2-Amino-5-Chlorobenzenesulfonamide
Linshang Chemical
HS Code |
548439 |
Chemical Formula | C6H7ClN2O2S |
Molar Mass | 206.65 g/mol |
Appearance | White to off - white solid |
Solubility In Water | Slightly soluble |
Melting Point | 177 - 181 °C |
Boiling Point | Decomposes before boiling |
Odor | Odorless |
As an accredited 2-Amino-5-Chlorobenzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 250g of 2 - amino - 5 - chlorobenzenesulfonamide in sealed, chemical - resistant bags. |
Storage | 2 - amino - 5 - chlorobenzenesulfonamide should be stored in a cool, dry, and well - ventilated area. Keep it away from heat sources, open flames, and direct sunlight to prevent decomposition. Store in a tightly closed container to avoid moisture absorption and contact with air - reactive substances. It should also be separated from incompatible materials such as strong oxidizers and acids. |
Shipping | 2 - amino - 5 - chlorobenzenesulfonamide is shipped in well - sealed containers. It must comply with regulations for chemical shipments, ensuring proper labeling, protection from physical damage, and transport in conditions preventing degradation. |
Competitive 2-Amino-5-Chlorobenzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com


As a leading 2-Amino-5-Chlorobenzenesulfonamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
In its molecule, benzene is the core skeleton. On benzene, there are benzene substituents. One of the amino groups (-NH ²), and the two chlorine atoms (-Cl), and the two have a specific arrangement at the position of the sulfonamide group (-SO ² NH ²). The nitrogen atoms of the amino-sulfonamide group all have solitary particles, which can be reversed. The chlorine atom has a shadow cloud density due to its stability. In the sulfonamide group
, the sulfur atom is an oxygen atom and an amino group. This makes the compound have certain properties. The interaction of the substituents of benzene, the daughter of benzene, gives the specific activity of the compound. Because of its nitrogen, oxygen, chlorine and other atoms, it can be formed and other effects, and may have many uses in the fields of physicochemical and material chemistry. In short, the 2-amino-5-chlorobenzenesulfonamide is exquisite, and its chemistry and use lay the foundation.
In the field of medicine, it is often used as a key intermediate to synthesize drugs. Because this compound has a specific chemical structure and activity, it can participate in the construction of drug molecules. For example, in the preparation of some antibacterial drugs, 2-amino-5-chlorobenzenesulfonamide can be used as a starting material to construct drug molecules with antibacterial activity through a series of chemical reactions, providing an effective means for the treatment of bacterial infections.
In the field of pesticides, it also has important value. It can act as an intermediate for synthesizing pesticides and help prepare high-efficiency pesticides. After rational chemical modification, pesticides can be given good insecticidal, bactericidal or herbicidal properties, which is of great significance for pest control and weed control in agricultural production, and helps to improve crop yield and quality.
In addition, it also has a place in the dye industry. Because of its structure, it can participate in the synthesis of dye molecules, giving dyes specific colors and properties. Through chemical synthesis, it can be integrated into the molecular structure of dyes to produce dyes with bright color and good fastness, meeting the diverse needs of textile, printing and dyeing industries for dyes. In conclusion, although 2-amino-5-chlorobenzenesulfonamide is an organic compound, it plays a key role in many industries such as medicine, pesticides, and dyes due to its unique chemical properties, and is indispensable for promoting the development of related industries.
This substance is mostly white to beige crystalline powder at room temperature, and it looks fine. When you smell it, there is little special odor emitted, and you smell it under your nose, only a flat smell. Taste it, it is impossible, but according to its properties, it must have no special taste.
The melting point is between 160-165 ° C. When the temperature gradually rises to this point, the compound slowly melts from a solid state to a liquid state, just like ice and snow melting in the warm sun. The boiling point is relatively high, about 403.3 ° C. It can boil into a gas state under a high temperature environment, just like the boiling of water. The density of
is about 1.61g/cm ³. If it is placed in a specific container for measurement, this value can be obtained. It is slightly heavier than most common substances, just like iron in wood. Under the same volume, its mass is even higher.
The solubility in water is very small, just like oil droplets entering water, it is difficult to melt with water, and only a very small amount can be dissolved to form a very thin solution that is almost transparent; in organic solvents such as ethanol and acetone, the solubility is slightly better, and it can be partially dissolved. The solution may be slightly yellow and transparent, depending on the amount of solubility. This is due to the principle of "similar miscibility", and its molecular structure is partially similar to that of organic solvents, so it is more easily miscible.
First, take 5-chloro-2-nitrobenzenesulfonyl chloride as the starting material. First, it reacts with ammonia, which has good nucleophilicity and can attack the sulfonyl chloride group to obtain 5-chloro-2-nitrobenzenesulfonamide. The reaction conditions in this step are relatively mild, but the existence of nitro groups requires careful selection of conditions for subsequent reduction steps. After iron powder, hydrochloric acid, etc. are used as reducing agents to convert the nitro group into an amino group. The combination of iron powder and hydrochloric acid can efficiently reduce the nitro group at a suitable temperature and reaction time, and finally obtain 2-amino-5-chlorobenzenesulfonamide. Although the raw materials are easier to obtain in this way, the iron powder reduction treatment is slightly more complex, and iron sludge is formed, or the product separation is not easy.
Second, 2-aminobenzoic acid is used as the starting point. First, 2-aminobenzoic acid is treated with sodium nitrite and hydrochloric acid to obtain diazonium salts. The diazonium salt has high activity, and then interacts with cuprous chloride and sulfonylation reagents to introduce chlorine atoms and sulfonamide groups. The diazotization reaction in this process requires precise temperature control to avoid the decomposition of diazonium salts. Subsequent reactions with cuprous chloride and sulfonylation reagents require fine adjustment of conditions to obtain higher yields. This approach can ingeniously construct the target molecular structure, but there are a few more steps, and strict control of reaction conditions is required.
Third, 2-chloro-5-nitrobenzamide is used as raw material. First reduce it to 2-chloro-5-aminobenzamide, and metal hydrides such as lithium aluminum hydride are commonly used as reducing agents. Lithium aluminum hydride has strong reduction ability and can efficiently reduce nitro to amino groups. After hydrolysis, sulfonylation and other steps, the amide bond is hydrolyzed first, and then the sulfonamide group is introduced, and the final product is obtained. Although the steps in this way are orderly, lithium aluminum hydride is active, and it needs strict anhydrous and anaerobic conditions when used, and the cost is high.
All kinds of synthesis methods have advantages and disadvantages. In practical operation, when the Fang family carefully chooses the appropriate method according to the availability of raw materials, cost considerations, product purity requirements and many other factors, it can get twice the result with half the effort to obtain pure 2-amino-5-chlorobenzenesulfonamide.
Bear the brunt, and safety protection is the key. This substance may be toxic and irritating, and it must be fully protected when exposed. When operating, in front of suitable protective clothing, strictly select protective gloves to prevent skin contact. If the skin is accidentally contaminated, rinse with plenty of water immediately and then seek medical treatment. At the same time, protective glasses are also indispensable to protect the eyes. If there is any accidental entry into the eyes, rinse with flowing water for a few minutes immediately and then seek medical attention.
Furthermore, ventilation conditions should not be underestimated. Where used, keep the air flowing smoothly to prevent the accumulation of volatile gas from the substance. If used in a confined space, effective ventilation equipment, such as a fume hood, should be set up to discharge the volatile gas in time, reduce the concentration in the air, in order to reduce the harm to the human body.
Repeat, storage also needs to be cautious. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Separate from oxidizing agents, acids, alkalis and other substances. Do not mix storage and transportation to prevent dangerous chemical reactions.
In addition, during use, accurate operation is essential. Strictly follow the established operating procedures and control the dosage and conditions of use. When weighing, accurate equipment is required to ensure that the dosage is correct. Reaction conditions such as temperature, pressure, time, etc., must also be strictly controlled to ensure the smooth progress of the reaction and avoid accidents.
In addition, the disposal of waste should not be ignored. Waste after use cannot be discarded at will, and should be properly disposed of in accordance with relevant environmental regulations. Or hand it over to a professional waste treatment agency and deal with it according to a specific process to prevent pollution to the environment.
In summary, when using 2-amino-5-chlorobenzenesulfonamide, care must be taken in terms of safety protection, ventilation, storage, operation and waste disposal. The purpose of safe and effective use must not be negligent.

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