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2,6-Dichloro-4-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride
Linshang Chemical
|
HS Code |
332271 |
| Chemical Formula | C7H2Cl3F3O2S |
| Molecular Weight | 319.41 |
| Appearance | Typically a solid (physical state may vary depending on conditions) |
| Solubility | Soluble in many organic solvents like dichloromethane, chloroform; likely insoluble in water due to non - polar nature of the benzene ring and hydrophobic trifluoromethyl group |
| Density | No widely - known value, but similar aromatic sulfonyl chlorides have densities greater than 1 g/cm³ |
| Purity | Typically sold in high - purity grades (e.g., 95%+ in commercial products) |
| Reactivity | Highly reactive towards nucleophiles such as amines, alcohols, and thiols due to the electrophilic nature of the sulfonyl chloride group |
| Hazard | Corrosive, can cause burns to skin and eyes; harmful if inhaled or ingested |
As an accredited 2,6-Dichloro-4-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 2,6 - dichloro - 4-(trifluoromethyl)benzene - 1 - sulfonyl chloride in sealed chemical - grade packaging. |
| Storage | 2,6 - dichloro - 4 - (trifluoromethyl)benzene - 1 - sulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat, ignition sources, and moisture. Store in a tightly sealed container, preferably in a corrosion - resistant material, as it is reactive. Avoid contact with incompatible substances like bases and reducing agents to prevent dangerous reactions. |
| Shipping | 2,6 - dichloro - 4 - (trifluoromethyl)benzene - 1 - sulfonyl chloride, a chemical, should be shipped in well - sealed, corrosion - resistant containers. Ensure compliance with hazardous chemical shipping regulations, with proper labeling for safe transportation. |
Competitive 2,6-Dichloro-4-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 2,6-dichloro-4- (trifluoromethyl) benzene-1-sulfonyl chloride?
2% 2C6-difluoro-4- (triethoxy) benzene-1-sulfonyl fluoride is an important raw material for organic synthesis. In the field of organic chemistry, it is often a key building block for the construction of complex organic molecules.
Looking at the way of organic synthesis, it can interact with many compounds through unique functional group reactions. For example, its sulfonyl fluoride group is highly active and can undergo nucleophilic substitution reactions with nucleophilic reagents. With this reactive property, chemists can integrate it into a specific molecular architecture to derive organic compounds with diverse functions, such as in medicinal chemistry, which can be used to construct molecules with specific pharmacological activities.
In the field of materials science, it also has outstanding performance. After appropriate chemical modification and polymerization, polymer materials with special properties can be prepared, or materials can be endowed with properties such as excellent corrosion resistance and low surface energy, which play a key role in the improvement of coatings, plastics and other materials.
Furthermore, in the field of fine chemicals, as a synthesis intermediate, it can assist in the synthesis of various fine chemicals, such as special surfactants, catalyst ligands, etc. With the precise regulation and derivatization of its structure, fine chemical products that meet different industrial needs can be prepared on demand, providing strong support for the development of related industries.
Looking at the way of organic synthesis, it can interact with many compounds through unique functional group reactions. For example, its sulfonyl fluoride group is highly active and can undergo nucleophilic substitution reactions with nucleophilic reagents. With this reactive property, chemists can integrate it into a specific molecular architecture to derive organic compounds with diverse functions, such as in medicinal chemistry, which can be used to construct molecules with specific pharmacological activities.
In the field of materials science, it also has outstanding performance. After appropriate chemical modification and polymerization, polymer materials with special properties can be prepared, or materials can be endowed with properties such as excellent corrosion resistance and low surface energy, which play a key role in the improvement of coatings, plastics and other materials.
Furthermore, in the field of fine chemicals, as a synthesis intermediate, it can assist in the synthesis of various fine chemicals, such as special surfactants, catalyst ligands, etc. With the precise regulation and derivatization of its structure, fine chemical products that meet different industrial needs can be prepared on demand, providing strong support for the development of related industries.
What are the physical properties of 2,6-dichloro-4- (trifluoromethyl) benzene-1-sulfonyl chloride?
2% 2C6-difluoro-4- (triethoxy) benzene-1-sulfonyl fluoride is a kind of organic compound. Its physical properties are complex, let me tell them one by one.
First appearance, this compound is mostly colorless to light yellow liquid under normal conditions, clear and transparent, sparkling luster can be seen under light, like morning dew reflecting the sun, pure and unique visual perception.
When it comes to smell, the smell it emits is quite special, like a light ether fragrance, but mixed with a little pungent smell unique to fluoride, but it is not strong and intolerable, but a weak and unique mixed smell.
Looking at its boiling point, it has been determined by many researchers that it is within a certain temperature range. This temperature breaks the balance of forces between molecules and changes from liquid to gaseous. The value of the boiling point has a deep impact on its existence in different environments and operations such as separation and purification.
As for the melting point, there is also a specific value. When the temperature drops below the melting point, the molecular activity of the compound gradually slows down, and it is arranged in an orderly manner close to each other. It solidifies from a liquid state to a solid state, such as a river ice seal, in an orderly manner.
Furthermore, solubility is also an important property. In organic solvents, such as some common ether and aromatic solvents, it exhibits good solubility, just like salt dissolves in water, which can be evenly dispersed to form a uniform and stable system. However, in water, its solubility is extremely limited. Due to the characteristics of molecular structure, the force between water molecules is weak, and it is difficult to blend with water, just like oil floating in water.
density also has a corresponding value. This value reflects the mass per unit volume. Compared with other substances, it can be judged in the mixed system. It is one of the key factors to consider in many chemical processes and experimental operations.
The physical properties of 2% 2C6-difluoro-4- (triethoxy) benzene-1-sulfonyl fluoride are of great significance in many fields such as organic synthesis and materials science, laying the foundation for related research and application.
First appearance, this compound is mostly colorless to light yellow liquid under normal conditions, clear and transparent, sparkling luster can be seen under light, like morning dew reflecting the sun, pure and unique visual perception.
When it comes to smell, the smell it emits is quite special, like a light ether fragrance, but mixed with a little pungent smell unique to fluoride, but it is not strong and intolerable, but a weak and unique mixed smell.
Looking at its boiling point, it has been determined by many researchers that it is within a certain temperature range. This temperature breaks the balance of forces between molecules and changes from liquid to gaseous. The value of the boiling point has a deep impact on its existence in different environments and operations such as separation and purification.
As for the melting point, there is also a specific value. When the temperature drops below the melting point, the molecular activity of the compound gradually slows down, and it is arranged in an orderly manner close to each other. It solidifies from a liquid state to a solid state, such as a river ice seal, in an orderly manner.
Furthermore, solubility is also an important property. In organic solvents, such as some common ether and aromatic solvents, it exhibits good solubility, just like salt dissolves in water, which can be evenly dispersed to form a uniform and stable system. However, in water, its solubility is extremely limited. Due to the characteristics of molecular structure, the force between water molecules is weak, and it is difficult to blend with water, just like oil floating in water.
density also has a corresponding value. This value reflects the mass per unit volume. Compared with other substances, it can be judged in the mixed system. It is one of the key factors to consider in many chemical processes and experimental operations.
The physical properties of 2% 2C6-difluoro-4- (triethoxy) benzene-1-sulfonyl fluoride are of great significance in many fields such as organic synthesis and materials science, laying the foundation for related research and application.
What are the chemical properties of 2,6-dichloro-4- (trifluoromethyl) benzene-1-sulfonyl chloride?
2% 2C6-difluoro-4- (triethoxymethyl) benzene-1-sulfonyl fluoride, an organic compound. Its chemical properties are unique and there are many things worth exploring.
In terms of its reactivity, the sulfonyl fluoride group is extremely active. In this group, the sulfur atom is connected to the fluorine atom, and the fluorine atom is highly electronegative. The electron cloud density of the sulfur atom decreases, making the sulfonyl fluoride group vulnerable to attack by nucleophiles. In case of nucleophiles, such as alcohols and amines, fluorine atoms are easily replaced, resulting in the formation of new compounds. For example, when reacted with alcohols, sulfonate esters can be formed. This reaction is often used in organic synthesis to build ester structures and is widely used in drug synthesis and materials science.
Looking at its stability, under normal conditions, the compound is relatively stable. However, under certain conditions, such as high temperature, strong acid or strong base environment, its structure will change. In strong base environment, sulfonyl fluoride groups may hydrolyze to form sulfonic acids or sulfonates. This property cannot be ignored in environmental chemistry and industrial production. Careful control of reaction conditions and storage environment is required to prevent compound deterioration.
From the perspective of its solubility, in view of the fact that there are both fluorine-containing groups and ethoxy groups in the molecule, it has good solubility in some organic solvents, such as dichloromethane, chloroform, and tetrahydrofuran, which facilitates its operation in organic synthesis, enabling it to participate in the reaction in a homogeneous system, improving the reaction efficiency and selectivity.
In short, 2% 2C6-difluoro-4- (triethoxy methyl) benzene-1-sulfonyl fluoride has broad application potential in many fields such as organic synthesis, materials science, and drug development due to its unique chemical properties. However, its chemical properties must be fully considered when using it, and it must be properly handled and preserved.
In terms of its reactivity, the sulfonyl fluoride group is extremely active. In this group, the sulfur atom is connected to the fluorine atom, and the fluorine atom is highly electronegative. The electron cloud density of the sulfur atom decreases, making the sulfonyl fluoride group vulnerable to attack by nucleophiles. In case of nucleophiles, such as alcohols and amines, fluorine atoms are easily replaced, resulting in the formation of new compounds. For example, when reacted with alcohols, sulfonate esters can be formed. This reaction is often used in organic synthesis to build ester structures and is widely used in drug synthesis and materials science.
Looking at its stability, under normal conditions, the compound is relatively stable. However, under certain conditions, such as high temperature, strong acid or strong base environment, its structure will change. In strong base environment, sulfonyl fluoride groups may hydrolyze to form sulfonic acids or sulfonates. This property cannot be ignored in environmental chemistry and industrial production. Careful control of reaction conditions and storage environment is required to prevent compound deterioration.
From the perspective of its solubility, in view of the fact that there are both fluorine-containing groups and ethoxy groups in the molecule, it has good solubility in some organic solvents, such as dichloromethane, chloroform, and tetrahydrofuran, which facilitates its operation in organic synthesis, enabling it to participate in the reaction in a homogeneous system, improving the reaction efficiency and selectivity.
In short, 2% 2C6-difluoro-4- (triethoxy methyl) benzene-1-sulfonyl fluoride has broad application potential in many fields such as organic synthesis, materials science, and drug development due to its unique chemical properties. However, its chemical properties must be fully considered when using it, and it must be properly handled and preserved.
What are the synthesis methods of 2,6-dichloro-4- (trifluoromethyl) benzene-1-sulfonyl chloride?
The synthesis of 2% 2C6 -dibromo-4- (triethoxy) benzene-1 -sulfonate is a crucial topic in the field of organic synthetic chemistry. This compound is widely used in many fields such as medicinal chemistry and materials science, so it is of great significance to explore its synthesis path. The following are the common synthesis methods:
First, benzene derivatives are used as starting materials. Through a halogenation reaction, bromine atoms are introduced into a specific position in the benzene ring to achieve the preparation of 2,6-dibromobenzene derivatives. This process requires careful selection of halogenation reagents and reaction conditions to ensure the precise positioning of bromine atoms. Then, through a nucleophilic substitution reaction, the triethoxy group is connected to the benzene ring. In this step, the activity and selectivity of the triethoxylation reagent are very important, and the reaction temperature, solvent and other conditions need to be carefully regulated to achieve an efficient and highly selective reaction. Finally, through the sulfonation reaction, the sulfonate group is introduced at a specific position of the benzene ring to obtain the final target product. The key to this synthesis route lies in the precise control of the reaction conditions in each step to avoid unnecessary side reactions.
Second, the strategy of gradually constructing the benzene ring is adopted. First, a suitable small molecule compound is used as the starting material to construct a phenyl ring precursor containing bromine atoms and triethoxy groups through a multi-step reaction. For example, classical organic reactions such as the Diels-Alder reaction can be used to construct a benzene ring skeleton. In this process, the structural design of the reactants and the optimization of reaction conditions are of paramount importance. Then, the functional group conversion of the constructed benzene ring precursor is carried out, and the sulfonate group is introduced to achieve the synthesis of the target compound. Although this method is more complicated, it can achieve precise control of the position and structure of the substituents on the benzene ring.
Third, the reaction is catalyzed by transition metals. Transition metal catalysts show excellent catalytic activity and selectivity in organic synthesis. Taking palladium catalysis as an example, the cross-coupling reaction catalyzed by palladium can be used to couple the benzene derivative containing bromine atom with the triethoxylation reagent to form a carbon-carbon bond efficiently. After that, the sulfonate group is introduced. This method can achieve the synthesis of the target product under relatively mild reaction conditions due to the unique properties of transition metal catalysts, and can effectively improve the efficiency and selectivity of the reaction.
The above synthesis methods have their own advantages and disadvantages. In practical application, the most suitable synthesis path should be carefully selected according to the availability of starting materials, reaction cost, and purity requirements of the target product.
First, benzene derivatives are used as starting materials. Through a halogenation reaction, bromine atoms are introduced into a specific position in the benzene ring to achieve the preparation of 2,6-dibromobenzene derivatives. This process requires careful selection of halogenation reagents and reaction conditions to ensure the precise positioning of bromine atoms. Then, through a nucleophilic substitution reaction, the triethoxy group is connected to the benzene ring. In this step, the activity and selectivity of the triethoxylation reagent are very important, and the reaction temperature, solvent and other conditions need to be carefully regulated to achieve an efficient and highly selective reaction. Finally, through the sulfonation reaction, the sulfonate group is introduced at a specific position of the benzene ring to obtain the final target product. The key to this synthesis route lies in the precise control of the reaction conditions in each step to avoid unnecessary side reactions.
Second, the strategy of gradually constructing the benzene ring is adopted. First, a suitable small molecule compound is used as the starting material to construct a phenyl ring precursor containing bromine atoms and triethoxy groups through a multi-step reaction. For example, classical organic reactions such as the Diels-Alder reaction can be used to construct a benzene ring skeleton. In this process, the structural design of the reactants and the optimization of reaction conditions are of paramount importance. Then, the functional group conversion of the constructed benzene ring precursor is carried out, and the sulfonate group is introduced to achieve the synthesis of the target compound. Although this method is more complicated, it can achieve precise control of the position and structure of the substituents on the benzene ring.
Third, the reaction is catalyzed by transition metals. Transition metal catalysts show excellent catalytic activity and selectivity in organic synthesis. Taking palladium catalysis as an example, the cross-coupling reaction catalyzed by palladium can be used to couple the benzene derivative containing bromine atom with the triethoxylation reagent to form a carbon-carbon bond efficiently. After that, the sulfonate group is introduced. This method can achieve the synthesis of the target product under relatively mild reaction conditions due to the unique properties of transition metal catalysts, and can effectively improve the efficiency and selectivity of the reaction.
The above synthesis methods have their own advantages and disadvantages. In practical application, the most suitable synthesis path should be carefully selected according to the availability of starting materials, reaction cost, and purity requirements of the target product.
What are the precautions for 2,6-dichloro-4- (trifluoromethyl) benzene-1-sulfonyl chloride during storage and transportation?
2% 2C6-difluoro-4- (trifluoromethyl) benzene-1-sulfonyl fluoride is a special chemical substance. During storage and transportation, many matters need to be paid attention to.
First words storage, this substance should be placed in a cool, dry and well-ventilated place. Because of its nature or more active, if it is in a high temperature and humid place, it may cause chemical reactions and cause deterioration of the substance. In addition, it must be stored separately from oxidants and bases, and must not be mixed. The edge oxidant reacts violently with bases or with this substance, endangering safety. At the same time, the storage area should be equipped with suitable materials to contain leaks to prevent accidental leakage.
As for transportation, it is necessary to ensure that the packaging is complete and sealed before transportation. Packaging materials must be able to withstand certain external forces and environmental changes to prevent material leakage. During transportation, vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. When driving, it is necessary to protect against sun exposure, rain and high temperature. Drivers and escorts must be familiar with the nature of the substance and emergency treatment methods, and must not stay in densely populated areas or near fire sources during transportation.
These precautions are to ensure the safety of 2% 2C6-difluoro-4- (trifluoromethyl) benzene-1-sulfonyl fluoride during storage and transportation, so that related operations can be carried out smoothly and accidents can be avoided.
First words storage, this substance should be placed in a cool, dry and well-ventilated place. Because of its nature or more active, if it is in a high temperature and humid place, it may cause chemical reactions and cause deterioration of the substance. In addition, it must be stored separately from oxidants and bases, and must not be mixed. The edge oxidant reacts violently with bases or with this substance, endangering safety. At the same time, the storage area should be equipped with suitable materials to contain leaks to prevent accidental leakage.
As for transportation, it is necessary to ensure that the packaging is complete and sealed before transportation. Packaging materials must be able to withstand certain external forces and environmental changes to prevent material leakage. During transportation, vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. When driving, it is necessary to protect against sun exposure, rain and high temperature. Drivers and escorts must be familiar with the nature of the substance and emergency treatment methods, and must not stay in densely populated areas or near fire sources during transportation.
These precautions are to ensure the safety of 2% 2C6-difluoro-4- (trifluoromethyl) benzene-1-sulfonyl fluoride during storage and transportation, so that related operations can be carried out smoothly and accidents can be avoided.
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