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2,4-Dichlorobenzene-1-Sulfonyl Chloride
Linshang Chemical
|
HS Code |
870489 |
| Chemical Formula | C6H3Cl3O2S |
| Molecular Weight | 245.51 |
| Appearance | Typically a solid |
| Color | May be white to off - white |
| Odor | Pungent odor |
| Melting Point | Specific value would need further research |
| Boiling Point | Specific value would need further research |
| Solubility In Water | Low solubility in water |
| Solubility In Organic Solvents | Soluble in many organic solvents like dichloromethane |
| Density | Specific value would need further research |
| Hazard Class | Corrosive, harmful if swallowed or in contact with skin and eyes |
As an accredited 2,4-Dichlorobenzene-1-Sulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 2,4 - dichlorobenzene - 1 - sulfonyl chloride in sealed chemical - grade packaging. |
| Storage | 2,4 - dichlorobenzene - 1 - sulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture absorption and decomposition. It's advisable to store it in a dedicated chemical storage cabinet, separated from incompatible substances to ensure safety. |
| Shipping | 2,4 - dichlorobenzene - 1 - sulfonyl chloride, a hazardous chemical, is shipped in tightly sealed, corrosion - resistant containers. It must comply with strict regulations, often via specialized carriers, ensuring safe transport to prevent leakage and exposure. |
Competitive 2,4-Dichlorobenzene-1-Sulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What are the physical properties of 2,4-dichlorobenzene-1-sulfonyl chloride?
2% 2C4-difluorobenzene-1-sulfonyl fluoride is a kind of organic compound. Its physical properties are unique.
Looking at its properties, under normal temperature and pressure, it is mostly colorless to slightly yellow liquid, clear and transparent, like a clear spring, without suspended impurities disturbing its purity.
As for the smell, this substance emits a weak and special smell, but it is by no means pungent and unpleasant. It is like a faint fragrance, hidden in the air, and can only be detected by careful sniffing.
When it comes to the boiling point, it is about a certain temperature range. The value of this temperature makes it sublimate from liquid to gaseous state under specific conditions, realizing the transformation of phase state. The melting point is in another numerical range. When the temperature drops to this range, it will condense from liquid to solid, just like water turns into ice when it encounters cold, and the shape changes but the essence remains unchanged.
In terms of density, it also has its specific value. Compared with common substances such as water, it is either light or heavy, which determines its floating and sinking situation in the mixed system. And its solubility is quite unique. In some organic solvents, it can be mutually soluble in a certain proportion, just like fish and water, but its solubility in water is extremely limited, just like the incompatibility of oil and water, and it is distinct.
These physical properties are their inherent characteristics, just like human nature, which determine their performance in various chemical reactions and practical applications. It is relied on by scientific research and industrial production.
Looking at its properties, under normal temperature and pressure, it is mostly colorless to slightly yellow liquid, clear and transparent, like a clear spring, without suspended impurities disturbing its purity.
As for the smell, this substance emits a weak and special smell, but it is by no means pungent and unpleasant. It is like a faint fragrance, hidden in the air, and can only be detected by careful sniffing.
When it comes to the boiling point, it is about a certain temperature range. The value of this temperature makes it sublimate from liquid to gaseous state under specific conditions, realizing the transformation of phase state. The melting point is in another numerical range. When the temperature drops to this range, it will condense from liquid to solid, just like water turns into ice when it encounters cold, and the shape changes but the essence remains unchanged.
In terms of density, it also has its specific value. Compared with common substances such as water, it is either light or heavy, which determines its floating and sinking situation in the mixed system. And its solubility is quite unique. In some organic solvents, it can be mutually soluble in a certain proportion, just like fish and water, but its solubility in water is extremely limited, just like the incompatibility of oil and water, and it is distinct.
These physical properties are their inherent characteristics, just like human nature, which determine their performance in various chemical reactions and practical applications. It is relied on by scientific research and industrial production.
What are the chemical properties of 2,4-dichlorobenzene-1-sulfonyl chloride?
2% 2C4-difluorobenzene-1-sulfonyl fluoride is an organic compound with the following chemical properties:
First, it has high nucleophilic substitution activity. The sulfonyl fluoride base in this molecule is active and vulnerable to attack by various nucleophilic reagents. Taking alcohols as an example, with the help of bases, the oxygen atom of the alcohol acts as a nucleophilic center, which can attack the sulfur atom of the sulfonyl fluoride group, and then let the fluoride ions leave to form sulfonate esters. This reaction is often used in organic synthesis to build ester bonds and is widely used in the fields of drug synthesis and material preparation. Another example is amine nucleophiles, which can undergo nucleophilic substitution with sulfonyl fluoride groups to produce sulfonamide compounds. These compounds are key structural units in medicinal chemistry, and many drug molecules contain this structure, which can be efficiently synthesized by this reaction.
Second, it can participate in the fluorination reaction. Since the molecule itself contains fluorine atoms, it can participate in the fluorination reaction as a fluorine source under specific conditions. When there are suitable reaction substrates and catalysts, it can transfer its own fluorine atoms to other molecules to introduce fluorine atoms into the target molecule. The introduction of fluorine atoms often significantly changes the physical and chemical properties of molecules, such as increasing the lipid solubility of molecules, improving the ability of drug molecules to cross biofilms, and enhancing the binding force between drugs and targets. It is of great significance in the development of new fluorinated drugs.
Third, it has a certain degree of oxidation. Sulfur in the sulfonyl fluoride group is in a higher oxidation state, so that the compound has a certain degree of oxidation. In some reaction systems, it can oxidize specific functional groups. For example, some low-priced metal ions can be oxidized to undergo a reduction reaction on their own. This oxidation property is used to regulate the reaction process or to achieve some special oxidation conversion reactions, but usually the reaction conditions need to be controlled to avoid excessive oxidation leading to increased side reactions.
First, it has high nucleophilic substitution activity. The sulfonyl fluoride base in this molecule is active and vulnerable to attack by various nucleophilic reagents. Taking alcohols as an example, with the help of bases, the oxygen atom of the alcohol acts as a nucleophilic center, which can attack the sulfur atom of the sulfonyl fluoride group, and then let the fluoride ions leave to form sulfonate esters. This reaction is often used in organic synthesis to build ester bonds and is widely used in the fields of drug synthesis and material preparation. Another example is amine nucleophiles, which can undergo nucleophilic substitution with sulfonyl fluoride groups to produce sulfonamide compounds. These compounds are key structural units in medicinal chemistry, and many drug molecules contain this structure, which can be efficiently synthesized by this reaction.
Second, it can participate in the fluorination reaction. Since the molecule itself contains fluorine atoms, it can participate in the fluorination reaction as a fluorine source under specific conditions. When there are suitable reaction substrates and catalysts, it can transfer its own fluorine atoms to other molecules to introduce fluorine atoms into the target molecule. The introduction of fluorine atoms often significantly changes the physical and chemical properties of molecules, such as increasing the lipid solubility of molecules, improving the ability of drug molecules to cross biofilms, and enhancing the binding force between drugs and targets. It is of great significance in the development of new fluorinated drugs.
Third, it has a certain degree of oxidation. Sulfur in the sulfonyl fluoride group is in a higher oxidation state, so that the compound has a certain degree of oxidation. In some reaction systems, it can oxidize specific functional groups. For example, some low-priced metal ions can be oxidized to undergo a reduction reaction on their own. This oxidation property is used to regulate the reaction process or to achieve some special oxidation conversion reactions, but usually the reaction conditions need to be controlled to avoid excessive oxidation leading to increased side reactions.
What are the main uses of 2,4-dichlorobenzene-1-sulfonyl chloride?
2% 2C4-difluorobenzene-1-sulfonyl fluoride is a key raw material in the field of organic synthesis and has important uses in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate. The construction of many drug molecules requires this as the starting material. Through a series of organic reactions, specific functional groups are introduced to shape the specific structure of the drug molecule and endow the drug with unique pharmacological activity. For example, when developing some new antibacterial drugs, 2% 2C4-difluorobenzene-1-sulfonyl fluoride can participate in the reaction to build a core skeleton. After modification, the drug can precisely act on the specific target of the pathogen and inhibit the growth and reproduction of the pathogen.
In the field of materials science, it also plays an important role. In the preparation of high-performance fluoropolymer materials, 2% 2C4-difluorobenzene-1-sulfonyl fluoride can be introduced into the polymer backbone as a modified monomer. In this way, the polymer is endowed with excellent chemical stability, weather resistance and low surface energy. Such fluoropolymer materials are widely used in high-end fields such as aerospace, electronics and electrical appliances. Sealing materials and coating materials used in aerospace fields can be modified to adapt to extreme environments and ensure the safe and stable operation of aircraft.
In pesticide chemistry, it is an important raw material for the synthesis of new and efficient pesticides. By rationally designing the reaction path, it is converted into pesticide ingredients with specific biological activities. Such pesticides have high selectivity and high-efficiency killing ability for pests, while having little impact on the environment, which meets the needs of modern green pesticide development. Some new pesticides, synthesized based on 2% 2C4-difluorobenzene-1-sulfonyl fluoride, can effectively control crop pests and ensure agricultural harvest.
In the field of medicinal chemistry, it is often used as a key intermediate. The construction of many drug molecules requires this as the starting material. Through a series of organic reactions, specific functional groups are introduced to shape the specific structure of the drug molecule and endow the drug with unique pharmacological activity. For example, when developing some new antibacterial drugs, 2% 2C4-difluorobenzene-1-sulfonyl fluoride can participate in the reaction to build a core skeleton. After modification, the drug can precisely act on the specific target of the pathogen and inhibit the growth and reproduction of the pathogen.
In the field of materials science, it also plays an important role. In the preparation of high-performance fluoropolymer materials, 2% 2C4-difluorobenzene-1-sulfonyl fluoride can be introduced into the polymer backbone as a modified monomer. In this way, the polymer is endowed with excellent chemical stability, weather resistance and low surface energy. Such fluoropolymer materials are widely used in high-end fields such as aerospace, electronics and electrical appliances. Sealing materials and coating materials used in aerospace fields can be modified to adapt to extreme environments and ensure the safe and stable operation of aircraft.
In pesticide chemistry, it is an important raw material for the synthesis of new and efficient pesticides. By rationally designing the reaction path, it is converted into pesticide ingredients with specific biological activities. Such pesticides have high selectivity and high-efficiency killing ability for pests, while having little impact on the environment, which meets the needs of modern green pesticide development. Some new pesticides, synthesized based on 2% 2C4-difluorobenzene-1-sulfonyl fluoride, can effectively control crop pests and ensure agricultural harvest.
What are the synthesis methods of 2,4-dichlorobenzene-1-sulfonyl chloride?
To prepare 2,4-dichlorobenzene-1-sulfonyl chloride, there are several synthesis methods:
First, benzene is used as the starting material. First, benzene and chlorine are substituted under the catalysis of iron trichloride to obtain chlorobenzene. Chlorobenzene is then reacted with chlorine, and after ingenious control of the reaction conditions, 2,4-dichlorobenzene can be obtained. Subsequently, 2,4-dichlorobenzene is co-heated with fuming sulfuric acid to achieve sulfonation and generate 2,4-dichlorobenzene sulfonic acid. Finally, 2,4-dichlorobenzene sulfonic acid interacts with phosphorus pentachloride, and the hydroxyl group in the sulfonic acid group is replaced by chlorine, and then 2,4-dichlorobenzene This process step is slightly complicated, but the raw material benzene is easy to obtain, and the cost may be controllable.
Second, toluene is used as the starting point. Toluene is first substituted with chlorine under light, and the hydrogen on the methyl group is replaced by chlorine to obtain benzyl chloride. Benzyl chloride is then substituted with chlorine under the action of the catalyst, and chlorine atoms at the 2,4 position can be introduced. After that, the chlorine atoms in the side chain are hydrolyzed to hydroxyl groups, which are then oxidized to carboxyl groups. Next, the carboxyl group is converted to acyl chloride, and the benzene ring is sulfonated at the same time. After appropriate steps are adjusted, the target product can be obtained. Although this approach has many steps, toluene is also a common raw material, and each step of the reaction has a mature method in organic synthesis. As long
Third, p-chlorotoluene is used as the starting material. P-chlorotoluene is first sulfonated, a sulfonic acid group is introduced at the ortho-position of p-methyl, and then the methyl is oxidized to a carboxyl group, and then the carboxyl group is converted to an acid chloride. Finally, under suitable conditions, chlorine atoms are introduced at the unsubstituted position on the benzene ring to obtain 2,4-dichlorobenzene-1-sulfonyl chloride. The starting material of this method is slightly special, but if the source of p-chlorotoluene is convenient, this synthetic route may be able to show advantages by virtue of its relatively simple steps.
All kinds of synthesis methods have advantages and disadvantages. In actual operation, it is necessary to comprehensively consider the cost of raw materials, reaction conditions, yield, and impact on the environment. After weighing, choose the most suitable one and use it.
First, benzene is used as the starting material. First, benzene and chlorine are substituted under the catalysis of iron trichloride to obtain chlorobenzene. Chlorobenzene is then reacted with chlorine, and after ingenious control of the reaction conditions, 2,4-dichlorobenzene can be obtained. Subsequently, 2,4-dichlorobenzene is co-heated with fuming sulfuric acid to achieve sulfonation and generate 2,4-dichlorobenzene sulfonic acid. Finally, 2,4-dichlorobenzene sulfonic acid interacts with phosphorus pentachloride, and the hydroxyl group in the sulfonic acid group is replaced by chlorine, and then 2,4-dichlorobenzene This process step is slightly complicated, but the raw material benzene is easy to obtain, and the cost may be controllable.
Second, toluene is used as the starting point. Toluene is first substituted with chlorine under light, and the hydrogen on the methyl group is replaced by chlorine to obtain benzyl chloride. Benzyl chloride is then substituted with chlorine under the action of the catalyst, and chlorine atoms at the 2,4 position can be introduced. After that, the chlorine atoms in the side chain are hydrolyzed to hydroxyl groups, which are then oxidized to carboxyl groups. Next, the carboxyl group is converted to acyl chloride, and the benzene ring is sulfonated at the same time. After appropriate steps are adjusted, the target product can be obtained. Although this approach has many steps, toluene is also a common raw material, and each step of the reaction has a mature method in organic synthesis. As long
Third, p-chlorotoluene is used as the starting material. P-chlorotoluene is first sulfonated, a sulfonic acid group is introduced at the ortho-position of p-methyl, and then the methyl is oxidized to a carboxyl group, and then the carboxyl group is converted to an acid chloride. Finally, under suitable conditions, chlorine atoms are introduced at the unsubstituted position on the benzene ring to obtain 2,4-dichlorobenzene-1-sulfonyl chloride. The starting material of this method is slightly special, but if the source of p-chlorotoluene is convenient, this synthetic route may be able to show advantages by virtue of its relatively simple steps.
All kinds of synthesis methods have advantages and disadvantages. In actual operation, it is necessary to comprehensively consider the cost of raw materials, reaction conditions, yield, and impact on the environment. After weighing, choose the most suitable one and use it.
What are the precautions for storing and transporting 2,4-dichlorobenzene-1-sulfonyl chloride?
2% 2C4-difluorobenzene-1-sulfonyl fluoride is a unique chemical substance. During storage and transportation, many important items must not be ignored.
The first storage place. This substance should be placed in a cool, dry and well ventilated place. Because of its nature or susceptibility to temperature and humidity, if it is in a warm and humid place, it may deteriorate. For example, in midsummer, if stored in a hot and dry place, its chemical properties may change. And it should be kept away from fire and heat sources, which are all risks of ignition. If it is near a fire, it may explode, and the danger will appear.
Furthermore, the packaging must be tight. Appropriate packaging materials are required to prevent leakage. It can be stored in a special sealed container to ensure that it does not come into contact with outside air, water vapor and other substances during storage. If the package is damaged, it will escape or react with surrounding substances, which will not only damage itself, but also endanger the surrounding environment and personal safety.
As for transportation, there are also many taboos. Handlers must be careful, pack and unload lightly, and do not collide or tip the container. If the bumps during transportation are too large, the package will break, and the consequences will be unimaginable. The transportation vehicle must also be clean, and no other chemicals will react with it. And corresponding emergency treatment equipment should be prepared during transportation. In case of leakage, rescue measures can be taken quickly.
In addition, transportation and storage should be carried out in strict accordance with relevant regulations and standards. Operators should also be professionally trained to be familiar with its characteristics and emergency treatment methods, so that 2% 2C4-difluorobenzene-1-sulfonyl fluoride can be stored and transported safely.
The first storage place. This substance should be placed in a cool, dry and well ventilated place. Because of its nature or susceptibility to temperature and humidity, if it is in a warm and humid place, it may deteriorate. For example, in midsummer, if stored in a hot and dry place, its chemical properties may change. And it should be kept away from fire and heat sources, which are all risks of ignition. If it is near a fire, it may explode, and the danger will appear.
Furthermore, the packaging must be tight. Appropriate packaging materials are required to prevent leakage. It can be stored in a special sealed container to ensure that it does not come into contact with outside air, water vapor and other substances during storage. If the package is damaged, it will escape or react with surrounding substances, which will not only damage itself, but also endanger the surrounding environment and personal safety.
As for transportation, there are also many taboos. Handlers must be careful, pack and unload lightly, and do not collide or tip the container. If the bumps during transportation are too large, the package will break, and the consequences will be unimaginable. The transportation vehicle must also be clean, and no other chemicals will react with it. And corresponding emergency treatment equipment should be prepared during transportation. In case of leakage, rescue measures can be taken quickly.
In addition, transportation and storage should be carried out in strict accordance with relevant regulations and standards. Operators should also be professionally trained to be familiar with its characteristics and emergency treatment methods, so that 2% 2C4-difluorobenzene-1-sulfonyl fluoride can be stored and transported safely.
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