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2-Bromo-1-Chloro-4-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
599995 |
| Chemical Formula | C7H3BrClF3 |
| Molecular Weight | 261.45 |
| Appearance | liquid (usually) |
| Color | colorless to light yellow |
| Odor | characteristic organic odor |
| Solubility In Water | insoluble (organic compound, typically non - water - soluble) |
| Solubility In Organic Solvents | soluble in common organic solvents like dichloromethane, toluene |
| Stability | stable under normal conditions, but reactive with strong oxidizing agents |
| Hazard Class | irritant (may cause eye, skin, and respiratory tract irritation) |
As an accredited 2-Bromo-1-Chloro-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle of 2 - bromo - 1 - chloro - 4 - (trifluoromethyl)benzene, well - sealed. |
| Storage | Store 2 - bromo - 1 - chloro - 4 - (trifluoromethyl)benzene in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Since it's a chemical, store it separately from oxidizing agents, reducing agents, and other incompatible substances to prevent reactions. |
| Shipping | 2 - bromo - 1 - chloro - 4 - (trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper handling during transit to prevent leakage and ensure safety. |
Competitive 2-Bromo-1-Chloro-4-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 2-Bromo-1-Chloro-4-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 2-bromo-1-chloro-4- (trifluoromethyl) benzene
2 - bromo - 1 - chloro - 4 - (trifluoromethyl) benzene is an organohalogenated aromatic hydrocarbon with unique chemical properties and is widely used in the field of organic synthesis.
In this compound, bromine (Br), chlorine (Cl) and trifluoromethyl (CF 🥰) are all key functional groups. From the perspective of electronic effect, trifluoromethyl has strong electron absorption, which can reduce the electron cloud density of the benzene ring and cause the activity of the electrophilic substitution reaction of the benzene ring to decrease. At the same time, this group affects the charge distribution on the benzene ring, so the electron cloud density of the adjacent and para-sites decreases more than that of the meta-sites, so the electrophiles are more inclined to attack the meta-sites.
Bromine and chlorine are also electron-withdrawing groups, but they can increase the electron cloud density of the benzene ring to a certain extent through p-π conjugation to the p-benzene ring power supply. However, the electron-withdrawing induction effect is stronger than the conjugation effect of the electron supply, and the electron cloud density of the benzene ring is still reduced in general. In the electrophilic substitution reaction, the halogen atom is an ortho and para-localized group. Because the halogen atom is conjugated with the benzene ring during the reaction, the positively charged intermediate can be dispersed on the halogen atom, which makes the ortho and para-substitution intermediates more stable.
2 - bromo - 1 - chloro - 4 - (trifluoromethyl) benzene can The first is a nucleophilic substitution reaction. Under appropriate conditions, bromine or chlorine atoms can be replaced by nucleophilic reagents. For example, when reacted with sodium alcohol, bromine atoms or chlorine atoms can be replaced by alkoxy groups to generate corresponding aryl ethers. The second is a metal-catalyzed coupling reaction. Under the action of metal catalysts such as palladium, it can be coupled with reagents containing borate esters or halogenated hydrocarbons to form carbon-carbon bonds, which can be used to synthesize organic molecules with complex structures. The third is a reduction reaction. Some groups in the molecule can be reduced under the action of specific reducing agents.
This compound is chemically active and has important uses in organic synthesis, medicinal chemistry, materials science and other fields. It can be used as a key intermediate for the preparation of various functional compounds.
In this compound, bromine (Br), chlorine (Cl) and trifluoromethyl (CF 🥰) are all key functional groups. From the perspective of electronic effect, trifluoromethyl has strong electron absorption, which can reduce the electron cloud density of the benzene ring and cause the activity of the electrophilic substitution reaction of the benzene ring to decrease. At the same time, this group affects the charge distribution on the benzene ring, so the electron cloud density of the adjacent and para-sites decreases more than that of the meta-sites, so the electrophiles are more inclined to attack the meta-sites.
Bromine and chlorine are also electron-withdrawing groups, but they can increase the electron cloud density of the benzene ring to a certain extent through p-π conjugation to the p-benzene ring power supply. However, the electron-withdrawing induction effect is stronger than the conjugation effect of the electron supply, and the electron cloud density of the benzene ring is still reduced in general. In the electrophilic substitution reaction, the halogen atom is an ortho and para-localized group. Because the halogen atom is conjugated with the benzene ring during the reaction, the positively charged intermediate can be dispersed on the halogen atom, which makes the ortho and para-substitution intermediates more stable.
2 - bromo - 1 - chloro - 4 - (trifluoromethyl) benzene can The first is a nucleophilic substitution reaction. Under appropriate conditions, bromine or chlorine atoms can be replaced by nucleophilic reagents. For example, when reacted with sodium alcohol, bromine atoms or chlorine atoms can be replaced by alkoxy groups to generate corresponding aryl ethers. The second is a metal-catalyzed coupling reaction. Under the action of metal catalysts such as palladium, it can be coupled with reagents containing borate esters or halogenated hydrocarbons to form carbon-carbon bonds, which can be used to synthesize organic molecules with complex structures. The third is a reduction reaction. Some groups in the molecule can be reduced under the action of specific reducing agents.
This compound is chemically active and has important uses in organic synthesis, medicinal chemistry, materials science and other fields. It can be used as a key intermediate for the preparation of various functional compounds.
What is the main use of 2-bromo-1-chloro-4- (trifluoromethyl) benzene?
2 - bromo - 1 - chloro - 4 - (trifluoromethyl) benzene (2 - bromo - 1 - chloro - 4 - (trifluoromethyl) benzene) is an organic compound, which is widely used in chemical and scientific research fields, mainly used in the following places:
First, the field of drug synthesis. This compound has a unique structure and can be used as a key intermediate to prepare drugs with specific biological activities. Because it contains halogen atoms and trifluoromethyl, it can affect the physicochemical properties, biological activities and pharmacokinetic properties of drug molecules. For example, the introduction of trifluoromethyl can often enhance the lipid solubility of drug molecules, improve their ability to penetrate biofilms, and then improve bioavailability. By means of organic synthesis, the compound can be reacted with other functionalized reagents to build a complex drug molecular skeleton, laying the foundation for the development of new drugs.
Second, the field of materials science. Due to its special chemical structure, it can be used to synthesize functional materials. For example, in the field of organic optoelectronic materials, the introduction of halogen atoms and trifluoromethyl can adjust the electron cloud distribution and energy level structure of materials, thereby affecting their optical and electrical properties. The polymer materials synthesized from this compound may have unique photoelectric conversion properties, which can be applied to organic Light Emitting Diode (OLED), solar cells and other devices to improve their performance and efficiency.
Third, pesticide research and development. The compound can be used as a starting material to prepare pesticide active ingredients through a series of reactions. The presence of halogen atoms and trifluoromethyl may give pesticides better biological activity and stability. For example, it can enhance the toxicity and selectivity to specific pests or pathogens, and has suitable degradation characteristics in the environment, which not only guarantees the effectiveness of pesticides, but also reduces the lasting impact on the environment.
Fourth, in the study of organic synthetic chemistry, 2-bromo-1-chloro-4 - (trifluoromethyl) benzene is often used as a model compound to explore new organic reaction mechanisms and synthesis methods. Due to its multi-functional group properties, various reactions such as nucleophilic substitution, electrophilic substitution, and metal catalytic coupling can be carried out. Researchers use this to study key factors such as reaction conditions, selectivity, and efficiency to promote the development of organic synthetic chemistry and provide theoretical and practical basis for designing more efficient and green synthesis routes.
First, the field of drug synthesis. This compound has a unique structure and can be used as a key intermediate to prepare drugs with specific biological activities. Because it contains halogen atoms and trifluoromethyl, it can affect the physicochemical properties, biological activities and pharmacokinetic properties of drug molecules. For example, the introduction of trifluoromethyl can often enhance the lipid solubility of drug molecules, improve their ability to penetrate biofilms, and then improve bioavailability. By means of organic synthesis, the compound can be reacted with other functionalized reagents to build a complex drug molecular skeleton, laying the foundation for the development of new drugs.
Second, the field of materials science. Due to its special chemical structure, it can be used to synthesize functional materials. For example, in the field of organic optoelectronic materials, the introduction of halogen atoms and trifluoromethyl can adjust the electron cloud distribution and energy level structure of materials, thereby affecting their optical and electrical properties. The polymer materials synthesized from this compound may have unique photoelectric conversion properties, which can be applied to organic Light Emitting Diode (OLED), solar cells and other devices to improve their performance and efficiency.
Third, pesticide research and development. The compound can be used as a starting material to prepare pesticide active ingredients through a series of reactions. The presence of halogen atoms and trifluoromethyl may give pesticides better biological activity and stability. For example, it can enhance the toxicity and selectivity to specific pests or pathogens, and has suitable degradation characteristics in the environment, which not only guarantees the effectiveness of pesticides, but also reduces the lasting impact on the environment.
Fourth, in the study of organic synthetic chemistry, 2-bromo-1-chloro-4 - (trifluoromethyl) benzene is often used as a model compound to explore new organic reaction mechanisms and synthesis methods. Due to its multi-functional group properties, various reactions such as nucleophilic substitution, electrophilic substitution, and metal catalytic coupling can be carried out. Researchers use this to study key factors such as reaction conditions, selectivity, and efficiency to promote the development of organic synthetic chemistry and provide theoretical and practical basis for designing more efficient and green synthesis routes.
What are the synthesis methods of 2-bromo-1-chloro-4- (trifluoromethyl) benzene
The common methods for synthesizing 2-bromo-1-chloro-4- (trifluoromethyl) benzene are as follows.
One is the halogenation reaction method. Using p-trifluoromethyl chlorobenzene as the starting material, the bromination reaction is first carried out with a brominating agent. Commonly used brominating agents such as liquid bromine interact with iron powder or iron tribromide in the presence of appropriate catalysts. This catalyst can promote the polarization of bromine molecules and is more prone to electrophilic substitution with the benzene ring to generate 2-bromo-1-chloro-4- (trifluoromethyl) benzene. When reacting, it is necessary to pay attention to the reaction temperature and the ratio of reactants. Excessive temperature may lead to the formation of polybrominated products, and improper ratio will also affect the yield.
The second is achieved by coupling reaction. For example, a suitable organometallic reagent containing chlorine, bromine and trifluoromethyl, such as Grignard reagent or organolithium reagent, is selected to couple with the corresponding halogenated aromatics under the action of a transition metal catalyst. Taking a palladium catalyst as an example, it can promote the activation of carbon-halogen bonds and couple the carbon in the organometallic reagent with the carbon in the halogenated aromatics. This method requires stricter reaction conditions and needs to be operated in an anhydrous and oxygen-free environment to prevent side reactions between the organometallic reagent and water and oxygen, which will affect the reaction process and
Third, the diazotization reaction can be used. First, p-trifluoromethylaniline is converted into a diazonium salt through a diazotization reaction, and then the diazoyl group is replaced by chlorine and bromine through a halogen substitution reaction. The diazotization reaction needs to be carried out in a low temperature and strong acid environment to ensure the stability of the diazoyl salt. Then the halogen substitution reaction needs to select suitable halogenating reagents, such as cuprous chloride, cuprous bromide, etc., to obtain the target product smoothly.
These three methods have their own advantages and disadvantages. The halogenation reaction is relatively simple to operate, but the selectivity is sometimes poor. The coupling reaction conditions are harsh, but the carbon-carbon bond can be accurately constructed. The diazotization reaction step is slightly complicated, and the specific group In actual synthesis, it is necessary to carefully choose the appropriate synthesis path according to many factors such as raw material availability, cost, yield and purity requirements.
One is the halogenation reaction method. Using p-trifluoromethyl chlorobenzene as the starting material, the bromination reaction is first carried out with a brominating agent. Commonly used brominating agents such as liquid bromine interact with iron powder or iron tribromide in the presence of appropriate catalysts. This catalyst can promote the polarization of bromine molecules and is more prone to electrophilic substitution with the benzene ring to generate 2-bromo-1-chloro-4- (trifluoromethyl) benzene. When reacting, it is necessary to pay attention to the reaction temperature and the ratio of reactants. Excessive temperature may lead to the formation of polybrominated products, and improper ratio will also affect the yield.
The second is achieved by coupling reaction. For example, a suitable organometallic reagent containing chlorine, bromine and trifluoromethyl, such as Grignard reagent or organolithium reagent, is selected to couple with the corresponding halogenated aromatics under the action of a transition metal catalyst. Taking a palladium catalyst as an example, it can promote the activation of carbon-halogen bonds and couple the carbon in the organometallic reagent with the carbon in the halogenated aromatics. This method requires stricter reaction conditions and needs to be operated in an anhydrous and oxygen-free environment to prevent side reactions between the organometallic reagent and water and oxygen, which will affect the reaction process and
Third, the diazotization reaction can be used. First, p-trifluoromethylaniline is converted into a diazonium salt through a diazotization reaction, and then the diazoyl group is replaced by chlorine and bromine through a halogen substitution reaction. The diazotization reaction needs to be carried out in a low temperature and strong acid environment to ensure the stability of the diazoyl salt. Then the halogen substitution reaction needs to select suitable halogenating reagents, such as cuprous chloride, cuprous bromide, etc., to obtain the target product smoothly.
These three methods have their own advantages and disadvantages. The halogenation reaction is relatively simple to operate, but the selectivity is sometimes poor. The coupling reaction conditions are harsh, but the carbon-carbon bond can be accurately constructed. The diazotization reaction step is slightly complicated, and the specific group In actual synthesis, it is necessary to carefully choose the appropriate synthesis path according to many factors such as raw material availability, cost, yield and purity requirements.
What are the physical properties of 2-bromo-1-chloro-4- (trifluoromethyl) benzene
2-Bromo-1-chloro-4- (trifluoromethyl) benzene is also an organic compound. It has specific physical properties, so let me tell you one by one.
First of all, its properties, under room temperature and pressure, are mostly colorless to light yellow liquids, which are clear and transparent in appearance and have a certain fluidity. This is determined by the arrangement and interaction of atoms in its molecular structure.
When it comes to the boiling point, it is between 190 and 200 ° C. Due to the existence of van der Waals forces between molecules, and the introduction of trifluoromethyl groups, the polarity of the molecules is changed, which in turn affects the intermolecular forces, causing the boiling point to be in this range. The value of its boiling point is crucial when separating and purifying this compound. According to this characteristic, it can be separated from the mixture by distillation.
And the melting point is about - 20 ° C. At this low temperature, the compound changes from liquid to solid. The melting point is also closely related to the molecular structure. The rigid structure of the benzene ring and the influence of substituents such as bromine, chlorine, and trifluoromethyl determine its melting point.
As for the density, it is about 1.7 g/cm ³. The value of density is related to its floating and sinking conditions in different media, and is an important reference index in chemical operations, such as liquid-liquid separation.
In terms of solubility, slightly soluble in water. This is because water is a polar solvent, and the overall polarity of this compound is relatively weak due to the presence of benzene ring, halogenated group and trifluoromethyl group. According to the principle of "similar miscibility", it is slightly soluble in water. However, it is soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc. This property is convenient for organic synthesis to select suitable solvents to promote the reaction.
The physical properties of 2-bromo-1-chloro-4- (trifluoromethyl) benzene are of great significance in organic synthesis, chemical production and other fields, and help chemists better control their properties and applications.
First of all, its properties, under room temperature and pressure, are mostly colorless to light yellow liquids, which are clear and transparent in appearance and have a certain fluidity. This is determined by the arrangement and interaction of atoms in its molecular structure.
When it comes to the boiling point, it is between 190 and 200 ° C. Due to the existence of van der Waals forces between molecules, and the introduction of trifluoromethyl groups, the polarity of the molecules is changed, which in turn affects the intermolecular forces, causing the boiling point to be in this range. The value of its boiling point is crucial when separating and purifying this compound. According to this characteristic, it can be separated from the mixture by distillation.
And the melting point is about - 20 ° C. At this low temperature, the compound changes from liquid to solid. The melting point is also closely related to the molecular structure. The rigid structure of the benzene ring and the influence of substituents such as bromine, chlorine, and trifluoromethyl determine its melting point.
As for the density, it is about 1.7 g/cm ³. The value of density is related to its floating and sinking conditions in different media, and is an important reference index in chemical operations, such as liquid-liquid separation.
In terms of solubility, slightly soluble in water. This is because water is a polar solvent, and the overall polarity of this compound is relatively weak due to the presence of benzene ring, halogenated group and trifluoromethyl group. According to the principle of "similar miscibility", it is slightly soluble in water. However, it is soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc. This property is convenient for organic synthesis to select suitable solvents to promote the reaction.
The physical properties of 2-bromo-1-chloro-4- (trifluoromethyl) benzene are of great significance in organic synthesis, chemical production and other fields, and help chemists better control their properties and applications.
What to pay attention to when storing and transporting 2-bromo-1-chloro-4- (trifluoromethyl) benzene
2-Bromo-1-chloro-4- (trifluoromethyl) benzene is also an organic compound. When storing and transporting, be sure to pay attention to many matters.
Bear the brunt, the storage environment is very important. This material should be placed in a cool, dry and well-ventilated place. It is easy to change its chemical properties due to heat. If it is in a humid place, it may cause adverse reactions such as hydrolysis, which will damage its quality. Temperature should be controlled within a specific range. Generally speaking, low temperature can reduce its volatilization and chemical reaction rate, but it should not be too low to prevent freezing from causing the container to break.
Furthermore, the packaging must be strong and tight. Containers of glass or specific plastic materials are commonly used, and they must be sealed without leakage. Glass containers are transparent and easy to observe the internal conditions; plastic ones are lightweight and have certain impact resistance. However, regardless of the material, they should be resistant to corrosion. Key information such as name and hazard nature should be clearly marked on the outside of the package for identification and disposal.
When transporting, strict specifications must be followed. This compound may be toxic and dangerous, and should be transported in accordance with the relevant regulations of hazardous chemicals. Transportation vehicles should be equipped with corresponding emergency equipment, such as fire extinguishers, leakage emergency treatment tools, etc. Escort personnel must also be professionally trained to be familiar with their characteristics and emergency measures. During transportation, avoid vibration, collision and high temperature, and be careful to prevent leakage caused by package damage.
In addition, storage and transportation places should be kept away from fire sources, heat sources and oxidants. Because it is an organic halide, it may be exposed to open flames, hot topics or oxidants, or there is a risk of combustion and explosion. And it should be stored and transported separately from food chemicals, active metals, etc., to prevent uncontrollable chemical reactions.
In short, during the storage and transportation of 2-bromo-1-chloro-4- (trifluoromethyl) benzene, care should be taken and strictly followed to ensure the safety of personnel and the environment from pollution, and to ensure the stability of its chemical properties.
Bear the brunt, the storage environment is very important. This material should be placed in a cool, dry and well-ventilated place. It is easy to change its chemical properties due to heat. If it is in a humid place, it may cause adverse reactions such as hydrolysis, which will damage its quality. Temperature should be controlled within a specific range. Generally speaking, low temperature can reduce its volatilization and chemical reaction rate, but it should not be too low to prevent freezing from causing the container to break.
Furthermore, the packaging must be strong and tight. Containers of glass or specific plastic materials are commonly used, and they must be sealed without leakage. Glass containers are transparent and easy to observe the internal conditions; plastic ones are lightweight and have certain impact resistance. However, regardless of the material, they should be resistant to corrosion. Key information such as name and hazard nature should be clearly marked on the outside of the package for identification and disposal.
When transporting, strict specifications must be followed. This compound may be toxic and dangerous, and should be transported in accordance with the relevant regulations of hazardous chemicals. Transportation vehicles should be equipped with corresponding emergency equipment, such as fire extinguishers, leakage emergency treatment tools, etc. Escort personnel must also be professionally trained to be familiar with their characteristics and emergency measures. During transportation, avoid vibration, collision and high temperature, and be careful to prevent leakage caused by package damage.
In addition, storage and transportation places should be kept away from fire sources, heat sources and oxidants. Because it is an organic halide, it may be exposed to open flames, hot topics or oxidants, or there is a risk of combustion and explosion. And it should be stored and transported separately from food chemicals, active metals, etc., to prevent uncontrollable chemical reactions.
In short, during the storage and transportation of 2-bromo-1-chloro-4- (trifluoromethyl) benzene, care should be taken and strictly followed to ensure the safety of personnel and the environment from pollution, and to ensure the stability of its chemical properties.
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