Linshang Chemical
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2,4,5-Trichlorobenzenesulphonyl Chloride
Linshang Chemical
|
HS Code |
101083 |
| Chemical Formula | C6H2Cl4O2S |
| Molecular Weight | 289.95 g/mol |
| Appearance | Solid (usually white to off - white) |
| Physical State At Room Temp | Solid |
| Boiling Point | Decomposes before boiling |
| Melting Point | 105 - 107 °C |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Odor | Pungent odor |
| Stability | Unstable in the presence of water and moisture, hydrolyzes |
| Hazard Class | Corrosive, harmful if swallowed, in contact with skin or if inhaled |
As an accredited 2,4,5-Trichlorobenzenesulphonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 - kg bottle of 2,4,5 - trichlorobenzenesulphonyl Chloride with secure chemical - resistant packaging. |
| Storage | 2,4,5 - Trichlorobenzenesulphonyl Chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat, flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to moisture, which could lead to decomposition and potential safety hazards. |
| Shipping | 2,4,5 - Trichlorobenzenesulphonyl Chloride is a hazardous chemical. Shipping requires proper packaging in accordance with regulations, like in sealed, corrosion - resistant containers. It must be labeled clearly and transported by approved carriers following strict safety protocols. |
Competitive 2,4,5-Trichlorobenzenesulphonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 2,4,5-trichlorobenzenesulfonyl chloride?
2% 2C4% 2C5-trifluorobenzoic anhydride is an important reagent in organic synthesis. It has a wide range of main uses and plays a key role in many fields.
In the field of drug synthesis, this reagent can participate in the construction process of many drug molecules. Due to its unique chemical structure, the fluorine atoms in it have special electronic effects and physiological activities, which can significantly change the properties of drug molecules, such as enhancing the lipid solubility of drugs, promoting their absorption and transport in vivo, and then improving the efficacy of drugs. For example, in the synthesis path of some antidepressants and antiviral drugs, 2% 2C4% 2C5-trifluorobenzoic anhydride is a key intermediate, which contributes greatly to the construction and modification of drug molecules.
In the field of materials science, it also has important functions. It can be used to prepare polymer materials with special properties. By virtue of its polymerization with other monomers, it can endow polymer materials with unique properties, such as excellent heat resistance, chemical stability and corrosion resistance. In aerospace, electronics and other fields that require strict material properties, such polymer materials prepared by 2% 2C4% 2C5 -trifluorobenzoic anhydride are very useful.
Furthermore, in the study of organic synthesis chemistry, 2% 2C4% 2C5 -trifluorobenzoic anhydride is often used as an acylating agent. It can acylate with alcohols, amines and other compounds, and efficiently introduce acyl functional groups, thus providing a convenient and effective way for the synthesis of various complex organic compounds. In the total synthesis of many natural products and the creation of new organic compounds, this property is frequently used to help chemists achieve precise synthesis and structural modification of target compounds.
In short, 2% 2C4% 2C5 -trifluorobenzoic anhydride occupies an indispensable position in the development process of modern chemistry and related industries due to its diverse and important uses.
In the field of drug synthesis, this reagent can participate in the construction process of many drug molecules. Due to its unique chemical structure, the fluorine atoms in it have special electronic effects and physiological activities, which can significantly change the properties of drug molecules, such as enhancing the lipid solubility of drugs, promoting their absorption and transport in vivo, and then improving the efficacy of drugs. For example, in the synthesis path of some antidepressants and antiviral drugs, 2% 2C4% 2C5-trifluorobenzoic anhydride is a key intermediate, which contributes greatly to the construction and modification of drug molecules.
In the field of materials science, it also has important functions. It can be used to prepare polymer materials with special properties. By virtue of its polymerization with other monomers, it can endow polymer materials with unique properties, such as excellent heat resistance, chemical stability and corrosion resistance. In aerospace, electronics and other fields that require strict material properties, such polymer materials prepared by 2% 2C4% 2C5 -trifluorobenzoic anhydride are very useful.
Furthermore, in the study of organic synthesis chemistry, 2% 2C4% 2C5 -trifluorobenzoic anhydride is often used as an acylating agent. It can acylate with alcohols, amines and other compounds, and efficiently introduce acyl functional groups, thus providing a convenient and effective way for the synthesis of various complex organic compounds. In the total synthesis of many natural products and the creation of new organic compounds, this property is frequently used to help chemists achieve precise synthesis and structural modification of target compounds.
In short, 2% 2C4% 2C5 -trifluorobenzoic anhydride occupies an indispensable position in the development process of modern chemistry and related industries due to its diverse and important uses.
What are the physical properties of 2,4,5-trichlorobenzenesulfonyl chloride?
2% 2C4% ethyl 2C5-trifluorobenzoate, this material has unique physicochemical properties. It is a colorless to light yellow transparent liquid with a light taste and a clear and translucent appearance.
The boiling point is about 195-197 ° C. This boiling point value makes it gradually change from liquid to gaseous at a specific temperature environment. When vaporizing, it needs to be heated to provide enough energy to overcome intermolecular forces. The melting point is about -22 ° C. At low temperatures, it condenses into a solid state, and the molecular arrangement changes from disorder to order, showing a solid-state stable structure.
Its density is about 1.325g/cm ³, which is slightly higher than the density of common water, so if placed in water, it will sink underwater. Its solubility is soluble in most organic solvents, such as ethanol, ether, etc., but it is difficult to dissolve in water. This is because the molecular structure of the fluorine atom has a high electronegativity, which makes the molecular polarity different from water. According to the principle of similar compatibility, it is difficult to dissolve in water, but has good compatibility with organic solvents.
In addition, 2% 2C4% 2C5-trifluorobenzoate ethyl ester has high chemical stability. Due to the strong electronegativity of fluorine atoms, the C-F bond energy increases, the molecular structure becomes stable, and it is not easy to chemically react with common substances. However, under specific conditions, such as strong acid, strong base or high temperature catalysis, its ester groups can undergo hydrolysis, alcoholysis and other reactions, showing unique chemical activity.
The boiling point is about 195-197 ° C. This boiling point value makes it gradually change from liquid to gaseous at a specific temperature environment. When vaporizing, it needs to be heated to provide enough energy to overcome intermolecular forces. The melting point is about -22 ° C. At low temperatures, it condenses into a solid state, and the molecular arrangement changes from disorder to order, showing a solid-state stable structure.
Its density is about 1.325g/cm ³, which is slightly higher than the density of common water, so if placed in water, it will sink underwater. Its solubility is soluble in most organic solvents, such as ethanol, ether, etc., but it is difficult to dissolve in water. This is because the molecular structure of the fluorine atom has a high electronegativity, which makes the molecular polarity different from water. According to the principle of similar compatibility, it is difficult to dissolve in water, but has good compatibility with organic solvents.
In addition, 2% 2C4% 2C5-trifluorobenzoate ethyl ester has high chemical stability. Due to the strong electronegativity of fluorine atoms, the C-F bond energy increases, the molecular structure becomes stable, and it is not easy to chemically react with common substances. However, under specific conditions, such as strong acid, strong base or high temperature catalysis, its ester groups can undergo hydrolysis, alcoholysis and other reactions, showing unique chemical activity.
What are the chemical properties of 2,4,5-trichlorobenzenesulfonyl chloride?
2% 2C4% 2C5-trifluorobenzoic acid trifluoroethyl ester, this is an organic compound. Its chemical properties are quite critical and of great significance to many fields.
First of all, it has a certain stability. This stability is derived from the characteristics of fluorine atoms in the molecular structure. Fluorine atoms are extremely electronegative, and the bond energy formed with carbon atoms is very strong, which makes the molecular structure stable and not easy to decompose or react easily due to common external factors.
Furthermore, its solubility is also worthy of attention. In organic solvents, it exhibits a certain solubility. Due to the fluoroalkyl group in the molecule, the fluoroalkyl group is hydrophobic, so the compound can have a good solubility in some organic solvents, such as common chloroform, dichloromethane, etc. However, the solubility in water is not good. Because the polarity of the water molecule is incompatible with the hydrophobic fluoroalkyl group of the compound.
In addition, its acidity cannot be ignored. The structure of benzoic acid makes it acidic. Under certain conditions, acid-base reactions can occur, giving protons. This acidic property can act as a catalyst or participate in acid-base equilibrium-related reactions, helping to regulate the process and direction of the reaction.
In terms of chemical reactivity, various reactions can occur due to different groups in the molecule. For example, the ester moiety can undergo hydrolysis reaction, and under acid-base catalysis, react with water to form corresponding acids and alcohols; while the aromatic ring moiety can undergo electrophilic substitution reaction, and under appropriate reagents and conditions, other substituents can be introduced into the aromatic ring, thereby expanding the variety and application range of its derived compounds. In short, the rich chemical properties of 2% 2C4% 2C5-trifluorobenzoate provide many possibilities for research and application in organic synthesis and related fields.
First of all, it has a certain stability. This stability is derived from the characteristics of fluorine atoms in the molecular structure. Fluorine atoms are extremely electronegative, and the bond energy formed with carbon atoms is very strong, which makes the molecular structure stable and not easy to decompose or react easily due to common external factors.
Furthermore, its solubility is also worthy of attention. In organic solvents, it exhibits a certain solubility. Due to the fluoroalkyl group in the molecule, the fluoroalkyl group is hydrophobic, so the compound can have a good solubility in some organic solvents, such as common chloroform, dichloromethane, etc. However, the solubility in water is not good. Because the polarity of the water molecule is incompatible with the hydrophobic fluoroalkyl group of the compound.
In addition, its acidity cannot be ignored. The structure of benzoic acid makes it acidic. Under certain conditions, acid-base reactions can occur, giving protons. This acidic property can act as a catalyst or participate in acid-base equilibrium-related reactions, helping to regulate the process and direction of the reaction.
In terms of chemical reactivity, various reactions can occur due to different groups in the molecule. For example, the ester moiety can undergo hydrolysis reaction, and under acid-base catalysis, react with water to form corresponding acids and alcohols; while the aromatic ring moiety can undergo electrophilic substitution reaction, and under appropriate reagents and conditions, other substituents can be introduced into the aromatic ring, thereby expanding the variety and application range of its derived compounds. In short, the rich chemical properties of 2% 2C4% 2C5-trifluorobenzoate provide many possibilities for research and application in organic synthesis and related fields.
What are the synthesis methods of 2,4,5-trichlorobenzenesulfonyl chloride?
2% 2C4% 2C5-trifluorobenzoic acid is an important intermediate in organic synthesis. There are many synthesis methods, which are described in detail below.
One is a fluorination method using 2,4,5-trichlorobenzoic acid as raw material. This is a classic method in which 2,4,5-trichlorobenzoic acid is reacted with a fluorinating agent, such as potassium fluoride, in a specific solvent, such as dimethyl sulfoxide, under the action of a catalyst at high temperature. The reaction mechanism is that fluorine atoms replace chlorine atoms to form the target product. The advantage of this method is that the raw materials are easily available and the reaction route is clear; however, there are also disadvantages. For example, the reaction conditions are harsh, high temperature and high pressure are required, and the catalyst is expensive and costly.
The second is a direct fluorination method using benzoic acid as the starting material. By selecting a specific fluorination reagent, such as Selectfluor, under appropriate reaction conditions, the benzene ring of benzoic acid is directly fluorinated, and then fluorine atoms are introduced to generate 2,4,5-trifluorobenzoic acid. The advantage of this method is that the steps are relatively simple and the atomic economy is high; however, the control of the reaction conditions is very strict, and the selectivity and activity of fluorinated reagents need to be precisely regulated, otherwise it is easy to produce side reactions and affect the purity and yield of the product.
The third is the Grignard reagent method using halogenated aromatics as raw materials. Grignard reagents are first prepared from halogenated aromatics, then react with carbon dioxide to form corresponding aryl carboxylic acids, and finally fluorine atoms are introduced through fluorination reactions. This approach is highly flexible and can be adjusted according to different raw materials and reaction conditions; however, the preparation process of Grignard reagent is cumbersome, requires an anhydrous and anaerobic environment, and requires high operation requirements.
Many of the above synthesis methods have their own advantages and disadvantages. In practical applications, factors such as raw material cost, reaction conditions, product purity and yield need to be comprehensively considered, and the best one should be selected to achieve efficient synthesis of 2,4,5-trifluorobenzoic acid.
One is a fluorination method using 2,4,5-trichlorobenzoic acid as raw material. This is a classic method in which 2,4,5-trichlorobenzoic acid is reacted with a fluorinating agent, such as potassium fluoride, in a specific solvent, such as dimethyl sulfoxide, under the action of a catalyst at high temperature. The reaction mechanism is that fluorine atoms replace chlorine atoms to form the target product. The advantage of this method is that the raw materials are easily available and the reaction route is clear; however, there are also disadvantages. For example, the reaction conditions are harsh, high temperature and high pressure are required, and the catalyst is expensive and costly.
The second is a direct fluorination method using benzoic acid as the starting material. By selecting a specific fluorination reagent, such as Selectfluor, under appropriate reaction conditions, the benzene ring of benzoic acid is directly fluorinated, and then fluorine atoms are introduced to generate 2,4,5-trifluorobenzoic acid. The advantage of this method is that the steps are relatively simple and the atomic economy is high; however, the control of the reaction conditions is very strict, and the selectivity and activity of fluorinated reagents need to be precisely regulated, otherwise it is easy to produce side reactions and affect the purity and yield of the product.
The third is the Grignard reagent method using halogenated aromatics as raw materials. Grignard reagents are first prepared from halogenated aromatics, then react with carbon dioxide to form corresponding aryl carboxylic acids, and finally fluorine atoms are introduced through fluorination reactions. This approach is highly flexible and can be adjusted according to different raw materials and reaction conditions; however, the preparation process of Grignard reagent is cumbersome, requires an anhydrous and anaerobic environment, and requires high operation requirements.
Many of the above synthesis methods have their own advantages and disadvantages. In practical applications, factors such as raw material cost, reaction conditions, product purity and yield need to be comprehensively considered, and the best one should be selected to achieve efficient synthesis of 2,4,5-trifluorobenzoic acid.
What are the precautions for using 2,4,5-trichlorobenzenesulfonyl chloride?
2% 2C4% 2C5-trifluorobenzoic anhydride is a chemical substance. When using it, many things need to be paid attention to.
First, safety protection must be comprehensive. This substance is corrosive and irritating to a certain extent, and can cause harm when it comes into contact with the human body. Therefore, when using it, you must wear suitable protective equipment, such as protective gloves, goggles, lab clothes, etc., to prevent it from coming into contact with the skin and eyes. If you come into contact accidentally, you should immediately rinse with plenty of water and seek medical treatment in time.
Second, storage conditions are also critical. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, and protected from direct sunlight. At the same time, it should be stored separately from oxidants and alkalis, and should not be mixed to avoid dangerous chemical reactions.
Third, the operation must be standardized during use. When taking it, the dosage should be precisely controlled to avoid waste and unnecessary risks. Operate in the fume hood to ensure air circulation, discharge volatile gases in time, reduce the concentration of harmful substances in the air, and ensure the safety of operators.
Fourth, its chemical reaction characteristics should be well known. 2% 2C4% 2C5 -trifluorobenzoic anhydride will react with a variety of substances. Before use, it is necessary to clarify the reaction mechanism and conditions with other reagents used, and strictly follow the operating procedures to prevent accidents caused by uncontrolled reactions.
Fifth, waste disposal should not be sloppy. After use, the remaining substances and waste should be properly disposed of in accordance with relevant regulations and should not be discarded at will to prevent pollution to the environment. Generally speaking, it needs to be disposed of by a professional treatment agency. Only with caution in all aspects of use can the safe and effective use of 2% 2C4% 2C5-trifluorobenzoic anhydride be ensured.
First, safety protection must be comprehensive. This substance is corrosive and irritating to a certain extent, and can cause harm when it comes into contact with the human body. Therefore, when using it, you must wear suitable protective equipment, such as protective gloves, goggles, lab clothes, etc., to prevent it from coming into contact with the skin and eyes. If you come into contact accidentally, you should immediately rinse with plenty of water and seek medical treatment in time.
Second, storage conditions are also critical. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, and protected from direct sunlight. At the same time, it should be stored separately from oxidants and alkalis, and should not be mixed to avoid dangerous chemical reactions.
Third, the operation must be standardized during use. When taking it, the dosage should be precisely controlled to avoid waste and unnecessary risks. Operate in the fume hood to ensure air circulation, discharge volatile gases in time, reduce the concentration of harmful substances in the air, and ensure the safety of operators.
Fourth, its chemical reaction characteristics should be well known. 2% 2C4% 2C5 -trifluorobenzoic anhydride will react with a variety of substances. Before use, it is necessary to clarify the reaction mechanism and conditions with other reagents used, and strictly follow the operating procedures to prevent accidents caused by uncontrolled reactions.
Fifth, waste disposal should not be sloppy. After use, the remaining substances and waste should be properly disposed of in accordance with relevant regulations and should not be discarded at will to prevent pollution to the environment. Generally speaking, it needs to be disposed of by a professional treatment agency. Only with caution in all aspects of use can the safe and effective use of 2% 2C4% 2C5-trifluorobenzoic anhydride be ensured.
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