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2-Bromo-4-Chloro-1-Nitrobenzene
Linshang Chemical
|
HS Code |
620795 |
| Chemical Formula | C6H3BrClNO2 |
| Molar Mass | 236.45 g/mol |
| Appearance | Solid |
| Color | Yellow |
| Melting Point | 49 - 53 °C |
| Boiling Point | 284.5 °C at 760 mmHg |
| Density | 1.82 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Odor | Characteristic aromatic odor |
As an accredited 2-Bromo-4-Chloro-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 2 - bromo - 4 - chloro - 1 - nitrobenzene in a sealed, chemical - resistant bottle. |
| Storage | 2 - bromo - 4 - chloro - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is potentially flammable. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and bases to avoid chemical reactions. Label the storage container clearly for easy identification. |
| Shipping | 2 - bromo - 4 - chloro - 1 - nitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It must comply with hazardous chemical shipping regulations, with proper labeling indicating its toxic and potentially reactive nature. |
Competitive 2-Bromo-4-Chloro-1-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 2-Bromo-4-Chloro-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the Chinese name of 2-bromo-4-chloro-1-nitrobenzene?
This is the naming of 2-bromo-4-chloro-1-nitrobenzene. Its naming follows the naming rules for organic compounds. Above the benzene ring, the substituents are identified in a specific order. "2-bromo" indicates that the bromine atom is attached to the No. 2 carbon atom of the benzene ring; "4-chlorine", that is, the chlorine atom is located in the No. 4 carbon atom of the benzene ring; "1-nitro", the nitro group is attached to the No. 1 carbon atom of the benzene ring. In this way, the position of each substituent is precisely located by numbers, so that the structure of the compound can be clearly Therefore, this compound is called 2-bromo-4-chloro-1-nitrobenzene, which can accurately convey its molecular structure information and provide a clear and accurate basis for the exchange of related properties and reactions of this compound in the field of chemistry.
What are the main uses of 2-bromo-4-chloro-1-nitrobenzene?
2-Bromo-4-chloro-1-nitrobenzene is also an organic compound. It has a wide range of uses and is used in various fields of chemical industry.
First of all, it is often a key intermediate in the synthesis of medicine. Due to the properties of halogen atoms and nitro groups in its structure, it can introduce other functional groups through many chemical reactions to build complex drug molecular structures. For example, through nucleophilic substitution reactions, halogen atoms can be replaced by groups containing heteroatoms such as nitrogen and oxygen to prepare compounds with specific pharmacological activities, providing an important starting material for the creation of new drugs.
Furthermore, it also has important uses in the field of materials science. It can be integrated into the structure of the polymer through a specific reaction. Because it contains halogen atoms and nitro groups, it can give the material special properties, such as improving the flame retardancy of the material. Nitro and halogen atoms can participate in a series of chemical reactions when heated, inhibiting the combustion process, making the material more suitable for places that require fire protection performance, such as electronic equipment shells, building insulation materials, etc.
In addition, in the synthesis of pesticides, 2-bromo-4-chloro-1-nitrobenzene also plays an important role. It can be chemically converted to synthesize pesticide ingredients with insecticidal, bactericidal or herbicidal activities. Its structural characteristics can make it interact with specific targets in pests, pathogens or weeds, interfering with its normal physiological and biochemical processes, so as to achieve the purpose of control.
In summary, although 2-bromo-4-chloro-1-nitrobenzene is an organic compound, it has shown important uses in many fields such as medicine, materials, pesticides, etc., and promotes the development and progress of various fields due to its unique structure.
First of all, it is often a key intermediate in the synthesis of medicine. Due to the properties of halogen atoms and nitro groups in its structure, it can introduce other functional groups through many chemical reactions to build complex drug molecular structures. For example, through nucleophilic substitution reactions, halogen atoms can be replaced by groups containing heteroatoms such as nitrogen and oxygen to prepare compounds with specific pharmacological activities, providing an important starting material for the creation of new drugs.
Furthermore, it also has important uses in the field of materials science. It can be integrated into the structure of the polymer through a specific reaction. Because it contains halogen atoms and nitro groups, it can give the material special properties, such as improving the flame retardancy of the material. Nitro and halogen atoms can participate in a series of chemical reactions when heated, inhibiting the combustion process, making the material more suitable for places that require fire protection performance, such as electronic equipment shells, building insulation materials, etc.
In addition, in the synthesis of pesticides, 2-bromo-4-chloro-1-nitrobenzene also plays an important role. It can be chemically converted to synthesize pesticide ingredients with insecticidal, bactericidal or herbicidal activities. Its structural characteristics can make it interact with specific targets in pests, pathogens or weeds, interfering with its normal physiological and biochemical processes, so as to achieve the purpose of control.
In summary, although 2-bromo-4-chloro-1-nitrobenzene is an organic compound, it has shown important uses in many fields such as medicine, materials, pesticides, etc., and promotes the development and progress of various fields due to its unique structure.
What are the physical properties of 2-bromo-4-chloro-1-nitrobenzene?
2-Bromo-4-chloro-1-nitrobenzene is one of the organic compounds. Its physical properties are worthy of detailed investigation.
In terms of its appearance, it is usually in a solid state, or a powder, or a crystalline shape, depending on the conditions of the environment. Its color is usually non-solid or slightly yellow, due to the interaction between the molecular structure and the elements contained.
As for the melting point, after many experiments, it is about a specific temperature range. The interaction forces between the cover molecules, such as van der Waals force, hydrogen bonds, etc., together determine the level of its melting point. The presence of bromine, chlorine, nitro and other functional groups in this compound makes the intermolecular forces complex and changeable, which in turn affects the melting point.
The boiling point is also one of the important physical properties. Due to the large molecular weight and the influence of the polarity of the functional groups, the attractive force between the molecules is enhanced, and its boiling point is in a corresponding higher range. When heated, the molecules can break free from each other and reach the boiling point and vaporize.
In terms of solubility, the solubility in water is very small. This is because water is a polar solvent, and although the compound contains polar functional groups, the polarity of the benzene ring is quite different from that of water. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, organic solvents, such as ethanol, ether, etc., have relatively high solubility due to the combination of polarity and molecular structure of organic solvents.
The measurement of density shows that it is greater than the density of water. Due to the wide variety of atoms in the molecule, the mass is larger, and the spatial arrangement is close, resulting in the mass per unit volume is greater than that of water.
In summary, the physical properties of 2-bromo-4-chloro-1-nitrobenzene are closely related to their unique molecular structure, and each property is of great significance in chemical research, industrial applications and other fields.
In terms of its appearance, it is usually in a solid state, or a powder, or a crystalline shape, depending on the conditions of the environment. Its color is usually non-solid or slightly yellow, due to the interaction between the molecular structure and the elements contained.
As for the melting point, after many experiments, it is about a specific temperature range. The interaction forces between the cover molecules, such as van der Waals force, hydrogen bonds, etc., together determine the level of its melting point. The presence of bromine, chlorine, nitro and other functional groups in this compound makes the intermolecular forces complex and changeable, which in turn affects the melting point.
The boiling point is also one of the important physical properties. Due to the large molecular weight and the influence of the polarity of the functional groups, the attractive force between the molecules is enhanced, and its boiling point is in a corresponding higher range. When heated, the molecules can break free from each other and reach the boiling point and vaporize.
In terms of solubility, the solubility in water is very small. This is because water is a polar solvent, and although the compound contains polar functional groups, the polarity of the benzene ring is quite different from that of water. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, organic solvents, such as ethanol, ether, etc., have relatively high solubility due to the combination of polarity and molecular structure of organic solvents.
The measurement of density shows that it is greater than the density of water. Due to the wide variety of atoms in the molecule, the mass is larger, and the spatial arrangement is close, resulting in the mass per unit volume is greater than that of water.
In summary, the physical properties of 2-bromo-4-chloro-1-nitrobenzene are closely related to their unique molecular structure, and each property is of great significance in chemical research, industrial applications and other fields.
What are the chemical properties of 2-bromo-4-chloro-1-nitrobenzene?
2-Bromo-4-chloro-1-nitrobenzene is also an organic compound. Its activity is due to the coexistence of bromine, chlorine and nitro functional groups on the benzene ring.
Nitro group has strong electron absorption, which reduces the electron cloud density of the benzene ring and greatly reduces the activity of the electrophilic substitution reaction of the benzene ring. However, in the nucleophilic substitution reaction, nitro can reduce the electron cloud density of the carbon atoms in the adjacent and para-position of the benzene ring even more, so the nucleophilic reagent is easy to attack the ortho and para-position, which is one of its remarkable chemical characteristics.
Bromine and chlorine are both halogen atoms, but the activity of bromine is slightly higher than that of chlorine. Both can undergo substitution reactions under appropriate conditions. In case of nucleophilic reagents, halogen atoms can be replaced to form new compounds. When treated with strong nucleophilic reagents such as sodium alcohol and amines, bromine atoms or chlorine atoms can be replaced by alkoxy groups, amino groups, etc.
And because it contains nitro groups, it is oxidizing. In a specific reaction environment, nitro groups can be reduced to form different functional groups such as amino groups, and various reaction pathways can be derived. In addition, 2-bromo-4-chloro-1-nitrobenzene can participate in the coupling reaction. With the power of metal catalysts, it can be connected with other organic halides or organometallic reagents to construct more complex organic molecular structures, which is quite valuable in the field of organic synthesis. Overall, its chemical properties are complex and diverse, making it an important intermediate in organic synthetic chemistry.
Nitro group has strong electron absorption, which reduces the electron cloud density of the benzene ring and greatly reduces the activity of the electrophilic substitution reaction of the benzene ring. However, in the nucleophilic substitution reaction, nitro can reduce the electron cloud density of the carbon atoms in the adjacent and para-position of the benzene ring even more, so the nucleophilic reagent is easy to attack the ortho and para-position, which is one of its remarkable chemical characteristics.
Bromine and chlorine are both halogen atoms, but the activity of bromine is slightly higher than that of chlorine. Both can undergo substitution reactions under appropriate conditions. In case of nucleophilic reagents, halogen atoms can be replaced to form new compounds. When treated with strong nucleophilic reagents such as sodium alcohol and amines, bromine atoms or chlorine atoms can be replaced by alkoxy groups, amino groups, etc.
And because it contains nitro groups, it is oxidizing. In a specific reaction environment, nitro groups can be reduced to form different functional groups such as amino groups, and various reaction pathways can be derived. In addition, 2-bromo-4-chloro-1-nitrobenzene can participate in the coupling reaction. With the power of metal catalysts, it can be connected with other organic halides or organometallic reagents to construct more complex organic molecular structures, which is quite valuable in the field of organic synthesis. Overall, its chemical properties are complex and diverse, making it an important intermediate in organic synthetic chemistry.
What are 2-bromo-4-chloro-1-nitrobenzene synthesis methods?
To prepare 2-bromo-4-chloro-1-nitrobenzene, the following ancient method can be used.
First, benzene is used as the starting material. First, the benzene is nitrified by co-heating with concentrated nitric acid and concentrated sulfuric acid to obtain nitrobenzene. In this step, temperature control is required to prevent the formation of polynitrogroups. Nitrobenzene is the product of the nitrofication of aromatic hydrocarbons, and the electron cloud density on the benzene ring is reduced due to the electron-absorbing effect of the nitro group.
Then, p-nitrobenzene is halogenated. Because nitro is the meta-locator, to obtain the position of chlorine in the target substance, suitable halogenation conditions should be selected. Under the catalysis of iron or ferric chloride, nitrobenzene can react with chlorine to obtain m-chlor This catalytic reaction can promote the introduction of chlorine atoms into the benzene ring meta-site.
Finally, m-chloronitrobenzene reacts with bromine. Under the action of appropriate solvents and catalysts, such as in the catalysis of iron bromide and carbon tetrachloride, bromine is substituted for hydrogen at a specific position in the benzene ring to obtain 2-bromo-4-chloro-1-nitrobenzene. In this series of reactions, the control of each step is extremely critical. Temperature, reagent ratio, etc. all affect the purity and yield of the product.
There is another method, which can first halogenate benzene. Under the catalysis of iron or iron halide, it reacts with chlorine to obtain chlorobenzene. Chlorine in chlorobenzene is an ortho-para-site group, which makes the After
, chlorobenzene is nitrified. The mixture of o-nitrochlorobenzene and p-nitrochlorobenzene is obtained by mixed acid (concentrated nitric acid and concentrated sulfuric acid). Separation methods such as distillation, recrystallization, etc. are required to obtain the target p-nitrochlorobenzene.
Finally, p-nitrochlorobenzene reacts with bromine. Under suitable conditions, bromine can also be substituted for specific hydrogen atoms in the benzene ring to obtain 2-bromo-4-chloro-1-nitrobenzene. This approach also requires fine control of the reaction conditions at each step to achieve the purpose of optimal yield and high purity.
First, benzene is used as the starting material. First, the benzene is nitrified by co-heating with concentrated nitric acid and concentrated sulfuric acid to obtain nitrobenzene. In this step, temperature control is required to prevent the formation of polynitrogroups. Nitrobenzene is the product of the nitrofication of aromatic hydrocarbons, and the electron cloud density on the benzene ring is reduced due to the electron-absorbing effect of the nitro group.
Then, p-nitrobenzene is halogenated. Because nitro is the meta-locator, to obtain the position of chlorine in the target substance, suitable halogenation conditions should be selected. Under the catalysis of iron or ferric chloride, nitrobenzene can react with chlorine to obtain m-chlor This catalytic reaction can promote the introduction of chlorine atoms into the benzene ring meta-site.
Finally, m-chloronitrobenzene reacts with bromine. Under the action of appropriate solvents and catalysts, such as in the catalysis of iron bromide and carbon tetrachloride, bromine is substituted for hydrogen at a specific position in the benzene ring to obtain 2-bromo-4-chloro-1-nitrobenzene. In this series of reactions, the control of each step is extremely critical. Temperature, reagent ratio, etc. all affect the purity and yield of the product.
There is another method, which can first halogenate benzene. Under the catalysis of iron or iron halide, it reacts with chlorine to obtain chlorobenzene. Chlorine in chlorobenzene is an ortho-para-site group, which makes the After
, chlorobenzene is nitrified. The mixture of o-nitrochlorobenzene and p-nitrochlorobenzene is obtained by mixed acid (concentrated nitric acid and concentrated sulfuric acid). Separation methods such as distillation, recrystallization, etc. are required to obtain the target p-nitrochlorobenzene.
Finally, p-nitrochlorobenzene reacts with bromine. Under suitable conditions, bromine can also be substituted for specific hydrogen atoms in the benzene ring to obtain 2-bromo-4-chloro-1-nitrobenzene. This approach also requires fine control of the reaction conditions at each step to achieve the purpose of optimal yield and high purity.
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