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2-(4-Chloro-2-Nitrobenzene)-Methyl Malonate
Linshang Chemical
|
HS Code |
254403 |
| Chemical Formula | C10H8ClNO6 |
| Molar Mass | 275.627 g/mol |
| Appearance | Solid (usually) |
| Physical State At Room Temp | Solid |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in some organic solvents like dichloromethane |
| Melting Point | Data - specific value needed from literature |
| Boiling Point | Data - specific value needed from literature |
| Density | Data - specific value needed from literature |
| Pka | Data - specific value needed from literature |
As an accredited 2-(4-Chloro-2-Nitrobenzene)-Methyl Malonate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2-(4 - chloro - 2 - nitrobenzene) - methyl Malonate in sealed chemical - grade bags. |
| Storage | Store 2-(4 - chloro - 2 - nitrobenzene) - methyl malonate in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container to prevent exposure to air and moisture. Separate it from incompatible substances like oxidizing agents and bases to avoid potential reactions. |
| Shipping | 2-(4 - chloro - 2 - nitrobenzene) - methyl Malonate is shipped in well - sealed containers, following strict chemical transportation regulations. Packaging ensures protection from damage, with special care for its potentially hazardous nature during transit. |
Competitive 2-(4-Chloro-2-Nitrobenzene)-Methyl Malonate prices that fit your budget—flexible terms and customized quotes for every order.
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2- (4-chloro-2-nitrobenzene) - What is the main use of methyl Malonate?
2 - (4-chloro-2-nitrobenzene) -methylmalonic acid ester, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. It can ingeniously construct complex organic compounds through a series of delicate chemical reactions.
It plays a pivotal role in the field of medicinal chemistry. With its unique chemical structure, it can derive compounds with specific biological activities, paving the way for the creation of new drugs. Scientists can carefully adjust the physical and chemical properties and biological activities of compounds by modifying and modifying their structures to meet the stringent needs of drug development.
In the field of materials science, it also shows unique value. Can participate in the preparation of materials with special properties, such as optical materials, electrical materials, etc. Because of its chemical structure, materials can be endowed with unique photoelectric properties, which can be used in optoelectronic devices, sensors and many other aspects, injecting new vitality into the development of materials science.
In addition, in pesticide chemistry, it also has outstanding performance. It can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides, providing strong support for agricultural pest control and helping the stable development of agriculture. In short, 2 - (4-chloro-2-nitrobenzene) -methylmalonate plays an important role in many fields, promoting the progress and development of various fields.
It plays a pivotal role in the field of medicinal chemistry. With its unique chemical structure, it can derive compounds with specific biological activities, paving the way for the creation of new drugs. Scientists can carefully adjust the physical and chemical properties and biological activities of compounds by modifying and modifying their structures to meet the stringent needs of drug development.
In the field of materials science, it also shows unique value. Can participate in the preparation of materials with special properties, such as optical materials, electrical materials, etc. Because of its chemical structure, materials can be endowed with unique photoelectric properties, which can be used in optoelectronic devices, sensors and many other aspects, injecting new vitality into the development of materials science.
In addition, in pesticide chemistry, it also has outstanding performance. It can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides, providing strong support for agricultural pest control and helping the stable development of agriculture. In short, 2 - (4-chloro-2-nitrobenzene) -methylmalonate plays an important role in many fields, promoting the progress and development of various fields.
What are the physical properties of 2- (4-chloro-2-nitrobenzene) -methyl Malonate
The physical properties of 2-% (4-chloro-2-nitrobenzene) -methylmalonic acid ester are very important, which is related to its experimental operation and application.
Its appearance is mostly solid, and the color may be white to light yellow, which is convenient for preliminary identification and observation in experiments.
In terms of melting point, it has been determined by many experiments and is roughly in a certain temperature range, but the specific value is affected by factors such as sample purity. The melting point is the temperature at which a substance changes from a solid state to a liquid state. For this compound, its melting point characteristics help to identify the purity and control the phase state under specific temperature conditions.
Solubility is also a key physical property. In organic solvents, such as common ethanol, ether, etc., it has a certain solubility. This property makes it easy to dissolve in suitable solvents as a reactant in organic synthesis reactions to promote the smooth progress of the reaction. In water, its solubility is relatively poor, which is related to the hydrophilicity of the functional groups contained in the molecular structure.
Density is also an important physical parameter. Although the exact value varies depending on the precise measurement conditions, it is roughly within a specific range. Density determines the distribution of the substance in different systems. When mixing solutions or involving operations such as stratification, the density characteristics are of important guiding significance.
In addition, the compound may have a certain odor, but the strength and characteristics of the odor are also affected by the environment and concentration. Its volatility is relatively low, and it is less lost due to volatilization at room temperature and pressure, which is conducive to storage and operation.
The above physical properties are of great significance in the fields of organic synthesis and chemical analysis. Experimenters can reasonably design reaction, separation and purification schemes according to their characteristics to achieve the expected chemical purposes.
Its appearance is mostly solid, and the color may be white to light yellow, which is convenient for preliminary identification and observation in experiments.
In terms of melting point, it has been determined by many experiments and is roughly in a certain temperature range, but the specific value is affected by factors such as sample purity. The melting point is the temperature at which a substance changes from a solid state to a liquid state. For this compound, its melting point characteristics help to identify the purity and control the phase state under specific temperature conditions.
Solubility is also a key physical property. In organic solvents, such as common ethanol, ether, etc., it has a certain solubility. This property makes it easy to dissolve in suitable solvents as a reactant in organic synthesis reactions to promote the smooth progress of the reaction. In water, its solubility is relatively poor, which is related to the hydrophilicity of the functional groups contained in the molecular structure.
Density is also an important physical parameter. Although the exact value varies depending on the precise measurement conditions, it is roughly within a specific range. Density determines the distribution of the substance in different systems. When mixing solutions or involving operations such as stratification, the density characteristics are of important guiding significance.
In addition, the compound may have a certain odor, but the strength and characteristics of the odor are also affected by the environment and concentration. Its volatility is relatively low, and it is less lost due to volatilization at room temperature and pressure, which is conducive to storage and operation.
The above physical properties are of great significance in the fields of organic synthesis and chemical analysis. Experimenters can reasonably design reaction, separation and purification schemes according to their characteristics to achieve the expected chemical purposes.
What is the synthesis method of 2- (4-chloro-2-nitrobenzene) -methyl Malonate
To prepare 2 - (4 - chloro - 2 - nitrobenzene) - methylmalonate, the method is as follows:
First take 4 - chloro - 2 - nitrobenzaldehyde, which is the starting material. Mix it with malonate in a suitable solvent, such as ethanol or toluene. Add an appropriate amount of base as a catalyst, usually piperidine or pyridine. The effect of base is to promote the reaction and cause the condensation reaction of the two to occur. During the reaction, the temperature should be controlled in an appropriate range, usually about 50 - 80 degrees Celsius. This temperature range is conducive to the smooth occurrence of the reaction and can avoid excessive side reactions.
After condensation reaction, 2 - (4 - chloro - 2 - nitrophenylmethylene) -methylmalonate can be obtained. Then the product is further catalyzed for hydrogenation. Select a suitable catalyst, such as palladium carbon catalyst, and react under hydrogen atmosphere. The reaction is carried out under certain pressure and temperature conditions, with a pressure of about 1 - 3 atmospheres and a temperature of about 30 - 60 degrees Celsius. In this process, the double bond on the methylene is hydrogenated and reduced, and finally 2 - (4 - chloro - 2 - nitrobenzene) -methylmalonate is obtained. Throughout the synthesis process, it is necessary to pay attention to the precise control of the reaction conditions, and the purity of the raw materials and reagents is also crucial, so that the target product with higher yield and purity can be obtained.
First take 4 - chloro - 2 - nitrobenzaldehyde, which is the starting material. Mix it with malonate in a suitable solvent, such as ethanol or toluene. Add an appropriate amount of base as a catalyst, usually piperidine or pyridine. The effect of base is to promote the reaction and cause the condensation reaction of the two to occur. During the reaction, the temperature should be controlled in an appropriate range, usually about 50 - 80 degrees Celsius. This temperature range is conducive to the smooth occurrence of the reaction and can avoid excessive side reactions.
After condensation reaction, 2 - (4 - chloro - 2 - nitrophenylmethylene) -methylmalonate can be obtained. Then the product is further catalyzed for hydrogenation. Select a suitable catalyst, such as palladium carbon catalyst, and react under hydrogen atmosphere. The reaction is carried out under certain pressure and temperature conditions, with a pressure of about 1 - 3 atmospheres and a temperature of about 30 - 60 degrees Celsius. In this process, the double bond on the methylene is hydrogenated and reduced, and finally 2 - (4 - chloro - 2 - nitrobenzene) -methylmalonate is obtained. Throughout the synthesis process, it is necessary to pay attention to the precise control of the reaction conditions, and the purity of the raw materials and reagents is also crucial, so that the target product with higher yield and purity can be obtained.
2- (4-chloro-2-nitrobenzene) - methyl Malonate during storage
When storing 2-% 284-chloro-2-nitrobenzene% 29-methylmalonate, many things need to be paid attention to. This compound is chemically active, and its storage environment is very critical.
Temperature and humidity of the first environment. It should be stored in a cool and dry place to prevent the reaction from being accelerated due to excessive temperature, or adverse reactions such as hydrolysis due to excessive humidity. High temperature can easily enhance the activity of molecules, or cause decomposition, polymerization, etc.; high humidity may damage its structure and affect quality.
Secondary is to avoid light. Light or photochemical reactions change its chemical structure. It should be stored in a light-shielding container, such as a brown bottle, to reduce the influence of light.
Furthermore, it needs to be isolated from other chemicals. Because it contains specific functional groups, or reacts with oxidizing and reducing substances, as well as acids and bases. If it coexists with strong oxidants, or has a violent oxidation reaction, it will cause dangerous accidents.
At the same time, the storage place must be well ventilated. If it volatilizes and produces harmful gases, good ventilation can be discharged in time, reducing the concentration in the air and reducing the harm to personnel and the environment.
In addition, the storage container should be well sealed. To prevent contact with air, avoid oxidation caused by oxygen, or reaction with carbon dioxide, water vapor, etc. And the material of the container needs to be adapted and does not react with the compound. For example, some plastic materials or interact with specific chemicals, suitable glass and metal containers should be selected.
During storage, regular inspection is also indispensable. Check the packaging for damage, leakage, and changes in the properties of the compound, such as color and odor, so as to detect problems and deal with them in time.
Temperature and humidity of the first environment. It should be stored in a cool and dry place to prevent the reaction from being accelerated due to excessive temperature, or adverse reactions such as hydrolysis due to excessive humidity. High temperature can easily enhance the activity of molecules, or cause decomposition, polymerization, etc.; high humidity may damage its structure and affect quality.
Secondary is to avoid light. Light or photochemical reactions change its chemical structure. It should be stored in a light-shielding container, such as a brown bottle, to reduce the influence of light.
Furthermore, it needs to be isolated from other chemicals. Because it contains specific functional groups, or reacts with oxidizing and reducing substances, as well as acids and bases. If it coexists with strong oxidants, or has a violent oxidation reaction, it will cause dangerous accidents.
At the same time, the storage place must be well ventilated. If it volatilizes and produces harmful gases, good ventilation can be discharged in time, reducing the concentration in the air and reducing the harm to personnel and the environment.
In addition, the storage container should be well sealed. To prevent contact with air, avoid oxidation caused by oxygen, or reaction with carbon dioxide, water vapor, etc. And the material of the container needs to be adapted and does not react with the compound. For example, some plastic materials or interact with specific chemicals, suitable glass and metal containers should be selected.
During storage, regular inspection is also indispensable. Check the packaging for damage, leakage, and changes in the properties of the compound, such as color and odor, so as to detect problems and deal with them in time.
2- (4-chloro-2-nitrobenzene) - What are the safety precautions when using methyl Malonate
2-% (4-chloro-2-nitrobenzene) -methylmalonate is a matter of safety and should be treated with caution. This chemical is dangerous, and its toxicity should not be underestimated, or it has many hazards to the human body. When exposed, be fully armed and wear suitable protective clothing, such as protective clothing and gloves, to prevent it from touching the skin, causing damage to the skin, or even percutaneous absorption, endangering health. Eye protection is also essential. Wear protective glasses to avoid splashing into the eyes and causing eye damage.
The operating environment should be well ventilated. If used in a confined space, its volatile gas will accumulate, or the risk of poisoning will increase greatly. The place of use should be equipped with perfect ventilation equipment to disperse harmful gases in time and keep the air fresh.
Furthermore, its chemical properties are lively, and it can be mixed with other substances or react violently. When using, read the instructions and related materials carefully to clarify what substances it will react with and avoid contact with contraindicated substances. When storing, it should also be stored separately according to its characteristics, away from fire and heat sources, to prevent it from being dangerous due to heat and fire.
When using this chemical, use precise equipment and operate it strictly according to the specified dosage to avoid uncontrolled reaction due to improper dosage and cause safety accidents. After use, properly dispose of the remaining items and waste, follow relevant environmental protection and safety regulations, and do not discard them at will, so as not to pollute the environment and endanger the safety of others. In short, the use of 2 -% (4 - chloro - 2 - nitrobenzene) -methylmalonate requires constant vigilance and strict adherence to safety procedures to ensure safe operation.
The operating environment should be well ventilated. If used in a confined space, its volatile gas will accumulate, or the risk of poisoning will increase greatly. The place of use should be equipped with perfect ventilation equipment to disperse harmful gases in time and keep the air fresh.
Furthermore, its chemical properties are lively, and it can be mixed with other substances or react violently. When using, read the instructions and related materials carefully to clarify what substances it will react with and avoid contact with contraindicated substances. When storing, it should also be stored separately according to its characteristics, away from fire and heat sources, to prevent it from being dangerous due to heat and fire.
When using this chemical, use precise equipment and operate it strictly according to the specified dosage to avoid uncontrolled reaction due to improper dosage and cause safety accidents. After use, properly dispose of the remaining items and waste, follow relevant environmental protection and safety regulations, and do not discard them at will, so as not to pollute the environment and endanger the safety of others. In short, the use of 2 -% (4 - chloro - 2 - nitrobenzene) -methylmalonate requires constant vigilance and strict adherence to safety procedures to ensure safe operation.
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