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2-Bromo-4-Chloro-1-Methylbenzene
Linshang Chemical
|
HS Code |
448381 |
| Chemical Formula | C7H6BrCl |
| Molar Mass | 207.48 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 221 - 223 °C |
| Density | 1.578 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 99 °C |
| Vapor Pressure | Low vapor pressure at room temperature |
| Odor | Characteristic aromatic odor |
As an accredited 2-Bromo-4-Chloro-1-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - bromo - 4 - chloro - 1 - methylbenzene packaged in a sealed glass bottle. |
| Storage | 2 - Bromo - 4 - chloro - 1 - methylbenzene should be stored in a cool, well - ventilated area away from heat sources and open flames. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, strong acids, and bases to prevent chemical reactions. Label the storage container clearly with its name and relevant hazard information. |
| Shipping | 2 - bromo - 4 - chloro - 1 - methylbenzene, a chemical, should be shipped in tightly - sealed, corrosion - resistant containers. Ensure proper labeling indicating its hazardous nature. Ship via carriers compliant with chemical transportation regulations. |
Competitive 2-Bromo-4-Chloro-1-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the Chinese name for 2 - bromo - 4 - chloro - 1 - methylbenzene?
The name of 2 + -bromo-4-chloro-1-methylbenzene is the name under the nomenclature system of organic compounds. According to the quaint and elegant style of "Tiangong Kaiwu", it should be as follows.
Looking at this compound, its core is the benzene ring, which is a common structure in organic chemistry, like the base of the mansion. On the benzene ring, there are different substituents. "2-bromo" means that at the position where the benzene ring is numbered 2, there is a bromine atom attached, and the bromine atom is like a thing in the side hall of the mansion, which has unique characteristics. " 4-Chlorine "means that at the place where the benzene ring is numbered 4, the chlorine atom is attached to it, and the chlorine and bromine have their own properties, and the two are above the benzene ring, each according to one side. And" 1-methyl "refers to the position where the benzene ring is numbered 1, which is connected by methyl groups. The methyl group is like the side decoration of the door of the mansion. Although it is small, it also affects the overall appearance.
If these three are combined, this compound is called" 2-bromo-4-chloro-1-methylbenzene ". This naming makes the structure of the organic compound clear. Although it is not as complicated and delicate as the process described in Tiangong Kaiwu, it is also the key to accurately convey the characteristics of the substance in the field of chemistry. The naming convention follows the norms of modern chemistry. Although it is not a traditional name in ancient times, it allows chemical researchers to accurately recognize and distinguish various organic compounds in a concise and clear manner, just like a new paradigm to describe the multitude of chemical substances.
Looking at this compound, its core is the benzene ring, which is a common structure in organic chemistry, like the base of the mansion. On the benzene ring, there are different substituents. "2-bromo" means that at the position where the benzene ring is numbered 2, there is a bromine atom attached, and the bromine atom is like a thing in the side hall of the mansion, which has unique characteristics. " 4-Chlorine "means that at the place where the benzene ring is numbered 4, the chlorine atom is attached to it, and the chlorine and bromine have their own properties, and the two are above the benzene ring, each according to one side. And" 1-methyl "refers to the position where the benzene ring is numbered 1, which is connected by methyl groups. The methyl group is like the side decoration of the door of the mansion. Although it is small, it also affects the overall appearance.
If these three are combined, this compound is called" 2-bromo-4-chloro-1-methylbenzene ". This naming makes the structure of the organic compound clear. Although it is not as complicated and delicate as the process described in Tiangong Kaiwu, it is also the key to accurately convey the characteristics of the substance in the field of chemistry. The naming convention follows the norms of modern chemistry. Although it is not a traditional name in ancient times, it allows chemical researchers to accurately recognize and distinguish various organic compounds in a concise and clear manner, just like a new paradigm to describe the multitude of chemical substances.
What are the physical properties of 2 - bromo - 4 - chloro - 1 - methylbenzene?
2 + -Bromo-4 + -chloro-1 + -methylbenzene is an organic compound with specific physical properties. It is mostly liquid at room temperature and pressure, and has a special odor.
Looking at its color, it is usually almost colorless, but it is affected by impurities or has a yellowish hue.
When it comes to boiling point, it is about 220-230 ° C. This is due to intermolecular forces, including van der Waals forces and weak hydrogen bonds. The boiling point makes the compound change from liquid to gaseous at a specific temperature.
In terms of melting point, it is roughly around -20 ° C. At this temperature, the substance melts from a solid state to a liquid state. The melting point is related to the close arrangement of molecules and the force.
The density of
is about 1.4 to 1.5 g/cm ³, which is larger than that of water, so when mixed with water, it will sink to the bottom.
In terms of solubility, this compound is difficult to dissolve in water because it is a non-polar or weakly polar molecule, while water is a polar molecule. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in many organic solvents, such as ethanol, ether, benzene, etc., because these organic solvents are similar to its polarity.
In addition, the vapor pressure of 2 + -bromo-4 + -chloro-1 + -methyl benzene cannot be ignored. It increases with the increase of temperature, which affects the equilibrium between the gas phase and the liquid phase, and plays an important role in its diffusion and transport in the environment.
In summary, the physical properties of 2 + -bromo-4 + -chloro-1 + -methyl benzene are of key significance for its application in chemical, pharmaceutical and other fields.
Looking at its color, it is usually almost colorless, but it is affected by impurities or has a yellowish hue.
When it comes to boiling point, it is about 220-230 ° C. This is due to intermolecular forces, including van der Waals forces and weak hydrogen bonds. The boiling point makes the compound change from liquid to gaseous at a specific temperature.
In terms of melting point, it is roughly around -20 ° C. At this temperature, the substance melts from a solid state to a liquid state. The melting point is related to the close arrangement of molecules and the force.
The density of
is about 1.4 to 1.5 g/cm ³, which is larger than that of water, so when mixed with water, it will sink to the bottom.
In terms of solubility, this compound is difficult to dissolve in water because it is a non-polar or weakly polar molecule, while water is a polar molecule. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in many organic solvents, such as ethanol, ether, benzene, etc., because these organic solvents are similar to its polarity.
In addition, the vapor pressure of 2 + -bromo-4 + -chloro-1 + -methyl benzene cannot be ignored. It increases with the increase of temperature, which affects the equilibrium between the gas phase and the liquid phase, and plays an important role in its diffusion and transport in the environment.
In summary, the physical properties of 2 + -bromo-4 + -chloro-1 + -methyl benzene are of key significance for its application in chemical, pharmaceutical and other fields.
What are the chemical properties of 2 - bromo - 4 - chloro - 1 - methylbenzene?
2 + -Bromo-4 + -chloro-1 + -methylbenzene is an organic compound. It has the commonality of aromatic hydrocarbons, and its properties are relatively stable due to the structure of the benzene ring. However, it can also participate in a variety of reactions.
First, the electrophilic substitution reaction is an important property. The electron cloud density of the benzene ring is high, which is attractive to electrophilic reagents. If under appropriate conditions, it can interact with electrophilic reagents such as halogenating agents, nitrifying agents, and sulfonating agents. Taking the halogenation reaction as an example, in the presence of catalysts such as iron or iron salts, halogen atoms can be further introduced onto the benzene ring, and due to the positioning effect of methyl, bromine atoms and chlorine atoms, the positions of new Methyl groups are ortho and para-sites, while bromine and chlorine are ortho and para-sites, but due to the electron-absorbing induction effect, the electron cloud density of the benzene ring decreases, and the reaction activity decreases slightly. Therefore, the new substituents mainly enter the ortho and para-sites of methyl groups, and factors such as steric hindrance need to be comprehensively considered.
Second, the reaction of side chain methyl. Affected by the benzene ring, the α-hydrogen of methyl groups has a certain activity. Under light or high temperature conditions, free radical substitution reactions can occur. For example, when irradiated with halogen elements (such as chlorine), the hydrogen on methyl groups can be gradually replaced by chlorine atoms to form chlorinated benzyl derivatives.
Third, reduction reaction. Under specific reducing agents and conditions, the benzene ring can be partially or completely reduced. If a special catalyst and a suitable hydrogen source are used, the benzene ring can be hydrogenated to form a corresponding alicyclic compound, and this reaction can change the structure and properties of the molecule.
Fourth, in the presence of some basic conditions or nucleophiles, although the nucleophilic substitution of the benzene ring is difficult to occur, due to the presence of bromine and chlorine atoms, under specific activation conditions, nucleophilic substitution reactions may occur. Bromine or chlorine atoms can be replaced by nucleophilic reagents to generate new derivatives.
The interaction of each group in 2 + -bromo-4 + -chloro-1 + -methylbenzene molecules exhibits diverse chemical properties and is of great significance in organic synthesis and other fields.
First, the electrophilic substitution reaction is an important property. The electron cloud density of the benzene ring is high, which is attractive to electrophilic reagents. If under appropriate conditions, it can interact with electrophilic reagents such as halogenating agents, nitrifying agents, and sulfonating agents. Taking the halogenation reaction as an example, in the presence of catalysts such as iron or iron salts, halogen atoms can be further introduced onto the benzene ring, and due to the positioning effect of methyl, bromine atoms and chlorine atoms, the positions of new Methyl groups are ortho and para-sites, while bromine and chlorine are ortho and para-sites, but due to the electron-absorbing induction effect, the electron cloud density of the benzene ring decreases, and the reaction activity decreases slightly. Therefore, the new substituents mainly enter the ortho and para-sites of methyl groups, and factors such as steric hindrance need to be comprehensively considered.
Second, the reaction of side chain methyl. Affected by the benzene ring, the α-hydrogen of methyl groups has a certain activity. Under light or high temperature conditions, free radical substitution reactions can occur. For example, when irradiated with halogen elements (such as chlorine), the hydrogen on methyl groups can be gradually replaced by chlorine atoms to form chlorinated benzyl derivatives.
Third, reduction reaction. Under specific reducing agents and conditions, the benzene ring can be partially or completely reduced. If a special catalyst and a suitable hydrogen source are used, the benzene ring can be hydrogenated to form a corresponding alicyclic compound, and this reaction can change the structure and properties of the molecule.
Fourth, in the presence of some basic conditions or nucleophiles, although the nucleophilic substitution of the benzene ring is difficult to occur, due to the presence of bromine and chlorine atoms, under specific activation conditions, nucleophilic substitution reactions may occur. Bromine or chlorine atoms can be replaced by nucleophilic reagents to generate new derivatives.
The interaction of each group in 2 + -bromo-4 + -chloro-1 + -methylbenzene molecules exhibits diverse chemical properties and is of great significance in organic synthesis and other fields.
Where is 2 - bromo - 4 - chloro - 1 - methylbenzene used?
2 + -Bromo-4-chloro-1-methylbenzene is one of the organic compounds. This compound is useful in many fields.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. Due to the properties of halogen atoms and methyl groups in its structure, other specific functional groups can be introduced through many organic reactions, and then complex molecular structures with specific biological activities can be constructed. For example, nucleophilic substitution reactions can be used to prepare new drug molecules with antibacterial, anti-inflammatory and other effects.
In the field of materials science, 2 + -bromo-4-chloro-1-methylbenzene is also useful. It can be used as a starting material to prepare polymer materials with special properties by means of polymerization. For example, it can be polymerized with specific monomers, or polymers with good thermal stability and optical properties can be prepared, which can be used in optical lenses, electronic device packaging materials, etc.
Furthermore, in the field of pesticide chemistry, it can be used to synthesize new pesticides. By modifying its structure, the product is endowed with specific biological activities, so as to achieve the purpose of high-efficiency insecticide and weeding. Due to the existence of halogen atoms and methyl groups, the lipophilic properties and electron cloud distribution of the compound can be adjusted, making it easier to interact with specific targets of pests and weeds, and improve the efficacy of pesticides.
In summary, 2 + -bromo-4-chloro-1-methylbenzene plays an important role in many fields such as medicine, materials, and pesticides, and is of great significance in promoting the development of related fields.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. Due to the properties of halogen atoms and methyl groups in its structure, other specific functional groups can be introduced through many organic reactions, and then complex molecular structures with specific biological activities can be constructed. For example, nucleophilic substitution reactions can be used to prepare new drug molecules with antibacterial, anti-inflammatory and other effects.
In the field of materials science, 2 + -bromo-4-chloro-1-methylbenzene is also useful. It can be used as a starting material to prepare polymer materials with special properties by means of polymerization. For example, it can be polymerized with specific monomers, or polymers with good thermal stability and optical properties can be prepared, which can be used in optical lenses, electronic device packaging materials, etc.
Furthermore, in the field of pesticide chemistry, it can be used to synthesize new pesticides. By modifying its structure, the product is endowed with specific biological activities, so as to achieve the purpose of high-efficiency insecticide and weeding. Due to the existence of halogen atoms and methyl groups, the lipophilic properties and electron cloud distribution of the compound can be adjusted, making it easier to interact with specific targets of pests and weeds, and improve the efficacy of pesticides.
In summary, 2 + -bromo-4-chloro-1-methylbenzene plays an important role in many fields such as medicine, materials, and pesticides, and is of great significance in promoting the development of related fields.
What are the preparation methods of 2 - bromo - 4 - chloro - 1 - methylbenzene?
There are several ways to prepare 2-bromo-4-chloro-1-methylbenzene.
First, p-methyl chlorobenzene is used as the starting material. This substance first meets the brominating agent. Under appropriate reaction conditions, such as in the presence of a catalyst, bromine atoms can replace hydrogen atoms at specific positions on the benzene ring. Commonly used catalysts include iron or iron salts. Iron can react with bromine to form iron bromide, which can promote the reaction of bromine with p-methyl chlorobenzene. In a suitable temperature and solvent environment, bromine preferentially attacks the ortho-site of methyl, because methyl is an ortho-para-site group and the ortho-site electron cloud density is relatively high, so 2-bromo-4-chloro-1-methylbenzene can be obtained.
Second, it can start from p-methyl bromobenzene. React p-methyl bromobenzene with a chlorinating agent, and in the same way, with the assistance of a catalyst, the chlorine atoms in the chlorinating agent will attack the benzene ring. Suitable chlorinating agents, such as chlorine gas, can selectively enter the ortho-site or para-site of methyl under the action of catalysts such as aluminum trichloride. After appropriate reaction regulation, such as controlling the reaction temperature, time and the proportion of reactants, chlorine atoms can mainly enter the methyl ortho-site, so as to obtain the target product 2-bromo-4-chloro-1-methylbenzene.
Third, take toluene as the starting material and conduct chlorination reaction first. Toluene reacts with chlorine under light or catalyst conditions, and chlorine atoms may enter the ortho-site or para-site of methyl to form a mixture of o-chlorotoluene and p-chlorotoluene. Subsequently, p-chlorotoluene is separated and then reacted with a brominating agent. Under suitable conditions, the bromine atom replaces the hydrogen atom of the methyl ortho-position on the p-chlorotoluene benzene ring, and 2-bromo-4-chloro-1-methylbenzene can also be obtained.
There are generally several methods for preparing 2-bromo-4-chloro-1-methylbenzene. Each method has its own advantages and disadvantages, and it is necessary to choose the appropriate method according to the actual situation.
First, p-methyl chlorobenzene is used as the starting material. This substance first meets the brominating agent. Under appropriate reaction conditions, such as in the presence of a catalyst, bromine atoms can replace hydrogen atoms at specific positions on the benzene ring. Commonly used catalysts include iron or iron salts. Iron can react with bromine to form iron bromide, which can promote the reaction of bromine with p-methyl chlorobenzene. In a suitable temperature and solvent environment, bromine preferentially attacks the ortho-site of methyl, because methyl is an ortho-para-site group and the ortho-site electron cloud density is relatively high, so 2-bromo-4-chloro-1-methylbenzene can be obtained.
Second, it can start from p-methyl bromobenzene. React p-methyl bromobenzene with a chlorinating agent, and in the same way, with the assistance of a catalyst, the chlorine atoms in the chlorinating agent will attack the benzene ring. Suitable chlorinating agents, such as chlorine gas, can selectively enter the ortho-site or para-site of methyl under the action of catalysts such as aluminum trichloride. After appropriate reaction regulation, such as controlling the reaction temperature, time and the proportion of reactants, chlorine atoms can mainly enter the methyl ortho-site, so as to obtain the target product 2-bromo-4-chloro-1-methylbenzene.
Third, take toluene as the starting material and conduct chlorination reaction first. Toluene reacts with chlorine under light or catalyst conditions, and chlorine atoms may enter the ortho-site or para-site of methyl to form a mixture of o-chlorotoluene and p-chlorotoluene. Subsequently, p-chlorotoluene is separated and then reacted with a brominating agent. Under suitable conditions, the bromine atom replaces the hydrogen atom of the methyl ortho-position on the p-chlorotoluene benzene ring, and 2-bromo-4-chloro-1-methylbenzene can also be obtained.
There are generally several methods for preparing 2-bromo-4-chloro-1-methylbenzene. Each method has its own advantages and disadvantages, and it is necessary to choose the appropriate method according to the actual situation.
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