Linshang Chemical
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2-Bromo-4-Chloro-1-Methoxybenzene
Linshang Chemical
|
HS Code |
753220 |
| Chemical Formula | C7H6BrClO |
| Molar Mass | 221.48 g/mol |
| Appearance | A colorless to light - yellow liquid |
| Boiling Point | Approximately 235 - 237 °C |
| Density | Typically around 1.6 - 1.7 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, and dichloromethane |
| Vapor Pressure | Low at room temperature |
| Flash Point | Probably around 100 - 110 °C |
| Odor | Characteristic organic halogen - containing odor |
As an accredited 2-Bromo-4-Chloro-1-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 2 - bromo - 4 - chloro - 1 - methoxybenzene packaged in a sealed glass bottle. |
| Storage | 2 - bromo - 4 - chloro - 1 - methoxybenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Since it may react with oxidizing agents, store it separately from such substances. Avoid storage near incompatible materials to ensure safety. |
| Shipping | 2 - bromo - 4 - chloro - 1 - methoxybenzene, a chemical, should be shipped in well - sealed, corrosion - resistant containers. Label containers clearly. Follow all relevant regulations for transporting hazardous chemicals to ensure safety during transit. |
Competitive 2-Bromo-4-Chloro-1-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the physical properties of 2-bromo-4-chloro-1-methoxybenzene?
2-Bromo-4-chloro-1-methoxybenzene is an organic compound. Its physical properties are unique and related to the physical properties of this compound. The details are as follows:
Looking at its properties, under normal temperature and pressure, 2-bromo-4-chloro-1-methoxybenzene is often in a liquid state. This is due to the moderate intermolecular force, which causes it to remain liquid in common temperature environments. Its color is usually colorless to light yellow, and its appearance is clear and transparent, as clear as water. Because the molecular structure does not contain special chromogenic groups, it does not show strong colors.
When it comes to density, the density of this compound is greater than that of water, which is about [X] g/cm ³. This is due to the existence of atoms with relatively large atomic mass such as bromine and chlorine in the molecule, which increases the molecular weight, and then the density is greater than that of water. If it is mixed with water, it will sink to the bottom of the water, and the two layers are obvious.
In terms of boiling point, the boiling point of 2-bromo-4-chloro-1-methoxybenzene is about [X] ° C. Due to the existence of van der Waals forces between molecules and the interaction between halogen atoms and methoxy groups, higher energy is required to overcome these forces, so that the molecules break free from the liquid phase and convert into the gas phase. Therefore, the boiling point is higher. The melting point of
is about [X] ° C. When the temperature drops to the melting point, the thermal motion of the molecules slows down, and under the action of crystal Gree, the molecules are arranged in an orderly manner to form a crystal structure.
In terms of solubility, it is difficult to dissolve in water, because water is a polar solvent, while the molecular polarity of 2-bromo-4-chloro-1-methoxybenzene is weak. According to the principle of "similar compatibility", the two are incompatible. However, it is soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc., because these organic solvents are similar to the intermolecular forces of the compound and can be miscible with each other.
In terms of volatility, relatively speaking, its volatility is weak. Due to the strong intermolecular force, molecules are not easy to escape from the liquid surface and evaporate slowly in the air, which also makes it relatively slow during storage and use.
The physical properties of 2-bromo-4-chloro-1-methoxybenzene are determined by its molecular structure. These properties are of great significance for its separation, purification and application in organic synthesis, chemical production and other fields.
Looking at its properties, under normal temperature and pressure, 2-bromo-4-chloro-1-methoxybenzene is often in a liquid state. This is due to the moderate intermolecular force, which causes it to remain liquid in common temperature environments. Its color is usually colorless to light yellow, and its appearance is clear and transparent, as clear as water. Because the molecular structure does not contain special chromogenic groups, it does not show strong colors.
When it comes to density, the density of this compound is greater than that of water, which is about [X] g/cm ³. This is due to the existence of atoms with relatively large atomic mass such as bromine and chlorine in the molecule, which increases the molecular weight, and then the density is greater than that of water. If it is mixed with water, it will sink to the bottom of the water, and the two layers are obvious.
In terms of boiling point, the boiling point of 2-bromo-4-chloro-1-methoxybenzene is about [X] ° C. Due to the existence of van der Waals forces between molecules and the interaction between halogen atoms and methoxy groups, higher energy is required to overcome these forces, so that the molecules break free from the liquid phase and convert into the gas phase. Therefore, the boiling point is higher. The melting point of
is about [X] ° C. When the temperature drops to the melting point, the thermal motion of the molecules slows down, and under the action of crystal Gree, the molecules are arranged in an orderly manner to form a crystal structure.
In terms of solubility, it is difficult to dissolve in water, because water is a polar solvent, while the molecular polarity of 2-bromo-4-chloro-1-methoxybenzene is weak. According to the principle of "similar compatibility", the two are incompatible. However, it is soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc., because these organic solvents are similar to the intermolecular forces of the compound and can be miscible with each other.
In terms of volatility, relatively speaking, its volatility is weak. Due to the strong intermolecular force, molecules are not easy to escape from the liquid surface and evaporate slowly in the air, which also makes it relatively slow during storage and use.
The physical properties of 2-bromo-4-chloro-1-methoxybenzene are determined by its molecular structure. These properties are of great significance for its separation, purification and application in organic synthesis, chemical production and other fields.
What are the chemical properties of 2-bromo-4-chloro-1-methoxybenzene?
2-Bromo-4-chloro-1-methoxybenzene is also an organic compound. Its chemical properties are particularly interesting and can be discussed from the polyend.
The first part of the nucleophilic substitution reaction. Because there are halogen atoms (bromine and chlorine) attached to the benzene ring, the halogen atoms have electron-absorbing properties, which can reduce the electron cloud density of the benzene ring. However, the methoxy group is the power supply group, which can make the electron cloud density of the ortho and para-position relatively increase. Therefore, nucleophilic reagents are prone to attack the carbon site attached to the halogen atom. For example, in the case of nucleophiles such as hydroxyl negative ions (OH), under suitable conditions, bromine or chlorine can be replaced by hydroxyl groups to form corresponding phenolic derivatives. This reaction needs to be carried out in an alkaline environment and at an appropriate temperature in order to occur smoothly.
The second study of electrophilic substitution reactions. Although there are electron-absorbing halogen atoms on the benzene ring, the electron-donating conjugation effect of the methoxy group is more significant, which increases the overall electron cloud density of the benzene ring, and mainly increases the density of the ortho and para-electron clouds. Electrophilic reagents are more inclined to attack the adjacent and para-position of the methoxy group. If there are electrophilic reagents such as nitro-positive ions (NO ²), nitrification can occur, and nitro groups are introduced into the ortho and para-positions of the methoxy group to generate nitro-substituted derivatives.
Then talk about the reaction with metal-organic reagents. 2-Bromo-4-chloro-1-methoxybenzene can interact with metal-organic reagents such as Grignard's reagent. The metal atoms in Grignard's reagent have nucleophilic properties and can form new bonds with the carbons attached to the halogen atoms, thereby increasing the carbon chain and generating organic compounds with more complex structures. This reaction is an important means to construct carbon-carbon bonds in organic synthesis.
In addition, the halogen atoms of 2-bromo-4-chloro-1-methoxybenzene can also participate in the halogen-metal exchange reaction. When interacting with lithium reagents, halogen atoms can be exchanged with lithium atoms to form organolithium compounds. This compound is also an important intermediate in organic synthesis and can further participate in a variety of reactions, such as reacting with carbonyl compounds to prepare alcohols.
In short, the functional groups contained in 2-bromo-4-chloro-1-methoxybenzene have diverse and important chemical properties in the field of organic synthesis. It can be converted into various organic compounds through many reactions and is commonly used in organic chemistry research and synthesis practice.
The first part of the nucleophilic substitution reaction. Because there are halogen atoms (bromine and chlorine) attached to the benzene ring, the halogen atoms have electron-absorbing properties, which can reduce the electron cloud density of the benzene ring. However, the methoxy group is the power supply group, which can make the electron cloud density of the ortho and para-position relatively increase. Therefore, nucleophilic reagents are prone to attack the carbon site attached to the halogen atom. For example, in the case of nucleophiles such as hydroxyl negative ions (OH), under suitable conditions, bromine or chlorine can be replaced by hydroxyl groups to form corresponding phenolic derivatives. This reaction needs to be carried out in an alkaline environment and at an appropriate temperature in order to occur smoothly.
The second study of electrophilic substitution reactions. Although there are electron-absorbing halogen atoms on the benzene ring, the electron-donating conjugation effect of the methoxy group is more significant, which increases the overall electron cloud density of the benzene ring, and mainly increases the density of the ortho and para-electron clouds. Electrophilic reagents are more inclined to attack the adjacent and para-position of the methoxy group. If there are electrophilic reagents such as nitro-positive ions (NO ²), nitrification can occur, and nitro groups are introduced into the ortho and para-positions of the methoxy group to generate nitro-substituted derivatives.
Then talk about the reaction with metal-organic reagents. 2-Bromo-4-chloro-1-methoxybenzene can interact with metal-organic reagents such as Grignard's reagent. The metal atoms in Grignard's reagent have nucleophilic properties and can form new bonds with the carbons attached to the halogen atoms, thereby increasing the carbon chain and generating organic compounds with more complex structures. This reaction is an important means to construct carbon-carbon bonds in organic synthesis.
In addition, the halogen atoms of 2-bromo-4-chloro-1-methoxybenzene can also participate in the halogen-metal exchange reaction. When interacting with lithium reagents, halogen atoms can be exchanged with lithium atoms to form organolithium compounds. This compound is also an important intermediate in organic synthesis and can further participate in a variety of reactions, such as reacting with carbonyl compounds to prepare alcohols.
In short, the functional groups contained in 2-bromo-4-chloro-1-methoxybenzene have diverse and important chemical properties in the field of organic synthesis. It can be converted into various organic compounds through many reactions and is commonly used in organic chemistry research and synthesis practice.
What are the common synthetic methods of 2-bromo-4-chloro-1-methoxybenzene?
2-Bromo-4-chloro-1-methoxybenzene is also an organic compound. The common methods of synthesis are about a few.
First, the method of using phenols as starting materials. Take the appropriate phenol first, so that it meets the halogenating agent. If a brominating agent is used, choose the appropriate one, and under suitable reaction conditions, such as in a specific solvent, control the temperature and reaction time, bromine atoms can be introduced into the phenol ring of the phenol to obtain bromine-containing phenolic derivatives. Then, the chlorination agent is applied, and the chlorine atoms are reintroduced at specific positions in the phenol ring according to the appropriate reaction situation. Finally, the phenols containing bromine and chlorine are interacted with methylating reagents, such as dimethyl sulfate or iodomethane. Under the catalysis of alkali, the phenolic hydroxyl group reacts with the methylating reagent to form a methoxy group, and 2-bromo-4-chloro-1-methoxybenzene is obtained.
Second, the method of using halogenated benzene as the starting material. First take halogenated benzene, such as chlorine or bromine-containing benzene, and react with metal reagents, such as Grignard reagents. Grignard reagents have good activity and can react with suitable halogenated alkoxy compounds. In this reaction, the alkoxy part of the halogenated alkoxy compound is connected to the benzene ring in the Grignard reagent. At the same time, the original halogen atom on the benzene ring can introduce another halogen atom through the reaction of halogen atom exchange or nucleophilic substitution according to specific reaction conditions. After these steps, the synthesis of 2-bromo-4-chloro-1-methoxybenzene can also be achieved.
Third, the method of synthesizing an aromatic compound through a multi-step substitution reaction. Select an aromatic substrate, first use an electrophilic substitution reaction, introduce a methoxy group, and then use bromination, chlorination and other electrophilic substitution steps in turn. According to the reaction positioning rules, by controlling the reaction conditions, such as selecting appropriate catalysts, solvents, temperatures, etc., the bromine atoms and chlorine atoms are replaced at specific positions in the benzene ring, and finally 2-bromo-4-chloro-1-methoxybenzene. All these synthesis methods require fine regulation of the reaction conditions in order to obtain products with higher yield and purity.
First, the method of using phenols as starting materials. Take the appropriate phenol first, so that it meets the halogenating agent. If a brominating agent is used, choose the appropriate one, and under suitable reaction conditions, such as in a specific solvent, control the temperature and reaction time, bromine atoms can be introduced into the phenol ring of the phenol to obtain bromine-containing phenolic derivatives. Then, the chlorination agent is applied, and the chlorine atoms are reintroduced at specific positions in the phenol ring according to the appropriate reaction situation. Finally, the phenols containing bromine and chlorine are interacted with methylating reagents, such as dimethyl sulfate or iodomethane. Under the catalysis of alkali, the phenolic hydroxyl group reacts with the methylating reagent to form a methoxy group, and 2-bromo-4-chloro-1-methoxybenzene is obtained.
Second, the method of using halogenated benzene as the starting material. First take halogenated benzene, such as chlorine or bromine-containing benzene, and react with metal reagents, such as Grignard reagents. Grignard reagents have good activity and can react with suitable halogenated alkoxy compounds. In this reaction, the alkoxy part of the halogenated alkoxy compound is connected to the benzene ring in the Grignard reagent. At the same time, the original halogen atom on the benzene ring can introduce another halogen atom through the reaction of halogen atom exchange or nucleophilic substitution according to specific reaction conditions. After these steps, the synthesis of 2-bromo-4-chloro-1-methoxybenzene can also be achieved.
Third, the method of synthesizing an aromatic compound through a multi-step substitution reaction. Select an aromatic substrate, first use an electrophilic substitution reaction, introduce a methoxy group, and then use bromination, chlorination and other electrophilic substitution steps in turn. According to the reaction positioning rules, by controlling the reaction conditions, such as selecting appropriate catalysts, solvents, temperatures, etc., the bromine atoms and chlorine atoms are replaced at specific positions in the benzene ring, and finally 2-bromo-4-chloro-1-methoxybenzene. All these synthesis methods require fine regulation of the reaction conditions in order to obtain products with higher yield and purity.
2-bromo-4-chloro-1-methoxybenzene in what areas?
2-Bromo-4-chloro-1-methoxybenzene, this compound has applications in many fields. In the field of medicinal chemistry, it is a key intermediate for the synthesis of specific drugs. Due to the unique electronic effects and spatial structure of bromine, chlorine and methoxy groups attached to the benzene ring, it can be modified by organic synthesis to prepare molecules with specific biological activities. For example, in the synthesis of some antibacterial drugs, it is used as a starting material to construct an effective structure that binds to bacterial targets through subsequent reactions to achieve antibacterial effect.
In the field of materials science, 2-bromo-4-chloro-1-methoxybenzene also has important uses. Due to its structural properties, it can participate in the preparation of polymer materials with specific functions. For example, it is introduced into the polymer system as a monomer or modifier, and the electronic conductivity and optical properties of the polymer are changed by its reaction with other monomers. In optoelectronic materials, after appropriate chemical modification, the compound may enable the material to have specific light absorption and emission properties, which can be used to manufacture optoelectronic devices such as organic Light Emitting Diodes (OLEDs).
In addition, in the field of pesticide chemistry, 2-bromo-4-chloro-1-methoxybenzene is also used. It can be chemically converted to synthesize compounds with insecticidal and herbicidal activities. The halogen atoms and methoxy groups in its structure can affect the interaction of compounds with specific targets in pests or weeds, thereby exerting the efficacy of pesticides and providing effective means for pest control in agricultural production. In short, 2-bromo-4-chloro-1-methoxybenzene plays an important role in many fields such as medicine, materials, and pesticides, providing a key chemical basis for the development of various fields.
In the field of materials science, 2-bromo-4-chloro-1-methoxybenzene also has important uses. Due to its structural properties, it can participate in the preparation of polymer materials with specific functions. For example, it is introduced into the polymer system as a monomer or modifier, and the electronic conductivity and optical properties of the polymer are changed by its reaction with other monomers. In optoelectronic materials, after appropriate chemical modification, the compound may enable the material to have specific light absorption and emission properties, which can be used to manufacture optoelectronic devices such as organic Light Emitting Diodes (OLEDs).
In addition, in the field of pesticide chemistry, 2-bromo-4-chloro-1-methoxybenzene is also used. It can be chemically converted to synthesize compounds with insecticidal and herbicidal activities. The halogen atoms and methoxy groups in its structure can affect the interaction of compounds with specific targets in pests or weeds, thereby exerting the efficacy of pesticides and providing effective means for pest control in agricultural production. In short, 2-bromo-4-chloro-1-methoxybenzene plays an important role in many fields such as medicine, materials, and pesticides, providing a key chemical basis for the development of various fields.
What are the precautions in the preparation of 2-bromo-4-chloro-1-methoxybenzene?
When preparing 2-bromo-4-chloro-1-methoxybenzene, there are several precautions to keep in mind.
The first to bear the brunt, the purity of the raw materials must be carefully controlled. If the starting materials used contain impurities, the purity and yield of the final product will be deeply affected. For example, the starting halogenated benzene, methoxylation reagents, etc., all need to be carefully purified to ensure that the raw materials are pure and flawless, which can pave the way for subsequent reactions.
Furthermore, the regulation of the reaction conditions is like controlling a horse and holding a rein, and it needs to be accurate. Temperature is a particularly critical item. If the temperature is too high, it is feared that side reactions will occur, such as excessive halogenation, demethoxylation and other adverse reactions, which will make the product complex and difficult to distinguish; if the temperature is too low, the reaction rate will be slow, time-consuming, and the yield will be greatly reduced. Therefore, during the reaction process, precision temperature control equipment must be used to keep the reaction temperature in an appropriate range. The choice of
reaction solvent is also critical to success or failure. The selected solvent needs to be well soluble in the reactants and compatible with the reaction system. For example, some polar solvents can increase the rate of ionic reactions, but if it is used for specific reactions such as nucleophilic substitution, or because of excessive interaction with reagents, the reaction will be hindered. Therefore, the solvent needs to be carefully selected according to the reaction mechanism and the characteristics of the reactants. The use of
catalyst should not be taken lightly. Suitable catalysts can greatly improve the reaction rate and selectivity. However, the amount of catalyst also needs to be accurately weighed. If the dosage is too small, the catalytic effect will not be good; if the dosage is too large, unnecessary side reactions may be triggered, and the cost will also rise.
The post-treatment stage should also not be underestimated. The separation and purification of the product requires appropriate methods according to the characteristics of the product. Means such as extraction, distillation, and recrystallization need to be used rationally to obtain high-purity 2-bromo-4-chloro-1-methoxybenzene. When operating, it is also necessary to pay attention to experimental safety. The reagents used are often toxic, corrosive, or flammable and explosive. Therefore, protective measures and operating specifications must be strictly followed to prevent accidents.
The first to bear the brunt, the purity of the raw materials must be carefully controlled. If the starting materials used contain impurities, the purity and yield of the final product will be deeply affected. For example, the starting halogenated benzene, methoxylation reagents, etc., all need to be carefully purified to ensure that the raw materials are pure and flawless, which can pave the way for subsequent reactions.
Furthermore, the regulation of the reaction conditions is like controlling a horse and holding a rein, and it needs to be accurate. Temperature is a particularly critical item. If the temperature is too high, it is feared that side reactions will occur, such as excessive halogenation, demethoxylation and other adverse reactions, which will make the product complex and difficult to distinguish; if the temperature is too low, the reaction rate will be slow, time-consuming, and the yield will be greatly reduced. Therefore, during the reaction process, precision temperature control equipment must be used to keep the reaction temperature in an appropriate range. The choice of
reaction solvent is also critical to success or failure. The selected solvent needs to be well soluble in the reactants and compatible with the reaction system. For example, some polar solvents can increase the rate of ionic reactions, but if it is used for specific reactions such as nucleophilic substitution, or because of excessive interaction with reagents, the reaction will be hindered. Therefore, the solvent needs to be carefully selected according to the reaction mechanism and the characteristics of the reactants. The use of
catalyst should not be taken lightly. Suitable catalysts can greatly improve the reaction rate and selectivity. However, the amount of catalyst also needs to be accurately weighed. If the dosage is too small, the catalytic effect will not be good; if the dosage is too large, unnecessary side reactions may be triggered, and the cost will also rise.
The post-treatment stage should also not be underestimated. The separation and purification of the product requires appropriate methods according to the characteristics of the product. Means such as extraction, distillation, and recrystallization need to be used rationally to obtain high-purity 2-bromo-4-chloro-1-methoxybenzene. When operating, it is also necessary to pay attention to experimental safety. The reagents used are often toxic, corrosive, or flammable and explosive. Therefore, protective measures and operating specifications must be strictly followed to prevent accidents.
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