Linshang Chemical
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2-Bromo-1-Chloro-3-Nitrobenzene
Linshang Chemical
|
HS Code |
276875 |
| Name | 2 - Bromo - 1 - Chloro - 3 - Nitrobenzene |
| Molecular Formula | C6H3BrClNO2 |
| Molar Mass | 240.45 g/mol |
| Appearance | Yellow solid (usually) |
| Boiling Point | Around 290 - 300 °C |
| Melting Point | 58 - 60 °C |
| Density | 1.848 g/cm³ (estimated for solids) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
As an accredited 2-Bromo-1-Chloro-3-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - bromo - 1 - chloro - 3 - nitrobenzene packaged in a sealed glass bottle. |
| Storage | 2 - bromo - 1 - chloro - 3 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. It is a hazardous chemical, so keep it in a locked storage cabinet, separated from incompatible substances like oxidizing agents, reducing agents, and bases. Store it in a tightly - sealed container to prevent leakage and exposure. |
| Shipping | 2 - bromo - 1 - chloro - 3 - nitrobenzene is shipped in sealed, corrosion - resistant containers. Shipment follows strict hazardous chemical regulations, ensuring proper labeling, handling, and transport to prevent spills and exposure during transit. |
Competitive 2-Bromo-1-Chloro-3-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 2-Bromo-1-Chloro-3-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 2-bromo-1-chloro-3-nitrobenzene?
2 - bromo - 1 - chloro - 3 - nitrobenzene is an organic compound whose molecules contain bromine, chlorine and nitro groups attached to the benzene ring. This compound has the following chemical properties:
- ** Nucleophilic Substitution Reaction **: Because the halogen atom (bromine and chlorine) is affected by the electron-absorbing effect of the nitro group, the electron cloud density of the benzene ring is reduced, the activity of the halogen atom is enhanced, and it is easily replaced by nucleophilic reagents. For example, when co-heated with an aqueous solution of sodium hydroxide, the hydroxyl group can replace the bromine or chlorine to form the corresponding phenolic compound; when reacted with sodium alcohol, the alkoxy group can replace the halogen atom to form
- ** Electrophilic Substitution Reaction **: Although the electron cloud density of benzene ring decreases due to the presence of nitro groups, the electrophilic substitution reaction activity is lower than that of benzene, but the electron cloud density of benzene ring is relatively high, and electrophilic reagents can still attack the meso. If it reacts with concentrated sulfuric acid and concentrated nitric acid mixed acid, a second nitro group can be introduced, which mainly generates 2-bromo-1-chloro-3,5-dinitrobenzene.
- ** Reduction Reaction **: Nitro groups can be reduced. Using iron and hydrochloric acid as reducing agents, nitro groups can be gradually reduced to amino groups to obtain 2-bromo-1-chloro-3-aminobenzene. This product is an important organic synthesis intermediate and can be used to prepare dyes, drugs, etc.
- ** Differences in the activity of halogen atoms **: Due to the high electron cloud density of bromine atoms and the large atomic radius, in some reactions, bromine atoms are more easily replaced than chlorine atoms, and have the characteristics of selective reactions. By controlling the reaction conditions, bromine atoms can be selectively replaced and chlorine atoms retained.
- ** Nucleophilic Substitution Reaction **: Because the halogen atom (bromine and chlorine) is affected by the electron-absorbing effect of the nitro group, the electron cloud density of the benzene ring is reduced, the activity of the halogen atom is enhanced, and it is easily replaced by nucleophilic reagents. For example, when co-heated with an aqueous solution of sodium hydroxide, the hydroxyl group can replace the bromine or chlorine to form the corresponding phenolic compound; when reacted with sodium alcohol, the alkoxy group can replace the halogen atom to form
- ** Electrophilic Substitution Reaction **: Although the electron cloud density of benzene ring decreases due to the presence of nitro groups, the electrophilic substitution reaction activity is lower than that of benzene, but the electron cloud density of benzene ring is relatively high, and electrophilic reagents can still attack the meso. If it reacts with concentrated sulfuric acid and concentrated nitric acid mixed acid, a second nitro group can be introduced, which mainly generates 2-bromo-1-chloro-3,5-dinitrobenzene.
- ** Reduction Reaction **: Nitro groups can be reduced. Using iron and hydrochloric acid as reducing agents, nitro groups can be gradually reduced to amino groups to obtain 2-bromo-1-chloro-3-aminobenzene. This product is an important organic synthesis intermediate and can be used to prepare dyes, drugs, etc.
- ** Differences in the activity of halogen atoms **: Due to the high electron cloud density of bromine atoms and the large atomic radius, in some reactions, bromine atoms are more easily replaced than chlorine atoms, and have the characteristics of selective reactions. By controlling the reaction conditions, bromine atoms can be selectively replaced and chlorine atoms retained.
What are 2-bromo-1-chloro-3-nitrobenzene synthesis methods?
There are many ways to synthesize 2-bromo-1-chloro-3-nitrobenzene.
First, benzene can be started from benzene. Shilling benzene is nitrified, using a mixed acid of sulfuric acid and nitric acid as a reagent, at a suitable temperature, benzene is converted to nitrobenzene. Subsequently, nitrobenzene is halogenated. In the halogenation step, chlorine atoms are introduced first, and chlorine gas and ferric chloride can be used as a catalytic system to generate m-chloro-nitrobenzene. Finally, bromine atoms are introduced, and liquid bromine and a suitable catalyst (such as iron powder) can be used to obtain 2-bromo-1-chloro-3-nitrobenzene. In this path, the precise control of the reaction conditions at each step is crucial. Excessive nitrification temperature may cause the formation of polynitroation by-products; the amount of catalyst and reaction time during halogenation will also affect the selectivity of the products.
Second, chlorobenzene can also be used as a raw material. First, chlorobenzene is nitrified, and the mixture of o-nitrochlorobenzene and p-nitrochlorobenzene is prepared by mixed acid treatment. After separation, o-nitrochlorobenzene is obtained. After that, the o-nitrochlorobenzene is brominated, and appropriate brominating reagents and conditions can be selected to introduce bromine atoms at the ortho site, thereby preparing the target product 2-bromo-1-chloro-3-nitrobenzene. In this approach, the separation of the mixture requires an effective method to ensure the purity of o-nitrochlorobenzene, which in turn affects the effect of subsequent bromination reactions.
Furthermore, bromobenzene can also be started from bromobenzene. First, bromobenzene is nitrified to obtain a mixture of nitrobromobenzene isomers, and then m-nitrobromobenzene is separated. Then, m-nitrobromobenzene is chlorinated under specific conditions, and chlorine atoms are successfully introduced with the help of suitable chlorination reagents and catalysts, and the final target compound is obtained. In this process, the selective control of the chlorination reaction is particularly important, and the influence of various reaction conditions on it needs to be
In conclusion, there are various methods for synthesizing 2-bromo-1-chloro-3-nitrobenzene, each with its own advantages and disadvantages. In actual operation, when considering the availability of raw materials, the difficulty of controlling reaction conditions, the purity and yield of the product, and many other factors, the optimal synthesis strategy can be selected.
First, benzene can be started from benzene. Shilling benzene is nitrified, using a mixed acid of sulfuric acid and nitric acid as a reagent, at a suitable temperature, benzene is converted to nitrobenzene. Subsequently, nitrobenzene is halogenated. In the halogenation step, chlorine atoms are introduced first, and chlorine gas and ferric chloride can be used as a catalytic system to generate m-chloro-nitrobenzene. Finally, bromine atoms are introduced, and liquid bromine and a suitable catalyst (such as iron powder) can be used to obtain 2-bromo-1-chloro-3-nitrobenzene. In this path, the precise control of the reaction conditions at each step is crucial. Excessive nitrification temperature may cause the formation of polynitroation by-products; the amount of catalyst and reaction time during halogenation will also affect the selectivity of the products.
Second, chlorobenzene can also be used as a raw material. First, chlorobenzene is nitrified, and the mixture of o-nitrochlorobenzene and p-nitrochlorobenzene is prepared by mixed acid treatment. After separation, o-nitrochlorobenzene is obtained. After that, the o-nitrochlorobenzene is brominated, and appropriate brominating reagents and conditions can be selected to introduce bromine atoms at the ortho site, thereby preparing the target product 2-bromo-1-chloro-3-nitrobenzene. In this approach, the separation of the mixture requires an effective method to ensure the purity of o-nitrochlorobenzene, which in turn affects the effect of subsequent bromination reactions.
Furthermore, bromobenzene can also be started from bromobenzene. First, bromobenzene is nitrified to obtain a mixture of nitrobromobenzene isomers, and then m-nitrobromobenzene is separated. Then, m-nitrobromobenzene is chlorinated under specific conditions, and chlorine atoms are successfully introduced with the help of suitable chlorination reagents and catalysts, and the final target compound is obtained. In this process, the selective control of the chlorination reaction is particularly important, and the influence of various reaction conditions on it needs to be
In conclusion, there are various methods for synthesizing 2-bromo-1-chloro-3-nitrobenzene, each with its own advantages and disadvantages. In actual operation, when considering the availability of raw materials, the difficulty of controlling reaction conditions, the purity and yield of the product, and many other factors, the optimal synthesis strategy can be selected.
In what areas is 2-bromo-1-chloro-3-nitrobenzene applied?
2-Bromo-1-chloro-3-nitrobenzene is an organic compound that has applications in many fields.
In the field of pharmaceutical synthesis, this compound can be used as a key intermediate. The bromine, chlorine and nitro functional groups attached to the guiene ring give it unique reactivity and chemical properties. With these functional groups, chemists can use a series of organic reactions, such as nucleophilic substitution reactions, reduction reactions, etc., to modify and construct its structure ingeniously, thereby synthesizing drug molecules with specific biological activities. For example, by nucleophilic substitution of specific nitrogenous and oxygen-containing nucleophiles with the compound, it is expected to construct new drugs with biological activities such as antibacterial and anti-tumor.
In the field of materials science, 2-bromo-1-chloro-3-nitrobenzene also has important uses. Because the functional groups in its structure can participate in the polymerization reaction, it can be used as a monomer or comonomer to prepare high-performance polymer materials. For example, by copolymerizing with compounds containing unsaturated bonds, new polymer materials with good thermal stability, mechanical properties and electrical properties can be prepared, which have potential applications in electronic devices, aerospace and other fields.
Furthermore, in the field of pesticide synthesis, this compound also has a place. Due to its special chemical structure, it has certain biological activity against certain pests or pathogens. After reasonable structural optimization and modification, high-efficiency and low-toxicity new pesticide products can be developed for pest control in agricultural production, helping to improve crop yield and quality.
In addition, in the research of organic synthetic chemistry, 2-bromo-1-chloro-3-nitrobenzene is often used as a model compound to explore new reaction mechanisms and synthesis methods. Scientists can deeply understand the nature and laws of organic reactions by studying the various chemical reactions they participate in, providing theoretical support and technical reserves for the development of organic synthetic chemistry.
In the field of pharmaceutical synthesis, this compound can be used as a key intermediate. The bromine, chlorine and nitro functional groups attached to the guiene ring give it unique reactivity and chemical properties. With these functional groups, chemists can use a series of organic reactions, such as nucleophilic substitution reactions, reduction reactions, etc., to modify and construct its structure ingeniously, thereby synthesizing drug molecules with specific biological activities. For example, by nucleophilic substitution of specific nitrogenous and oxygen-containing nucleophiles with the compound, it is expected to construct new drugs with biological activities such as antibacterial and anti-tumor.
In the field of materials science, 2-bromo-1-chloro-3-nitrobenzene also has important uses. Because the functional groups in its structure can participate in the polymerization reaction, it can be used as a monomer or comonomer to prepare high-performance polymer materials. For example, by copolymerizing with compounds containing unsaturated bonds, new polymer materials with good thermal stability, mechanical properties and electrical properties can be prepared, which have potential applications in electronic devices, aerospace and other fields.
Furthermore, in the field of pesticide synthesis, this compound also has a place. Due to its special chemical structure, it has certain biological activity against certain pests or pathogens. After reasonable structural optimization and modification, high-efficiency and low-toxicity new pesticide products can be developed for pest control in agricultural production, helping to improve crop yield and quality.
In addition, in the research of organic synthetic chemistry, 2-bromo-1-chloro-3-nitrobenzene is often used as a model compound to explore new reaction mechanisms and synthesis methods. Scientists can deeply understand the nature and laws of organic reactions by studying the various chemical reactions they participate in, providing theoretical support and technical reserves for the development of organic synthetic chemistry.
What are the physical properties of 2-bromo-1-chloro-3-nitrobenzene?
2 - bromo - 1 - chloro - 3 - nitrobenzene is a kind of organic compound. Its physical properties are unique, let me explain in detail for you.
Looking at its appearance, it is often a colorless to light yellow liquid, which exists stably under normal temperature and pressure. Its smell is unique, although it does not have a pungent feeling, it also has its own special smell, which can be noticed by ordinary people at close range.
When it comes to melting point, it is within a specific temperature range. This value is one of its important physical parameters, which is related to its phase transformation. When exposed to low temperature, it can be converted from liquid to solid state, just like ice crystals condensing, and the shape changes to reveal its physical properties. The boiling point of
is also a key property. When it reaches a certain temperature, the liquid boils and turns into a gaseous state. The temperature of this temperature is determined by factors such as intermolecular forces. The boiling point of 2-bromo-1-chloro-3-nitrobenzene reflects the difficulty of its gasification.
In terms of density, it is heavier than water. If mixed with water, it will sink underwater, like a stone falling abyss pool, which is distinct. This property is of great significance in many application scenarios.
Solubility is also a significant feature. In organic solvents, such as alcohols and ethers, it shows good solubility, just like fish entering water and dispersing freely. However, in water, the solubility is very small, and the two are difficult to blend, just like the barrier between oil and water.
In addition, its volatility is relatively low, and it is not easy to evaporate rapidly in the air, and it can maintain its liquid or solid state for a certain period of time.
In summary, the physical properties of 2-bromo-1-chloro-3-nitrobenzene are rich and diverse, which not only determine its behavior in various environments, but also lay a solid foundation for its application in chemical industry, scientific research and many other fields.
Looking at its appearance, it is often a colorless to light yellow liquid, which exists stably under normal temperature and pressure. Its smell is unique, although it does not have a pungent feeling, it also has its own special smell, which can be noticed by ordinary people at close range.
When it comes to melting point, it is within a specific temperature range. This value is one of its important physical parameters, which is related to its phase transformation. When exposed to low temperature, it can be converted from liquid to solid state, just like ice crystals condensing, and the shape changes to reveal its physical properties. The boiling point of
is also a key property. When it reaches a certain temperature, the liquid boils and turns into a gaseous state. The temperature of this temperature is determined by factors such as intermolecular forces. The boiling point of 2-bromo-1-chloro-3-nitrobenzene reflects the difficulty of its gasification.
In terms of density, it is heavier than water. If mixed with water, it will sink underwater, like a stone falling abyss pool, which is distinct. This property is of great significance in many application scenarios.
Solubility is also a significant feature. In organic solvents, such as alcohols and ethers, it shows good solubility, just like fish entering water and dispersing freely. However, in water, the solubility is very small, and the two are difficult to blend, just like the barrier between oil and water.
In addition, its volatility is relatively low, and it is not easy to evaporate rapidly in the air, and it can maintain its liquid or solid state for a certain period of time.
In summary, the physical properties of 2-bromo-1-chloro-3-nitrobenzene are rich and diverse, which not only determine its behavior in various environments, but also lay a solid foundation for its application in chemical industry, scientific research and many other fields.
What are the precautions in the preparation of 2-bromo-1-chloro-3-nitrobenzene?
When preparing 2-bromo-1-chloro-3-nitrobenzene, many things need to be paid attention to. The preparation of this compound is mostly based on benzene derivatives as starting materials, and is achieved by halogenation, nitrification and other reactions.
The purity of the first raw material. The benzene derivatives, halogenating reagents and nitrifying reagents used must be up to standard. If the raw material contains impurities, reaction or by-products, the purity and yield of the product will decrease. If the halogenating reagent is impure, or other halogen atoms are introduced, the composition of the product will be complicated.
The second time is the precise control of the reaction conditions. Temperature, reaction time and the ratio of reactants all have a great impact on the reaction. In the halogenation reaction, the temperature is too high, which may cause the formation of polyhalogenated products; in the nitration reaction, if the temperature is improper, or the positional isomer is formed, or the benzene ring is oxidized and destroyed. And the proportion of each reactant must also be strictly controlled, the proportion is out of balance, or the reaction cannot proceed as expected, and the yield is greatly reduced.
Furthermore, the safety of the reaction process cannot be ignored. Halogenation and nitrification reactions are dangerous. Halogenated reagents such as bromine and chlorine are highly corrosive and toxic. The operation must be in a well-ventilated environment and wear protective equipment to prevent them from contacting the skin and respiratory tract. The mixed acid of nitric acid and sulfuric acid used in the nitrification reaction is extremely corrosive, and the reaction is exothermic. It is necessary to add reagents slowly and effectively control the temperature to prevent danger caused by runaway After
and the separation and purification of the product. After the reaction, the product is often mixed with unreacted raw materials, by-products and catalysts. It is crucial to choose a suitable separation method, such as extraction, distillation, recrystallization, etc. During extraction, choose the right extractant to efficiently separate the product; for recrystallization, choose a suitable solvent to improve the purity of the product and reach the expected standard.
The purity of the first raw material. The benzene derivatives, halogenating reagents and nitrifying reagents used must be up to standard. If the raw material contains impurities, reaction or by-products, the purity and yield of the product will decrease. If the halogenating reagent is impure, or other halogen atoms are introduced, the composition of the product will be complicated.
The second time is the precise control of the reaction conditions. Temperature, reaction time and the ratio of reactants all have a great impact on the reaction. In the halogenation reaction, the temperature is too high, which may cause the formation of polyhalogenated products; in the nitration reaction, if the temperature is improper, or the positional isomer is formed, or the benzene ring is oxidized and destroyed. And the proportion of each reactant must also be strictly controlled, the proportion is out of balance, or the reaction cannot proceed as expected, and the yield is greatly reduced.
Furthermore, the safety of the reaction process cannot be ignored. Halogenation and nitrification reactions are dangerous. Halogenated reagents such as bromine and chlorine are highly corrosive and toxic. The operation must be in a well-ventilated environment and wear protective equipment to prevent them from contacting the skin and respiratory tract. The mixed acid of nitric acid and sulfuric acid used in the nitrification reaction is extremely corrosive, and the reaction is exothermic. It is necessary to add reagents slowly and effectively control the temperature to prevent danger caused by runaway After
and the separation and purification of the product. After the reaction, the product is often mixed with unreacted raw materials, by-products and catalysts. It is crucial to choose a suitable separation method, such as extraction, distillation, recrystallization, etc. During extraction, choose the right extractant to efficiently separate the product; for recrystallization, choose a suitable solvent to improve the purity of the product and reach the expected standard.
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