Linshang Chemical
PRODUCTS
2-Amino-4-Chloro-Benzenemethanol
Linshang Chemical
|
HS Code |
902560 |
| Chemical Formula | C7H8ClNO |
| Molecular Weight | 157.597 g/mol |
| Appearance | Solid (likely white or off - white powder) |
| Solubility In Water | Low solubility due to non - polar benzene ring and relatively small polar groups |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone, dichloromethane |
| Odor | May have a faint, characteristic organic odor |
| Pka | The amino group can have a pKa value relevant for its basicity in solution |
| Stability | Stable under normal conditions, but may react with strong oxidizing or reducing agents |
As an accredited 2-Amino-4-Chloro-Benzenemethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - amino - 4 - chloro - benzenemethanol packaged in a sealed, labeled container. |
| Storage | 2 - amino - 4 - chloro - benzenemethanol should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and direct sunlight. Store in a tightly - sealed container to prevent moisture absorption and contact with air, which could potentially lead to degradation. Separate it from oxidizing agents and incompatible substances to avoid chemical reactions. |
| Shipping | 2 - amino - 4 - chloro - benzenemethanol should be shipped in well - sealed containers, compliant with chemical transportation regulations. Packing must prevent leakage, and appropriate hazard labels indicating its nature should be affixed for safe transit. |
Competitive 2-Amino-4-Chloro-Benzenemethanol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Amino-4-Chloro-Benzenemethanol in China?
As a trusted 2-Amino-4-Chloro-Benzenemethanol manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Amino-4-Chloro-Benzenemethanol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 2-amino-4-chloro-benzenemethanol?
2-Amino-4-chlorobenzyl alcohol, an organic compound with specific chemical properties. Its molecules contain an amino group (-NH2O), a chlorine atom (-Cl), and a hydroxymethyl group (-CH2O OH).
In terms of reactivity, the amino group is basic and can form salts with acids. It can also participate in nucleophilic substitution reactions. In case of acyl halide or acid anhydride, the nitrogen atom in the amino group will attack the acyl carbon and form amide compounds.
Although the chlorine atom is attached to the benzene ring, its activity is lower than that of the halogen atom in the halogenated alkane due to the conjugated system of the benzene ring. However, under certain conditions, such as strong nucleophilic reagents, high temperatures, and catalysts, it can still be replaced. Like reacting with phenols, chlorine atoms are replaced by phenoxy groups.
Hydroxymethyl is active, and hydroxyl groups can undergo various reactions. Hydroxyl groups can be oxidized, and weak oxidants such as Sarit reagent can oxidize them to aldehyde groups to obtain 2-amino-4-chlorobenzaldehyde; strong oxidants such as potassium permanganate can be further oxidized to carboxyl groups to form 2-amino-4-chlorobenzoic acid. In addition, hydroxyl groups can be esterified with carboxylic acids under acid catalysis to form corresponding ester compounds.
In terms of physical properties, the compound has a certain solubility in water due to its polar groups, and the melting and boiling point is also affected due to the formation of hydrogen bonds between molecules. At the same time, the benzene ring imparts a certain aromaticity, making it more soluble in organic solvents such as ethanol and ether.
In short, 2-amino-4-chlorobenzyl alcohol has various chemical properties due to its functional groups. It is widely used in the field of organic synthesis and can be used as an intermediate to prepare a variety of organic compounds containing nitrogen, chlorine and oxygen.
In terms of reactivity, the amino group is basic and can form salts with acids. It can also participate in nucleophilic substitution reactions. In case of acyl halide or acid anhydride, the nitrogen atom in the amino group will attack the acyl carbon and form amide compounds.
Although the chlorine atom is attached to the benzene ring, its activity is lower than that of the halogen atom in the halogenated alkane due to the conjugated system of the benzene ring. However, under certain conditions, such as strong nucleophilic reagents, high temperatures, and catalysts, it can still be replaced. Like reacting with phenols, chlorine atoms are replaced by phenoxy groups.
Hydroxymethyl is active, and hydroxyl groups can undergo various reactions. Hydroxyl groups can be oxidized, and weak oxidants such as Sarit reagent can oxidize them to aldehyde groups to obtain 2-amino-4-chlorobenzaldehyde; strong oxidants such as potassium permanganate can be further oxidized to carboxyl groups to form 2-amino-4-chlorobenzoic acid. In addition, hydroxyl groups can be esterified with carboxylic acids under acid catalysis to form corresponding ester compounds.
In terms of physical properties, the compound has a certain solubility in water due to its polar groups, and the melting and boiling point is also affected due to the formation of hydrogen bonds between molecules. At the same time, the benzene ring imparts a certain aromaticity, making it more soluble in organic solvents such as ethanol and ether.
In short, 2-amino-4-chlorobenzyl alcohol has various chemical properties due to its functional groups. It is widely used in the field of organic synthesis and can be used as an intermediate to prepare a variety of organic compounds containing nitrogen, chlorine and oxygen.
What are the common synthetic methods of 2-amino-4-chloro-benzenemethanol?
The common synthesis methods of 2-amino-4-chlorobenzyl alcohol have many ways, and now it is your turn to be detailed.
First, the method of using 2-amino-4-chlorobenzoic acid as the starting material. First, this acid and lithium aluminum hydride are reacted in a suitable organic solvent, such as anhydrous tetrahydrofuran, at low temperature and in a nitrogen-protected atmosphere. Lithium aluminum hydride has strong reductivity and can reduce carboxyl groups to alcohol hydroxyl groups, resulting in the target product 2-amino-4-chlorobenzyl alcohol. This process requires strict control of the reaction temperature and time. If the temperature is too low, the reaction will be slow, and if it is too high, it will easily cause side reactions. After the reaction is completed, a pure product can be obtained through post-treatment steps such as hydrolysis, extraction, and column chromatography.
Second, 2-nitro-4-chlorobenzoic acid is used as the starting material. First, iron powder, hydrochloric acid, etc. are used as reducing agents to reduce nitro groups to amino groups to obtain 2-amino-4-chlorobenzoic acid. Subsequently, as mentioned above, the carboxyl group is reduced to alcohol hydroxyl groups by lithium aluminum hydride. Although this path has a little more steps, the raw materials are relatively easy to obtain and are also commonly used methods. It should be noted that during the reduction of iron powder, the pH of the reaction system has a great impact on the reaction and must be carefully regulated.
Third, 2-amino-4-chlorobenzaldehyde is used as the raw material. In the presence of a catalyst, sodium borohydride or sodium cyanoborohydride is used as the reducing agent and reacts in alcohol solvents such as methanol or ethanol. Reducing agents such as sodium borohydride can selectively reduce aldehyde groups to alcohol hydroxyl groups, and the conditions are relatively mild and there are few side reactions. After the reaction is completed, the product can be obtained by simple filtration, concentration, recrystallization and other operations. This method is easy to operate and does not require harsh equipment, making it quite practical.
In short, the methods for synthesizing 2-amino-4-chlorobenzyl alcohol have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as raw material availability, cost, and product purity requirements, and choose the most suitable one.
First, the method of using 2-amino-4-chlorobenzoic acid as the starting material. First, this acid and lithium aluminum hydride are reacted in a suitable organic solvent, such as anhydrous tetrahydrofuran, at low temperature and in a nitrogen-protected atmosphere. Lithium aluminum hydride has strong reductivity and can reduce carboxyl groups to alcohol hydroxyl groups, resulting in the target product 2-amino-4-chlorobenzyl alcohol. This process requires strict control of the reaction temperature and time. If the temperature is too low, the reaction will be slow, and if it is too high, it will easily cause side reactions. After the reaction is completed, a pure product can be obtained through post-treatment steps such as hydrolysis, extraction, and column chromatography.
Second, 2-nitro-4-chlorobenzoic acid is used as the starting material. First, iron powder, hydrochloric acid, etc. are used as reducing agents to reduce nitro groups to amino groups to obtain 2-amino-4-chlorobenzoic acid. Subsequently, as mentioned above, the carboxyl group is reduced to alcohol hydroxyl groups by lithium aluminum hydride. Although this path has a little more steps, the raw materials are relatively easy to obtain and are also commonly used methods. It should be noted that during the reduction of iron powder, the pH of the reaction system has a great impact on the reaction and must be carefully regulated.
Third, 2-amino-4-chlorobenzaldehyde is used as the raw material. In the presence of a catalyst, sodium borohydride or sodium cyanoborohydride is used as the reducing agent and reacts in alcohol solvents such as methanol or ethanol. Reducing agents such as sodium borohydride can selectively reduce aldehyde groups to alcohol hydroxyl groups, and the conditions are relatively mild and there are few side reactions. After the reaction is completed, the product can be obtained by simple filtration, concentration, recrystallization and other operations. This method is easy to operate and does not require harsh equipment, making it quite practical.
In short, the methods for synthesizing 2-amino-4-chlorobenzyl alcohol have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as raw material availability, cost, and product purity requirements, and choose the most suitable one.
In what areas is 2-amino-4-chloro-benzenemethanol applied?
2-Amino-4-chloro-benzenemethanol, Chinese name 2-amino-4-chlorobenzyl alcohol, this substance has wonderful uses in medicine, chemical industry and other fields.
In the field of medicine, it is a key intermediate. Because it contains amino and chlorine atoms, it has unique chemical activity and can synthesize a variety of bioactive compounds through a series of reactions. It can be used to prepare antibacterial drugs, which can enhance the inhibition or killing effect of specific bacteria by modifying the structure; or it can be used to develop anti-tumor drugs, which interfere with the growth and proliferation of tumor cells by interacting with tumor cell targets.
In the chemical industry, it has made great contributions to organic synthetic chemistry. It can be used as a starting material to build complex organic molecular structures through cleverly designed reaction paths. In the branch of materials science, it may be able to participate in the synthesis of special functional materials. For example, polymerization with specific monomers to generate polymer materials with unique optical and electrical properties, which can be used in optoelectronic devices, such as organic Light Emitting Diodes (OLEDs), to improve their luminous efficiency and stability.
Furthermore, it also has potential in the creation of pesticides. It can be derived from compounds that have high-efficiency repellent or toxic effects on pests, and due to structural characteristics, it may be environmentally friendly, ensuring agricultural production while reducing the negative impact on the ecological environment.
In conclusion, 2 - amino - 4 - chloro - benzenemethanol occupies an important position in many industries such as medicine, chemical industry, and pesticide due to its unique structure, providing many possibilities for innovation and development in related fields.
In the field of medicine, it is a key intermediate. Because it contains amino and chlorine atoms, it has unique chemical activity and can synthesize a variety of bioactive compounds through a series of reactions. It can be used to prepare antibacterial drugs, which can enhance the inhibition or killing effect of specific bacteria by modifying the structure; or it can be used to develop anti-tumor drugs, which interfere with the growth and proliferation of tumor cells by interacting with tumor cell targets.
In the chemical industry, it has made great contributions to organic synthetic chemistry. It can be used as a starting material to build complex organic molecular structures through cleverly designed reaction paths. In the branch of materials science, it may be able to participate in the synthesis of special functional materials. For example, polymerization with specific monomers to generate polymer materials with unique optical and electrical properties, which can be used in optoelectronic devices, such as organic Light Emitting Diodes (OLEDs), to improve their luminous efficiency and stability.
Furthermore, it also has potential in the creation of pesticides. It can be derived from compounds that have high-efficiency repellent or toxic effects on pests, and due to structural characteristics, it may be environmentally friendly, ensuring agricultural production while reducing the negative impact on the ecological environment.
In conclusion, 2 - amino - 4 - chloro - benzenemethanol occupies an important position in many industries such as medicine, chemical industry, and pesticide due to its unique structure, providing many possibilities for innovation and development in related fields.
What are the physical properties of 2-amino-4-chloro-benzenemethanol?
2-Amino-4-chloro-benzenemethanol is one of the organic compounds. Depending on its physical properties, it may be in a solid state at room temperature and pressure.
Its melting point has a specific value due to the intermolecular force. There are amino groups, chlorine atoms and benzyl alcohol structures in the molecule of this compound, which can cause the formation of hydrogen bonds and other forces between molecules, so that its melting point is within a certain range. I have not checked the specific data in detail.
When it comes to boiling point, the energy required for boiling is determined by factors such as the relative mass of the molecule, the type and intensity of the intermolecular force. However, there is no exact research data, and it is difficult to state the exact boiling point.
In terms of solubility, the amino group has a certain hydrophilicity, and the benzene ring and chlorine atoms have hydrophobicity. It may have a certain solubility in water, but the overall solubility is limited due to the influence of hydrophobic groups such as the benzene ring. In organic solvents, such as ethanol, acetone, etc., due to the principle of similarity and miscibility, its solubility may be higher, and the molecular structure is similar to that of organic solvent molecules and can interact with each other.
On the appearance, if there is no impurity interference, or it is a white to off-white solid powder, this is a common appearance of many benzene-containing organic compounds with relatively regular structures. Its smell, or due to molecular structure characteristics, has a weak special smell, but without professional equipment and sensitive sense of smell, it may be difficult for ordinary people to detect. The density of
is also affected by the molecular structure and packing mode. Although there is no measured data, it is inferred that the density may be similar to that of common benzene-containing organic compounds, and it is within a reasonable range.
Its melting point has a specific value due to the intermolecular force. There are amino groups, chlorine atoms and benzyl alcohol structures in the molecule of this compound, which can cause the formation of hydrogen bonds and other forces between molecules, so that its melting point is within a certain range. I have not checked the specific data in detail.
When it comes to boiling point, the energy required for boiling is determined by factors such as the relative mass of the molecule, the type and intensity of the intermolecular force. However, there is no exact research data, and it is difficult to state the exact boiling point.
In terms of solubility, the amino group has a certain hydrophilicity, and the benzene ring and chlorine atoms have hydrophobicity. It may have a certain solubility in water, but the overall solubility is limited due to the influence of hydrophobic groups such as the benzene ring. In organic solvents, such as ethanol, acetone, etc., due to the principle of similarity and miscibility, its solubility may be higher, and the molecular structure is similar to that of organic solvent molecules and can interact with each other.
On the appearance, if there is no impurity interference, or it is a white to off-white solid powder, this is a common appearance of many benzene-containing organic compounds with relatively regular structures. Its smell, or due to molecular structure characteristics, has a weak special smell, but without professional equipment and sensitive sense of smell, it may be difficult for ordinary people to detect. The density of
is also affected by the molecular structure and packing mode. Although there is no measured data, it is inferred that the density may be similar to that of common benzene-containing organic compounds, and it is within a reasonable range.
What is the market price of 2-amino-4-chloro-benzenemethanol?
2-Amino-4-chlorobenzyl alcohol, the market price of this product is difficult to determine. The market situation changes rapidly and fluctuates due to many factors.
First, the supply of goods is the key. If the production area is abundant, the supply of raw materials is abundant, and the preparation process is advanced, the output can be improved, and the supply of goods in the market is sufficient, the price may stabilize or even drop. On the contrary, if the raw materials are scarce, the preparation is difficult, the output is limited, and the supply is tight, the price will rise.
Second, the demand trend has a great impact. In the field of medicine, if the research and development of new drugs with this as a key intermediate progresses smoothly, clinical demand surges, or the production scale of downstream pharmaceutical companies expands, the demand for them increases sharply, and the price will be pushed up. And if the development of related industries is sluggish, the demand is sluggish, and the price may be under pressure.
Third, the state of market competition cannot be ignored. If there are many suppliers in the city, the competition is fierce, and each is competing for market share, or price promotion is reduced to win the favor of buyers. However, if the market is almost monopolized, or only a few suppliers control resources, their pricing power is strong, and the price may remain high.
Fourth, policies and regulations and economic trends also affect the price. Environmental protection policies have become stricter, production is limited, costs have increased, and prices may rise. The economy is prosperous, the market is active, and various industries are developing vigorously, and demand drives prices up; in the economic downturn, consumption and production are suppressed, and prices may also decline.
To know its accurate market price, you need to often look at the chemical raw material trading platform, industry information, and communicate with the industry merchants to grasp the real-time dynamics of its price.
First, the supply of goods is the key. If the production area is abundant, the supply of raw materials is abundant, and the preparation process is advanced, the output can be improved, and the supply of goods in the market is sufficient, the price may stabilize or even drop. On the contrary, if the raw materials are scarce, the preparation is difficult, the output is limited, and the supply is tight, the price will rise.
Second, the demand trend has a great impact. In the field of medicine, if the research and development of new drugs with this as a key intermediate progresses smoothly, clinical demand surges, or the production scale of downstream pharmaceutical companies expands, the demand for them increases sharply, and the price will be pushed up. And if the development of related industries is sluggish, the demand is sluggish, and the price may be under pressure.
Third, the state of market competition cannot be ignored. If there are many suppliers in the city, the competition is fierce, and each is competing for market share, or price promotion is reduced to win the favor of buyers. However, if the market is almost monopolized, or only a few suppliers control resources, their pricing power is strong, and the price may remain high.
Fourth, policies and regulations and economic trends also affect the price. Environmental protection policies have become stricter, production is limited, costs have increased, and prices may rise. The economy is prosperous, the market is active, and various industries are developing vigorously, and demand drives prices up; in the economic downturn, consumption and production are suppressed, and prices may also decline.
To know its accurate market price, you need to often look at the chemical raw material trading platform, industry information, and communicate with the industry merchants to grasp the real-time dynamics of its price.
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