Linshang Chemical
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2-Amino-5-Chloro-2-Phenylbenzenemethanol
Linshang Chemical
|
HS Code |
808729 |
| Chemical Formula | C13H12ClNO |
| Molecular Weight | 233.69 |
| Appearance | Solid (usually white to off - white powder) |
| Melting Point | Specific value depends on purity, typically in a certain range |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in some organic solvents like ethanol, dichloromethane |
| Density | Value varies with conditions |
| Pka | Relevant to its acidic - basic properties in solution |
| Flash Point | Determined by standard methods for flammability assessment |
As an accredited 2-Amino-5-Chloro-2-Phenylbenzenemethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - amino - 5 - chloro - 2 - phenylbenzenemethanol in sealed plastic bags for protection. |
| Storage | Store 2 - amino - 5 - chloro - 2 - phenylbenzenemethanol in a cool, dry place, away from direct sunlight and heat sources. Keep it in a tightly sealed container to prevent exposure to air and moisture, which could potentially lead to degradation. Store it separately from incompatible substances like strong oxidizing agents or acids to avoid chemical reactions. |
| Shipping | 2 - amino - 5 - chloro - 2 - phenylbenzenemethanol should be shipped in well - sealed containers, compliant with chemical transport regulations. Ensure proper labeling indicating its nature. Ship via carriers experienced in handling such chemicals to prevent spills and ensure safe transit. |
Competitive 2-Amino-5-Chloro-2-Phenylbenzenemethanol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Amino-5-Chloro-2-Phenylbenzenemethanol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 2-amino-5-chloro-2-phenylbenzenemethanol?
2 - amino - 5 - chloro - 2 - phenylbenzenemethanol is an organic compound whose chemical properties are worth exploring. This compound contains an amino group (-NH ²), a chlorine atom (-Cl), and a structural part of benzyl alcohol.
Let's talk about the amino group first. The amino group is basic because its nitrogen atom has lone pairs of electrons and can accept protons. When exposed to acid, the amino group is easy to react with acid to form salts. This property can be used in organic synthesis to separate or purify mixtures containing this compound. For example, if there are other non-basic impurities in the mixed system, an appropriate amount of acid can be added to dissolve the compound containing amino groups into salts in the aqueous phase, separate from the impurities in the organic phase, and then adjust the pH value to precipitate the compound.
Chlorine atoms also have important chemical activities in this compound. It can participate in nucleophilic substitution reactions, because the chlorine atom is a good leaving group, when there is a nucleophilic reagent, the nucleophilic reagent will attack the carbon atom connected to the chlorine, and the chlorine atom will leave to form a new organic compound. For example, using sodium oxide as a nucleophilic reagent, the anion of alcohol and oxygen attacks the carbon atom, and the chlorine atom leaves to form an ether compound. This reaction is an important method for constructing carbon-oxygen bonds and is often used in organic synthesis.
In addition, the structure of benzyl alcohol gives the compound a certain lipid solubility. The benzene ring has a conjugated system, which is relatively stable in nature and can enhance the interaction between the compound and non-polar solvents. The methanol group (CH 2O OH) can participate in the esterification reaction and react with carboxylic acids under acid catalysis to form esters. This ester product may have applications in the fields of fragrances, pharmaceuticals, etc.
In addition, the carbon atom connected to the benzene ring in this compound may participate in some special reactions due to the presence of substituents such as amino and chlorine atoms in its ortho-positions, and the electron cloud density distribution is affected, such as electrophilic substitution reactions. The location effect of the substituent will determine the position of the new substituent entering the benzene ring.
2-amino-5-chloro-2-phenylbenzenemethanol has rich chemical properties, which lay the foundation for its application in many fields such as organic synthesis and drug development.
Let's talk about the amino group first. The amino group is basic because its nitrogen atom has lone pairs of electrons and can accept protons. When exposed to acid, the amino group is easy to react with acid to form salts. This property can be used in organic synthesis to separate or purify mixtures containing this compound. For example, if there are other non-basic impurities in the mixed system, an appropriate amount of acid can be added to dissolve the compound containing amino groups into salts in the aqueous phase, separate from the impurities in the organic phase, and then adjust the pH value to precipitate the compound.
Chlorine atoms also have important chemical activities in this compound. It can participate in nucleophilic substitution reactions, because the chlorine atom is a good leaving group, when there is a nucleophilic reagent, the nucleophilic reagent will attack the carbon atom connected to the chlorine, and the chlorine atom will leave to form a new organic compound. For example, using sodium oxide as a nucleophilic reagent, the anion of alcohol and oxygen attacks the carbon atom, and the chlorine atom leaves to form an ether compound. This reaction is an important method for constructing carbon-oxygen bonds and is often used in organic synthesis.
In addition, the structure of benzyl alcohol gives the compound a certain lipid solubility. The benzene ring has a conjugated system, which is relatively stable in nature and can enhance the interaction between the compound and non-polar solvents. The methanol group (CH 2O OH) can participate in the esterification reaction and react with carboxylic acids under acid catalysis to form esters. This ester product may have applications in the fields of fragrances, pharmaceuticals, etc.
In addition, the carbon atom connected to the benzene ring in this compound may participate in some special reactions due to the presence of substituents such as amino and chlorine atoms in its ortho-positions, and the electron cloud density distribution is affected, such as electrophilic substitution reactions. The location effect of the substituent will determine the position of the new substituent entering the benzene ring.
2-amino-5-chloro-2-phenylbenzenemethanol has rich chemical properties, which lay the foundation for its application in many fields such as organic synthesis and drug development.
What are the physical properties of 2-amino-5-chloro-2-phenylbenzenemethanol?
2 - amino - 5 - chloro - 2 - phenylbenzenemethanol is an organic compound, and its physical properties are quite important, which is related to the application of this substance in many fields.
The appearance of this compound may be crystalline, and the texture is delicate, just like crystal clear ice crystals. Under specific light, or shimmering. Its color may be white and pure like snow, symbolizing extremely high purity. This property is crucial in some experiments or production processes that require strict color.
Melting point is also a key physical property. After precise determination, its melting point is in a specific temperature range. At this temperature, the compound gradually melts from solid to liquid, just like ice and snow melting in warm sunlight. The melting point range can be used as an important basis for identifying the authenticity and purity of this compound. If the melting point deviation is too large, or it implies that it contains impurities, the purity is not good.
In terms of solubility, 2-amino-5-chloro-2-phenylbenzenemethanol in different solvents. In some organic solvents, such as ethanol and acetone, or show good solubility, it can be uniformly dispersed to form a clear solution, which is as natural and smooth as salt into water; in water, its solubility is poor, only a small amount can be dissolved, and the rest may be suspended, just like fine sand in water is difficult to completely blend. This solubility characteristic needs to be carefully considered when separating, purifying and preparing related solutions.
In addition, density is also a physical property that cannot be ignored. Its density is specific, reflecting the mass of the substance contained in a unit volume. This property is of great significance in terms of quantitative calculation of substances, mixing ratio control, etc., which is related to the accuracy of experimental results and the stability of the production process.
The physical properties of 2 - amino - 5 - chloro - 2 - phenylbenzenemethanol, from appearance, melting point, solubility to density, have a profound impact on its research and application. Only through in-depth understanding can we make good use of this compound.
The appearance of this compound may be crystalline, and the texture is delicate, just like crystal clear ice crystals. Under specific light, or shimmering. Its color may be white and pure like snow, symbolizing extremely high purity. This property is crucial in some experiments or production processes that require strict color.
Melting point is also a key physical property. After precise determination, its melting point is in a specific temperature range. At this temperature, the compound gradually melts from solid to liquid, just like ice and snow melting in warm sunlight. The melting point range can be used as an important basis for identifying the authenticity and purity of this compound. If the melting point deviation is too large, or it implies that it contains impurities, the purity is not good.
In terms of solubility, 2-amino-5-chloro-2-phenylbenzenemethanol in different solvents. In some organic solvents, such as ethanol and acetone, or show good solubility, it can be uniformly dispersed to form a clear solution, which is as natural and smooth as salt into water; in water, its solubility is poor, only a small amount can be dissolved, and the rest may be suspended, just like fine sand in water is difficult to completely blend. This solubility characteristic needs to be carefully considered when separating, purifying and preparing related solutions.
In addition, density is also a physical property that cannot be ignored. Its density is specific, reflecting the mass of the substance contained in a unit volume. This property is of great significance in terms of quantitative calculation of substances, mixing ratio control, etc., which is related to the accuracy of experimental results and the stability of the production process.
The physical properties of 2 - amino - 5 - chloro - 2 - phenylbenzenemethanol, from appearance, melting point, solubility to density, have a profound impact on its research and application. Only through in-depth understanding can we make good use of this compound.
What are the main uses of 2-amino-5-chloro-2-phenylbenzenemethanol?
2 - amino - 5 - chloro - 2 - phenylbenzenemethanol, the Chinese name may be called 2 - amino - 5 - chloro - 2 - phenylbenzyl alcohol. This compound has important uses in many fields.
In the field of medicinal chemistry, it is a key intermediate in organic synthesis. Taking the creation of new antibacterial drugs as an example, through clever chemical modification and structural modification, the drug may be endowed with unique antibacterial activity and show excellent efficacy against specific drug-resistant bacteria. Because of the amino group, chlorine atom and benzene ring in the structure, it can precisely combine with key targets in bacteria and interfere with the normal physiological metabolism of bacteria, so as to achieve the purpose of antibacterial.
In the field of materials science, this compound may be able to participate in the preparation of high-performance materials. For example, when preparing polymer materials with special optical or electrical properties, it is introduced into the polymer backbone as a functional monomer. With its unique structure, the material has unique photochromic or conductive properties, which has great application potential in frontier fields such as optoelectronic devices and sensors.
In organic synthetic chemistry, it serves as an important building block for the construction of complex organic molecules. Because it contains multiple active check points, it can be cleverly spliced with other organic reagents through a variety of classic organic reactions, such as nucleophilic substitution, oxidation reduction, etc., to construct complex and diverse organic compounds, providing rich materials and possibilities for the innovative development of organic synthetic chemistry.
From this point of view, although 2 - amino - 5 - chloro - 2 - phenylbenzenemethanol is an organic compound, it plays an indispensable role in many fields such as medicine, materials, organic synthesis, etc., and promotes technological innovation and progress in various fields.
In the field of medicinal chemistry, it is a key intermediate in organic synthesis. Taking the creation of new antibacterial drugs as an example, through clever chemical modification and structural modification, the drug may be endowed with unique antibacterial activity and show excellent efficacy against specific drug-resistant bacteria. Because of the amino group, chlorine atom and benzene ring in the structure, it can precisely combine with key targets in bacteria and interfere with the normal physiological metabolism of bacteria, so as to achieve the purpose of antibacterial.
In the field of materials science, this compound may be able to participate in the preparation of high-performance materials. For example, when preparing polymer materials with special optical or electrical properties, it is introduced into the polymer backbone as a functional monomer. With its unique structure, the material has unique photochromic or conductive properties, which has great application potential in frontier fields such as optoelectronic devices and sensors.
In organic synthetic chemistry, it serves as an important building block for the construction of complex organic molecules. Because it contains multiple active check points, it can be cleverly spliced with other organic reagents through a variety of classic organic reactions, such as nucleophilic substitution, oxidation reduction, etc., to construct complex and diverse organic compounds, providing rich materials and possibilities for the innovative development of organic synthetic chemistry.
From this point of view, although 2 - amino - 5 - chloro - 2 - phenylbenzenemethanol is an organic compound, it plays an indispensable role in many fields such as medicine, materials, organic synthesis, etc., and promotes technological innovation and progress in various fields.
What are 2-amino-5-chloro-2-phenylbenzenemethanol synthesis methods?
To prepare 2 - amino - 5 - chloro - 2 - phenylbenzenemethanol, the method of organic synthesis is often followed. There are many methods, and the following are common methods.
First, it can be started from the corresponding halogenated aromatic hydrocarbon. First, take the halogenated benzene containing the appropriate substituent, and introduce the amino group by nucleophilic substitution reaction. When the halogen atom is active, it can react with ammonia or amine reagents under suitable conditions. For example, in a suitable solvent, there is a base present to promote the reaction, so that the halogen atom is replaced by an amino group. Then, through Grignard reaction or similar organometallic reagents, phenyl is introduced. The phenyl magnesium halide (Grignard reagent) reacts with intermediates containing halogenated hydrocarbon groups to form carbon-carbon bonds and construct the structure of 2-phenyl. Finally, the corresponding carbonyl compounds are reduced to obtain the target alcohol hydroxyl group. If a suitable reducing agent, such as sodium borohydride, is used to reduce the carbonyl group to a hydroxyl group under mild conditions, then 2-amino-5-chloro-2-phenylbenzenemethanol.
Second, aldol or ketone can also be used as the starting material. First, aromatic aldol or aromatic ketone containing amino and chlorine atoms is prepared, and phenyl is introduced through the nucleophilic addition reaction of aldol and ketone. For example, organolithium reagent or Grignard reagent is reacted with aromatic aldehyde or aromatic ketone to generate the corresponding alkoxide intermediate, and alcohol is obtained after hydrolysis. Subsequent protection and deprotection of amino groups may be required to prevent unnecessary changes in the reaction, to ensure that the reaction proceeds in the direction of the target product, and to accurately synthesize 2-amino-5-chloro-2-phenylbenzenemethanol.
When synthesizing this compound, attention should be paid to the conditions of each step of the reaction. Factors such as temperature, solvent, and the proportion of reactants all have a significant impact on the yield and selectivity of the reaction. And the separation and purification after each step of the reaction is also the key, and suitable separation methods, such as column chromatography, recrystallization, etc., are required to obtain pure intermediates and final products to ensure the success of the synthesis.
First, it can be started from the corresponding halogenated aromatic hydrocarbon. First, take the halogenated benzene containing the appropriate substituent, and introduce the amino group by nucleophilic substitution reaction. When the halogen atom is active, it can react with ammonia or amine reagents under suitable conditions. For example, in a suitable solvent, there is a base present to promote the reaction, so that the halogen atom is replaced by an amino group. Then, through Grignard reaction or similar organometallic reagents, phenyl is introduced. The phenyl magnesium halide (Grignard reagent) reacts with intermediates containing halogenated hydrocarbon groups to form carbon-carbon bonds and construct the structure of 2-phenyl. Finally, the corresponding carbonyl compounds are reduced to obtain the target alcohol hydroxyl group. If a suitable reducing agent, such as sodium borohydride, is used to reduce the carbonyl group to a hydroxyl group under mild conditions, then 2-amino-5-chloro-2-phenylbenzenemethanol.
Second, aldol or ketone can also be used as the starting material. First, aromatic aldol or aromatic ketone containing amino and chlorine atoms is prepared, and phenyl is introduced through the nucleophilic addition reaction of aldol and ketone. For example, organolithium reagent or Grignard reagent is reacted with aromatic aldehyde or aromatic ketone to generate the corresponding alkoxide intermediate, and alcohol is obtained after hydrolysis. Subsequent protection and deprotection of amino groups may be required to prevent unnecessary changes in the reaction, to ensure that the reaction proceeds in the direction of the target product, and to accurately synthesize 2-amino-5-chloro-2-phenylbenzenemethanol.
When synthesizing this compound, attention should be paid to the conditions of each step of the reaction. Factors such as temperature, solvent, and the proportion of reactants all have a significant impact on the yield and selectivity of the reaction. And the separation and purification after each step of the reaction is also the key, and suitable separation methods, such as column chromatography, recrystallization, etc., are required to obtain pure intermediates and final products to ensure the success of the synthesis.
What 2-amino-5-chloro-2-phenylbenzenemethanol need to pay attention to when storing and transporting
2-Amino-5-chloro-2-phenylbenzyl alcohol is an organic compound. During storage and transportation, many key issues need to be paid attention to to to ensure its quality and safety.
Bear the brunt, the storage environment is very important. It should be placed in a cool, dry and well-ventilated place. If the ambient temperature is too high, the chemical properties of this compound may change due to heat, or even cause decomposition reactions. Humid environments can easily make substances damp, or cause adverse reactions such as hydrolysis, which in turn affect purity and quality. Therefore, the storage place must be strictly controlled by temperature and humidity.
Secondly, it is necessary to pay attention to the tightness of packaging. A well-sealed packaging material should be used to prevent the intrusion of external factors such as air and moisture. Because 2-amino-5-chloro-2-phenylbenzyl alcohol contains active groups such as amino groups and hydroxyl groups, it is very easy to react with oxygen, carbon dioxide and other components in the air. Sealed packaging can effectively reduce the probability of such reactions.
Furthermore, the transportation process cannot be ignored. Handle with care to avoid damage to the packaging. Because of its sensitivity, excessive vibration, collision or rupture of the package will cause material leakage, which is not only wasteful but also a safety hazard. The means of transportation also need to maintain suitable environmental conditions to ensure stable temperature and humidity.
In addition, 2-amino-5-chloro-2-phenylbenzyl alcohol may be toxic and irritating. When storing and transporting, staff must take appropriate protective measures, such as wearing protective gloves, masks, goggles, etc., to prevent contact and inhalation and ensure personal safety.
In short, storing and transporting 2-amino-5-chloro-2-phenylbenzyl alcohol requires careful attention from various aspects such as the environment, packaging, handling and personnel protection to ensure that the whole process is safe and the quality of the material is not affected.
Bear the brunt, the storage environment is very important. It should be placed in a cool, dry and well-ventilated place. If the ambient temperature is too high, the chemical properties of this compound may change due to heat, or even cause decomposition reactions. Humid environments can easily make substances damp, or cause adverse reactions such as hydrolysis, which in turn affect purity and quality. Therefore, the storage place must be strictly controlled by temperature and humidity.
Secondly, it is necessary to pay attention to the tightness of packaging. A well-sealed packaging material should be used to prevent the intrusion of external factors such as air and moisture. Because 2-amino-5-chloro-2-phenylbenzyl alcohol contains active groups such as amino groups and hydroxyl groups, it is very easy to react with oxygen, carbon dioxide and other components in the air. Sealed packaging can effectively reduce the probability of such reactions.
Furthermore, the transportation process cannot be ignored. Handle with care to avoid damage to the packaging. Because of its sensitivity, excessive vibration, collision or rupture of the package will cause material leakage, which is not only wasteful but also a safety hazard. The means of transportation also need to maintain suitable environmental conditions to ensure stable temperature and humidity.
In addition, 2-amino-5-chloro-2-phenylbenzyl alcohol may be toxic and irritating. When storing and transporting, staff must take appropriate protective measures, such as wearing protective gloves, masks, goggles, etc., to prevent contact and inhalation and ensure personal safety.
In short, storing and transporting 2-amino-5-chloro-2-phenylbenzyl alcohol requires careful attention from various aspects such as the environment, packaging, handling and personnel protection to ensure that the whole process is safe and the quality of the material is not affected.
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