Linshang Chemical
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2-Bromo-1-Chloro-4-Nitrobenzene
Linshang Chemical
|
HS Code |
263499 |
| Chemical Formula | C6H3BrClNO2 |
| Molecular Weight | 236.45 |
| Appearance | Solid (usually pale - yellow to yellow - brown) |
| Boiling Point | Approximately 285 - 290 °C |
| Melting Point | 67 - 71 °C |
| Density | 1.81 g/cm³ (estimated) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Odor | Pungent |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
| Hazard Class | Irritant (may cause skin, eye and respiratory irritation) |
As an accredited 2-Bromo-1-Chloro-4-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram pack of 2 - bromo - 1 - chloro - 4 - nitrobenzene in a sealed chemical - grade container. |
| Storage | 2 - bromo - 1 - chloro - 4 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store it in a tightly sealed container, preferably made of corrosion - resistant materials. Label the container clearly to prevent misidentification. This helps maintain its stability and reduces risks associated with its reactivity and toxicity. |
| Shipping | 2 - bromo - 1 - chloro - 4 - nitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported by approved carriers following strict hazardous chemical shipping regulations to ensure safety during transit. |
Competitive 2-Bromo-1-Chloro-4-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 2-Bromo-1-Chloro-4-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 2 - bromo - 1 - chloro - 4 - nitrobenzene?
2 + - + bromo-1-chloro-4-nitrobenzene, this is an organic compound. Its physical properties are quite critical and it is widely used in chemical and scientific research fields.
Looking at its appearance, under normal temperature and pressure, it is mostly a light yellow to light brown crystalline solid. Its melting point range is about 52-55 ° C. The melting point is also the critical temperature for a substance to change from a solid state to a liquid state. The melting point of this compound is moderate. Under many chemical operations and experimental conditions, it is easier to achieve solid-liquid transformation, which is convenient for handling and participating in the reaction.
The boiling point is related to the temperature at which the compound changes from a liquid state to a gas state. The boiling point of 2-bromo-1-chloro-4-nitrobenzene is about 275-280 ℃. A higher boiling point indicates that the compound has strong intermolecular forces and requires higher energy to vaporize.
When it comes to solubility, this compound is difficult to dissolve in water. For water, polar solvents are also. The polarity of the molecular structure of 2-bromo-1-chloro-4-nitrobenzene is relatively weak. According to the principle of "similar miscibility", its solubility in water is very small. However, it is soluble in organic solvents such as ethanol, ether, and dichloromethane. Many organic solvents are weakly polar or non-polar, and they are similar in structure to the compound, so they can be mutually soluble. This solubility property makes it possible to achieve specific goals with the help of suitable organic solvents in organic synthesis, extraction and separation operations.
Density is also one of the important physical properties. The density of 2-bromo-1-chloro-4-nitrobenzene is about 1.87 g/cm ³, which is greater than the density of water. This property is of great significance when it involves operations such as liquid-liquid separation, because it will sink to the bottom of the water after mixing with water, which is conducive to separation by stratification and other means.
In addition, the compound is volatile and will evaporate slowly at room temperature, emitting a special odor. During use and storage, it is necessary to pay attention to ventilation and other safety measures to prevent inhalation from causing harm to the human body.
Looking at its appearance, under normal temperature and pressure, it is mostly a light yellow to light brown crystalline solid. Its melting point range is about 52-55 ° C. The melting point is also the critical temperature for a substance to change from a solid state to a liquid state. The melting point of this compound is moderate. Under many chemical operations and experimental conditions, it is easier to achieve solid-liquid transformation, which is convenient for handling and participating in the reaction.
The boiling point is related to the temperature at which the compound changes from a liquid state to a gas state. The boiling point of 2-bromo-1-chloro-4-nitrobenzene is about 275-280 ℃. A higher boiling point indicates that the compound has strong intermolecular forces and requires higher energy to vaporize.
When it comes to solubility, this compound is difficult to dissolve in water. For water, polar solvents are also. The polarity of the molecular structure of 2-bromo-1-chloro-4-nitrobenzene is relatively weak. According to the principle of "similar miscibility", its solubility in water is very small. However, it is soluble in organic solvents such as ethanol, ether, and dichloromethane. Many organic solvents are weakly polar or non-polar, and they are similar in structure to the compound, so they can be mutually soluble. This solubility property makes it possible to achieve specific goals with the help of suitable organic solvents in organic synthesis, extraction and separation operations.
Density is also one of the important physical properties. The density of 2-bromo-1-chloro-4-nitrobenzene is about 1.87 g/cm ³, which is greater than the density of water. This property is of great significance when it involves operations such as liquid-liquid separation, because it will sink to the bottom of the water after mixing with water, which is conducive to separation by stratification and other means.
In addition, the compound is volatile and will evaporate slowly at room temperature, emitting a special odor. During use and storage, it is necessary to pay attention to ventilation and other safety measures to prevent inhalation from causing harm to the human body.
What are the chemical properties of 2 - bromo - 1 - chloro - 4 - nitrobenzene?
2 + -Bromo-1-chloro-4-nitrobenzene is one of the organic compounds. Its chemical properties are unique and can be explored.
In this compound, bromine, chlorine and nitro are all important functional groups. Nitro has strong electron-absorbing properties, which can reduce the electron cloud density of the benzene ring and reduce the electrophilic substitution activity of the benzene ring. Due to the induction and conjugation effects of nitro groups, the electron cloud density of the adjacent and para-potential of the benzene ring decreases even more, so the electrophilic reagents are more likely to attack the intermediate position.
Although bromine and chlorine are halogen atoms, they also have electron-absorbing induction effects, but their electron-giving conjugation effects also exist, which generally reduce the electron cloud density of the benzene ring less than that of the nitro group. In the electrophilic substitution reaction, the halogen atom is an ortho-and para-localization group, which interacts with the localization effect of the nitro group.
2 + -bromo-1-chloro-4-nitrobenzene can participate in many chemical reactions. For example, in the nucleophilic substitution reaction, the electron cloud density of the benzene ring is reduced due to nitro electron absorption, and the carbon atom attached to the halogen atom is more susceptible to attack by nucleophiles, and the halogen atom can be replaced by the nucleophilic group. In addition, under certain conditions, the nitro group can also be reduced to an amino group, and more compounds can be derived.
In the field of organic synthesis, 2 + -bromo-1-chloro-4-nitrobenzene can be used as a key intermediate. By ingeniously designing reaction routes and taking advantage of the characteristics of its functional groups, complex and functional organic compounds can be prepared. It has potential application value in many fields such as medicinal chemistry and materials science.
In this compound, bromine, chlorine and nitro are all important functional groups. Nitro has strong electron-absorbing properties, which can reduce the electron cloud density of the benzene ring and reduce the electrophilic substitution activity of the benzene ring. Due to the induction and conjugation effects of nitro groups, the electron cloud density of the adjacent and para-potential of the benzene ring decreases even more, so the electrophilic reagents are more likely to attack the intermediate position.
Although bromine and chlorine are halogen atoms, they also have electron-absorbing induction effects, but their electron-giving conjugation effects also exist, which generally reduce the electron cloud density of the benzene ring less than that of the nitro group. In the electrophilic substitution reaction, the halogen atom is an ortho-and para-localization group, which interacts with the localization effect of the nitro group.
2 + -bromo-1-chloro-4-nitrobenzene can participate in many chemical reactions. For example, in the nucleophilic substitution reaction, the electron cloud density of the benzene ring is reduced due to nitro electron absorption, and the carbon atom attached to the halogen atom is more susceptible to attack by nucleophiles, and the halogen atom can be replaced by the nucleophilic group. In addition, under certain conditions, the nitro group can also be reduced to an amino group, and more compounds can be derived.
In the field of organic synthesis, 2 + -bromo-1-chloro-4-nitrobenzene can be used as a key intermediate. By ingeniously designing reaction routes and taking advantage of the characteristics of its functional groups, complex and functional organic compounds can be prepared. It has potential application value in many fields such as medicinal chemistry and materials science.
What are the synthesis methods of 2 - bromo - 1 - chloro - 4 - nitrobenzene?
The preparation of 2-bromo-1-chloro-4-nitrobenzene can be achieved by the following paths.
First, chlorobenzene is used as the starting material. Under appropriate conditions, the reaction of nitrification of chlorobenzene is carried out. Under the appropriate conditions, mixed acid (mixture of nitric acid and sulfuric acid) is used as the reagent. The electron cloud density on the benzene ring of chlorobenzene is higher, and the nitro group (-NO -2) will preferentially replace the hydrogen atom at the o-and para-position of the chlorine atom on the benzene ring. Due to the fact that the chlorine atom is an o-para-position group and the steric resistance relationship, the main product is Subsequently, p-chloronitrobenzene is brominated with bromine, and iron bromide (FeBr) is used as a catalyst. Bromine atoms will replace hydrogen atoms at the nitro-meta position on the benzene ring to obtain 2-bromo-1-chloro-4-nitrobenzene. The key to this path lies in the precise control of nitration reaction conditions and the effective use of subsequent bromine reaction catalysts.
Second, bromobenzene is used as the starting material. Similarly, bromobenzene is nitrified in the first order, because bromine atoms are also ortho-para-sites, and through acid mixing, p-bromonitrobenzene is formed. Then, the chlorination reaction of p-bromo-nitrobenzene with chlorine in the presence of a suitable catalyst (such as ferric trichloride FeCl 🥰) occurs, and the chlorine atom will replace the hydrogen atom at the nitro-meso position on the benzene ring to obtain the target product 2-bromo-1-chloro-4-nitrobenzene. This path needs to pay attention to the reaction temperature and acid mixing ratio during the nitration of bromobenzene, and the subsequent chlorination reaction needs to pay attention to the flux of chlorine gas and the reaction time.
Third, if nitrobenzene is used as the starting material. Nitrobenzene reacts with bromine first, and under the action of the catalyst, m-bromo-nitroben 2-Bromo-1-chloro-4-nitrobenzene can be obtained by chlorination reaction of m-bromo-nitrobenzene with chlorine gas. However, due to the nitro group as the meta-localization group, it is difficult to selectively control the subsequent reaction, and there may be many side reactions. The actual operation requires more fine regulation.
First, chlorobenzene is used as the starting material. Under appropriate conditions, the reaction of nitrification of chlorobenzene is carried out. Under the appropriate conditions, mixed acid (mixture of nitric acid and sulfuric acid) is used as the reagent. The electron cloud density on the benzene ring of chlorobenzene is higher, and the nitro group (-NO -2) will preferentially replace the hydrogen atom at the o-and para-position of the chlorine atom on the benzene ring. Due to the fact that the chlorine atom is an o-para-position group and the steric resistance relationship, the main product is Subsequently, p-chloronitrobenzene is brominated with bromine, and iron bromide (FeBr) is used as a catalyst. Bromine atoms will replace hydrogen atoms at the nitro-meta position on the benzene ring to obtain 2-bromo-1-chloro-4-nitrobenzene. The key to this path lies in the precise control of nitration reaction conditions and the effective use of subsequent bromine reaction catalysts.
Second, bromobenzene is used as the starting material. Similarly, bromobenzene is nitrified in the first order, because bromine atoms are also ortho-para-sites, and through acid mixing, p-bromonitrobenzene is formed. Then, the chlorination reaction of p-bromo-nitrobenzene with chlorine in the presence of a suitable catalyst (such as ferric trichloride FeCl 🥰) occurs, and the chlorine atom will replace the hydrogen atom at the nitro-meso position on the benzene ring to obtain the target product 2-bromo-1-chloro-4-nitrobenzene. This path needs to pay attention to the reaction temperature and acid mixing ratio during the nitration of bromobenzene, and the subsequent chlorination reaction needs to pay attention to the flux of chlorine gas and the reaction time.
Third, if nitrobenzene is used as the starting material. Nitrobenzene reacts with bromine first, and under the action of the catalyst, m-bromo-nitroben 2-Bromo-1-chloro-4-nitrobenzene can be obtained by chlorination reaction of m-bromo-nitrobenzene with chlorine gas. However, due to the nitro group as the meta-localization group, it is difficult to selectively control the subsequent reaction, and there may be many side reactions. The actual operation requires more fine regulation.
Where is 2 - bromo - 1 - chloro - 4 - nitrobenzene used?
2 + -Bromo-1-chloro-4-nitrobenzene is useful in various fields.
In the field of pharmaceutical synthesis, this compound can be a key intermediate. Due to the characteristics of halogen atoms and nitro groups in its structure, it can introduce other functional groups through various chemical reactions to construct molecules with specific pharmacological activities. For example, halogen atoms can react with nucleophiles such as nitrogen and oxygen through nucleophilic substitution reactions to synthesize complex drug molecules for disease prevention and treatment.
In the field of materials science, it also has important uses. It can be used as a starting material for the synthesis of special polymer materials. Through appropriate polymerization reactions, its structural units are introduced into the polymer chain, giving the material unique properties, such as enhancing the heat resistance and chemical corrosion resistance of the material. Because of its nitro and halogen atoms, they can participate in the formation of intermolecular forces, which affect the aggregate structure and properties of the material.
Furthermore, in the field of organic synthesis chemistry research, 2 + -bromo-1-chloro-4-nitrobenzene is often used as a model compound. Researchers can study the various reactions it participates in, such as electrophilic substitution, nucleophilic substitution, reduction reactions, etc., to further explore the reaction mechanism, providing theoretical basis and practical experience for the development of organic synthesis methodologies, and helping to develop more efficient and green organic synthesis strategies.
In addition, in the dye industry, this compound can be appropriately modified or can be used to synthesize new dyes. Its structure can impart specific color and stability to dyes, meeting the requirements of dye properties in different fields, such as textile printing and dyeing, ink manufacturing and other industries.
In the field of pharmaceutical synthesis, this compound can be a key intermediate. Due to the characteristics of halogen atoms and nitro groups in its structure, it can introduce other functional groups through various chemical reactions to construct molecules with specific pharmacological activities. For example, halogen atoms can react with nucleophiles such as nitrogen and oxygen through nucleophilic substitution reactions to synthesize complex drug molecules for disease prevention and treatment.
In the field of materials science, it also has important uses. It can be used as a starting material for the synthesis of special polymer materials. Through appropriate polymerization reactions, its structural units are introduced into the polymer chain, giving the material unique properties, such as enhancing the heat resistance and chemical corrosion resistance of the material. Because of its nitro and halogen atoms, they can participate in the formation of intermolecular forces, which affect the aggregate structure and properties of the material.
Furthermore, in the field of organic synthesis chemistry research, 2 + -bromo-1-chloro-4-nitrobenzene is often used as a model compound. Researchers can study the various reactions it participates in, such as electrophilic substitution, nucleophilic substitution, reduction reactions, etc., to further explore the reaction mechanism, providing theoretical basis and practical experience for the development of organic synthesis methodologies, and helping to develop more efficient and green organic synthesis strategies.
In addition, in the dye industry, this compound can be appropriately modified or can be used to synthesize new dyes. Its structure can impart specific color and stability to dyes, meeting the requirements of dye properties in different fields, such as textile printing and dyeing, ink manufacturing and other industries.
What are the precautions in the preparation of 2 - bromo - 1 - chloro - 4 - nitrobenzene?
When preparing 2-bromo-1-chloro-4-nitrobenzene, many precautions need to be kept in mind.
Bear the brunt, and the raw materials must be well selected. The purity of the raw materials such as bromine, chlorine and nitrobenzene used must meet the corresponding standards. If the raw materials are impure, impurities may cause side reactions during the reaction process, resulting in poor product purity and yield. Just like marching and fighting, if the grain and grass are defective, the combat strength of the army will be difficult to guarantee.
Furthermore, it is crucial to control the reaction conditions. Temperature needs to be precisely regulated, and this reaction is extremely sensitive to temperature. If the temperature is too high, side reactions may occur in large quantities, generating unnecessary by-products; if the temperature is too low, the reaction rate will be slow, time-consuming, and may lead to incomplete reactions. Just like cooking a delicious dish, the temperature is not properly controlled, and the taste and color of the dish will be greatly reduced. The reaction time cannot be ignored, and it needs to be reasonably set according to the reaction process and experimental experience to ensure that the reaction is fully carried out.
The choice and construction of the reaction device should not be underestimated. The device must ensure good airtightness, otherwise the leakage of the reactants or products will not only endanger the safety of the experimenters, but also affect the accuracy of the reaction results. And the material of the device needs to fit the reaction characteristics to avoid chemical reactions with the reactants or products.
During operation, the order of feeding is particularly critical. All kinds of reactants should be added in an orderly manner according to the reaction mechanism and experimental requirements. Improper feeding sequence may cause the reaction to go out of control in an instant, causing danger or reducing the reaction efficiency.
After the reaction is over, the separation and purification of the product is also a key link. According to the physical and chemical properties of the product and impurities, suitable separation methods can be selected, such as extraction, distillation, recrystallization, etc., to obtain high-purity products.
In addition, experimental safety must not be forgotten. This reaction involves toxic and harmful chemicals such as bromine and chlorine. The operation must be carried out in a well-ventilated environment. The experimenters need to wear protective clothing, protective gloves and goggles, etc., and strictly abide by laboratory safety rules to prevent accidents.
The process of preparing 2-bromo-1-chloro-4-nitrobenzene is complicated and all links are closely connected. Only by being cautious about all precautions can we successfully achieve the experimental goals and obtain satisfactory results.
Bear the brunt, and the raw materials must be well selected. The purity of the raw materials such as bromine, chlorine and nitrobenzene used must meet the corresponding standards. If the raw materials are impure, impurities may cause side reactions during the reaction process, resulting in poor product purity and yield. Just like marching and fighting, if the grain and grass are defective, the combat strength of the army will be difficult to guarantee.
Furthermore, it is crucial to control the reaction conditions. Temperature needs to be precisely regulated, and this reaction is extremely sensitive to temperature. If the temperature is too high, side reactions may occur in large quantities, generating unnecessary by-products; if the temperature is too low, the reaction rate will be slow, time-consuming, and may lead to incomplete reactions. Just like cooking a delicious dish, the temperature is not properly controlled, and the taste and color of the dish will be greatly reduced. The reaction time cannot be ignored, and it needs to be reasonably set according to the reaction process and experimental experience to ensure that the reaction is fully carried out.
The choice and construction of the reaction device should not be underestimated. The device must ensure good airtightness, otherwise the leakage of the reactants or products will not only endanger the safety of the experimenters, but also affect the accuracy of the reaction results. And the material of the device needs to fit the reaction characteristics to avoid chemical reactions with the reactants or products.
During operation, the order of feeding is particularly critical. All kinds of reactants should be added in an orderly manner according to the reaction mechanism and experimental requirements. Improper feeding sequence may cause the reaction to go out of control in an instant, causing danger or reducing the reaction efficiency.
After the reaction is over, the separation and purification of the product is also a key link. According to the physical and chemical properties of the product and impurities, suitable separation methods can be selected, such as extraction, distillation, recrystallization, etc., to obtain high-purity products.
In addition, experimental safety must not be forgotten. This reaction involves toxic and harmful chemicals such as bromine and chlorine. The operation must be carried out in a well-ventilated environment. The experimenters need to wear protective clothing, protective gloves and goggles, etc., and strictly abide by laboratory safety rules to prevent accidents.
The process of preparing 2-bromo-1-chloro-4-nitrobenzene is complicated and all links are closely connected. Only by being cautious about all precautions can we successfully achieve the experimental goals and obtain satisfactory results.
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