Linshang Chemical
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2-Bromo-1-Chloro-5-Fluoro-3-Methylbenzene
Linshang Chemical
|
HS Code |
958356 |
| Chemical Formula | C7H5BrClF |
| Molecular Weight | 225.47 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 200 - 210 °C |
| Density | Estimated based on similar compounds, around 1.6 - 1.8 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Vapor Pressure | Low at room temperature |
| Flash Point | Caution, flammable, flash point likely around 80 - 90 °C |
As an accredited 2-Bromo-1-Chloro-5-Fluoro-3-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram vial containing 2 - bromo - 1 - chloro - 5 - fluoro - 3 - methylbenzene, tightly sealed. |
| Storage | 2 - bromo - 1 - chloro - 5 - fluoro - 3 - methylbenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant material, to prevent leakage and contact with air or moisture, which could potentially lead to decomposition or reaction. |
| Shipping | 2 - bromo - 1 - chloro - 5 - fluoro - 3 - methylbenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported under proper regulatory guidelines, ensuring safety from spillage and exposure during transit. |
Competitive 2-Bromo-1-Chloro-5-Fluoro-3-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 2-bromo-1-chloro-5-fluoro-3-methylbenzene?
2-Bromo-1-chloro-5-fluoro-3-methylbenzene is one of the organic compounds. Its chemical structure can be regarded as the benzene ring as the group, and there are different substituents at various positions on the ring.
The first view benzene ring, which is a six-membered ring structure, is composed of six carbon atoms connected to each other by conjugated double bonds, and is in the shape of a plane regular hexagon, with unique stability and electron cloud distribution characteristics.
On the benzene ring, the second position is connected with a bromo atom (bromo). Bromine atom, one of the halogen elements, has a large atomic radius and high electronegativity. It has a significant impact on the distribution of electron clouds in molecules, which can change the electron cloud density of the benzene ring, and then affect the chemical activity and reaction check point of the molecule.
The first position is connected with chlorine atoms (chloro), which is also a halogen element. Its properties are similar to those of bromine, but the atomic radius and electronegativity are slightly different. The existence of chlorine atoms also participates in changing the distribution pattern of benzene ring electron clouds, interacting with bromine atoms and jointly affecting the chemical behavior of molecules.
The fifth position is connected to fluorine atoms (fluoro), which is the most electronegative of halogen elements. Due to its high electronegativity, it strongly attracts electrons, resulting in a significant change in the density of the benzene ring electron cloud near the fifth position, which has a significant effect on the polarity, reactivity and spatial structure of the molecule.
The third position has methyl substitution. Methyl is a kind of alkyl group, which has an electron-pushing effect, which is opposite to the electron-withdrawing effect of halogen atoms. Its existence can partially cancel the electron-withdrawing effect of halogen atoms on the benzene ring electron cloud, and regulate the electron cloud density and spatial steric resistance of the molecule to a certain extent.
Overall, the chemical structure of 2-bromo-1-chloro-5-fluoro-3-methylbenzene exhibits unique physical and chemical properties due to the different types, positions and electronic effects of different substituents on the benzene ring. It shows specific reactivity and application potential in many fields such as organic synthesis and medicinal chemistry due to its structural properties.
The first view benzene ring, which is a six-membered ring structure, is composed of six carbon atoms connected to each other by conjugated double bonds, and is in the shape of a plane regular hexagon, with unique stability and electron cloud distribution characteristics.
On the benzene ring, the second position is connected with a bromo atom (bromo). Bromine atom, one of the halogen elements, has a large atomic radius and high electronegativity. It has a significant impact on the distribution of electron clouds in molecules, which can change the electron cloud density of the benzene ring, and then affect the chemical activity and reaction check point of the molecule.
The first position is connected with chlorine atoms (chloro), which is also a halogen element. Its properties are similar to those of bromine, but the atomic radius and electronegativity are slightly different. The existence of chlorine atoms also participates in changing the distribution pattern of benzene ring electron clouds, interacting with bromine atoms and jointly affecting the chemical behavior of molecules.
The fifth position is connected to fluorine atoms (fluoro), which is the most electronegative of halogen elements. Due to its high electronegativity, it strongly attracts electrons, resulting in a significant change in the density of the benzene ring electron cloud near the fifth position, which has a significant effect on the polarity, reactivity and spatial structure of the molecule.
The third position has methyl substitution. Methyl is a kind of alkyl group, which has an electron-pushing effect, which is opposite to the electron-withdrawing effect of halogen atoms. Its existence can partially cancel the electron-withdrawing effect of halogen atoms on the benzene ring electron cloud, and regulate the electron cloud density and spatial steric resistance of the molecule to a certain extent.
Overall, the chemical structure of 2-bromo-1-chloro-5-fluoro-3-methylbenzene exhibits unique physical and chemical properties due to the different types, positions and electronic effects of different substituents on the benzene ring. It shows specific reactivity and application potential in many fields such as organic synthesis and medicinal chemistry due to its structural properties.
What are the physical properties of 2-bromo-1-chloro-5-fluoro-3-methylbenzene?
2-Bromo-1-chloro-5-fluoro-3-methylbenzene is a kind of organic compound. Its physical properties are quite important and are fundamental to many chemical applications.
First of all, its phase state, under room temperature and pressure, this compound is often in a liquid state. Looking at its color, it is mostly colorless and transparent, but it may be slightly yellow due to the mixing of impurities. This is a characteristic that can be recognized by the naked eye, and can be used as a basis for preliminary judgment at the beginning of experimental inspection.
As for the smell, it has a special aromatic aroma. This smell is not popular with everyone, but in the chemical environment, it is one of its signs. The perception of odor, although your mileage may vary, can be initially identified by professionals.
Its boiling point is also a key physical property. Experimentally determined, the boiling point is about a specific temperature range. This temperature limit varies slightly due to experimental conditions, but it can be generally used as a reference. The boiling point is related to the separation and purification of compounds. In the method of distillation, the boiling point can be effectively separated to obtain pure 2-bromo-1-chloro-5-fluoro-3-methylbenzene.
The melting point is also a property that cannot be ignored. The determination of the melting point requires precise equipment and operation. Its melting point is near a certain temperature point, which can be used as evidence for the identification of compounds. The characteristics of melting point are crucial in the study of solid-state and liquid-state transitions of substances.
In terms of solubility, 2-bromo-1-chloro-5-fluoro-3-methyl benzene is soluble in many organic solvents, such as ethanol, ether, etc. However, its solubility in water is very small and almost insoluble. This property is based on the hydrophilicity of its molecular structure. The forces between organic solvents and the molecules of the compound are adapted, so they are soluble, and the forces between water and the compound molecules are greatly different, resulting in insolubility. The difference in solubility can be used as a criterion for solvent selection in operations such as extraction.
Density is also one of its physical properties. Its density is higher than that of water, and in the stratification experiment, it can be seen that it sinks to the bottom of the water. This density characteristic can be effectively separated according to the density difference in the process involving liquid-liquid separation, such as liquid separation operation.
In summary, the physical properties of 2-bromo-1-chloro-5-fluoro-3-methyl benzene, such as phase state, color, odor, boiling point, melting point, solubility, density, etc. are of great significance in chemical experiments, industrial production and other fields, and are the basis for related operations and research.
First of all, its phase state, under room temperature and pressure, this compound is often in a liquid state. Looking at its color, it is mostly colorless and transparent, but it may be slightly yellow due to the mixing of impurities. This is a characteristic that can be recognized by the naked eye, and can be used as a basis for preliminary judgment at the beginning of experimental inspection.
As for the smell, it has a special aromatic aroma. This smell is not popular with everyone, but in the chemical environment, it is one of its signs. The perception of odor, although your mileage may vary, can be initially identified by professionals.
Its boiling point is also a key physical property. Experimentally determined, the boiling point is about a specific temperature range. This temperature limit varies slightly due to experimental conditions, but it can be generally used as a reference. The boiling point is related to the separation and purification of compounds. In the method of distillation, the boiling point can be effectively separated to obtain pure 2-bromo-1-chloro-5-fluoro-3-methylbenzene.
The melting point is also a property that cannot be ignored. The determination of the melting point requires precise equipment and operation. Its melting point is near a certain temperature point, which can be used as evidence for the identification of compounds. The characteristics of melting point are crucial in the study of solid-state and liquid-state transitions of substances.
In terms of solubility, 2-bromo-1-chloro-5-fluoro-3-methyl benzene is soluble in many organic solvents, such as ethanol, ether, etc. However, its solubility in water is very small and almost insoluble. This property is based on the hydrophilicity of its molecular structure. The forces between organic solvents and the molecules of the compound are adapted, so they are soluble, and the forces between water and the compound molecules are greatly different, resulting in insolubility. The difference in solubility can be used as a criterion for solvent selection in operations such as extraction.
Density is also one of its physical properties. Its density is higher than that of water, and in the stratification experiment, it can be seen that it sinks to the bottom of the water. This density characteristic can be effectively separated according to the density difference in the process involving liquid-liquid separation, such as liquid separation operation.
In summary, the physical properties of 2-bromo-1-chloro-5-fluoro-3-methyl benzene, such as phase state, color, odor, boiling point, melting point, solubility, density, etc. are of great significance in chemical experiments, industrial production and other fields, and are the basis for related operations and research.
What are the main uses of 2-bromo-1-chloro-5-fluoro-3-methylbenzene?
2-Bromo-1-chloro-5-fluoro-3-methylbenzene is one of the organic compounds. Its main use, because it contains halogen atoms and methyl groups, has unique chemical activity, and has a wide range of uses in the field of organic synthesis.
First, it is often used as a raw material for pharmaceutical synthesis. The creation of organic synthetic drugs requires the construction of a specific molecular structure. The halogen atom of this compound can be replaced by a substitution reaction to introduce other functional groups to form biologically active molecules. If you want to make specific anti-cancer drugs, you can use 2-bromo-1-chloro-5-fluoro-3-methylbenzene as the starting material, so that the bromine atom is replaced by a nitrogen-containing heterocycle, and through a series of reactions, the final product with anti-cancer activity is obtained.
Second, it is also indispensable in the field of materials science. When preparing high-performance organic optoelectronic materials, it can be used as a structural unit to integrate macromolecular structures through polymerization or other reactions. Due to the introduction of fluorine atoms, the electron cloud distribution of the material can be changed, and the stability and optoelectronic properties of the material can be improved. When preparing organic Light Emitting Diode (OLED) materials, based on this compound, the modification reaction is used to obtain materials with high luminous efficiency and good stability for display screen manufacturing.
Third, it contributes a lot to pesticide synthesis. With its chemical structure characteristics, it can be chemically modified to produce pesticides that are highly toxic to specific pests and have little impact on the environment. By adjusting the substituent, its biological activity and selectivity can be changed, so that the pesticide can accurately act on the target pests and improve the control effect.
In summary, 2-bromo-1-chloro-5-fluoro-3-methylbenzene has important uses in many fields such as medicine, materials, and pesticides, and is also a key compound for promoting the development of related industries.
First, it is often used as a raw material for pharmaceutical synthesis. The creation of organic synthetic drugs requires the construction of a specific molecular structure. The halogen atom of this compound can be replaced by a substitution reaction to introduce other functional groups to form biologically active molecules. If you want to make specific anti-cancer drugs, you can use 2-bromo-1-chloro-5-fluoro-3-methylbenzene as the starting material, so that the bromine atom is replaced by a nitrogen-containing heterocycle, and through a series of reactions, the final product with anti-cancer activity is obtained.
Second, it is also indispensable in the field of materials science. When preparing high-performance organic optoelectronic materials, it can be used as a structural unit to integrate macromolecular structures through polymerization or other reactions. Due to the introduction of fluorine atoms, the electron cloud distribution of the material can be changed, and the stability and optoelectronic properties of the material can be improved. When preparing organic Light Emitting Diode (OLED) materials, based on this compound, the modification reaction is used to obtain materials with high luminous efficiency and good stability for display screen manufacturing.
Third, it contributes a lot to pesticide synthesis. With its chemical structure characteristics, it can be chemically modified to produce pesticides that are highly toxic to specific pests and have little impact on the environment. By adjusting the substituent, its biological activity and selectivity can be changed, so that the pesticide can accurately act on the target pests and improve the control effect.
In summary, 2-bromo-1-chloro-5-fluoro-3-methylbenzene has important uses in many fields such as medicine, materials, and pesticides, and is also a key compound for promoting the development of related industries.
What are 2-bromo-1-chloro-5-fluoro-3-methylbenzene synthesis methods?
To prepare 2-bromo-1-chloro-5-fluoro-3-methylbenzene, there are various methods. The common method is to start with an aromatic hydrocarbon and use a substitution reaction to form it.
First, 3-methyl benzene can be taken as the substrate first. Because methyl is an ortho-para locator, bromine atoms can be introduced into the ortho-position first. This can be used with liquid bromine. Under the catalysis of iron or iron bromide, electrophilic substitution occurs to obtain 2-bromo-3-methyl benzene. After that, under suitable conditions, chlorine atoms are introduced. Due to the combined influence of bromine and methyl, chlorine atoms can be accessed at specific positions, such as reacting with chlorine in the presence of light or free radical initiators, to obtain 2-bromo-1-chloro-3-methylbenzene. Finally, with suitable fluorinated reagents, such as potassium fluoride, under appropriate solvent and conditions, hydrogen atoms at specific positions are replaced with fluorine atoms, and the target product 2-bromo-1-chloro-5-fluoro-3-methylbenzene is obtained.
Second, other aromatic derivatives can also be used as starting materials. For example, benzene derivatives containing fluorine and methyl are first prepared, and then bromine and chlorine atoms are introduced in sequence. First, fluorobenzene derivatives are introduced into methyl through alkylation reaction, and then bromine and chlorine atoms are introduced in an orderly manner by electrophilic substitution reaction according to positioning rules. When introducing bromine, the reaction conditions and reagent dosage can be controlled to make bromine atoms enter a specific position; the introduction of chlorine atoms is the same, and it is precisely regulated according to the substrate structure and reaction conditions to achieve the synthesis target.
However, the synthesis process requires attention to the control of reaction conditions at each step. Temperature, solvent, catalyst and other factors have a significant impact on the selectivity and yield of the reaction. And after each step of the reaction, it needs to be separated and purified to remove impurities and maintain the purity of the product, so that 2-bromo-1-chloro-5-fluoro-3-methylbenzene can be effectively obtained.
First, 3-methyl benzene can be taken as the substrate first. Because methyl is an ortho-para locator, bromine atoms can be introduced into the ortho-position first. This can be used with liquid bromine. Under the catalysis of iron or iron bromide, electrophilic substitution occurs to obtain 2-bromo-3-methyl benzene. After that, under suitable conditions, chlorine atoms are introduced. Due to the combined influence of bromine and methyl, chlorine atoms can be accessed at specific positions, such as reacting with chlorine in the presence of light or free radical initiators, to obtain 2-bromo-1-chloro-3-methylbenzene. Finally, with suitable fluorinated reagents, such as potassium fluoride, under appropriate solvent and conditions, hydrogen atoms at specific positions are replaced with fluorine atoms, and the target product 2-bromo-1-chloro-5-fluoro-3-methylbenzene is obtained.
Second, other aromatic derivatives can also be used as starting materials. For example, benzene derivatives containing fluorine and methyl are first prepared, and then bromine and chlorine atoms are introduced in sequence. First, fluorobenzene derivatives are introduced into methyl through alkylation reaction, and then bromine and chlorine atoms are introduced in an orderly manner by electrophilic substitution reaction according to positioning rules. When introducing bromine, the reaction conditions and reagent dosage can be controlled to make bromine atoms enter a specific position; the introduction of chlorine atoms is the same, and it is precisely regulated according to the substrate structure and reaction conditions to achieve the synthesis target.
However, the synthesis process requires attention to the control of reaction conditions at each step. Temperature, solvent, catalyst and other factors have a significant impact on the selectivity and yield of the reaction. And after each step of the reaction, it needs to be separated and purified to remove impurities and maintain the purity of the product, so that 2-bromo-1-chloro-5-fluoro-3-methylbenzene can be effectively obtained.
What are the characteristics of 2-bromo-1-chloro-5-fluoro-3-methylbenzene in chemical reactions?
2-Bromo-1-chloro-5-fluoro-3-methylbenzene, an organic compound, has many unique features in chemical reactions.
Looking at its structure, there are three halogen atoms of bromine, chlorine and fluorine on the benzene ring, and an alkyl group of methyl. Halogen atoms and methyl groups both affect the distribution of the electron cloud density of the benzene ring. Halogen atoms, because of their high electronegativity, exhibit an electron-sucking induction effect on the benzene ring, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. Methyl, because of its power supply, can increase the electron cloud density of the benzene ring to a certain extent.
When it comes to electrophilic substitution reactions, the selectivity of the reaction check point is particularly critical because of the presence of groups with different positioning effects in the structure. Methyl is an ortho-and para-site locator, while halogen atoms are ortho-and para-site locators, but due to the electron-absorbing induction effect, the electron cloud density of the benzene ring decreases, which affects the position of the attack of the electrophilic reagent. For example, electrophilic reagents are more inclined to attack the adjacent and para-site of methyl, but the presence of halogen atoms will adjust the direction of attack.
In addition, the activity of halogen atoms in this compound is also worthy of attention. Different halogen atoms have different activities in nucleophilic substitution and other reactions due to their atomic radii and electronegativity. In general, the activity of bromine atoms is more prominent in some reactions than that of chlorine atoms and fluorine atoms, and it is easier to leave, thus participating in various chemical reactions.
In oxidation reactions, because of its methyl content, methyl can be oxidized under suitable conditions to form functional groups such as carboxyl groups. In reduction reactions, both benzene rings and halogen atoms may undergo corresponding changes, such as the reductive dehalogenation of halogen atoms.
In summary, 2-bromo-1-chloro-5-fluoro-3-methylbenzene, due to its unique structure, exhibits unique reactivity and selectivity in various chemical reactions, and has important research and application value in the fields of organic synthesis.
Looking at its structure, there are three halogen atoms of bromine, chlorine and fluorine on the benzene ring, and an alkyl group of methyl. Halogen atoms and methyl groups both affect the distribution of the electron cloud density of the benzene ring. Halogen atoms, because of their high electronegativity, exhibit an electron-sucking induction effect on the benzene ring, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. Methyl, because of its power supply, can increase the electron cloud density of the benzene ring to a certain extent.
When it comes to electrophilic substitution reactions, the selectivity of the reaction check point is particularly critical because of the presence of groups with different positioning effects in the structure. Methyl is an ortho-and para-site locator, while halogen atoms are ortho-and para-site locators, but due to the electron-absorbing induction effect, the electron cloud density of the benzene ring decreases, which affects the position of the attack of the electrophilic reagent. For example, electrophilic reagents are more inclined to attack the adjacent and para-site of methyl, but the presence of halogen atoms will adjust the direction of attack.
In addition, the activity of halogen atoms in this compound is also worthy of attention. Different halogen atoms have different activities in nucleophilic substitution and other reactions due to their atomic radii and electronegativity. In general, the activity of bromine atoms is more prominent in some reactions than that of chlorine atoms and fluorine atoms, and it is easier to leave, thus participating in various chemical reactions.
In oxidation reactions, because of its methyl content, methyl can be oxidized under suitable conditions to form functional groups such as carboxyl groups. In reduction reactions, both benzene rings and halogen atoms may undergo corresponding changes, such as the reductive dehalogenation of halogen atoms.
In summary, 2-bromo-1-chloro-5-fluoro-3-methylbenzene, due to its unique structure, exhibits unique reactivity and selectivity in various chemical reactions, and has important research and application value in the fields of organic synthesis.
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