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2-Aminobenzenesulfonic Acid-2'-Chlorophenyl Ester
Linshang Chemical
|
HS Code |
175568 |
| Chemical Formula | C12H10ClNO3S |
| Molecular Weight | 283.73 |
| Appearance | Solid (usually) |
| Odor | Typically faint, characteristic organic odor |
| Melting Point | Data - specific value needed from literature |
| Boiling Point | Data - specific value needed from literature |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in some common organic solvents like ethanol, acetone |
| Density | Data - specific value needed from literature |
| Stability | Stable under normal conditions, may decompose under extreme heat or in presence of strong oxidants |
As an accredited 2-Aminobenzenesulfonic Acid-2'-Chlorophenyl Ester factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - aminobenzenesulfonic Acid - 2'-chlorophenyl Ester in sealed chemical - grade package. |
| Storage | 2 - aminobenzenesulfonic Acid - 2'-chlorophenyl Ester should be stored in a cool, dry place. Keep it away from heat sources, open flames, and direct sunlight. Store in a well - ventilated area, preferably in a tightly sealed container to prevent moisture absorption and exposure to air, which could potentially lead to degradation or chemical reactions. |
| Shipping | 2 - aminobenzenesulfonic Acid - 2'-chlorophenyl Ester is shipped in sealed, corrosion - resistant containers. Shipment adheres to strict chemical transportation regulations, ensuring safe transit to prevent any leakage or reaction risks. |
Competitive 2-Aminobenzenesulfonic Acid-2'-Chlorophenyl Ester prices that fit your budget—flexible terms and customized quotes for every order.
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2-aminobenzenesulfonic chemical structure of Acid-2 '-chlorophenyl Ester
The chemical structure of 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester is one of the structures of organic compounds. Looking at this name, it can be seen that it is composed of several parts.
The first is the "2-aminobenzenesulfonic acid" part. The benzenesulfonic acid is based on the benzene ring, and the sulfonic acid group (-SO 🥰 H) is connected to the benzene ring, and there is an amino group (-NH ²) substitution at the second position of the benzene ring. This part endows the compound with certain acidity and basicity and reactivity. The amino group can participate in many nucleophilic reactions, and the sulfonic acid group is acidic and can form sal
The second is the "2 '-chlorophenyl ester" part, which means that the first position of the benzene ring is connected with a chlorine atom (-Cl). This chlorine atom can affect the polarity and spatial structure of the molecule, and then affect its physical and chemical properties, such as nucleophilic substitution reactivity. And this chlorophenyl group is connected to the aforementioned 2-aminobenzene sulfonic acid through an ester bond, and the formation of an ester bond (-COO -) connects the two parts into a whole.
The chemical structure of this whole has unique physical and chemical properties due to the interaction of functional groups in each part. For example, due to the existence of amino groups, sulfonic acid groups and chlorine atoms, it has different solubility in different solvents and can participate in a variety of organic reactions, and may have potential applications in organic synthesis and medicinal chemistry. Its structural characteristics determine that it can be used as an intermediate to construct more complex organic molecules through further reactions.
The first is the "2-aminobenzenesulfonic acid" part. The benzenesulfonic acid is based on the benzene ring, and the sulfonic acid group (-SO 🥰 H) is connected to the benzene ring, and there is an amino group (-NH ²) substitution at the second position of the benzene ring. This part endows the compound with certain acidity and basicity and reactivity. The amino group can participate in many nucleophilic reactions, and the sulfonic acid group is acidic and can form sal
The second is the "2 '-chlorophenyl ester" part, which means that the first position of the benzene ring is connected with a chlorine atom (-Cl). This chlorine atom can affect the polarity and spatial structure of the molecule, and then affect its physical and chemical properties, such as nucleophilic substitution reactivity. And this chlorophenyl group is connected to the aforementioned 2-aminobenzene sulfonic acid through an ester bond, and the formation of an ester bond (-COO -) connects the two parts into a whole.
The chemical structure of this whole has unique physical and chemical properties due to the interaction of functional groups in each part. For example, due to the existence of amino groups, sulfonic acid groups and chlorine atoms, it has different solubility in different solvents and can participate in a variety of organic reactions, and may have potential applications in organic synthesis and medicinal chemistry. Its structural characteristics determine that it can be used as an intermediate to construct more complex organic molecules through further reactions.
2-aminobenzenesulfonic the physical properties of Acid-2 '-chlorophenyl Ester
2-Aminobenzenesulfonic acid-2 '-chlorophenyl ester, this is an organic compound, its physical properties are unique, let me tell you in detail.
Looking at its morphology, under room temperature, it is mostly white to light yellow crystalline powder. This morphological feature is not only convenient for storage, but also conducive to subsequent processing and use. Its powder has a fine texture and uniform particle size. In many reaction systems, it can be fully contacted with other substances, laying the foundation for the smooth progress of chemical reactions.
When it comes to melting point, this compound has a high melting point and is roughly in a certain temperature range. The high melting point indicates that its intermolecular force is strong and its structure is relatively stable. During the heating process, it needs to absorb more energy to break the bonds between molecules and realize the transition from solid to liquid. This property allows it to maintain a solid structure at higher temperatures, and it is not easy to melt and deform. The application under specific high temperature conditions is extremely critical.
In terms of solubility, 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester exhibits a certain solubility in organic solvents. Organic solvents such as common ethanol and acetone can dissolve the compound to a certain extent. However, its solubility in water is poor. This difference in solubility is closely related to the molecular structure of the compound. The hydrophobic groups such as benzene ring contained in the molecule make it more inclined to interact with organic solvents, but have a weaker affinity for water molecules. This property has important guiding significance in the separation, purification and construction of specific reaction systems of compounds.
In addition, the density of 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester is also one of its important physical properties. Its density value is specific, reflecting the mass of the substance contained in the unit volume. In practice, density information helps to accurately measure the amount of the compound, ensuring that the reaction is carried out according to the expected stoichiometric ratio, and is indispensable for accurately controlling the chemical reaction process and product quality.
In summary, the white to pale yellow crystalline powder morphology, high melting point, specific solubility and density of 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester together constitute its unique physical properties, providing an important basis for its application in many fields such as organic synthesis and materials science.
Looking at its morphology, under room temperature, it is mostly white to light yellow crystalline powder. This morphological feature is not only convenient for storage, but also conducive to subsequent processing and use. Its powder has a fine texture and uniform particle size. In many reaction systems, it can be fully contacted with other substances, laying the foundation for the smooth progress of chemical reactions.
When it comes to melting point, this compound has a high melting point and is roughly in a certain temperature range. The high melting point indicates that its intermolecular force is strong and its structure is relatively stable. During the heating process, it needs to absorb more energy to break the bonds between molecules and realize the transition from solid to liquid. This property allows it to maintain a solid structure at higher temperatures, and it is not easy to melt and deform. The application under specific high temperature conditions is extremely critical.
In terms of solubility, 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester exhibits a certain solubility in organic solvents. Organic solvents such as common ethanol and acetone can dissolve the compound to a certain extent. However, its solubility in water is poor. This difference in solubility is closely related to the molecular structure of the compound. The hydrophobic groups such as benzene ring contained in the molecule make it more inclined to interact with organic solvents, but have a weaker affinity for water molecules. This property has important guiding significance in the separation, purification and construction of specific reaction systems of compounds.
In addition, the density of 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester is also one of its important physical properties. Its density value is specific, reflecting the mass of the substance contained in the unit volume. In practice, density information helps to accurately measure the amount of the compound, ensuring that the reaction is carried out according to the expected stoichiometric ratio, and is indispensable for accurately controlling the chemical reaction process and product quality.
In summary, the white to pale yellow crystalline powder morphology, high melting point, specific solubility and density of 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester together constitute its unique physical properties, providing an important basis for its application in many fields such as organic synthesis and materials science.
2-aminobenzenesulfonic What are the main uses of Acid-2 '-chlorophenyl Ester?
2-Aminobenzenesulfonic acid-2 '-chlorophenyl ester is one of the organic compounds. It has a wide range of main uses and plays an important role in many fields such as chemical industry and medicine.
In the chemical industry, this compound is often a key intermediate in organic synthesis. Due to its special structure, many complex and functional organic compounds can be derived through various chemical reactions. Through carefully designed reaction paths, it can be cleverly combined with different reagents to shape products with unique structures and properties, laying the foundation for the development and synthesis of new materials, and helping to create materials with special properties such as high stability, unique optical or electrical properties, which are used in electronic devices, polymer materials and other fields.
In the field of medicine, 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester also has potential medicinal value. Its molecular structural properties may enable it to interact with specific targets in organisms. Or it can be modified and optimized to become a drug molecule with specific pharmacological activity for the treatment of diseases. For example, in some studies, its structure has been modified to explore its impact on biological pathways related to specific diseases, providing the possibility for the development of new drugs, or for specific diseases, showing anti-inflammatory, antibacterial, anti-tumor and other pharmacological effects, contributing to human health and well-being.
In summary, 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester, with its unique structure, plays an important role in the chemical and pharmaceutical fields, and has a profound impact on the development of related fields.
In the chemical industry, this compound is often a key intermediate in organic synthesis. Due to its special structure, many complex and functional organic compounds can be derived through various chemical reactions. Through carefully designed reaction paths, it can be cleverly combined with different reagents to shape products with unique structures and properties, laying the foundation for the development and synthesis of new materials, and helping to create materials with special properties such as high stability, unique optical or electrical properties, which are used in electronic devices, polymer materials and other fields.
In the field of medicine, 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester also has potential medicinal value. Its molecular structural properties may enable it to interact with specific targets in organisms. Or it can be modified and optimized to become a drug molecule with specific pharmacological activity for the treatment of diseases. For example, in some studies, its structure has been modified to explore its impact on biological pathways related to specific diseases, providing the possibility for the development of new drugs, or for specific diseases, showing anti-inflammatory, antibacterial, anti-tumor and other pharmacological effects, contributing to human health and well-being.
In summary, 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester, with its unique structure, plays an important role in the chemical and pharmaceutical fields, and has a profound impact on the development of related fields.
2-aminobenzenesulfonic are the preparation methods of Acid-2 '-chlorophenyl Ester
The method for preparing 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester has many ways and is described as follows.
First, 2-aminobenzenesulfonic acid and 2-chlorophenol are used as raw materials, and a shrinking agent is added in an appropriate solvent to promote the reaction. If dichloromethane is selected as the solvent, dicyclohexyl carbodiimide (DCC) is used as the shrinking agent, and 4-dimethylaminopyridine (DMAP) is used as the catalyst. Add 2-aminobenzenesulfonic acid and 2-chlorophenol in an appropriate ratio, such as the ratio of substances 1:1.2, and add them to the dichloromethane solution containing DCC and DMAP in turn, and stir the reaction at room temperature. In this process, DCC can activate the carboxyl group, and DMAP accelerates the reaction process. After the reaction is completed, the dicyclohexylurea precipitate is filtered off, and the filtrate is distilled under reduced pressure to remove the solvent, and then purified by column chromatography to obtain the target product.
Second, 2-aminobenzenesulfonic acid is first made into acid chloride, and then reacted with 2-chlorophenol. 2-aminobenzenesulfonic acid is reacted with sulfoxide chloride to obtain 2-aminobenzenesulfonic acid. A small amount of N, N-dimethylformamide (DMF) can be added as a catalyst during the reaction, and the reaction is completed by heating and refluxing. After the excess of thionyl chloride is evaporated, the obtained 2-aminobenzenesulfonyl chloride is dissolved in an appropriate amount of tetrahydrofuran, and slowly added dropwise to the tetrahydrofuran solution containing 2-chlorophenol and triethylamine. Triethylamine can neutralize the hydrogen chloride generated by the reaction. After the dropwise addition is completed, the reaction is stirred at room temperature for several times. After the reaction is completed, water is added to quench, and the organic phase is dried, concentrated, and then purified by recrystallization or column chromatography to obtain 2-aminobenzenesulfonate-2 '-chlorophenyl ester.
Third, the sulfonate exchange reaction is used. The reaction of a free ester of 2-aminobenzenesulfonic acid, such as methyl ester, with 2-chlorophenol under basic conditions and in the presence of a phase transfer catalyst. With potassium carbonate as the base and tetrabutylammonium bromide as the phase transfer catalyst, it is heated and refluxed in acetonitrile solvent. In the basic environment, 2-chlorophenol is converted into phenoxy anion, which attacks the carbonyl carbon of 2-aminobenzenesulfonic acid methyl ester and undergoes ester exchange reaction. At the end of the reaction, 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester is finally obtained through separation and purification steps such as extraction, drying, concentration, column chromatography, etc.
First, 2-aminobenzenesulfonic acid and 2-chlorophenol are used as raw materials, and a shrinking agent is added in an appropriate solvent to promote the reaction. If dichloromethane is selected as the solvent, dicyclohexyl carbodiimide (DCC) is used as the shrinking agent, and 4-dimethylaminopyridine (DMAP) is used as the catalyst. Add 2-aminobenzenesulfonic acid and 2-chlorophenol in an appropriate ratio, such as the ratio of substances 1:1.2, and add them to the dichloromethane solution containing DCC and DMAP in turn, and stir the reaction at room temperature. In this process, DCC can activate the carboxyl group, and DMAP accelerates the reaction process. After the reaction is completed, the dicyclohexylurea precipitate is filtered off, and the filtrate is distilled under reduced pressure to remove the solvent, and then purified by column chromatography to obtain the target product.
Second, 2-aminobenzenesulfonic acid is first made into acid chloride, and then reacted with 2-chlorophenol. 2-aminobenzenesulfonic acid is reacted with sulfoxide chloride to obtain 2-aminobenzenesulfonic acid. A small amount of N, N-dimethylformamide (DMF) can be added as a catalyst during the reaction, and the reaction is completed by heating and refluxing. After the excess of thionyl chloride is evaporated, the obtained 2-aminobenzenesulfonyl chloride is dissolved in an appropriate amount of tetrahydrofuran, and slowly added dropwise to the tetrahydrofuran solution containing 2-chlorophenol and triethylamine. Triethylamine can neutralize the hydrogen chloride generated by the reaction. After the dropwise addition is completed, the reaction is stirred at room temperature for several times. After the reaction is completed, water is added to quench, and the organic phase is dried, concentrated, and then purified by recrystallization or column chromatography to obtain 2-aminobenzenesulfonate-2 '-chlorophenyl ester.
Third, the sulfonate exchange reaction is used. The reaction of a free ester of 2-aminobenzenesulfonic acid, such as methyl ester, with 2-chlorophenol under basic conditions and in the presence of a phase transfer catalyst. With potassium carbonate as the base and tetrabutylammonium bromide as the phase transfer catalyst, it is heated and refluxed in acetonitrile solvent. In the basic environment, 2-chlorophenol is converted into phenoxy anion, which attacks the carbonyl carbon of 2-aminobenzenesulfonic acid methyl ester and undergoes ester exchange reaction. At the end of the reaction, 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester is finally obtained through separation and purification steps such as extraction, drying, concentration, column chromatography, etc.
2-aminobenzenesulfonic Acid-2 '-chlorophenyl Ester in the process of use
2-Aminobenzenesulfonic acid-2 '-chlorophenyl ester is a very important chemical substance. During use, there are many key precautions that must be paid attention to.
Bear the brunt, and safety protection should not be ignored. This chemical may be toxic and irritating, and may cause damage to the human body if it touches the skin, eyes, or inhales its dust and vapor. Therefore, when using it, be sure to wear appropriate protective equipment, such as protective gloves, protective glasses, and gas masks, to fully protect yourself. Once accidentally touched, rinse with plenty of water immediately, and seek medical attention in a timely manner according to the specific situation.
Furthermore, storage conditions cannot be ignored. Store it in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its chemical properties or relative activity, improper storage environment may cause it to deteriorate or cause dangerous reactions. At the same time, it should be stored separately from oxidizing agents, acids, alkalis and other substances, and must not be mixed to prevent violent chemical reactions.
Operating specifications during use are essential. Be sure to strictly follow the established operating procedures and precisely control the reaction conditions, such as temperature, pH, reaction time, etc. Because of its reactivity and product characteristics, it is extremely sensitive to the reaction conditions, slightly deviated, or cause the reaction to fail, or even cause safety accidents. Use suitable reaction vessels and instruments and ensure that they are clean, dry and not damaged to ensure the smooth progress of the reaction.
Finally, the disposal of waste after use should not be underestimated. It is necessary to follow relevant environmental regulations and regulations, and properly dispose of waste containing this substance, and must not be discarded at will to avoid pollution to the environment.
In short, when using 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester, safety protection, storage conditions, operating specifications and waste disposal should be treated with caution, and must not be taken lightly, so as to ensure the safety and smooth use process.
Bear the brunt, and safety protection should not be ignored. This chemical may be toxic and irritating, and may cause damage to the human body if it touches the skin, eyes, or inhales its dust and vapor. Therefore, when using it, be sure to wear appropriate protective equipment, such as protective gloves, protective glasses, and gas masks, to fully protect yourself. Once accidentally touched, rinse with plenty of water immediately, and seek medical attention in a timely manner according to the specific situation.
Furthermore, storage conditions cannot be ignored. Store it in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its chemical properties or relative activity, improper storage environment may cause it to deteriorate or cause dangerous reactions. At the same time, it should be stored separately from oxidizing agents, acids, alkalis and other substances, and must not be mixed to prevent violent chemical reactions.
Operating specifications during use are essential. Be sure to strictly follow the established operating procedures and precisely control the reaction conditions, such as temperature, pH, reaction time, etc. Because of its reactivity and product characteristics, it is extremely sensitive to the reaction conditions, slightly deviated, or cause the reaction to fail, or even cause safety accidents. Use suitable reaction vessels and instruments and ensure that they are clean, dry and not damaged to ensure the smooth progress of the reaction.
Finally, the disposal of waste after use should not be underestimated. It is necessary to follow relevant environmental regulations and regulations, and properly dispose of waste containing this substance, and must not be discarded at will to avoid pollution to the environment.
In short, when using 2-aminobenzenesulfonic acid-2 '-chlorophenyl ester, safety protection, storage conditions, operating specifications and waste disposal should be treated with caution, and must not be taken lightly, so as to ensure the safety and smooth use process.
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