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2-Bromo-1,3-Dichloro-5-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
652628 |
| Name | 2-Bromo-1,3-Dichloro-5-(Trifluoromethyl)Benzene |
| Molecular Formula | C7H2BrCl2F3 |
| Molecular Weight | 291.9 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 194 - 196 °C |
| Melting Point | N/A |
| Density | 1.819 g/mL at 25 °C |
| Flash Point | 83 °C |
| Solubility | Insoluble in water, soluble in organic solvents like ethanol, ether |
| Purity | Typically high - purity (e.g., 98%+ in commercial products) |
| Vapor Pressure | Low vapor pressure at room temperature |
| Refractive Index | 1.493 (20 °C) |
As an accredited 2-Bromo-1,3-Dichloro-5-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle packaging for 2 - bromo - 1,3 - dichloro - 5 - (trifluoromethyl)benzene. |
| Storage | 2 - bromo - 1,3 - dichloro - 5 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container made of a compatible material, like glass, to prevent leakage and protect it from moisture and air, which could potentially cause degradation. |
| Shipping | 2 - bromo - 1,3 - dichloro - 5 - (trifluoromethyl)benzene is shipped in sealed, corrosion - resistant containers. It's handled with care due to its chemical nature, following strict regulations for hazardous chemicals during transportation. |
Competitive 2-Bromo-1,3-Dichloro-5-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Bromo-1,3-Dichloro-5-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene?
2-Bromo-1,3-dichloro-5- (trifluoromethyl) benzene is a genus of organohalogenated aromatic hydrocarbons. Its physical properties are as follows:
Looking at its morphology, under room temperature and pressure, it is mostly colorless to light yellow liquid. Those with pure quality are clear and transparent. However, due to impurities, it may be slightly dyed.
Smell its smell, which has a special aromatic smell. This smell originates from the benzene ring structure, but the presence of halogen atoms and trifluoromethyl makes its smell different from ordinary benzene compounds. It has a pungent feeling. If you inhale too much, it may harm the human body. When operating, it should be done in a well-ventilated place.
To measure its boiling point, due to the action of bromine, chlorine, trifluoromethyl and other groups in the molecule, the intermolecular force increases, and the boiling point is higher, about 200-220 ° C. The high boiling point indicates that it needs more energy to change from liquid to gaseous state. This characteristic is quite critical in chemical operations such as separation and purification.
Measuring its melting point has no exact literature. However, according to the structure speculation, due to the asymmetry of the molecular structure and the irregular lattice arrangement, the melting point should be low, or in the range of -20 ° C to 0 ° C. The lower melting point causes it to be liquid at room temperature, which requires lower temperature conditions for storage and transportation.
Looking at its solubility, because the benzene ring is a non-polar structure, and the halogen atom and trifluoromethyl have a certain polarity, so the substance is slightly soluble in water, in the aqueous phase, because of its weak interaction with water molecules, it is difficult to dissolve with water. However, in organic solvents, such as ethanol, ether, dichloromethane, etc., the solubility is quite good. Due to the principle of similar phase dissolution, it is adapted to the intermolecular interaction of organic solvents and can be uniformly dispersed.
Its density is greater than that of water, about 1.8-2.0 g/cm ³. Due to the large atomic weight of halogen atoms and trifluoromethyl atoms in the molecule, the mass per unit volume is large. When it comes to operations such as liquid-liquid separation, this characteristic can be used because it will sink underwater.
In terms of its volatility, although the boiling point is high, it still has a certain degree of volatility. In an open environment, the molecules are constantly moving, and some of them will escape from the liquid state into the gas phase, so they need to be properly sealed when stored to prevent their volatilization loss and avoid their volatilization to the environment, causing pollution and safety hazards.
Looking at its morphology, under room temperature and pressure, it is mostly colorless to light yellow liquid. Those with pure quality are clear and transparent. However, due to impurities, it may be slightly dyed.
Smell its smell, which has a special aromatic smell. This smell originates from the benzene ring structure, but the presence of halogen atoms and trifluoromethyl makes its smell different from ordinary benzene compounds. It has a pungent feeling. If you inhale too much, it may harm the human body. When operating, it should be done in a well-ventilated place.
To measure its boiling point, due to the action of bromine, chlorine, trifluoromethyl and other groups in the molecule, the intermolecular force increases, and the boiling point is higher, about 200-220 ° C. The high boiling point indicates that it needs more energy to change from liquid to gaseous state. This characteristic is quite critical in chemical operations such as separation and purification.
Measuring its melting point has no exact literature. However, according to the structure speculation, due to the asymmetry of the molecular structure and the irregular lattice arrangement, the melting point should be low, or in the range of -20 ° C to 0 ° C. The lower melting point causes it to be liquid at room temperature, which requires lower temperature conditions for storage and transportation.
Looking at its solubility, because the benzene ring is a non-polar structure, and the halogen atom and trifluoromethyl have a certain polarity, so the substance is slightly soluble in water, in the aqueous phase, because of its weak interaction with water molecules, it is difficult to dissolve with water. However, in organic solvents, such as ethanol, ether, dichloromethane, etc., the solubility is quite good. Due to the principle of similar phase dissolution, it is adapted to the intermolecular interaction of organic solvents and can be uniformly dispersed.
Its density is greater than that of water, about 1.8-2.0 g/cm ³. Due to the large atomic weight of halogen atoms and trifluoromethyl atoms in the molecule, the mass per unit volume is large. When it comes to operations such as liquid-liquid separation, this characteristic can be used because it will sink underwater.
In terms of its volatility, although the boiling point is high, it still has a certain degree of volatility. In an open environment, the molecules are constantly moving, and some of them will escape from the liquid state into the gas phase, so they need to be properly sealed when stored to prevent their volatilization loss and avoid their volatilization to the environment, causing pollution and safety hazards.
What are the main uses of 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene?
2-Bromo-1,3-dichloro-5- (trifluoromethyl) benzene, Chinese name 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene, this substance is widely used.
In the field of medical chemistry, it is often used as a key intermediate. Drug molecules with specific structures can be cleverly constructed through multi-step reactions. Due to the presence of halogen atoms and trifluoromethyl atoms on the benzene ring, it endows the molecule with unique physical and chemical properties, which can change the lipid solubility, stability and interaction mode of compounds with biological targets. For example, when developing antiviral and antitumor drugs, this substance can participate in the reaction to build a core skeleton, laying the foundation for the development of new specific drugs.
In the field of materials science, it also plays an important role. It can be used to synthesize functional polymer materials. Due to its special substituents, the material can have such as chemical corrosion resistance, high temperature resistance and unique optical properties. For example, the preparation of high-performance coatings, adding monomers containing this structure to participate in the polymerization reaction, the stability and durability of the coating in harsh environments are greatly improved; in the synthesis of optoelectronic device materials, its structural characteristics can be used to optimize the photoelectric conversion efficiency and other properties of the material.
In addition, in organic synthesis chemistry, it is an important starting material. With the help of classic organic reactions such as nucleophilic substitution of halogen atoms and metal catalytic coupling, many organic compounds with diverse structures have been derived, providing rich choices for organic synthesis chemists to explore new reaction paths and compound structures, and greatly promoting the development of organic synthesis chemistry.
In the field of medical chemistry, it is often used as a key intermediate. Drug molecules with specific structures can be cleverly constructed through multi-step reactions. Due to the presence of halogen atoms and trifluoromethyl atoms on the benzene ring, it endows the molecule with unique physical and chemical properties, which can change the lipid solubility, stability and interaction mode of compounds with biological targets. For example, when developing antiviral and antitumor drugs, this substance can participate in the reaction to build a core skeleton, laying the foundation for the development of new specific drugs.
In the field of materials science, it also plays an important role. It can be used to synthesize functional polymer materials. Due to its special substituents, the material can have such as chemical corrosion resistance, high temperature resistance and unique optical properties. For example, the preparation of high-performance coatings, adding monomers containing this structure to participate in the polymerization reaction, the stability and durability of the coating in harsh environments are greatly improved; in the synthesis of optoelectronic device materials, its structural characteristics can be used to optimize the photoelectric conversion efficiency and other properties of the material.
In addition, in organic synthesis chemistry, it is an important starting material. With the help of classic organic reactions such as nucleophilic substitution of halogen atoms and metal catalytic coupling, many organic compounds with diverse structures have been derived, providing rich choices for organic synthesis chemists to explore new reaction paths and compound structures, and greatly promoting the development of organic synthesis chemistry.
What are the synthesis methods of 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene?
There are several methods for synthesizing 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene.
One is the halogenation reaction path. Using benzene derivatives containing trifluoromethyl as the starting material, under appropriate reaction conditions, bromine atoms are first introduced. Suitable brominating reagents, such as bromine (\ (Br_ {2}\)), can be used with catalysts, such as iron powder (\ (Fe\)) or iron tribromide (\ (FeBr_ {3}\)), which is a classic method for brominating aromatic compounds. In this reaction system, the specific position on the benzene ring is selectively replaced by bromine atoms at the target position due to electron cloud density and substituent localization effect. Then, chlorine atoms are introduced. Appropriate chlorination reagents, such as chlorine (\ (Cl_ {2}\)), and catalysts such as aluminum trichloride (\ (AlCl_ {3}\)), are selected, and chlorine atoms are introduced at the specified position by controlling the reaction temperature, time and reagent ratio, and finally 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene is obtained.
The second is a nucleophilic substitution reaction using halogenated aromatics as raw materials. Select a suitable halogenated aromatic hydrocarbon with some halogen atoms and trifluoromethyl substituents on the benzene ring. By reacting with the nucleophilic reagent, the nucleophilic reagent attacks the carbon atoms attached to the halogen atoms on the benzene ring, and the halogen atoms leave as a leaving group to realize the substitution of the halogen atoms, so as to construct the structure of the target product. Careful selection of nucleophilic reagents and reaction conditions is required to ensure the selectivity and yield of the reaction. For example, choose a suitable base to adjust the pH of the reaction system and optimize the solvent environment to enhance the activity and solubility of the nucleophilic reagent, so that the reaction can proceed smoothly.
The third is the coupling reaction catalyzed by transition metals. Using benzene derivatives containing different halogen atoms and trifluoromethyl as substrates, transition metal catalysts such as palladium (\ (Pd\)) catalysts are used to catalyze coupling reactions between substrates with the assistance of ligands. This method can precisely connect different halogen atoms and substituents to specific positions in the benzene ring. Through rational design of substrate structures, careful selection of transition metal catalysts, ligands and reaction conditions, the efficiency and selectivity of the reaction can be effectively improved, and efficient synthesis of 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene can be achieved.
One is the halogenation reaction path. Using benzene derivatives containing trifluoromethyl as the starting material, under appropriate reaction conditions, bromine atoms are first introduced. Suitable brominating reagents, such as bromine (\ (Br_ {2}\)), can be used with catalysts, such as iron powder (\ (Fe\)) or iron tribromide (\ (FeBr_ {3}\)), which is a classic method for brominating aromatic compounds. In this reaction system, the specific position on the benzene ring is selectively replaced by bromine atoms at the target position due to electron cloud density and substituent localization effect. Then, chlorine atoms are introduced. Appropriate chlorination reagents, such as chlorine (\ (Cl_ {2}\)), and catalysts such as aluminum trichloride (\ (AlCl_ {3}\)), are selected, and chlorine atoms are introduced at the specified position by controlling the reaction temperature, time and reagent ratio, and finally 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene is obtained.
The second is a nucleophilic substitution reaction using halogenated aromatics as raw materials. Select a suitable halogenated aromatic hydrocarbon with some halogen atoms and trifluoromethyl substituents on the benzene ring. By reacting with the nucleophilic reagent, the nucleophilic reagent attacks the carbon atoms attached to the halogen atoms on the benzene ring, and the halogen atoms leave as a leaving group to realize the substitution of the halogen atoms, so as to construct the structure of the target product. Careful selection of nucleophilic reagents and reaction conditions is required to ensure the selectivity and yield of the reaction. For example, choose a suitable base to adjust the pH of the reaction system and optimize the solvent environment to enhance the activity and solubility of the nucleophilic reagent, so that the reaction can proceed smoothly.
The third is the coupling reaction catalyzed by transition metals. Using benzene derivatives containing different halogen atoms and trifluoromethyl as substrates, transition metal catalysts such as palladium (\ (Pd\)) catalysts are used to catalyze coupling reactions between substrates with the assistance of ligands. This method can precisely connect different halogen atoms and substituents to specific positions in the benzene ring. Through rational design of substrate structures, careful selection of transition metal catalysts, ligands and reaction conditions, the efficiency and selectivity of the reaction can be effectively improved, and efficient synthesis of 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene can be achieved.
What are the precautions for storing and transporting 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene?
2-Bromo-1,3-dichloro-5- (trifluoromethyl) benzene is an organic compound. During storage and transportation, many matters need to be paid careful attention.
First talk about storage. Because of its nature or more active, the first storage environment is dry. Moisture can easily lead to adverse reactions such as hydrolysis, resulting in quality deterioration, so it should be placed in a dry and waterless place. And it may be volatile and toxic, and it must be stored in a well-ventilated place to prevent the accumulation of harmful gases and threaten human health. In addition, this compound is sensitive to heat, and high temperature may promote its decomposition or cause dangerous reactions. It should be stored in a cool place away from direct sunlight and heat sources. At the same time, it should be stored separately from oxidizing agents, reducing agents, alkalis, etc., because it may react violently with these substances and cause safety accidents.
As for transportation, the packaging must be solid and tight. In order to prevent the packaging from being damaged due to bumps and collisions during transportation and material leakage. Transportation vehicles should also be selected in a well-ventilated and non-flammable place. Transportation personnel should be professionally trained and familiar with the characteristics of this compound and emergency treatment methods. During transportation, it is necessary to pay close attention to environmental factors such as temperature and humidity, drive according to the specified route, and avoid densely populated areas and sensitive areas. If a leak occurs during transportation, emergency measures should be taken immediately, evacuate personnel, seal the scene, and report to relevant departments in a timely manner. In conclusion, when storing and transporting 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene, it is necessary to strictly control the environment, packaging, personnel, and other aspects to ensure safety and avoid accidents.
First talk about storage. Because of its nature or more active, the first storage environment is dry. Moisture can easily lead to adverse reactions such as hydrolysis, resulting in quality deterioration, so it should be placed in a dry and waterless place. And it may be volatile and toxic, and it must be stored in a well-ventilated place to prevent the accumulation of harmful gases and threaten human health. In addition, this compound is sensitive to heat, and high temperature may promote its decomposition or cause dangerous reactions. It should be stored in a cool place away from direct sunlight and heat sources. At the same time, it should be stored separately from oxidizing agents, reducing agents, alkalis, etc., because it may react violently with these substances and cause safety accidents.
As for transportation, the packaging must be solid and tight. In order to prevent the packaging from being damaged due to bumps and collisions during transportation and material leakage. Transportation vehicles should also be selected in a well-ventilated and non-flammable place. Transportation personnel should be professionally trained and familiar with the characteristics of this compound and emergency treatment methods. During transportation, it is necessary to pay close attention to environmental factors such as temperature and humidity, drive according to the specified route, and avoid densely populated areas and sensitive areas. If a leak occurs during transportation, emergency measures should be taken immediately, evacuate personnel, seal the scene, and report to relevant departments in a timely manner. In conclusion, when storing and transporting 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene, it is necessary to strictly control the environment, packaging, personnel, and other aspects to ensure safety and avoid accidents.
What are the effects of 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene on the environment and human health?
2-Bromo-1,3-dichloro-5- (trifluoromethyl) benzene is also an organic compound. Although the ancients did not see this specific thing firsthand due to the impact of the environment and human health, it can be inferred from today's scientific principles.
In terms of the environment, such halogenated aromatic hydrocarbon compounds are quite stable and difficult to degrade naturally. If released in the environment, or remain in the soil or water body for a long time. It may cause soil deterioration, hinder the uptake of nutrients by plant roots, hinder plant growth, or reduce crop yield. In water bodies, or affect the survival of aquatic organisms. Due to its special chemical structure, or enriched by aquatic organisms, it is passed along the food chain, resulting in the accumulation of toxins in higher organisms.
As for human health, this compound may enter the human body through respiratory, dietary, and skin contact. Inhalation through the respiratory tract, or irritation of respiratory mucosa, causing cough, asthma, etc. If ingested through diet, or involving the digestive system, it can cause gastrointestinal discomfort, nausea and vomiting. And because it contains halogen atoms and fluoromethyl atoms, it may interfere with the human endocrine system and affect the normal secretion and regulation of hormones. Long-term exposure may even cause mutation and carcinogenesis, damage the genetic material of human cells, and increase the risk of cancer.
In summary, although the ancient people had not heard of this thing, it is now known from scientific understanding that 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene has potential harm to the environment and human health. It should be handled with caution to prevent it from escaping into the environment and avoid excessive human exposure.
In terms of the environment, such halogenated aromatic hydrocarbon compounds are quite stable and difficult to degrade naturally. If released in the environment, or remain in the soil or water body for a long time. It may cause soil deterioration, hinder the uptake of nutrients by plant roots, hinder plant growth, or reduce crop yield. In water bodies, or affect the survival of aquatic organisms. Due to its special chemical structure, or enriched by aquatic organisms, it is passed along the food chain, resulting in the accumulation of toxins in higher organisms.
As for human health, this compound may enter the human body through respiratory, dietary, and skin contact. Inhalation through the respiratory tract, or irritation of respiratory mucosa, causing cough, asthma, etc. If ingested through diet, or involving the digestive system, it can cause gastrointestinal discomfort, nausea and vomiting. And because it contains halogen atoms and fluoromethyl atoms, it may interfere with the human endocrine system and affect the normal secretion and regulation of hormones. Long-term exposure may even cause mutation and carcinogenesis, damage the genetic material of human cells, and increase the risk of cancer.
In summary, although the ancient people had not heard of this thing, it is now known from scientific understanding that 2-bromo-1,3-dichloro-5- (trifluoromethyl) benzene has potential harm to the environment and human health. It should be handled with caution to prevent it from escaping into the environment and avoid excessive human exposure.
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