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2-Bromo-4-Chloro-1-(Difluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
905666 |
| Chemical Formula | C7H4BrClF2O |
| Molar Mass | 257.46 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approximately 190 - 200 °C |
| Density | Around 1.7 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, ethyl acetate |
| Vapor Pressure | Low at room temperature |
As an accredited 2-Bromo-4-Chloro-1-(Difluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 2 - bromo - 4 - chloro - 1 - (difluoromethoxy)benzene in a sealed glass bottle. |
| Storage | 2 - bromo - 4 - chloro - 1 - (difluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to air or moisture which could potentially lead to decomposition or reactivity issues. |
| Shipping | 2 - bromo - 4 - chloro - 1 - (difluoromethoxy)benzene is shipped in accordance with strict chemical transport regulations. It's carefully packaged to prevent leakage, with proper labeling for hazard warnings, and transported via approved carriers. |
Competitive 2-Bromo-4-Chloro-1-(Difluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the physical properties of 2-bromo-4-chloro-1- (difluoromethoxy) benzene?
2-Bromo-4-chloro-1- (difluoromethoxy) benzene is one of the organic compounds. Looking at its physical properties, at room temperature, this substance is probably a colorless to pale yellow liquid, or it may be in solid form, depending on its specific structure and intermolecular forces.
When it comes to boiling point, due to the presence of halogen atoms such as bromine and chlorine and difluoromethoxy groups in the molecule, these groups enhance the intermolecular forces, so its boiling point is relatively high. However, the exact boiling point value needs to be determined by accurate experimental determination, because different experimental conditions will also affect it.
Its melting point is also restricted by the molecular structure. The presence of halogen atoms and methoxy groups results in a more regular arrangement of molecules, which in turn increases the melting point.
The density of this compound is higher than that of water. If mixed with water, it will sink to the bottom of the water.
In terms of solubility, considering that it is an organic compound, according to the principle of similar phase dissolution, it should have good solubility in organic solvents such as ethanol, ether, dichloromethane, etc. However, its solubility in water is quite limited, because water is a polar solvent, and the polarity of this compound is relatively weak.
In addition, its vapor pressure is low, indicating that under normal temperature and pressure, its tendency to volatilize is small. The physical properties of 2-bromo-4-chloro-1- (difluoromethoxy) benzene are influenced by the synergy of the groups in its molecular structure. The in-depth understanding of its physical properties is of crucial significance for related chemical research, industrial production and practical applications.
When it comes to boiling point, due to the presence of halogen atoms such as bromine and chlorine and difluoromethoxy groups in the molecule, these groups enhance the intermolecular forces, so its boiling point is relatively high. However, the exact boiling point value needs to be determined by accurate experimental determination, because different experimental conditions will also affect it.
Its melting point is also restricted by the molecular structure. The presence of halogen atoms and methoxy groups results in a more regular arrangement of molecules, which in turn increases the melting point.
The density of this compound is higher than that of water. If mixed with water, it will sink to the bottom of the water.
In terms of solubility, considering that it is an organic compound, according to the principle of similar phase dissolution, it should have good solubility in organic solvents such as ethanol, ether, dichloromethane, etc. However, its solubility in water is quite limited, because water is a polar solvent, and the polarity of this compound is relatively weak.
In addition, its vapor pressure is low, indicating that under normal temperature and pressure, its tendency to volatilize is small. The physical properties of 2-bromo-4-chloro-1- (difluoromethoxy) benzene are influenced by the synergy of the groups in its molecular structure. The in-depth understanding of its physical properties is of crucial significance for related chemical research, industrial production and practical applications.
What are the chemical properties of 2-bromo-4-chloro-1- (difluoromethoxy) benzene
2-Bromo-4-chloro-1- (difluoromethoxy) benzene is an organic compound with unique chemical properties. Its molecules contain functional groups such as bromine, chlorine, and difluoromethoxy. The functional groups interact with each other, resulting in the compound showing diverse chemical properties.
First of all its substituent properties. Bromine and chlorine are both halogen atoms, and the halogen atoms have an electron-absorbing induction effect, which can reduce the electron cloud density of the benzene ring. The larger the radius of the bromine atom and the more significant steric resistance, which affects the regioselectivity of the electrophilic substitution reaction on the benzene ring. Although the radius of the chlorine atom is smaller than that of bromine, it also affects the electron cloud distribution of the benzene ring due to the electron-withdrawing effect. Under the combined influence of the two, the reactivity of the compound is changed compared with that of unsubstituted benzene in the electrophilic substitution reaction, and the reaction check point tends to be relatively high in the electron cloud density.
The second discussion on difluoromethoxy. Among the difluoromethoxy groups, the fluorine atom is extremely electronegative, and the strong electron-withdrawing effect makes the group as a whole also electron-withdrawing, further reducing the electron cloud density of the benzene ring. At the same time, its unique structure endows the compound with a certain lipid solubility, which affects its solubility in different solvents. In the fields of organic synthesis and medicinal chemistry, this solubility characteristic may
Furthermore, this compound can participate in halogenated hydrocarbon-related reactions because it contains multiple halogen atoms. If under appropriate conditions, bromine atoms or chlorine atoms can undergo nucleophilic substitution reactions and be replaced by other nucleophilic reagents, which provides the possibility for the construction of new carbon-heteroatom bonds in organic synthesis, and is an important reaction path for the synthesis of complex organic molecules.
In addition, the oxygen atom in the difluoromethoxy group can act as a hydrogen bond receptor. Under appropriate circumstances, or with compounds containing active hydrogen, hydrogen bonds can be formed, which affects the physical properties of compounds, such as melting point, boiling point, etc. In the fields of supramolecular chemistry and crystal engineering, hydrogen bonds are crucial for molecular self-assembly and crystal structure construction.
In conclusion, the characteristics and interactions of functional groups contained in 2-bromo-4-chloro-1 - (difluoromethoxy) benzene have shown potential application value in many fields such as organic synthesis, medicinal chemistry, and materials science. Its chemical properties provide a rich exploration space for researchers to carry out related research.
First of all its substituent properties. Bromine and chlorine are both halogen atoms, and the halogen atoms have an electron-absorbing induction effect, which can reduce the electron cloud density of the benzene ring. The larger the radius of the bromine atom and the more significant steric resistance, which affects the regioselectivity of the electrophilic substitution reaction on the benzene ring. Although the radius of the chlorine atom is smaller than that of bromine, it also affects the electron cloud distribution of the benzene ring due to the electron-withdrawing effect. Under the combined influence of the two, the reactivity of the compound is changed compared with that of unsubstituted benzene in the electrophilic substitution reaction, and the reaction check point tends to be relatively high in the electron cloud density.
The second discussion on difluoromethoxy. Among the difluoromethoxy groups, the fluorine atom is extremely electronegative, and the strong electron-withdrawing effect makes the group as a whole also electron-withdrawing, further reducing the electron cloud density of the benzene ring. At the same time, its unique structure endows the compound with a certain lipid solubility, which affects its solubility in different solvents. In the fields of organic synthesis and medicinal chemistry, this solubility characteristic may
Furthermore, this compound can participate in halogenated hydrocarbon-related reactions because it contains multiple halogen atoms. If under appropriate conditions, bromine atoms or chlorine atoms can undergo nucleophilic substitution reactions and be replaced by other nucleophilic reagents, which provides the possibility for the construction of new carbon-heteroatom bonds in organic synthesis, and is an important reaction path for the synthesis of complex organic molecules.
In addition, the oxygen atom in the difluoromethoxy group can act as a hydrogen bond receptor. Under appropriate circumstances, or with compounds containing active hydrogen, hydrogen bonds can be formed, which affects the physical properties of compounds, such as melting point, boiling point, etc. In the fields of supramolecular chemistry and crystal engineering, hydrogen bonds are crucial for molecular self-assembly and crystal structure construction.
In conclusion, the characteristics and interactions of functional groups contained in 2-bromo-4-chloro-1 - (difluoromethoxy) benzene have shown potential application value in many fields such as organic synthesis, medicinal chemistry, and materials science. Its chemical properties provide a rich exploration space for researchers to carry out related research.
What is the main use of 2-bromo-4-chloro-1- (difluoromethoxy) benzene?
2-Bromo-4-chloro-1- (difluoromethoxy) benzene is also an organic compound. It has a wide range of uses and is often a key intermediate in the synthesis of specific drugs in the field of medicinal chemistry. Due to the unique arrangement of halogen atoms and difluoromethoxy groups in the structure, it is endowed with specific reactivity and biological activity. It can be introduced into other functional groups through various chemical reactions to build complex drug molecular structures.
It also has important applications in the field of pesticide chemistry. Its structural characteristics make it potentially insecticidal, bactericidal or herbicidal. It can be modified to develop new high-efficiency and low-toxicity pesticides, protect crop growth and increase agricultural output.
In the field of materials science, it may be able to participate in the synthesis of functional materials. Due to its fluorine-containing structure, it can endow materials with special physical and chemical properties, such as improving chemical resistance, thermal stability and surface properties of materials, etc., and is used in the research and development of high-end materials, such as special coatings, high-performance engineering plastics, etc.
In addition, it is an important synthetic block in the study of organic synthesis chemistry. Chemists use its unique reactivity to carry out research on various organic reactions, expand organic synthesis methodologies, and provide the basis and possibility for the creation of new compounds.
It also has important applications in the field of pesticide chemistry. Its structural characteristics make it potentially insecticidal, bactericidal or herbicidal. It can be modified to develop new high-efficiency and low-toxicity pesticides, protect crop growth and increase agricultural output.
In the field of materials science, it may be able to participate in the synthesis of functional materials. Due to its fluorine-containing structure, it can endow materials with special physical and chemical properties, such as improving chemical resistance, thermal stability and surface properties of materials, etc., and is used in the research and development of high-end materials, such as special coatings, high-performance engineering plastics, etc.
In addition, it is an important synthetic block in the study of organic synthesis chemistry. Chemists use its unique reactivity to carry out research on various organic reactions, expand organic synthesis methodologies, and provide the basis and possibility for the creation of new compounds.
What is the synthesis method of 2-bromo-4-chloro-1- (difluoromethoxy) benzene
To prepare 2-bromo-4-chloro-1- (difluoromethoxy) benzene, the following method can be used.
First take an appropriate phenolic compound, such as p-chlorophenol. The oxygen of the phenolic hydroxyl group in p-chlorophenol is nucleophilic and can react with difluorohalomethane under alkaline conditions. Usually bases such as potassium carbonate are used as acid binding agents, and in appropriate solvents such as N, N-dimethylformamide (DMF), the nucleophilic substitution reaction occurs between the two. The halogen atom in difluorohalomethane is affected by the electron-withdrawing effect of difluoromethyl, which is highly active and easy to be attacked by phenoxy negative ions, thereby forming a product of difluoromethoxy substitution, that is, p-chlorophenyl difluoromethyl ether.
Then, this chlorophenyl difluoromethyl ether is brominated. Liquid bromine can be used as a bromination reagent, and iron powder or iron tribromide can be used as a catalyst. Because the methoxy group is an ortho-para-site group and the para-site has been occupied by chlorine, the bromine atom will be mainly replaced by the ortho-site of the methoxy group, so that the target product 2-bromo-4-chloro-1 - (difluorome The reaction temperature and reagent dosage should be controlled to ensure the selectivity and yield of the reaction. After the reaction is completed, the pure 2-bromo-4-chloro-1 - (difluoromethoxy) benzene can be obtained by conventional separation and purification methods such as extraction, washing, drying, distillation or column chromatography.
First take an appropriate phenolic compound, such as p-chlorophenol. The oxygen of the phenolic hydroxyl group in p-chlorophenol is nucleophilic and can react with difluorohalomethane under alkaline conditions. Usually bases such as potassium carbonate are used as acid binding agents, and in appropriate solvents such as N, N-dimethylformamide (DMF), the nucleophilic substitution reaction occurs between the two. The halogen atom in difluorohalomethane is affected by the electron-withdrawing effect of difluoromethyl, which is highly active and easy to be attacked by phenoxy negative ions, thereby forming a product of difluoromethoxy substitution, that is, p-chlorophenyl difluoromethyl ether.
Then, this chlorophenyl difluoromethyl ether is brominated. Liquid bromine can be used as a bromination reagent, and iron powder or iron tribromide can be used as a catalyst. Because the methoxy group is an ortho-para-site group and the para-site has been occupied by chlorine, the bromine atom will be mainly replaced by the ortho-site of the methoxy group, so that the target product 2-bromo-4-chloro-1 - (difluorome The reaction temperature and reagent dosage should be controlled to ensure the selectivity and yield of the reaction. After the reaction is completed, the pure 2-bromo-4-chloro-1 - (difluoromethoxy) benzene can be obtained by conventional separation and purification methods such as extraction, washing, drying, distillation or column chromatography.
What are the precautions for 2-bromo-4-chloro-1- (difluoromethoxy) benzene in storage and transportation?
2-Bromo-4-chloro-1 - (difluoromethoxy) benzene, this is an organic compound. When storing and transporting, many matters must be paid attention to.
The first to bear the brunt, the storage environment must be dry and cool. Because it is afraid of water, it will deteriorate in contact with water or cause reactions such as hydrolysis. The temperature of the warehouse should be controlled within a specific range to prevent the chemical properties from changing due to excessive temperature and causing danger.
Furthermore, keep away from fire and heat sources. Organic compounds are many flammable, and this substance is no exception. Near fire, heat sources, or cause combustion or even explosion, endangering the safety of personnel and facilities.
Third, the storage place should be well ventilated. If the ventilation is not good, the volatile vapor is easy to accumulate, increase the risk of combustion and explosion, and is harmful to human health.
Fourth, the packaging must be tight. To prevent leakage, because it may be toxic and corrosive, leakage not only causes material loss, pollution of the environment, contact with the human body will also cause harm. When transporting, choose suitable containers and transportation tools to ensure that there is no leakage on the way.
In addition, it should be stored and transported separately from oxidants, acids and other substances. Because of its active chemical nature, contact with these substances, or a violent reaction, dangerous.
At the same time, the storage and transportation places should be equipped with suitable fire equipment and leakage emergency treatment equipment. In the event of an accident, it can be responded to in time to reduce the damage hazard. The relevant operators must also be professionally trained to be familiar with their characteristics and safe operation practices.
The first to bear the brunt, the storage environment must be dry and cool. Because it is afraid of water, it will deteriorate in contact with water or cause reactions such as hydrolysis. The temperature of the warehouse should be controlled within a specific range to prevent the chemical properties from changing due to excessive temperature and causing danger.
Furthermore, keep away from fire and heat sources. Organic compounds are many flammable, and this substance is no exception. Near fire, heat sources, or cause combustion or even explosion, endangering the safety of personnel and facilities.
Third, the storage place should be well ventilated. If the ventilation is not good, the volatile vapor is easy to accumulate, increase the risk of combustion and explosion, and is harmful to human health.
Fourth, the packaging must be tight. To prevent leakage, because it may be toxic and corrosive, leakage not only causes material loss, pollution of the environment, contact with the human body will also cause harm. When transporting, choose suitable containers and transportation tools to ensure that there is no leakage on the way.
In addition, it should be stored and transported separately from oxidants, acids and other substances. Because of its active chemical nature, contact with these substances, or a violent reaction, dangerous.
At the same time, the storage and transportation places should be equipped with suitable fire equipment and leakage emergency treatment equipment. In the event of an accident, it can be responded to in time to reduce the damage hazard. The relevant operators must also be professionally trained to be familiar with their characteristics and safe operation practices.
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