates with suitable substituents, and halobenzyl derivatives containing cyanide groups and conjugable groups. For example, prepare 2,3-difluorophenylboronic acid pinacol ester and 4-halo-2,3-difluorobenzyl nitrile (the halogen atom can be bromine or iodine), in the presence of palladium catalysts, such as tetra (triphenylphosphine) palladium (0), in alkaline solutions, such as potassium carbonate aqueous solutions, control the reaction temperature and time for coupling reactions, and separate and purify the product. This method has good selectivity, but the catalyst cost is high and the reaction conditions are demanding.
First, start with the compound containing cyanobenzyl group and benzyl group, and introduce fluorine atoms through halogenation reaction. First, take a suitable benzyl derivative, such as p-cyanobenzyl chloride, place it in a reactor, dissolve it in an appropriate amount of organic solvent, such as dichloromethane, at low temperature and in the presence of a catalyst, pass a fluorine-containing halogenation reagent, such as a mixture of hydrogen fluoride and antimony trifluoride, control the reaction temperature and time, so that the benzyl group is selectively halogenated ortho-to generate 2-fluoro-4-cyanobenzyl intermediate, and then introduce another fluorine atom under similar conditions to obtain the target product. This process requires fine regulation of the reaction conditions. Due to the high activity of fluorine atoms, improper operation is easy to cause polyhalogenation or side reactions.
Second, the cyanyl and benzyl structures are constructed with fluoroaromatic hydrocarbons as starting materials. Take 2,3-difluorotoluene, first convert the methyl group into a carboxyl group through oxidation reaction, and use potassium permanganate or potassium dichromate as an oxidant to react with an appropriate solvent and acid-base conditions to obtain 2,3-difluorobenzoic acid. Then the carboxyl group is converted into an acyl chloride, treated with sulfoxide chloride, and then nucleophilic substitution reaction occurs with cyanide reagents, such as cuprous cyanide, under the action of a suitable temperature and catalyst, and a cyano group is introduced to obtain 2,3-difluoro-4-cyanobenzyl. There are many steps in this path, but the reaction in each step is relatively mild and easy to control.
Third, it is synthesized by coupling reactions such as Suzuki coupling. First prepare fluorine-containing aromatic hydrocarbon borates with suitable substituents, and halobenzyl derivatives containing cyanide groups and conjugable groups. For example, prepare 2,3-difluorophenylboronic acid pinacol ester and 4-halo-2,3-difluorobenzyl nitrile (the halogen atom can be bromine or iodine), in the presence of palladium catalysts, such as tetra (triphenylphosphine) palladium (0), in alkaline solutions, such as potassium carbonate aqueous solutions, control the reaction temperature and time for coupling reactions, and separate and purify the product. This method has good selectivity, but the catalyst cost is high and the reaction conditions are demanding.
What are the physical properties of 2,3-dichloro-4-fluoronitrobenzene?
2% 2C3-difluoro-4-cyanobenzyl alcohol is a very important compound in the field of organic synthesis. Its physical properties are particularly critical, and it is related to its performance in various reactions and practical applications.
Looking at its properties, under normal temperature and pressure, 2% 2C3-difluoro-4-cyanobenzyl alcohol is mostly white to white solid. This morphological feature makes it more convenient to store and transport than liquid substances, and its stability is also good.
When it comes to melting point, the melting point of this compound is within a specific range. Accurate melting point data is crucial for its purity determination. Pure 2% 2C3-difluoro-4-cyanobenzyl alcohol has a relatively fixed melting point. If it contains impurities, the melting point may be deviated or the melting range may be widened. This is one of the effective means to identify its quality.
In terms of solubility, 2% 2C3-difluoro-4-cyanobenzyl alcohol exhibits certain solubility in organic solvents. Common organic solvents, such as dichloromethane, chloroform, tetrahydrofuran, etc., have different degrees of solubility. In dichloromethane, it can be well dissolved, which is of great significance in the operation of organic synthesis reactions. Because it can fully mix the reactants and promote the smooth progress of the reaction. However, in water, its solubility is poor due to the proportion and interaction of polar and non-polar parts in the molecular structure.
In addition, the density of 2% 2C3-difluoro-4-cyanobenzyl alcohol is also an important physical property. Although its density data is relatively fixed, it is indispensable to consider density in precise chemical production and experimental operations. In the process of material ratio, separation and purification, density factors will affect the final result.
In summary, the physical properties of 2% 2C3-difluoro-4-cyanobenzyl alcohol, including its morphology, melting point, solubility and density at room temperature, play a pivotal role in its application in many fields such as organic synthesis and drug development. In-depth understanding and precise grasp of its physical properties can more effectively exert its chemical value and promote the development and progress of related fields.
Looking at its properties, under normal temperature and pressure, 2% 2C3-difluoro-4-cyanobenzyl alcohol is mostly white to white solid. This morphological feature makes it more convenient to store and transport than liquid substances, and its stability is also good.
When it comes to melting point, the melting point of this compound is within a specific range. Accurate melting point data is crucial for its purity determination. Pure 2% 2C3-difluoro-4-cyanobenzyl alcohol has a relatively fixed melting point. If it contains impurities, the melting point may be deviated or the melting range may be widened. This is one of the effective means to identify its quality.
In terms of solubility, 2% 2C3-difluoro-4-cyanobenzyl alcohol exhibits certain solubility in organic solvents. Common organic solvents, such as dichloromethane, chloroform, tetrahydrofuran, etc., have different degrees of solubility. In dichloromethane, it can be well dissolved, which is of great significance in the operation of organic synthesis reactions. Because it can fully mix the reactants and promote the smooth progress of the reaction. However, in water, its solubility is poor due to the proportion and interaction of polar and non-polar parts in the molecular structure.
In addition, the density of 2% 2C3-difluoro-4-cyanobenzyl alcohol is also an important physical property. Although its density data is relatively fixed, it is indispensable to consider density in precise chemical production and experimental operations. In the process of material ratio, separation and purification, density factors will affect the final result.
In summary, the physical properties of 2% 2C3-difluoro-4-cyanobenzyl alcohol, including its morphology, melting point, solubility and density at room temperature, play a pivotal role in its application in many fields such as organic synthesis and drug development. In-depth understanding and precise grasp of its physical properties can more effectively exert its chemical value and promote the development and progress of related fields.
What is the market price of 2,3-dichloro-4-fluoronitrobenzene?
I have not heard of the market value of "2,3-difluoro-4-cyanobenzyl". However, if you want to know the price of this product, you need to look at various reasons.
First, the price of raw materials has a serious impact. If all the raw materials required for its preparation are readily available and affordable, the cost of this product may be low, and its price may be low; if the raw materials are rare and expensive, the cost must be high, and its market price should not be low.
Second, the method of preparation and the difficulty are also related to its price. If the preparation method is simple and requires less manpower, material resources, and financial resources, the price may be moderate; if the preparation process is complicated, exquisite equipment, rare reagents are required, and multiple steps are time-consuming, the price will be high.
Third, the situation of market supply and demand is necessary. If there are many people seeking this product, but there are few suppliers, the merchant will be rare and expensive, and the price will rise; if the supply exceeds the demand, the merchant will sell its goods, or reduce the price to promote it.
Fourth, the origin and transportation also involve its price. The origin is close to the city, the transportation is convenient, and the cost is saved, the price may be low; if the origin is remote, the transportation is difficult, and the cost is huge, the price may be high.
There is also a difference in quality. High-quality ones meet strict standards, and the price may be higher than that of regular products. And different merchants have different pricing due to different business strategies and cost calculations.
Therefore, if you want to determine the market price of "2,3-difluoro-4-cyanobenzyl", you should carefully consider the raw materials, production methods, supply and demand, transportation, quality, etc., and then you can get a more accurate price.
First, the price of raw materials has a serious impact. If all the raw materials required for its preparation are readily available and affordable, the cost of this product may be low, and its price may be low; if the raw materials are rare and expensive, the cost must be high, and its market price should not be low.
Second, the method of preparation and the difficulty are also related to its price. If the preparation method is simple and requires less manpower, material resources, and financial resources, the price may be moderate; if the preparation process is complicated, exquisite equipment, rare reagents are required, and multiple steps are time-consuming, the price will be high.
Third, the situation of market supply and demand is necessary. If there are many people seeking this product, but there are few suppliers, the merchant will be rare and expensive, and the price will rise; if the supply exceeds the demand, the merchant will sell its goods, or reduce the price to promote it.
Fourth, the origin and transportation also involve its price. The origin is close to the city, the transportation is convenient, and the cost is saved, the price may be low; if the origin is remote, the transportation is difficult, and the cost is huge, the price may be high.
There is also a difference in quality. High-quality ones meet strict standards, and the price may be higher than that of regular products. And different merchants have different pricing due to different business strategies and cost calculations.
Therefore, if you want to determine the market price of "2,3-difluoro-4-cyanobenzyl", you should carefully consider the raw materials, production methods, supply and demand, transportation, quality, etc., and then you can get a more accurate price.
What are the precautions for storing and transporting 2,3-dichloro-4-fluoronitrobenzene?
2% 2C3-difluoro-4-methoxyphenyl needs to pay attention to many key matters during storage and transportation to ensure its quality and safety.
First, the storage place must be dry and well ventilated. This substance is susceptible to moisture intrusion. If the storage environment humidity is high, or it may cause chemical reactions, resulting in quality deterioration. Therefore, a dry and well-ventilated place should be selected to avoid contact with humid air.
Second, temperature control is essential. It needs to be placed in a cool place, away from heat sources and open flames. Because it is more sensitive to temperature, high temperature environment may damage its stability and even trigger dangerous reactions. The ideal storage temperature should be maintained in a specific range. Different substances may vary. For such chemicals, it is usually 5 ° C - 25 ° C.
Third, when storing, it should be stored separately from oxidants, acids, bases and other substances. 2% 2C3-difluoro-4-methoxyphenyl is chemically active. Contact with the above substances or severe chemical reaction occurs, resulting in serious consequences such as fire and explosion.
Fourth, during transportation, the packaging must be tight. Choose suitable packaging materials to ensure that there is no leakage during transportation bumps. The packaging should have good sealing and pressure resistance, commonly used such as special plastic drums or metal drums, and supplemented by buffer materials to avoid collision damage.
Fifth, the transport vehicle should meet the standards for the transportation of hazardous chemicals. Equipped with corresponding safety facilities and emergency treatment equipment, such as fire extinguishers, leakage emergency treatment tools, etc. Transport personnel also need to undergo professional training, familiar with the characteristics of the substance and emergency treatment methods to deal with emergencies.
First, the storage place must be dry and well ventilated. This substance is susceptible to moisture intrusion. If the storage environment humidity is high, or it may cause chemical reactions, resulting in quality deterioration. Therefore, a dry and well-ventilated place should be selected to avoid contact with humid air.
Second, temperature control is essential. It needs to be placed in a cool place, away from heat sources and open flames. Because it is more sensitive to temperature, high temperature environment may damage its stability and even trigger dangerous reactions. The ideal storage temperature should be maintained in a specific range. Different substances may vary. For such chemicals, it is usually 5 ° C - 25 ° C.
Third, when storing, it should be stored separately from oxidants, acids, bases and other substances. 2% 2C3-difluoro-4-methoxyphenyl is chemically active. Contact with the above substances or severe chemical reaction occurs, resulting in serious consequences such as fire and explosion.
Fourth, during transportation, the packaging must be tight. Choose suitable packaging materials to ensure that there is no leakage during transportation bumps. The packaging should have good sealing and pressure resistance, commonly used such as special plastic drums or metal drums, and supplemented by buffer materials to avoid collision damage.
Fifth, the transport vehicle should meet the standards for the transportation of hazardous chemicals. Equipped with corresponding safety facilities and emergency treatment equipment, such as fire extinguishers, leakage emergency treatment tools, etc. Transport personnel also need to undergo professional training, familiar with the characteristics of the substance and emergency treatment methods to deal with emergencies.
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