Linshang Chemical
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2-Amino-3-Chloro-4-Fluoronitrobenzene
Linshang Chemical
|
HS Code |
205429 |
| Chemical Formula | C6H4ClFN2O2 |
| Molecular Weight | 190.56 |
| Appearance | Solid (usually a powder or crystalline solid) |
| Color | Typically pale - colored |
| Odor | May have a characteristic, somewhat pungent odor |
| Melting Point | Data varies, but generally in a specific temperature range |
| Solubility In Water | Low solubility in water |
| Solubility In Organic Solvents | Soluble in some organic solvents like ethanol, acetone |
| Density | Specific density value based on experimental determination |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
| Hazardous Nature | May be toxic, harmful if swallowed, inhaled or in contact with skin |
As an accredited 2-Amino-3-Chloro-4-Fluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 25 kg of 2 - amino - 3 - chloro - 4 - fluoronitrobenzene packaged in sealed drums. |
| Storage | 2 - amino - 3 - chloro - 4 - fluoronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent moisture and air exposure, which could potentially lead to chemical reactions. Store it separately from oxidizing agents, acids, and bases to avoid dangerous reactions. |
| Shipping | 2 - amino - 3 - chloro - 4 - fluoronitrobenzene is a chemical. Shipping should be in well - sealed containers, compliant with hazardous chemical regulations. Ensure proper labeling, temperature control during transit to prevent degradation and potential hazards. |
Competitive 2-Amino-3-Chloro-4-Fluoronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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As a leading 2-Amino-3-Chloro-4-Fluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-amino-3-chloro-4-fluoronitrobenzene?
The main uses of 2-amino-3-chloro-4-fluorobenzoylbenzene are not directly recorded in Tiangong Kaiwu, but based on ancient and modern chemical knowledge and applications, this compound should have important uses in industry and scientific research.
In the field of dye synthesis, due to its special chemical structure, it may be used as a key intermediate. In ancient dye production, attention was paid to the characteristics of raw materials. The amino, chlorine, fluorine and other groups contained in this compound can give the dye unique color and stability. For example, in ancient times, natural plants and minerals were used to make dyes, and the pursuit of lasting and bright color was pursued. After a specific chemical reaction, this compound can introduce different chromophore groups to generate colorful, sun-resistant and washable dyes, which are used in fabric printing and dyeing to make the fabric color more outstanding, and have important applications in clothing, home textiles and other industries.
also has potential value in medicinal chemistry. Ancient medicine has a tradition of exploring drug components and curative effects. The structure of this compound may be similar to some bioactive molecules, and it can be used as a lead compound for drug research and development. Its special groups can interact with targets in vivo, regulate physiological functions, and be used to develop antibacterial, anti-inflammatory, anti-tumor and other drugs to serve human health.
In the research and development of pesticides, it may play a role. Ancient agriculture attached great importance to pest control. Although the methods are different from today, the concepts are similar. This compound has biological activity against specific pests or pathogens, and through reasonable modification and formulation, it can be made into highly efficient, low-toxic, and environmentally friendly pesticides to protect crops, increase yields, and ensure food supply.
In the field of dye synthesis, due to its special chemical structure, it may be used as a key intermediate. In ancient dye production, attention was paid to the characteristics of raw materials. The amino, chlorine, fluorine and other groups contained in this compound can give the dye unique color and stability. For example, in ancient times, natural plants and minerals were used to make dyes, and the pursuit of lasting and bright color was pursued. After a specific chemical reaction, this compound can introduce different chromophore groups to generate colorful, sun-resistant and washable dyes, which are used in fabric printing and dyeing to make the fabric color more outstanding, and have important applications in clothing, home textiles and other industries.
also has potential value in medicinal chemistry. Ancient medicine has a tradition of exploring drug components and curative effects. The structure of this compound may be similar to some bioactive molecules, and it can be used as a lead compound for drug research and development. Its special groups can interact with targets in vivo, regulate physiological functions, and be used to develop antibacterial, anti-inflammatory, anti-tumor and other drugs to serve human health.
In the research and development of pesticides, it may play a role. Ancient agriculture attached great importance to pest control. Although the methods are different from today, the concepts are similar. This compound has biological activity against specific pests or pathogens, and through reasonable modification and formulation, it can be made into highly efficient, low-toxic, and environmentally friendly pesticides to protect crops, increase yields, and ensure food supply.
What are the synthesis methods of 2-amino-3-chloro-4-fluoronitrobenzene?
To prepare 2-amino-3-chloro-4-fluorobenzophenone, the method is as follows:
First, start with the acylation reaction. Select an appropriate aromatic halide, such as chlorine and fluorine-containing halobenzene, and react with an acylating reagent, such as the corresponding acid chloride or acid anhydride, under the catalysis of Lewis acid (such as anhydrous aluminum trichloride), in a suitable solvent (such as dichloromethane, dichloroethane, etc.). This step aims to introduce the acyl group into the halobenzene to form a preliminary ketone intermediate. The reaction temperature should be controlled between low temperature and room temperature, depending on the activity of the substrate. The reaction duration varies. Depending on the reaction process, it is monitored by thin layer chromatography.
Following the amination step. The intermediate needs to be protected by an appropriate protective group to prevent the specific functional group from being disturbed by side reactions during amination. Commonly used protective groups such as tert-butoxycarbonyl (Boc), etc. After protection, an amination reagent, such as an alcohol solution of ammonia gas, an amine compound, etc., reacts with the intermediate in an appropriate solvent (such as ethanol, N, N-dimethylformamide, etc.) in the presence of a base (such as potassium carbonate, sodium carbonate). This reaction temperature may need to be warmed to tens of degrees Celsius, and the duration may take several hours to ten hours. It is also controlled by monitoring means. After the reaction is completed, the protective group is removed, and the method of acidification is commonly used, such as treatment with dilute hydrochloric acid, etc., to obtain the crude product of the target product.
In addition, you can try to construct the parent body of benzophenone first, and then carry out the order of halogenation and amination. Appropriate benzoic acid derivatives are esterified with alcohols and then reacted with Grignard reagents to form a benzophenone structure. After that, chlorine and fluorine atoms are introduced on the benzene ring, and halogenation reactions can be used, such as chlorination agents (such as sulfoxide chloride, phosphorus oxychloride, etc.), fluorination agents (such as potassium fluoride, Selectfluor, etc.), and halogenation is carried out under suitable conditions After halogenation, the operation of amination is carried out. The method is as above, and 2-amino-3-chloro-4-fluorobenzophenone can also be obtained.
The advantages and disadvantages of each method are mutually present. The method of acylation initiation is relatively direct, but the reaction conditions need to be carefully adjusted to avoid side reactions; the method of first forming benzophenone precursor, although the route is slightly longer, the reaction selectivity of each step is easy to control. In actual operation, when the requirements of raw material availability, cost, yield and purity are selected carefully.
First, start with the acylation reaction. Select an appropriate aromatic halide, such as chlorine and fluorine-containing halobenzene, and react with an acylating reagent, such as the corresponding acid chloride or acid anhydride, under the catalysis of Lewis acid (such as anhydrous aluminum trichloride), in a suitable solvent (such as dichloromethane, dichloroethane, etc.). This step aims to introduce the acyl group into the halobenzene to form a preliminary ketone intermediate. The reaction temperature should be controlled between low temperature and room temperature, depending on the activity of the substrate. The reaction duration varies. Depending on the reaction process, it is monitored by thin layer chromatography.
Following the amination step. The intermediate needs to be protected by an appropriate protective group to prevent the specific functional group from being disturbed by side reactions during amination. Commonly used protective groups such as tert-butoxycarbonyl (Boc), etc. After protection, an amination reagent, such as an alcohol solution of ammonia gas, an amine compound, etc., reacts with the intermediate in an appropriate solvent (such as ethanol, N, N-dimethylformamide, etc.) in the presence of a base (such as potassium carbonate, sodium carbonate). This reaction temperature may need to be warmed to tens of degrees Celsius, and the duration may take several hours to ten hours. It is also controlled by monitoring means. After the reaction is completed, the protective group is removed, and the method of acidification is commonly used, such as treatment with dilute hydrochloric acid, etc., to obtain the crude product of the target product.
In addition, you can try to construct the parent body of benzophenone first, and then carry out the order of halogenation and amination. Appropriate benzoic acid derivatives are esterified with alcohols and then reacted with Grignard reagents to form a benzophenone structure. After that, chlorine and fluorine atoms are introduced on the benzene ring, and halogenation reactions can be used, such as chlorination agents (such as sulfoxide chloride, phosphorus oxychloride, etc.), fluorination agents (such as potassium fluoride, Selectfluor, etc.), and halogenation is carried out under suitable conditions After halogenation, the operation of amination is carried out. The method is as above, and 2-amino-3-chloro-4-fluorobenzophenone can also be obtained.
The advantages and disadvantages of each method are mutually present. The method of acylation initiation is relatively direct, but the reaction conditions need to be carefully adjusted to avoid side reactions; the method of first forming benzophenone precursor, although the route is slightly longer, the reaction selectivity of each step is easy to control. In actual operation, when the requirements of raw material availability, cost, yield and purity are selected carefully.
What are the physical properties of 2-amino-3-chloro-4-fluoronitrobenzene?
The physical properties of 2-% hydroxy-3-chloro-4-fluorobenzoyl group, with characteristics such as color, state, taste, melting boiling point, solubility, density, etc.
This substance may be solid at room temperature, and may be white to white powder in appearance. It is delicate like snow and soft to the touch. Smell it, or have a specific smell, but it is not pungent and foul, but has a unique smell of chemicals.
On its melting point, melting point or in a specific range, such as about [X] ° C, this is determined by intermolecular forces and structures. When heated to the melting point, the solid phase will gradually melt into a liquid phase, like ice and snow melting in the warm sun. The boiling point is around [X] ° C. When heated to this point, the liquid phase will rapidly transform into the gas phase, and the molecules will be able to break free from each other.
In terms of solubility, in organic solvents, such as ethanol and acetone, there may be a certain solubility. Ethanol is like the spirit of water, interacting with the molecules of this substance, causing the latter to gradually melt into it to form a uniform and stable solution. However, in water, the solubility may be limited, and because the polarity of the molecular structure does not match that of water, it is difficult for oil and water to blend.
Density is also an important physical property, or heavier than water. It is placed in water, such as a stone sinking abyss, and slowly settles to the bottom. Due to the tight accumulation of molecules, the mass per unit volume is large.
Its stability is also the key physical property. Under normal conditions, or with certain stability, the molecular structure can be maintained relatively stable. However, under special conditions such as strong acid, strong base or high temperature, strong oxidant, etc., the chemical bonds in the molecule may be broken and rearranged by impact, triggering chemical reactions and changing their physical properties. In case of strong acid, hydroxyl or protonation, a series of chain reactions will be triggered, rewriting its chemical fate.
This substance may be solid at room temperature, and may be white to white powder in appearance. It is delicate like snow and soft to the touch. Smell it, or have a specific smell, but it is not pungent and foul, but has a unique smell of chemicals.
On its melting point, melting point or in a specific range, such as about [X] ° C, this is determined by intermolecular forces and structures. When heated to the melting point, the solid phase will gradually melt into a liquid phase, like ice and snow melting in the warm sun. The boiling point is around [X] ° C. When heated to this point, the liquid phase will rapidly transform into the gas phase, and the molecules will be able to break free from each other.
In terms of solubility, in organic solvents, such as ethanol and acetone, there may be a certain solubility. Ethanol is like the spirit of water, interacting with the molecules of this substance, causing the latter to gradually melt into it to form a uniform and stable solution. However, in water, the solubility may be limited, and because the polarity of the molecular structure does not match that of water, it is difficult for oil and water to blend.
Density is also an important physical property, or heavier than water. It is placed in water, such as a stone sinking abyss, and slowly settles to the bottom. Due to the tight accumulation of molecules, the mass per unit volume is large.
Its stability is also the key physical property. Under normal conditions, or with certain stability, the molecular structure can be maintained relatively stable. However, under special conditions such as strong acid, strong base or high temperature, strong oxidant, etc., the chemical bonds in the molecule may be broken and rearranged by impact, triggering chemical reactions and changing their physical properties. In case of strong acid, hydroxyl or protonation, a series of chain reactions will be triggered, rewriting its chemical fate.
What are the chemical properties of 2-amino-3-chloro-4-fluoronitrobenzene?
The chemical properties of 2-% amino-3-chloro-4-fluorobenzoyl are as follows:
This compound has a certain alkalinity due to its amino group, and can form salts with acids. Its amino nitrogen atom has lone pair electrons and can participate in nucleophilic reactions. For example, acylation reactions occur with acyl halides, acid anhydrides, etc., to form amide compounds. This reaction is commonly used in organic synthesis to prepare amide-containing structural drugs or materials.
Chlorine atoms, as halogen atoms, have strong reactivity. In nucleophilic substitution reactions, chlorine atoms can be replaced by various nucleophilic reagents. For example, the reaction with sodium alcohol can generate corresponding ethers, and the reaction with amines can produce nitrogen-containing substitutes. However, the reaction conditions need to be finely regulated according to the specific reagents and substrate activities, and are usually carried out with suitable organic solvents and catalysts.
The introduction of fluorine atoms greatly affects the distribution and spatial structure of molecular electron clouds. Fluorine atoms are highly electronegative and have a strong electron-absorbing induction effect, which reduces the electron cloud density of the benzene ring, affects the electrophilic substitution reaction activity and regioselectivity on the benzene ring, and often makes the reaction more inclined to meta-substitution. And due to the high C-F bond energy, fluorine-containing compounds often have high chemical stability and biological activity. They are widely used in pesticides and medicine, which can improve the metabolic stability and bioavailability of compounds.
In the benzoyl moiety, the carbonyl group has strong polarity, and the carbon has a partial positive charge. It is susceptible to attack by nucleophilic reagents, and nucleophilic addition reactions occur. For example, acetal or hemiacetal structures are formed with alcohols under acid catalysis. Reaction with Grignard reagents can build new carbon-carbon bonds, expand the molecular carbon skeleton, and provide an effective path for the synthesis of complex organic compounds.
In addition, the whole molecule contains multiple different functional groups, and the interaction between functional groups makes the reaction activity and selectivity more complex. When designing a synthesis route or studying the reaction mechanism, it is necessary to comprehensively consider the properties and interactions of each functional group, and optimize the reaction conditions through reasonable protection and deprotection strategies to achieve efficient synthesis and specific transformation of the target product.
This compound has a certain alkalinity due to its amino group, and can form salts with acids. Its amino nitrogen atom has lone pair electrons and can participate in nucleophilic reactions. For example, acylation reactions occur with acyl halides, acid anhydrides, etc., to form amide compounds. This reaction is commonly used in organic synthesis to prepare amide-containing structural drugs or materials.
Chlorine atoms, as halogen atoms, have strong reactivity. In nucleophilic substitution reactions, chlorine atoms can be replaced by various nucleophilic reagents. For example, the reaction with sodium alcohol can generate corresponding ethers, and the reaction with amines can produce nitrogen-containing substitutes. However, the reaction conditions need to be finely regulated according to the specific reagents and substrate activities, and are usually carried out with suitable organic solvents and catalysts.
The introduction of fluorine atoms greatly affects the distribution and spatial structure of molecular electron clouds. Fluorine atoms are highly electronegative and have a strong electron-absorbing induction effect, which reduces the electron cloud density of the benzene ring, affects the electrophilic substitution reaction activity and regioselectivity on the benzene ring, and often makes the reaction more inclined to meta-substitution. And due to the high C-F bond energy, fluorine-containing compounds often have high chemical stability and biological activity. They are widely used in pesticides and medicine, which can improve the metabolic stability and bioavailability of compounds.
In the benzoyl moiety, the carbonyl group has strong polarity, and the carbon has a partial positive charge. It is susceptible to attack by nucleophilic reagents, and nucleophilic addition reactions occur. For example, acetal or hemiacetal structures are formed with alcohols under acid catalysis. Reaction with Grignard reagents can build new carbon-carbon bonds, expand the molecular carbon skeleton, and provide an effective path for the synthesis of complex organic compounds.
In addition, the whole molecule contains multiple different functional groups, and the interaction between functional groups makes the reaction activity and selectivity more complex. When designing a synthesis route or studying the reaction mechanism, it is necessary to comprehensively consider the properties and interactions of each functional group, and optimize the reaction conditions through reasonable protection and deprotection strategies to achieve efficient synthesis and specific transformation of the target product.
What is the price range of 2-amino-3-chloro-4-fluoronitrobenzene in the market?
Today there are 2-amino-3-chloro-4-fluorobenzoyl benzene, what is the price in the market? This is a raw material for fine chemicals, and the range of its price is related to various factors.
If the source of the raw material is different, the quality and quantity are different, and the price also changes. If the source is wide and easy to obtain, the price may be slightly flat; if the source is rare and difficult to harvest, the price will be high.
The simplicity of the process is also the main reason. If the preparation of this product requires a multi-step reaction, the conditions are harsh, time-consuming and labor-intensive, and the reagents used are expensive, the cost will be high, and its price in the market will also be high; if the process is simple, the energy consumption is low, the cost will drop, and the price will also decrease.
The situation of market supply and demand, especially the price. If there are many people who want it, but there are few people who supply it, the so-called "rare things are expensive", the price will rise; if the supply exceeds the demand, the business wants to sell it quickly, and the price may fall.
At present, 2-amino-3-chloro-4-fluorobenzoyl benzene is in the market, and its price per kilogram is about 500 yuan to 2,000 yuan. However, this is only an approximate number, and the market conditions are ever-changing, and the price is also Or due to unexpected events, such as a sudden decrease in the output of raw materials, or a sharp drop in costs due to the introduction of new technologies, the price can be changed. To know the real-time price, it is necessary to carefully observe the dynamics of the chemical market and consult the merchants and industry personnel to obtain the exact number.
If the source of the raw material is different, the quality and quantity are different, and the price also changes. If the source is wide and easy to obtain, the price may be slightly flat; if the source is rare and difficult to harvest, the price will be high.
The simplicity of the process is also the main reason. If the preparation of this product requires a multi-step reaction, the conditions are harsh, time-consuming and labor-intensive, and the reagents used are expensive, the cost will be high, and its price in the market will also be high; if the process is simple, the energy consumption is low, the cost will drop, and the price will also decrease.
The situation of market supply and demand, especially the price. If there are many people who want it, but there are few people who supply it, the so-called "rare things are expensive", the price will rise; if the supply exceeds the demand, the business wants to sell it quickly, and the price may fall.
At present, 2-amino-3-chloro-4-fluorobenzoyl benzene is in the market, and its price per kilogram is about 500 yuan to 2,000 yuan. However, this is only an approximate number, and the market conditions are ever-changing, and the price is also Or due to unexpected events, such as a sudden decrease in the output of raw materials, or a sharp drop in costs due to the introduction of new technologies, the price can be changed. To know the real-time price, it is necessary to carefully observe the dynamics of the chemical market and consult the merchants and industry personnel to obtain the exact number.
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