Linshang Chemical
PRODUCTS
2-Bromo-1-Chloro-4-(Trifluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
948620 |
| Chemical Formula | C7H3BrClF3O |
| Molecular Weight | 275.45 |
As an accredited 2-Bromo-1-Chloro-4-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle packaging for 2 - bromo - 1 - chloro - 4 - (trifluoromethoxy)benzene. |
| Storage | 2 - bromo - 1 - chloro - 4 - (trifluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it may be flammable. Keep it in a tightly - sealed container to prevent leakage and exposure to air or moisture, which could potentially cause chemical reactions. Store it separately from oxidizing agents and reactive substances. |
| Shipping | 2 - bromo - 1 - chloro - 4 - (trifluoromethoxy)benzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict chemical transportation regulations to ensure safe transit, minimizing risks during handling and transport. |
Competitive 2-Bromo-1-Chloro-4-(Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Bromo-1-Chloro-4-(Trifluoromethoxy)Benzene in China?
As a trusted 2-Bromo-1-Chloro-4-(Trifluoromethoxy)Benzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Bromo-1-Chloro-4-(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 2-bromo-1-chloro-4- (trifluoromethoxy) benzene?
2 - bromo - 1 - chloro - 4 - (trifluoromethoxy) benzene is an organic compound with unique chemical properties. Due to the existence of halogen atoms and fluoroalkoxy groups, it has special reactivity and physical properties.
First talk about its nucleophilic substitution reaction. Due to the high activity of halogen atoms bromine and chlorine, it is easy to be replaced by nucleophilic reagents. In case of hydroxyl negative ions (OH), bromine or chlorine atoms can be replaced by hydroxyl groups to form benzene derivatives containing hydroxyl groups. The reaction conditions are different, and the substitution position and rate are different. The alkaline environment and suitable solvents can accelerate the nucleophilic substitution process.
Let's talk about its aromatic related reactions. This compound has benzene ring, aromatic, and can undergo electrophilic substitution reaction. Because the electron cloud of the benzene ring is affected by halogen atoms and trifluoromethoxy, the density distribution of the electron cloud changes. Trifluoromethoxy has strong electron absorption, which reduces the density of the electron cloud of the benzene ring and weakens the activity of the electrophilic substitution reaction. However, under certain conditions, the electrophilic reagent can still attack the benzene ring. For example, it reacts with nitro positive ions (NO 2) to form nitro substitutes, and the substitution positions are mostly at relatively high electron cloud densities.
From the perspective of physical properties, the compound contains bromine, chlorine, fluorine and other halogen atoms, and its molecular polarity is large, resulting in different boiling points and melting points from common benzene derivatives. And the introduction of trifluoromethoxy increases the molecular fat solubility, and the solubility In conclusion, 2-bromo-1-chloro-4- (trifluoromethoxy) benzene exhibits diverse chemical properties due to the interaction of its functional groups, and can be used as an important intermediate in the field of organic synthesis for the preparation of complex organic compounds.
First talk about its nucleophilic substitution reaction. Due to the high activity of halogen atoms bromine and chlorine, it is easy to be replaced by nucleophilic reagents. In case of hydroxyl negative ions (OH), bromine or chlorine atoms can be replaced by hydroxyl groups to form benzene derivatives containing hydroxyl groups. The reaction conditions are different, and the substitution position and rate are different. The alkaline environment and suitable solvents can accelerate the nucleophilic substitution process.
Let's talk about its aromatic related reactions. This compound has benzene ring, aromatic, and can undergo electrophilic substitution reaction. Because the electron cloud of the benzene ring is affected by halogen atoms and trifluoromethoxy, the density distribution of the electron cloud changes. Trifluoromethoxy has strong electron absorption, which reduces the density of the electron cloud of the benzene ring and weakens the activity of the electrophilic substitution reaction. However, under certain conditions, the electrophilic reagent can still attack the benzene ring. For example, it reacts with nitro positive ions (NO 2) to form nitro substitutes, and the substitution positions are mostly at relatively high electron cloud densities.
From the perspective of physical properties, the compound contains bromine, chlorine, fluorine and other halogen atoms, and its molecular polarity is large, resulting in different boiling points and melting points from common benzene derivatives. And the introduction of trifluoromethoxy increases the molecular fat solubility, and the solubility In conclusion, 2-bromo-1-chloro-4- (trifluoromethoxy) benzene exhibits diverse chemical properties due to the interaction of its functional groups, and can be used as an important intermediate in the field of organic synthesis for the preparation of complex organic compounds.
What are the common synthesis methods of 2-bromo-1-chloro-4- (trifluoromethoxy) benzene?
2-Bromo-1-chloro-4- (trifluoromethoxy) benzene is also an organic compound. Its common synthesis method is to rely on nucleophilic substitution, halogenation and other reactions.
The method of nucleophilic substitution is often to use a nucleophilic reagent containing trifluoromethoxy to interact with halogenated benzene substrates. For example, trifluoromethanol and halogenated benzene may be obtained under suitable reaction conditions. When reacting, pay attention to the choice of solvent. Polar aprotic solvents, such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), etc., are often good choices, which can promote the activity of nucleophilic reagents and make the reaction proceed smoothly. Temperature, type and amount of alkali also affect the effectiveness of the reaction. Temperature and appropriate amount of alkali can increase the rate and yield of the reaction.
halogenation method is also commonly used. The benzene derivative containing trifluoromethoxy is first prepared, and then the halogenation reaction is carried out. When brominating, bromine, N-bromosuccinimide (NBS), etc. can be selected as brominating agents; chlorine gas, thionyl chloride, etc. can be selected for chlorination. However, the selectivity of the halogenation reaction is crucial, and it is often necessary to adjust the reaction conditions, such as temperature, light, catalyst, etc., in order to achieve the optimal production of the target product.
In addition, reactions involving organometallic reagents, such as palladium-catalyzed cross-coupling reactions, may also be the path for the synthesis of this compound. Organometallic reagents containing trifluoromethoxy groups and halogenated aromatics may be obtained with the help of palladium catalysts and ligands. These reaction conditions are relatively mild and highly selective, making them advantageous for the synthesis of complex organic compounds.
Synthesis of 2-bromo-1-chloro-4- (trifluoromethoxy) benzene requires careful consideration of factors such as the availability of raw materials, the difficulty of reaction, and the high or low yield according to the actual situation, and the optimal synthesis path can be selected to achieve the purpose of efficient preparation.
The method of nucleophilic substitution is often to use a nucleophilic reagent containing trifluoromethoxy to interact with halogenated benzene substrates. For example, trifluoromethanol and halogenated benzene may be obtained under suitable reaction conditions. When reacting, pay attention to the choice of solvent. Polar aprotic solvents, such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), etc., are often good choices, which can promote the activity of nucleophilic reagents and make the reaction proceed smoothly. Temperature, type and amount of alkali also affect the effectiveness of the reaction. Temperature and appropriate amount of alkali can increase the rate and yield of the reaction.
halogenation method is also commonly used. The benzene derivative containing trifluoromethoxy is first prepared, and then the halogenation reaction is carried out. When brominating, bromine, N-bromosuccinimide (NBS), etc. can be selected as brominating agents; chlorine gas, thionyl chloride, etc. can be selected for chlorination. However, the selectivity of the halogenation reaction is crucial, and it is often necessary to adjust the reaction conditions, such as temperature, light, catalyst, etc., in order to achieve the optimal production of the target product.
In addition, reactions involving organometallic reagents, such as palladium-catalyzed cross-coupling reactions, may also be the path for the synthesis of this compound. Organometallic reagents containing trifluoromethoxy groups and halogenated aromatics may be obtained with the help of palladium catalysts and ligands. These reaction conditions are relatively mild and highly selective, making them advantageous for the synthesis of complex organic compounds.
Synthesis of 2-bromo-1-chloro-4- (trifluoromethoxy) benzene requires careful consideration of factors such as the availability of raw materials, the difficulty of reaction, and the high or low yield according to the actual situation, and the optimal synthesis path can be selected to achieve the purpose of efficient preparation.
Where is 2-bromo-1-chloro-4- (trifluoromethoxy) benzene used?
2 - bromo - 1 - chloro - 4 - (trifluoromethoxy) benzene is an important intermediate in organic synthesis and has significant applications in medicine, pesticides, materials science and other fields.
In the field of medicine, its application is quite wide. Due to the unique properties of bromine, chlorine and trifluoromethoxy in the molecular structure, it can be used as a key structural fragment to participate in the construction of many drug molecules. Taking the development of anti-cancer drugs as an example, through rational design, this compound is introduced into the drug molecule. Its halogen atom and trifluoromethoxy can regulate the electron cloud distribution and spatial configuration of the molecule, affect the binding ability and affinity of the drug and the target, and then improve the inhibitory effect of the drug on cancer cells. In the study of antibacterial drugs, the compound can destroy the cell wall or cell membrane synthesis process of bacteria by virtue of its own structural characteristics, and exhibit antibacterial activity.
In the field of pesticides, 2-bromo-1-chloro-4 - (trifluoromethoxy) benzene is also of great value. In the development of pesticides, its structure can endow pesticides with a special mechanism of action on the nervous system or respiratory system of pests. The strong electron-absorbing properties of trifluoromethoxy and the reactivity of halogen atoms can enhance the inhibitory effect of pesticides on specific enzymes in pests, causing physiological dysfunction of pests and achieving insecticidal purposes. In terms of herbicides, it can inhibit weed growth by interfering with photosynthesis or hormone balance of weeds, and because of its unique structure, it may have the advantages of environmental friendliness and low residue.
In the field of materials science, the use of this compound cannot be ignored. In organic optoelectronic materials, it can be used as a functional monomer to participate in the synthesis of polymers. Its special structure can regulate the photoelectric properties of materials, such as improving the charge transfer efficiency of materials and improving the luminescence properties. Introducing it into polymer materials may lead to the preparation of new materials with special optical and electrical properties, which can be used in organic Light Emitting Diodes (OLEDs), solar cells and other devices to promote the development and innovation of materials science.
In the field of medicine, its application is quite wide. Due to the unique properties of bromine, chlorine and trifluoromethoxy in the molecular structure, it can be used as a key structural fragment to participate in the construction of many drug molecules. Taking the development of anti-cancer drugs as an example, through rational design, this compound is introduced into the drug molecule. Its halogen atom and trifluoromethoxy can regulate the electron cloud distribution and spatial configuration of the molecule, affect the binding ability and affinity of the drug and the target, and then improve the inhibitory effect of the drug on cancer cells. In the study of antibacterial drugs, the compound can destroy the cell wall or cell membrane synthesis process of bacteria by virtue of its own structural characteristics, and exhibit antibacterial activity.
In the field of pesticides, 2-bromo-1-chloro-4 - (trifluoromethoxy) benzene is also of great value. In the development of pesticides, its structure can endow pesticides with a special mechanism of action on the nervous system or respiratory system of pests. The strong electron-absorbing properties of trifluoromethoxy and the reactivity of halogen atoms can enhance the inhibitory effect of pesticides on specific enzymes in pests, causing physiological dysfunction of pests and achieving insecticidal purposes. In terms of herbicides, it can inhibit weed growth by interfering with photosynthesis or hormone balance of weeds, and because of its unique structure, it may have the advantages of environmental friendliness and low residue.
In the field of materials science, the use of this compound cannot be ignored. In organic optoelectronic materials, it can be used as a functional monomer to participate in the synthesis of polymers. Its special structure can regulate the photoelectric properties of materials, such as improving the charge transfer efficiency of materials and improving the luminescence properties. Introducing it into polymer materials may lead to the preparation of new materials with special optical and electrical properties, which can be used in organic Light Emitting Diodes (OLEDs), solar cells and other devices to promote the development and innovation of materials science.
What are the physical properties of 2-bromo-1-chloro-4- (trifluoromethoxy) benzene?
2 - bromo - 1 - chloro - 4 - (trifluoromethoxy) benzene is an organic compound with unique physical properties. The appearance of this compound is often colorless to light yellow liquid, which exists stably at room temperature and pressure. Looking at its color, it is colorless to light yellow, just like the warm sun in the early morning, fresh and soft.
As far as its boiling point is concerned, it is about a specific temperature range, and the exact value fluctuates due to many factors. The characteristics of boiling point are like the node of life's journey. Under certain conditions, matter undergoes a phase change. Its boiling point is closely related to the intermolecular force. The stronger the intermolecular force, the higher the boiling point. The presence of bromine, chlorine, and trifluoromethoxy in this compound makes the intermolecular forces unique, which in turn affects the boiling point.
Melting point is also an important physical property. Although the specific melting point data needs to be determined experimentally, the approximate range can be inferred according to the structural characteristics. At the melting point, the substance transitions from solid to liquid, just like ice and snow gradually melting under the warm sun in spring. The arrangement and interaction of molecules play a key role in the change of melting point. The complexity of the structure of this compound determines the unique arrangement of molecules, which affects the melting point.
In terms of density, it is relatively moderate. Density reflects the mass per unit volume of a substance, just like a scale for measuring the "compactness" of a substance. Its density depends on the type and arrangement of atoms, and the atomic weight and spatial distribution of bromine, chlorine and trifluoromethoxy give this compound a specific density.
In terms of solubility, it exhibits a certain solubility in organic solvents such as ethanol and ether. Organic solvents are like "friendly mediators" and can interact with the compound to disperse the molecules. However, the solubility in water is not good. Due to the large difference between the polarity of water and the structural characteristics of the compound, it is difficult to form an effective interaction. It is like two different worlds and difficult to blend.
Low volatility, relatively stable molecules, and not easy to escape into the air. Volatility is like the "active level" of a substance. Low volatility sexual
The above physical properties are all derived from the unique molecular structure of 2-bromo-1-chloro-4 - (trifluoromethoxy) benzene, which is related to each other and together describes the physical "picture" of this compound.
As far as its boiling point is concerned, it is about a specific temperature range, and the exact value fluctuates due to many factors. The characteristics of boiling point are like the node of life's journey. Under certain conditions, matter undergoes a phase change. Its boiling point is closely related to the intermolecular force. The stronger the intermolecular force, the higher the boiling point. The presence of bromine, chlorine, and trifluoromethoxy in this compound makes the intermolecular forces unique, which in turn affects the boiling point.
Melting point is also an important physical property. Although the specific melting point data needs to be determined experimentally, the approximate range can be inferred according to the structural characteristics. At the melting point, the substance transitions from solid to liquid, just like ice and snow gradually melting under the warm sun in spring. The arrangement and interaction of molecules play a key role in the change of melting point. The complexity of the structure of this compound determines the unique arrangement of molecules, which affects the melting point.
In terms of density, it is relatively moderate. Density reflects the mass per unit volume of a substance, just like a scale for measuring the "compactness" of a substance. Its density depends on the type and arrangement of atoms, and the atomic weight and spatial distribution of bromine, chlorine and trifluoromethoxy give this compound a specific density.
In terms of solubility, it exhibits a certain solubility in organic solvents such as ethanol and ether. Organic solvents are like "friendly mediators" and can interact with the compound to disperse the molecules. However, the solubility in water is not good. Due to the large difference between the polarity of water and the structural characteristics of the compound, it is difficult to form an effective interaction. It is like two different worlds and difficult to blend.
Low volatility, relatively stable molecules, and not easy to escape into the air. Volatility is like the "active level" of a substance. Low volatility sexual
The above physical properties are all derived from the unique molecular structure of 2-bromo-1-chloro-4 - (trifluoromethoxy) benzene, which is related to each other and together describes the physical "picture" of this compound.
What are the precautions in the preparation of 2-bromo-1-chloro-4- (trifluoromethoxy) benzene?
When preparing 2-bromo-1-chloro-4- (trifluoromethoxy) benzene, many precautions need to be engraved in mind.
Bear the brunt, and the selection of raw materials must be rigorous. The quality of the starting materials used has a profound impact on the purity and yield of the product. It is necessary to carefully check the source of the raw materials to ensure that their purity is up to standard and the impurity content is low, so as to avoid impurities from deriving side reactions during the reaction process and hindering the smooth progress of the main reaction.
Furthermore, the control of the reaction conditions is the key. In terms of temperature, this reaction is extremely sensitive to temperature changes. If the temperature is too high, it may cause frequent side reactions and reduce the selectivity of the product; if the temperature is too low, the reaction rate will be slow and Therefore, it is necessary to precisely adjust the temperature, and with the help of precision temperature control equipment, the temperature of the reaction system is constant in a suitable range. Take common similar reactions as an example, the reaction temperature may fluctuate in a narrow range, and this specific range needs to be carefully explored based on past experience and previous exploratory experiments. Pressure cannot be ignored either. Some reactions can be carried out efficiently under specific pressure conditions. If the pressure is deviated, the reaction process may be blocked. If this reaction involves gas participation, it is especially necessary to pay attention to pressure changes, use pressure monitoring devices, and adjust them in a timely manner to meet the reaction requirements.
The use of catalysts is also a top priority. Suitable catalysts can significantly accelerate the reaction rate and reduce the activation energy of the reaction. However, the type and dosage of catalysts need to be carefully selected. Different catalysts have very different effects on the selectivity of the reaction, and it is difficult to achieve the expected reaction effect with too much or too little dosage. It is necessary to screen suitable catalysts according to the reaction mechanism and past experience, and optimize the dosage through experiments.
Monitoring of the reaction process is indispensable. With the help of analytical methods such as thin layer chromatography (TLC) and gas chromatography (GC), real-time insight into the reaction process. Know the consumption of raw materials and the amount of product formation, and stop the reaction at the appropriate time to prevent excessive reaction from causing product decomposition or by-products to increase.
The post-treatment stage should not be underestimated. Product separation and purification are crucial. Due to the reaction system or impurities such as unreacted raw materials, by-products and catalysts, suitable separation methods, such as extraction, distillation, column chromatography, etc., need to be selected to obtain high-purity target products. During operation, pay attention to the control of conditions in each link to prevent product loss or the introduction of new impurities.
When preparing 2-bromo-1-chloro-4 - (trifluoromethoxy) benzene, all links are closely connected, and any detail omission may have an adverse impact on the quality and yield of the final product. It is necessary to be careful and take steps.
Bear the brunt, and the selection of raw materials must be rigorous. The quality of the starting materials used has a profound impact on the purity and yield of the product. It is necessary to carefully check the source of the raw materials to ensure that their purity is up to standard and the impurity content is low, so as to avoid impurities from deriving side reactions during the reaction process and hindering the smooth progress of the main reaction.
Furthermore, the control of the reaction conditions is the key. In terms of temperature, this reaction is extremely sensitive to temperature changes. If the temperature is too high, it may cause frequent side reactions and reduce the selectivity of the product; if the temperature is too low, the reaction rate will be slow and Therefore, it is necessary to precisely adjust the temperature, and with the help of precision temperature control equipment, the temperature of the reaction system is constant in a suitable range. Take common similar reactions as an example, the reaction temperature may fluctuate in a narrow range, and this specific range needs to be carefully explored based on past experience and previous exploratory experiments. Pressure cannot be ignored either. Some reactions can be carried out efficiently under specific pressure conditions. If the pressure is deviated, the reaction process may be blocked. If this reaction involves gas participation, it is especially necessary to pay attention to pressure changes, use pressure monitoring devices, and adjust them in a timely manner to meet the reaction requirements.
The use of catalysts is also a top priority. Suitable catalysts can significantly accelerate the reaction rate and reduce the activation energy of the reaction. However, the type and dosage of catalysts need to be carefully selected. Different catalysts have very different effects on the selectivity of the reaction, and it is difficult to achieve the expected reaction effect with too much or too little dosage. It is necessary to screen suitable catalysts according to the reaction mechanism and past experience, and optimize the dosage through experiments.
Monitoring of the reaction process is indispensable. With the help of analytical methods such as thin layer chromatography (TLC) and gas chromatography (GC), real-time insight into the reaction process. Know the consumption of raw materials and the amount of product formation, and stop the reaction at the appropriate time to prevent excessive reaction from causing product decomposition or by-products to increase.
The post-treatment stage should not be underestimated. Product separation and purification are crucial. Due to the reaction system or impurities such as unreacted raw materials, by-products and catalysts, suitable separation methods, such as extraction, distillation, column chromatography, etc., need to be selected to obtain high-purity target products. During operation, pay attention to the control of conditions in each link to prevent product loss or the introduction of new impurities.
When preparing 2-bromo-1-chloro-4 - (trifluoromethoxy) benzene, all links are closely connected, and any detail omission may have an adverse impact on the quality and yield of the final product. It is necessary to be careful and take steps.
Scan to WhatsApp
