Linshang Chemical
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2,4-Difluoro-3-Chloronitrobenzene
Linshang Chemical
|
HS Code |
258831 |
| Chemical Formula | C6H2ClF2NO2 |
| Molecular Weight | 193.54 |
| Appearance | Solid |
| Color | Yellowish - white |
| Melting Point | 53 - 57 °C |
| Boiling Point | 222 - 224 °C |
| Density | 1.599 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like dichloromethane, ethyl acetate |
| Flash Point | 98.2 °C |
| Vapor Pressure | Low at room temperature |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 2,4-Difluoro-3-Chloronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 25 - kg drum packaging for 2,4 - difluoro - 3 - chloronitrobenzene chemical. |
| Storage | 2,4 - difluoro - 3 - chloronitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat, sparks, and open flames as it is potentially flammable. Store it in a tightly sealed container to prevent leakage and exposure to air or moisture. Separate it from incompatible substances like oxidizing agents and reducing agents to avoid dangerous reactions. |
| Shipping | 2,4 - difluoro - 3 - chloronitrobenzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations to ensure safe transport, with proper labeling and documentation for handling and storage. |
Competitive 2,4-Difluoro-3-Chloronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2,4-Difluoro-3-Chloronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2,4-difluoro-3-chloronitrobenzene?
2% 2C4-diene-3-halobenzylbenzene is an organic compound or the like. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry to synthesize various biologically active drugs. Due to its special structure, it endows the synthesized drugs with unique pharmacological properties, or has antibacterial, antiviral, anti-tumor and other effects, paving the way for the creation of new specific drugs.
In the field of materials science, it also plays an important role. Through specific chemical reactions, it can be introduced into polymer materials to improve material properties, such as enhancing material stability, heat resistance and mechanical properties. It makes the materials more widely used in fields such as aerospace, electronics and electrical appliances that require strict material properties.
In addition, in the field of organic synthetic chemistry, as a reaction substrate or reagent, it participates in the synthesis of many complex organic compounds. Due to its unique chemical structure and reactivity, it can provide novel paths and methods for organic synthesis, enabling chemists to create organic molecules with unique structures and specific functions, and promoting the development of organic synthetic chemistry.
Guanfu's "Tiangong Kaiji", although 2% 2C4-diene-3-halobenzylbenzene was not well documented at that time, but from an ancient perspective, such compounds may also show their unique functions in the fields of chemical industry and drug preparation. Although the technical means were limited at that time, over time, if the characteristics of this object could be recognized, it would presumably be able to be used for people's livelihood and promote the progress of the process technology at that time.
In the field of materials science, it also plays an important role. Through specific chemical reactions, it can be introduced into polymer materials to improve material properties, such as enhancing material stability, heat resistance and mechanical properties. It makes the materials more widely used in fields such as aerospace, electronics and electrical appliances that require strict material properties.
In addition, in the field of organic synthetic chemistry, as a reaction substrate or reagent, it participates in the synthesis of many complex organic compounds. Due to its unique chemical structure and reactivity, it can provide novel paths and methods for organic synthesis, enabling chemists to create organic molecules with unique structures and specific functions, and promoting the development of organic synthetic chemistry.
Guanfu's "Tiangong Kaiji", although 2% 2C4-diene-3-halobenzylbenzene was not well documented at that time, but from an ancient perspective, such compounds may also show their unique functions in the fields of chemical industry and drug preparation. Although the technical means were limited at that time, over time, if the characteristics of this object could be recognized, it would presumably be able to be used for people's livelihood and promote the progress of the process technology at that time.
What are the physical properties of 2,4-difluoro-3-chloronitrobenzene?
2% 2C4-diene-3-chlorobenzylbenzene, this is an organic compound. Its physical properties are quite important and are related to many practical applications.
is the first to bear the brunt, the substance has a specific melting point and boiling point. The melting point is the temperature at which a substance changes from a solid to a liquid state, and the boiling point is the temperature at which the liquid state changes to a gas state. Knowing these two accurately is crucial for controlling its state under different temperature conditions. In chemical production, the degree of heating or cooling can be determined according to the melting point and boiling point to ensure that the reaction is carried out in a suitable state.
Furthermore, its solubility cannot be ignored. This compound has different solubility in different solvents. In organic solvents, such as ethanol, ether, etc., it may exhibit good solubility, while in water it may not. This property plays a significant role in separation, purification, and selection of chemical reaction media. If you want to separate the substance from the mixture, you can choose a suitable solvent to dissolve it according to its solubility, and then achieve the purpose of separation.
Density is also one of its important physical properties. Density reflects the mass of the substance per unit volume. Knowing the density helps to accurately measure its dosage in actual operation. In some reactions that require strict proportions of substances, density data can help to determine the exact amount of feed.
In addition, its appearance is also an important characteristic. It can be presented as a solid crystal or a liquid state. If it is a solid state, the crystal morphology, color, etc. are all factors that characterize its characteristics. In the liquid state, the color and transparency can also reflect its purity and some of its intrinsic properties.
The above physical properties are interrelated and affect each other, and together constitute the physical cognition of 2% 2C4-diene-3-chlorobenzylbenzene, providing a solid foundation for its application in chemical industry, scientific research and other fields.
is the first to bear the brunt, the substance has a specific melting point and boiling point. The melting point is the temperature at which a substance changes from a solid to a liquid state, and the boiling point is the temperature at which the liquid state changes to a gas state. Knowing these two accurately is crucial for controlling its state under different temperature conditions. In chemical production, the degree of heating or cooling can be determined according to the melting point and boiling point to ensure that the reaction is carried out in a suitable state.
Furthermore, its solubility cannot be ignored. This compound has different solubility in different solvents. In organic solvents, such as ethanol, ether, etc., it may exhibit good solubility, while in water it may not. This property plays a significant role in separation, purification, and selection of chemical reaction media. If you want to separate the substance from the mixture, you can choose a suitable solvent to dissolve it according to its solubility, and then achieve the purpose of separation.
Density is also one of its important physical properties. Density reflects the mass of the substance per unit volume. Knowing the density helps to accurately measure its dosage in actual operation. In some reactions that require strict proportions of substances, density data can help to determine the exact amount of feed.
In addition, its appearance is also an important characteristic. It can be presented as a solid crystal or a liquid state. If it is a solid state, the crystal morphology, color, etc. are all factors that characterize its characteristics. In the liquid state, the color and transparency can also reflect its purity and some of its intrinsic properties.
The above physical properties are interrelated and affect each other, and together constitute the physical cognition of 2% 2C4-diene-3-chlorobenzylbenzene, providing a solid foundation for its application in chemical industry, scientific research and other fields.
What are the synthesis methods of 2,4-difluoro-3-chloronitrobenzene?
To prepare 2,4-diene-3-halocarbonyl benzene, there are various methods. Common ones are obtained by starting with benzene and changing it through several steps.
First, benzene and halogenated alkenyl acyl halides are catalyzed by Lewy's acid such as aluminum trichloride. The halogen atom in the halogenated alkenyl acyl halogen is connected to the alkenyl group and the acyl group. Under suitable conditions, the phenyl ring interacts with the acylating agent, and the hydrogen of the phenyl ring is replaced by the alkenyl acyl group to obtain the alkenyl benzophenone intermediate product. This step requires temperature control, time control and precise material ratio to increase the yield and selectivity of the reaction.
times, halogenate the obtained intermediate product. Halogenation method, or use halogen elemental substance in a suitable solvent, such as carbon tetrachloride, under the action of light or initiator, to introduce a specific position of the alkenyl group into the halogen atom. Or use a halogenating reagent, such as N-halogenated succinimide (NXS), to achieve selective addition of halogen atoms under mild conditions.
There is another method, which can first prepare halogen-containing benzene derivatives, and then react with alkenylation and carbonylation to construct the target structure. For example, halogenated alkenylbenzene is first used as a raw material, through a metal-catalyzed coupling reaction, and is connected with an alkenylation reagent to obtain halogenated alkenylbenzene. After the carbonylation reaction with the participation of carbon monoxide, in the presence of an appropriate catalyst and base, a carbonyl group is introduced at a suitable check point of alkenyl benzene to obtain 2,4-diene-3-halocarbonyl benzene.
Preparation of this compound, each method has its advantages and disadvantages. The former method of Fu-Ke acylation initiation is relatively simple, but the Fu-Ke reaction conditions are relatively harsh, and the selectivity of the halogenation step needs to be well controlled. The latter method of first halophenylation and then carbonylation, although the structure can be precisely constructed, the reagents used may be expensive, and the reaction conditions need to be carefully regulated.
First, benzene and halogenated alkenyl acyl halides are catalyzed by Lewy's acid such as aluminum trichloride. The halogen atom in the halogenated alkenyl acyl halogen is connected to the alkenyl group and the acyl group. Under suitable conditions, the phenyl ring interacts with the acylating agent, and the hydrogen of the phenyl ring is replaced by the alkenyl acyl group to obtain the alkenyl benzophenone intermediate product. This step requires temperature control, time control and precise material ratio to increase the yield and selectivity of the reaction.
times, halogenate the obtained intermediate product. Halogenation method, or use halogen elemental substance in a suitable solvent, such as carbon tetrachloride, under the action of light or initiator, to introduce a specific position of the alkenyl group into the halogen atom. Or use a halogenating reagent, such as N-halogenated succinimide (NXS), to achieve selective addition of halogen atoms under mild conditions.
There is another method, which can first prepare halogen-containing benzene derivatives, and then react with alkenylation and carbonylation to construct the target structure. For example, halogenated alkenylbenzene is first used as a raw material, through a metal-catalyzed coupling reaction, and is connected with an alkenylation reagent to obtain halogenated alkenylbenzene. After the carbonylation reaction with the participation of carbon monoxide, in the presence of an appropriate catalyst and base, a carbonyl group is introduced at a suitable check point of alkenyl benzene to obtain 2,4-diene-3-halocarbonyl benzene.
Preparation of this compound, each method has its advantages and disadvantages. The former method of Fu-Ke acylation initiation is relatively simple, but the Fu-Ke reaction conditions are relatively harsh, and the selectivity of the halogenation step needs to be well controlled. The latter method of first halophenylation and then carbonylation, although the structure can be precisely constructed, the reagents used may be expensive, and the reaction conditions need to be carefully regulated.
What are the precautions for storing and transporting 2,4-difluoro-3-chloronitrobenzene?
2% 2C4-diene-3-chloroacetylbenzene requires attention to many matters during storage and transportation. This is a particularly important link in fine chemicals, related to safety and quality.
When storing, first, the temperature must be strictly controlled. The properties of this compound may change due to temperature fluctuations. If the temperature is too high, it may cause decomposition, polymerization and other reactions, causing it to deteriorate. Therefore, it should be stored in a cool place, generally at 5 ° C - 25 ° C. Second, the humidity should not be underestimated. Humid environment may cause the compound to absorb moisture, affecting purity and even inducing reactions such as hydrolysis. Choose a dry place, and the relative humidity should be maintained at 40% - 60%. Third, the storage container must be carefully selected. Corrosion-resistant materials, such as glass, specific plastics or stainless steel, should be used to prevent the container from reacting with the compound and staining the product. And the container must be well sealed to avoid contact with the air, because of oxygen, carbon dioxide, etc. in the air or react with it.
During transportation, safety should bear the brunt. The compound may be dangerous, and the transportation vehicle must meet the transportation standards for dangerous goods and be equipped with corresponding fire and first aid equipment. Second, ensure smooth transportation, avoid bumps and vibrations, and prevent packaging damage. Third, the packaging must be sturdy, and warning signs should be posted as required to let relevant personnel clearly know its characteristics and dangers. And transportation personnel should receive professional training, be familiar with emergency handling methods, and be able to respond properly in case of emergencies to ensure the safety of personnel and the environment.
When storing, first, the temperature must be strictly controlled. The properties of this compound may change due to temperature fluctuations. If the temperature is too high, it may cause decomposition, polymerization and other reactions, causing it to deteriorate. Therefore, it should be stored in a cool place, generally at 5 ° C - 25 ° C. Second, the humidity should not be underestimated. Humid environment may cause the compound to absorb moisture, affecting purity and even inducing reactions such as hydrolysis. Choose a dry place, and the relative humidity should be maintained at 40% - 60%. Third, the storage container must be carefully selected. Corrosion-resistant materials, such as glass, specific plastics or stainless steel, should be used to prevent the container from reacting with the compound and staining the product. And the container must be well sealed to avoid contact with the air, because of oxygen, carbon dioxide, etc. in the air or react with it.
During transportation, safety should bear the brunt. The compound may be dangerous, and the transportation vehicle must meet the transportation standards for dangerous goods and be equipped with corresponding fire and first aid equipment. Second, ensure smooth transportation, avoid bumps and vibrations, and prevent packaging damage. Third, the packaging must be sturdy, and warning signs should be posted as required to let relevant personnel clearly know its characteristics and dangers. And transportation personnel should receive professional training, be familiar with emergency handling methods, and be able to respond properly in case of emergencies to ensure the safety of personnel and the environment.
What are the effects of 2,4-difluoro-3-chloronitrobenzene on the environment and human health?
The impact of 2% 2C4-diene-3-chloroformylbenzene on the environment and human health is related to people's livelihood and cannot be ignored.
This substance may have multiple effects in the environment. If it is released into the atmosphere or diffuses with airflow, it interacts with various components in the air. Because of its special chemical structure, or changes the chemical composition of the atmosphere, it affects the oxidation of the atmosphere, thereby interfering with the process of atmospheric self-purification. In aquatic ecosystems, if it flows into rivers, lakes and seas, it may cause water pollution. Because of its chemical properties, it may pose a threat to the survival and reproduction of aquatic organisms. Or damage the cell structure and physiological function of aquatic organisms, resulting in a decrease in biodiversity. In the soil environment, its residue or change the structure and function of soil microbial community, affect soil nutrient circulation and transformation, and endanger soil ecological balance.
As for human health, exposure to this substance is also risky. Inhalation through the respiratory tract can reach the lungs, damaging the organization and function of the lungs. It may cause respiratory inflammation, make people cough, asthma, long-term exposure, or even cause lung diseases. If it is contacted through the skin, it may enter the human blood circulation due to its fat solubility and other properties, or penetrate the skin barrier. It then interferes with the normal physiological metabolism of the human body, involving important organs such as the liver and kidneys. Oral intake, in the digestive system, or interacts with the gastrointestinal mucosa, causes gastrointestinal discomfort and affects digestion and absorption function.
In addition, it may have potential genotoxicity, interfere with the normal replication and transcription of human genetic material, cause gene mutation and other problems, and affect the health of future generations. Therefore, such substances should be handled with caution, and their production, use and discharge should be strictly controlled to protect the environment and human health.
This substance may have multiple effects in the environment. If it is released into the atmosphere or diffuses with airflow, it interacts with various components in the air. Because of its special chemical structure, or changes the chemical composition of the atmosphere, it affects the oxidation of the atmosphere, thereby interfering with the process of atmospheric self-purification. In aquatic ecosystems, if it flows into rivers, lakes and seas, it may cause water pollution. Because of its chemical properties, it may pose a threat to the survival and reproduction of aquatic organisms. Or damage the cell structure and physiological function of aquatic organisms, resulting in a decrease in biodiversity. In the soil environment, its residue or change the structure and function of soil microbial community, affect soil nutrient circulation and transformation, and endanger soil ecological balance.
As for human health, exposure to this substance is also risky. Inhalation through the respiratory tract can reach the lungs, damaging the organization and function of the lungs. It may cause respiratory inflammation, make people cough, asthma, long-term exposure, or even cause lung diseases. If it is contacted through the skin, it may enter the human blood circulation due to its fat solubility and other properties, or penetrate the skin barrier. It then interferes with the normal physiological metabolism of the human body, involving important organs such as the liver and kidneys. Oral intake, in the digestive system, or interacts with the gastrointestinal mucosa, causes gastrointestinal discomfort and affects digestion and absorption function.
In addition, it may have potential genotoxicity, interfere with the normal replication and transcription of human genetic material, cause gene mutation and other problems, and affect the health of future generations. Therefore, such substances should be handled with caution, and their production, use and discharge should be strictly controlled to protect the environment and human health.
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