Linshang Chemical
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2-Bromo-1-Chloro-3-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
749580 |
| Chemical Formula | C7H3BrClF3 |
| Molar Mass | 261.45 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 195 - 197 °C |
| Melting Point | N/A |
| Density | 1.738 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, ethyl acetate |
| Flash Point | 79.4 °C |
| Vapor Pressure | Low at room temperature |
| Stability | Stable under normal conditions but may react with strong oxidizing agents |
As an accredited 2-Bromo-1-Chloro-3-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2 - bromo - 1 - chloro - 3 - (trifluoromethyl)benzene in a sealed chemical - grade bottle. |
| Storage | 2 - bromo - 1 - chloro - 3 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials like glass. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential reactions. |
| Shipping | 2 - bromo - 1 - chloro - 3 - (trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling and secure packaging to prevent spills during transit. |
Competitive 2-Bromo-1-Chloro-3-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 2-bromo-1-chloro-3- (trifluoromethyl) benzene?
2-Bromo-1-chloro-3- (trifluoromethyl) benzene is also an organic compound. It has unique chemical properties and is very important in the field of organic synthesis.
In this compound, bromine, chlorine and trifluoromethyl are all active functional groups, giving it diverse reactivity. Bromine atoms are highly active and can participate in nucleophilic substitution reactions, such as interacting with nucleophiles such as alkoxides and amines. Bromine atoms can be replaced by nucleophilic groups to form new carbon-heteroatomic bonds. In this process, the electrons of the nucleophilic reagent attack the carbon atoms connected to the bromine atoms, and the bromine ions leave to form new compounds.
Chlorine atoms also have some activity, although slightly inferior to bromine atoms, they can also participate in similar nucleophilic substitution reactions under suitable conditions. And because of its electronegativity, it can affect the electron cloud density distribution of the benzene ring and affect the reactivity at other positions on the benzene ring.
Trifluoromethyl is a strong electron-absorbing group, which significantly reduces the electron cloud density of the benzene ring, making the benzene ring more vulnerable to attack by electrophilic reagents, and at the same time changes the regioselectivity of the substitution reaction on the benzene ring. In the electrophilic substitution reaction, the reaction check point tends to be meta-site. Due to the electron-withdrawing induction effect and conjugation effect of trifluoromethyl, the electron cloud density of the ortho and para-site decreases even more, and the meta-site is relatively high. Therefore, electrophilic reagents attack meta-sites.
In addition, 2-bromo-1-chloro-3 - (trifluoromethyl) benzene can participate in metal-catalyzed reactions, such as palladium-catalyzed cross-coupling reactions. In such reactions, the halogen atom of the compound is coupled with the metal-containing organic reagent to form a carbon-carbon bond or a carbon-heteroatomic bond, providing an effective way to construct complex organic molecular structures. And because of its fluorine-containing atoms, the derived products often have special physical, chemical and biological activities, and have great application potential in the fields of medicine, pesticides and materials science.
In this compound, bromine, chlorine and trifluoromethyl are all active functional groups, giving it diverse reactivity. Bromine atoms are highly active and can participate in nucleophilic substitution reactions, such as interacting with nucleophiles such as alkoxides and amines. Bromine atoms can be replaced by nucleophilic groups to form new carbon-heteroatomic bonds. In this process, the electrons of the nucleophilic reagent attack the carbon atoms connected to the bromine atoms, and the bromine ions leave to form new compounds.
Chlorine atoms also have some activity, although slightly inferior to bromine atoms, they can also participate in similar nucleophilic substitution reactions under suitable conditions. And because of its electronegativity, it can affect the electron cloud density distribution of the benzene ring and affect the reactivity at other positions on the benzene ring.
Trifluoromethyl is a strong electron-absorbing group, which significantly reduces the electron cloud density of the benzene ring, making the benzene ring more vulnerable to attack by electrophilic reagents, and at the same time changes the regioselectivity of the substitution reaction on the benzene ring. In the electrophilic substitution reaction, the reaction check point tends to be meta-site. Due to the electron-withdrawing induction effect and conjugation effect of trifluoromethyl, the electron cloud density of the ortho and para-site decreases even more, and the meta-site is relatively high. Therefore, electrophilic reagents attack meta-sites.
In addition, 2-bromo-1-chloro-3 - (trifluoromethyl) benzene can participate in metal-catalyzed reactions, such as palladium-catalyzed cross-coupling reactions. In such reactions, the halogen atom of the compound is coupled with the metal-containing organic reagent to form a carbon-carbon bond or a carbon-heteroatomic bond, providing an effective way to construct complex organic molecular structures. And because of its fluorine-containing atoms, the derived products often have special physical, chemical and biological activities, and have great application potential in the fields of medicine, pesticides and materials science.
What are the common synthesis methods of 2-bromo-1-chloro-3- (trifluoromethyl) benzene?
2-Bromo-1-chloro-3- (trifluoromethyl) benzene is also an organic compound. Its common synthesis method is mostly based on the halogenation of aromatic hydrocarbons and the reaction of trifluoromethylation.
To obtain this substance, it is often started with m-chlorotoluene. M-chlorotoluene is first brominated, using bromine as the bromine source. Under the catalysis of appropriate catalysts, such as iron powder or iron tribromide, under heating conditions, the bromine atom replaces the hydrogen at a specific position on the benzene ring to obtain 2-bromo-1-chloro-3-methylbenzene. The key to this step is to control the amount of catalyst, reaction temperature and time to increase the yield and selectivity of the target product.
Then, trifluoromethylation of 2-bromo-1-chloro-3-methylbenzene can be carried out. Nucleophilic substitution method can be used to react with trifluoromethylating reagents, such as sodium trifluoromethanesulfonate (CF-SO-Na), in organic solvents such as dimethyl sulfoxide (DMSO), in the presence of a certain temperature and base. The base is often potassium carbonate, etc., which can promote the positive reaction. In this step, attention should be paid to the ratio of reagents and reaction conditions to prevent side reactions.
Another method is to use m-chlorobromobenzene as the starting material. M-chlorobromobenzene is first trifluoromethylated, followed by chlorination. The reagents and conditions used for trifluoromethylation are similar to the above. Chlorination uses chlorine gas as the chlorine source, and under the action of light or catalyst, chlorine atoms are introduced into the benzene ring. This process also requires strict control of the reaction conditions to achieve the desired synthetic effect.
Synthesis of 2-bromo-1-chloro-3- (trifluoromethyl) benzene, the optimization of the reaction conditions at each step, the purification and separation of the intermediate are all essential, and the purity and yield of the final product are related.
To obtain this substance, it is often started with m-chlorotoluene. M-chlorotoluene is first brominated, using bromine as the bromine source. Under the catalysis of appropriate catalysts, such as iron powder or iron tribromide, under heating conditions, the bromine atom replaces the hydrogen at a specific position on the benzene ring to obtain 2-bromo-1-chloro-3-methylbenzene. The key to this step is to control the amount of catalyst, reaction temperature and time to increase the yield and selectivity of the target product.
Then, trifluoromethylation of 2-bromo-1-chloro-3-methylbenzene can be carried out. Nucleophilic substitution method can be used to react with trifluoromethylating reagents, such as sodium trifluoromethanesulfonate (CF-SO-Na), in organic solvents such as dimethyl sulfoxide (DMSO), in the presence of a certain temperature and base. The base is often potassium carbonate, etc., which can promote the positive reaction. In this step, attention should be paid to the ratio of reagents and reaction conditions to prevent side reactions.
Another method is to use m-chlorobromobenzene as the starting material. M-chlorobromobenzene is first trifluoromethylated, followed by chlorination. The reagents and conditions used for trifluoromethylation are similar to the above. Chlorination uses chlorine gas as the chlorine source, and under the action of light or catalyst, chlorine atoms are introduced into the benzene ring. This process also requires strict control of the reaction conditions to achieve the desired synthetic effect.
Synthesis of 2-bromo-1-chloro-3- (trifluoromethyl) benzene, the optimization of the reaction conditions at each step, the purification and separation of the intermediate are all essential, and the purity and yield of the final product are related.
Where is 2-bromo-1-chloro-3- (trifluoromethyl) benzene used?
2 - bromo - 1 - chloro - 3 - (trifluoromethyl) benzene is an organic compound, which has applications in various fields.
In the field of medicinal chemistry, such aromatic compounds containing halides and trifluoromethyl are often used as intermediates in drug synthesis. Trifluoromethyl has strong electron-absorbing and lipophilic properties, and the introduction of drug molecules can change the physical and chemical properties of compounds, such as improving lipid solubility, which is beneficial for drugs to penetrate biofilms and enhance bioavailability. Taking the development of some anti-cancer drugs as an example, the use of this compound to construct specific structural fragments may enhance the affinity between drugs and target proteins and enhance anti-cancer activity.
In the field of materials science, it can be used to prepare special polymer materials. Due to its structure containing halogen atoms and trifluoromethyl groups, it can endow materials with unique properties. If fluoropolymers are prepared, they can improve the chemical stability, weather resistance and low surface energy of materials. Such polymers may be used in coatings, plastics and other fields to prepare materials with self-cleaning and corrosion resistance.
In the field of pesticide chemistry, the compound also has potential applications. The presence of halogen atoms and trifluoromethyl groups may enhance the biological activity and stability of the compound. Using this as a raw material to synthesize pesticides may have high inhibition and killing effects on specific pests and pathogens. Moreover, due to the stable structure, it degrades slowly in the environment and can maintain long-term efficacy.
In the field of organic synthesis chemistry, as an important intermediate, it can participate in many organic reactions, such as nucleophilic substitution reactions, metal catalytic coupling reactions, etc. Through these reactions, complex organic molecular structures can be constructed, providing an important foundation for the development of organic synthesis chemistry.
In the field of medicinal chemistry, such aromatic compounds containing halides and trifluoromethyl are often used as intermediates in drug synthesis. Trifluoromethyl has strong electron-absorbing and lipophilic properties, and the introduction of drug molecules can change the physical and chemical properties of compounds, such as improving lipid solubility, which is beneficial for drugs to penetrate biofilms and enhance bioavailability. Taking the development of some anti-cancer drugs as an example, the use of this compound to construct specific structural fragments may enhance the affinity between drugs and target proteins and enhance anti-cancer activity.
In the field of materials science, it can be used to prepare special polymer materials. Due to its structure containing halogen atoms and trifluoromethyl groups, it can endow materials with unique properties. If fluoropolymers are prepared, they can improve the chemical stability, weather resistance and low surface energy of materials. Such polymers may be used in coatings, plastics and other fields to prepare materials with self-cleaning and corrosion resistance.
In the field of pesticide chemistry, the compound also has potential applications. The presence of halogen atoms and trifluoromethyl groups may enhance the biological activity and stability of the compound. Using this as a raw material to synthesize pesticides may have high inhibition and killing effects on specific pests and pathogens. Moreover, due to the stable structure, it degrades slowly in the environment and can maintain long-term efficacy.
In the field of organic synthesis chemistry, as an important intermediate, it can participate in many organic reactions, such as nucleophilic substitution reactions, metal catalytic coupling reactions, etc. Through these reactions, complex organic molecular structures can be constructed, providing an important foundation for the development of organic synthesis chemistry.
What are the physical properties of 2-bromo-1-chloro-3- (trifluoromethyl) benzene?
2-Bromo-1-chloro-3- (trifluoromethyl) benzene is a kind of organic compound. According to its physical properties, at room temperature, it is mostly colorless to pale yellow liquid with a special odor. This odor may be unique due to the presence of halogen atoms and trifluoromethyl. Its density is heavier than that of water, and it is insoluble in water, but it can be soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc. Due to the principle of similar miscibility, the structure of this compound is similar to that of organic solvents.
The values of its boiling point and melting point are affected by the intermolecular force. The presence of halogen atoms and trifluoromethyl atoms in the molecule enhances the intermolecular force and increases the boiling point. Specifically, the boiling point or within a certain range is between [X] ° C and [X] ° C, which varies slightly due to different experimental conditions and determination methods or values. The melting point is also in a specific range due to structural characteristics, about [X] ° C.
In addition, the volatility of this compound is relatively low, due to the large molecular weight and strong intermolecular forces. Its vapor pressure is small at room temperature, which makes it less volatile in general environments.
The physical properties of 2-bromo-1-chloro-3- (trifluoromethyl) benzene are closely related to its molecular structure, which is of great significance for its application in organic synthesis, chemical production and other fields.
The values of its boiling point and melting point are affected by the intermolecular force. The presence of halogen atoms and trifluoromethyl atoms in the molecule enhances the intermolecular force and increases the boiling point. Specifically, the boiling point or within a certain range is between [X] ° C and [X] ° C, which varies slightly due to different experimental conditions and determination methods or values. The melting point is also in a specific range due to structural characteristics, about [X] ° C.
In addition, the volatility of this compound is relatively low, due to the large molecular weight and strong intermolecular forces. Its vapor pressure is small at room temperature, which makes it less volatile in general environments.
The physical properties of 2-bromo-1-chloro-3- (trifluoromethyl) benzene are closely related to its molecular structure, which is of great significance for its application in organic synthesis, chemical production and other fields.
What are the storage conditions for 2-bromo-1-chloro-3- (trifluoromethyl) benzene?
2-Bromo-1-chloro-3- (trifluoromethyl) benzene is also an organic compound. Its storage conditions are related to the stability and safety of this substance and cannot be ignored.
Those who bear the brunt should be placed in a cool and well-ventilated place. Because the temperature is too high or the ventilation is not smooth, it is easy to cause this compound to chemically react, or decompose, or polymerize, or even cause dangerous conditions. Therefore, the temperature of the warehouse should be controlled within an appropriate range, and the ventilation equipment should always be kept in good operation, so that the air can circulate smoothly.
Furthermore, it should be kept away from fire and heat sources. This compound may be at risk of burning or exploding in case of open flames, hot topics, or. In the storage place, smoking and all open flame operations are strictly prohibited. Electrical equipment must also be explosion-proof to prevent the accumulation of static electricity and the generation of electric sparks.
In addition, it needs to be stored separately with oxidants and food chemicals. The oxidant is highly oxidizing and comes into contact with 2-bromo-1-chloro-3- (trifluoromethyl) benzene, or triggers a violent oxidation reaction, causing accidents. And when stored separately from food chemicals, it is to prevent food contamination and ensure food safety.
Packaging is also quite important. Sealed packaging should be used to prevent leakage. Packaging materials should be corrosion-resistant and pressure-resistant to resist the erosion of compounds and maintain the integrity of the package. And the name of the chemical, characteristics, hazards and emergency treatment methods must be clearly marked on the package.
During storage, regular inspection is required. Check whether the package is damaged or leaked, and whether the properties of the compound have changed. If there is any abnormality, immediate measures must be taken to repair the package or transfer materials to avoid the expansion of the harm.
When handling, also be cautious. Pack light and unload lightly, do not damage the package to prevent compound leakage. Operators should wear appropriate protective equipment, such as protective clothing, gloves, goggles, etc., to ensure their own safety.
Those who bear the brunt should be placed in a cool and well-ventilated place. Because the temperature is too high or the ventilation is not smooth, it is easy to cause this compound to chemically react, or decompose, or polymerize, or even cause dangerous conditions. Therefore, the temperature of the warehouse should be controlled within an appropriate range, and the ventilation equipment should always be kept in good operation, so that the air can circulate smoothly.
Furthermore, it should be kept away from fire and heat sources. This compound may be at risk of burning or exploding in case of open flames, hot topics, or. In the storage place, smoking and all open flame operations are strictly prohibited. Electrical equipment must also be explosion-proof to prevent the accumulation of static electricity and the generation of electric sparks.
In addition, it needs to be stored separately with oxidants and food chemicals. The oxidant is highly oxidizing and comes into contact with 2-bromo-1-chloro-3- (trifluoromethyl) benzene, or triggers a violent oxidation reaction, causing accidents. And when stored separately from food chemicals, it is to prevent food contamination and ensure food safety.
Packaging is also quite important. Sealed packaging should be used to prevent leakage. Packaging materials should be corrosion-resistant and pressure-resistant to resist the erosion of compounds and maintain the integrity of the package. And the name of the chemical, characteristics, hazards and emergency treatment methods must be clearly marked on the package.
During storage, regular inspection is required. Check whether the package is damaged or leaked, and whether the properties of the compound have changed. If there is any abnormality, immediate measures must be taken to repair the package or transfer materials to avoid the expansion of the harm.
When handling, also be cautious. Pack light and unload lightly, do not damage the package to prevent compound leakage. Operators should wear appropriate protective equipment, such as protective clothing, gloves, goggles, etc., to ensure their own safety.
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