Linshang Chemical
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2-Bromo-4-Chloro-1-Fluorobenzene
Linshang Chemical
|
HS Code |
640494 |
| Chemical Formula | C6H3BrClF |
| Molar Mass | 211.44 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 186 - 188 °C |
| Melting Point | N/A |
| Density | 1.739 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 73 °C |
| Refractive Index | 1.562 - 1.564 |
As an accredited 2-Bromo-4-Chloro-1-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 mL glass bottle filled with 50 g of 2 - bromo - 4 - chloro - 1 - fluorobenzene. |
| Storage | 2 - bromo - 4 - chloro - 1 - fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals to avoid potential chemical reactions. Follow proper labeling and safety protocols. |
| Shipping | 2 - bromo - 4 - chloro - 1 - fluorobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported under conditions that prevent exposure to heat, ignition sources, and incompatible substances, ensuring safe transit. |
Competitive 2-Bromo-4-Chloro-1-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 2-Bromo-4-Chloro-1-Fluorobenzene in China?
As a trusted 2-Bromo-4-Chloro-1-Fluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 2-Bromo-4-Chloro-1-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 2-bromo-4-chloro-1-fluorobenzene?
2-Bromo-4-chloro-1-fluorobenzene is also an organic compound. Its main use is wide, and it is a key intermediate in the field of pharmaceutical synthesis. When doctors make special drugs, they rely on this as a basis to build an exquisite molecular structure to become a good medicine for the world.
In the process of pesticide creation, 2-bromo-4-chloro-1-fluorobenzene also plays a crucial role. Farmers make high-efficiency and low-toxicity pesticides to protect crops. They often use this substance as a starting material. After many reactions, they can obtain good agents that can remove pests and protect crops.
In the field of material science, its use should not be underestimated. It can be used to prepare polymer materials with special properties, such as materials with excellent weather resistance and chemical stability, to meet the needs of high-end fields such as aerospace, electronics and electrical appliances.
This compound is effective in many fields due to its unique chemical structure. It is an important angle in organic synthesis and a boost to the progress of various industries.
In the process of pesticide creation, 2-bromo-4-chloro-1-fluorobenzene also plays a crucial role. Farmers make high-efficiency and low-toxicity pesticides to protect crops. They often use this substance as a starting material. After many reactions, they can obtain good agents that can remove pests and protect crops.
In the field of material science, its use should not be underestimated. It can be used to prepare polymer materials with special properties, such as materials with excellent weather resistance and chemical stability, to meet the needs of high-end fields such as aerospace, electronics and electrical appliances.
This compound is effective in many fields due to its unique chemical structure. It is an important angle in organic synthesis and a boost to the progress of various industries.
What are the physical properties of 2-bromo-4-chloro-1-fluorobenzene?
2-Bromo-4-chloro-1-fluorobenzene is one of the organic compounds. Its physical properties are very important and are related to many chemical applications.
First of all, its appearance, under room temperature and pressure, is often colorless to light yellow liquid, clear and transparent, and it looks quite fluid. This appearance characteristic is the key basis for the preliminary identification of this compound.
As for the boiling point, it is about a certain temperature range. Due to the existence of intermolecular forces, it needs to supply a considerable amount of energy to transform it from liquid to gaseous. This boiling point value is crucial for the separation and purification of this compound. When performing operations such as distillation, it can be effectively separated from the mixture according to the characteristics of boiling point.
Melting point is also one of its important physical properties. The level of melting point is closely related to the arrangement of molecules. At a specific temperature, solid 2-bromo-4-chloro-1-fluorobenzene will melt into a liquid state. This property has a significant impact on the storage and transportation of substances. If the ambient temperature is close to or above its melting point, the morphology of the substance will change, or it will affect subsequent use.
In terms of density, 2-bromo-4-chloro-1-fluorobenzene has a certain density value. This density property plays an important role in operations such as liquid-liquid separation or mixing. Through the difference in density, methods such as liquid separation can be used to achieve separation from other liquids.
Solubility is also a property that cannot be ignored. In organic solvents, 2-bromo-4-chloro-1-fluorobenzene often exhibits good solubility. For example, it can be soluble in common organic solvents such as ether and dichloromethane. However, in water, its solubility is poor. This difference in solubility provides guidance for the selection of suitable solvents in chemical experiments and industrial production. In organic synthesis reactions, the choice of appropriate solvents not only affects the rate of reaction, but also affects the purity and yield of the product.
In addition, the volatility of 2-bromo-4-chloro-1-fluorobenzene also has its own characteristics. Although not highly volatile, some molecules will still escape into the air under certain conditions, such as higher temperatures or well-ventilated areas. This volatility needs to be considered in terms of environmental safety in storage and use.
In conclusion, the physical properties of 2-bromo-4-chloro-1-fluorobenzene, such as appearance, boiling point, melting point, density, solubility, and volatility, are interrelated and have their own uses. They are all indispensable factors for chemical research, industrial production, and related fields of operation and application.
First of all, its appearance, under room temperature and pressure, is often colorless to light yellow liquid, clear and transparent, and it looks quite fluid. This appearance characteristic is the key basis for the preliminary identification of this compound.
As for the boiling point, it is about a certain temperature range. Due to the existence of intermolecular forces, it needs to supply a considerable amount of energy to transform it from liquid to gaseous. This boiling point value is crucial for the separation and purification of this compound. When performing operations such as distillation, it can be effectively separated from the mixture according to the characteristics of boiling point.
Melting point is also one of its important physical properties. The level of melting point is closely related to the arrangement of molecules. At a specific temperature, solid 2-bromo-4-chloro-1-fluorobenzene will melt into a liquid state. This property has a significant impact on the storage and transportation of substances. If the ambient temperature is close to or above its melting point, the morphology of the substance will change, or it will affect subsequent use.
In terms of density, 2-bromo-4-chloro-1-fluorobenzene has a certain density value. This density property plays an important role in operations such as liquid-liquid separation or mixing. Through the difference in density, methods such as liquid separation can be used to achieve separation from other liquids.
Solubility is also a property that cannot be ignored. In organic solvents, 2-bromo-4-chloro-1-fluorobenzene often exhibits good solubility. For example, it can be soluble in common organic solvents such as ether and dichloromethane. However, in water, its solubility is poor. This difference in solubility provides guidance for the selection of suitable solvents in chemical experiments and industrial production. In organic synthesis reactions, the choice of appropriate solvents not only affects the rate of reaction, but also affects the purity and yield of the product.
In addition, the volatility of 2-bromo-4-chloro-1-fluorobenzene also has its own characteristics. Although not highly volatile, some molecules will still escape into the air under certain conditions, such as higher temperatures or well-ventilated areas. This volatility needs to be considered in terms of environmental safety in storage and use.
In conclusion, the physical properties of 2-bromo-4-chloro-1-fluorobenzene, such as appearance, boiling point, melting point, density, solubility, and volatility, are interrelated and have their own uses. They are all indispensable factors for chemical research, industrial production, and related fields of operation and application.
What is the chemistry of 2-bromo-4-chloro-1-fluorobenzene?
2-Bromo-4-chloro-1-fluorobenzene is also a halogenated aromatic hydrocarbon. Its chemical properties are worth exploring.
In this compound, the presence of bromine, chlorine and fluorine halogen atoms has a deep impact on its chemical behavior. Halogen atoms have electron-absorbing properties, which can reduce the electron cloud density of the benzene ring, and the electrophilic substitution activity of the benzene ring is weaker than that of benzene.
In the electrophilic substitution reaction, the halogen atom is an ortho-and para-localized group. However, due to the different electronegativity of fluorine, chlorine and bromine, the effect on the electron cloud density of the benzene ring is also different. Fluorine has the strongest electronegativity, and its electron-absorbing induction effect is significant. Although it is an ortho-and para-localization group, its reactivity is slightly lower than that of bromine and chlorine-substituted derivatives. Under the localization effect of bromine and chlorine, electrophilic reagents are more likely to attack its ortho-and para-positions.
In the nucleophilic substitution reaction, halogen atoms can be replaced by nucleophilic reagents. Due to the different bond energies of carbon-halogen bonds, the reactivity is also different. Generally speaking, the bond energy of carbon-bromine bonds is less than that of carbon-chlorine bonds and carbon-fluorine bonds, so bromine atoms are relatively easier to be replaced. If there are strong nucleophilic reagents such as sodium alcohol and amines, bromine atoms can be
In addition, 2-bromo-4-chloro-1-fluorobenzene also has unique performance in some metal catalyzed reactions. For example, under palladium catalysis, a coupling reaction can occur, and it can react with alkenyl, aryl-containing halides or boric acids to form carbon-carbon bonds, expand its molecular structure, and is widely used in the field of organic synthesis.
And because of the presence of halogen atoms, it can participate in the elimination reaction. Under the action of a strong base, the halogen atom dehalides hydrogen from the ortho-hydrogen atom to form an unsaturated phenyne intermediate, and then undergoes a subsequent reaction. This is also one of its important chemical properties.
In summary, the properties of 2-bromo-4-chloro-1-fluorobenzene halogen atoms exhibit diverse chemical properties, providing a rich reaction path for the construction of complex organic molecular structures in the field of organic synthetic chemistry.
In this compound, the presence of bromine, chlorine and fluorine halogen atoms has a deep impact on its chemical behavior. Halogen atoms have electron-absorbing properties, which can reduce the electron cloud density of the benzene ring, and the electrophilic substitution activity of the benzene ring is weaker than that of benzene.
In the electrophilic substitution reaction, the halogen atom is an ortho-and para-localized group. However, due to the different electronegativity of fluorine, chlorine and bromine, the effect on the electron cloud density of the benzene ring is also different. Fluorine has the strongest electronegativity, and its electron-absorbing induction effect is significant. Although it is an ortho-and para-localization group, its reactivity is slightly lower than that of bromine and chlorine-substituted derivatives. Under the localization effect of bromine and chlorine, electrophilic reagents are more likely to attack its ortho-and para-positions.
In the nucleophilic substitution reaction, halogen atoms can be replaced by nucleophilic reagents. Due to the different bond energies of carbon-halogen bonds, the reactivity is also different. Generally speaking, the bond energy of carbon-bromine bonds is less than that of carbon-chlorine bonds and carbon-fluorine bonds, so bromine atoms are relatively easier to be replaced. If there are strong nucleophilic reagents such as sodium alcohol and amines, bromine atoms can be
In addition, 2-bromo-4-chloro-1-fluorobenzene also has unique performance in some metal catalyzed reactions. For example, under palladium catalysis, a coupling reaction can occur, and it can react with alkenyl, aryl-containing halides or boric acids to form carbon-carbon bonds, expand its molecular structure, and is widely used in the field of organic synthesis.
And because of the presence of halogen atoms, it can participate in the elimination reaction. Under the action of a strong base, the halogen atom dehalides hydrogen from the ortho-hydrogen atom to form an unsaturated phenyne intermediate, and then undergoes a subsequent reaction. This is also one of its important chemical properties.
In summary, the properties of 2-bromo-4-chloro-1-fluorobenzene halogen atoms exhibit diverse chemical properties, providing a rich reaction path for the construction of complex organic molecular structures in the field of organic synthetic chemistry.
What are 2-bromo-4-chloro-1-fluorobenzene synthesis methods?
There are several methods for synthesizing 2-bromo-4-chloro-1-fluorobenzene.
First, benzene can be started. First, benzene and bromine under the action of catalysts such as iron bromide undergo an electrophilic substitution reaction to obtain bromobenzene. Next, bromobenzene is chlorinated. When catalyzed by an appropriate catalyst such as iron powder, chlorine atoms can replace hydrogen atoms at specific positions on the benzene ring to obtain 4-chloro-2-bromobenzene. Finally, a specific fluorine-containing reagent, such as potassium fluoride, is used to replace a hydrogen atom on the benzene ring with a fluorine atom under suitable solvents and conditions to obtain 2-bromo-4-chloro-1-fluorobenzene. This process requires attention to the precise control of the reaction conditions in each step, such as temperature, catalyst dosage, etc., because different conditions will affect the substitution position and product purity.
Second, start from other halogenated benzene derivatives. For example, if there is a suitable polyhalogenated benzene, and the position of the halogen atom is related to the target product, it can be replaced by a selective halogen atom. If the difference in the activity of different halogen atoms is taken advantage of, under specific reagents and conditions, no halogen atom is gradually replaced into the desired halogen atom. If a halogenated benzene contains bromine and the position of the chlorine atom is similar to the target, only the hydrogen at a specific position needs to be replaced by a fluorine atom, and the commonly used reagents and conditions for nucleophilic substitution reactions can be selected. Under the condition of having little effect on other halogen atoms, the fluorine atom can be introduced to achieve the synthesis of 2-bromo-4-chloro-1-fluorobenzene. The key to this method is to deeply understand and apply the activity and reaction selectivity of halogen atoms.
Third, by means of the reaction of aryl diazonium salts. First, an aryl amine containing a suitable substituent is prepared, and an aryl diaz Subsequently, reagents containing bromine, chlorine and fluorine are selected to react with diazonium salts at different stages, and corresponding halogen atoms are gradually introduced. For example, bromine atoms are introduced first, and the diazonium groups are replaced by bromine atoms under specific reaction conditions, and then chlorine and fluorine atoms are introduced in sequence. The advantage of this method is that the reaction steps are relatively flexible, and the target product synthesis can be achieved by rationally designing the structure and reaction sequence of diazonium salts. However, the diazotization reaction conditions are harsh, and temperature and other conditions need to be strictly controlled to prevent side reactions such as decomposition of diazonium salts from occurring.
First, benzene can be started. First, benzene and bromine under the action of catalysts such as iron bromide undergo an electrophilic substitution reaction to obtain bromobenzene. Next, bromobenzene is chlorinated. When catalyzed by an appropriate catalyst such as iron powder, chlorine atoms can replace hydrogen atoms at specific positions on the benzene ring to obtain 4-chloro-2-bromobenzene. Finally, a specific fluorine-containing reagent, such as potassium fluoride, is used to replace a hydrogen atom on the benzene ring with a fluorine atom under suitable solvents and conditions to obtain 2-bromo-4-chloro-1-fluorobenzene. This process requires attention to the precise control of the reaction conditions in each step, such as temperature, catalyst dosage, etc., because different conditions will affect the substitution position and product purity.
Second, start from other halogenated benzene derivatives. For example, if there is a suitable polyhalogenated benzene, and the position of the halogen atom is related to the target product, it can be replaced by a selective halogen atom. If the difference in the activity of different halogen atoms is taken advantage of, under specific reagents and conditions, no halogen atom is gradually replaced into the desired halogen atom. If a halogenated benzene contains bromine and the position of the chlorine atom is similar to the target, only the hydrogen at a specific position needs to be replaced by a fluorine atom, and the commonly used reagents and conditions for nucleophilic substitution reactions can be selected. Under the condition of having little effect on other halogen atoms, the fluorine atom can be introduced to achieve the synthesis of 2-bromo-4-chloro-1-fluorobenzene. The key to this method is to deeply understand and apply the activity and reaction selectivity of halogen atoms.
Third, by means of the reaction of aryl diazonium salts. First, an aryl amine containing a suitable substituent is prepared, and an aryl diaz Subsequently, reagents containing bromine, chlorine and fluorine are selected to react with diazonium salts at different stages, and corresponding halogen atoms are gradually introduced. For example, bromine atoms are introduced first, and the diazonium groups are replaced by bromine atoms under specific reaction conditions, and then chlorine and fluorine atoms are introduced in sequence. The advantage of this method is that the reaction steps are relatively flexible, and the target product synthesis can be achieved by rationally designing the structure and reaction sequence of diazonium salts. However, the diazotization reaction conditions are harsh, and temperature and other conditions need to be strictly controlled to prevent side reactions such as decomposition of diazonium salts from occurring.
2-bromo-4-chloro-1-fluorobenzene need to pay attention to when storing and transporting
2-Bromo-4-chloro-1-fluorobenzene is also an organic compound. When storing and transporting it, many matters must be paid attention to.
First storage, because it has certain chemical activity, it should be stored in a cool and ventilated warehouse. If the warehouse temperature is too high, it may cause its chemical reaction to intensify and cause danger. Therefore, the temperature in the warehouse should be controlled in a suitable range and protected from direct sunlight. This is because light may promote its decomposition or cause other reactions. In addition, it should be stored separately from oxidants, acids, bases and other substances, because it is easy to react chemically with such substances, or even cause serious accidents such as fire and explosion. And the storage place should be equipped with suitable materials to contain the leakage, in case of accidental leakage, it can be dealt with in time to prevent its spread and cause greater harm.
As for transportation, the transportation vehicle must ensure safety and reliability. Before transportation, the vehicle must be carefully checked to ensure that there is no hidden danger of leakage. During transportation, it should be protected from exposure to the sun, rain, and high temperature. When loading and unloading, the operator should be light and light, and must not operate brutally to prevent material leakage due to package damage. The packaging materials used must also meet relevant standards, have good sealing and corrosion resistance, and ensure the stability of the material during transportation. At the same time, the transportation personnel should be familiar with the characteristics of this compound and emergency treatment methods. In case of an emergency, they can respond quickly and properly to minimize the harm. Therefore, the safety of 2-bromo-4-chloro-1-fluorobenzene during storage and transportation must be ensured.
First storage, because it has certain chemical activity, it should be stored in a cool and ventilated warehouse. If the warehouse temperature is too high, it may cause its chemical reaction to intensify and cause danger. Therefore, the temperature in the warehouse should be controlled in a suitable range and protected from direct sunlight. This is because light may promote its decomposition or cause other reactions. In addition, it should be stored separately from oxidants, acids, bases and other substances, because it is easy to react chemically with such substances, or even cause serious accidents such as fire and explosion. And the storage place should be equipped with suitable materials to contain the leakage, in case of accidental leakage, it can be dealt with in time to prevent its spread and cause greater harm.
As for transportation, the transportation vehicle must ensure safety and reliability. Before transportation, the vehicle must be carefully checked to ensure that there is no hidden danger of leakage. During transportation, it should be protected from exposure to the sun, rain, and high temperature. When loading and unloading, the operator should be light and light, and must not operate brutally to prevent material leakage due to package damage. The packaging materials used must also meet relevant standards, have good sealing and corrosion resistance, and ensure the stability of the material during transportation. At the same time, the transportation personnel should be familiar with the characteristics of this compound and emergency treatment methods. In case of an emergency, they can respond quickly and properly to minimize the harm. Therefore, the safety of 2-bromo-4-chloro-1-fluorobenzene during storage and transportation must be ensured.
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